Title:
MULTI-PEG LIPID COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2020/097376
Kind Code:
A8
Abstract:
The compounds disclosed herein (e.g., compounds of Formula (I), (II), (III), and (IV)) comprise a lipid substructure comprising a hydrophobic moiety and a hydrophilic moiety; and two or more polymeric groups (e.g., two or more polyethylene glycol (PEG) groups). The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
Inventors:
KARVE SHRIRANG (US)
ZHANG YI (US)
DEROSA FRANK (US)
HEARTLEIN MICHAEL (US)
ZHANG YI (US)
DEROSA FRANK (US)
HEARTLEIN MICHAEL (US)
Application Number:
PCT/US2019/060335
Publication Date:
June 10, 2021
Filing Date:
November 07, 2019
Export Citation:
Assignee:
TRANSLATE BIO INC (US)
International Classes:
C08G65/331; A61K38/00; A61K47/50; A61K47/54; C08G65/332; C08G65/333
Attorney, Agent or Firm:
ESPINO, Christine et al. (US)
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