Title:
MULTI-SPECIFIC ANTIBODY TARGETING BCMA, GPRC5D AND T CELLS AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/236889
Kind Code:
A1
Abstract:
The present application relates to a multi-specific binding molecule targeting BCMA, GPRC5D and T cell receptors. Specifically, the present application discloses a BCMA-GPRC5D-CD3 multi-specific antibody, which can activate T cells while binding to tumor surface antigens, thereby promoting specific killing of tumor cells by T cells, especially BCMA or GPRC5D-positive multiple myeloma. The present application also provides a preparation method for and an application of the multi-specific binding molecule.
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Inventors:
FU YAYUAN (CN)
YOU SHUMEI (CN)
LIAO JINGLI (CN)
CAO ZHUOXIAO (CN)
TANG RENHONG (CN)
YOU SHUMEI (CN)
LIAO JINGLI (CN)
CAO ZHUOXIAO (CN)
TANG RENHONG (CN)
Application Number:
PCT/CN2023/098241
Publication Date:
December 14, 2023
Filing Date:
June 05, 2023
Export Citation:
Assignee:
SHANDONG SIMCERE BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
A61K39/395; C07K16/46; A61P35/00; C07K16/28; C07K16/30; C07K19/00; C12N5/10; C12N15/13; C12N15/63; C12P21/00
Domestic Patent References:
| WO2022174813A1 | 2022-08-25 | |||
| WO2022175255A2 | 2022-08-25 | |||
| WO2023036326A1 | 2023-03-16 |
Foreign References:
| CN112384534A | 2021-02-19 | |||
| CN112368019A | 2021-02-12 | |||
| CN109715667A | 2019-05-03 |
Other References:
LANCMAN GUIDO, RICHTER JOSHUA, CHARI AJAI: "Bispecifics, trispecifics, and other novel immune treatments in myeloma", HEMATOLOGY, vol. 2020, no. 1, 4 December 2020 (2020-12-04), pages 264 - 271, XP055964173, DOI: 10.1182/hematology.2020000110
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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