MULTI-SPECIFIC BINDING PROTEINS FOR CANCER TREATMENT

WIPO Patent Application WO/2021/064137

A3

The present invention relates to novel B7H6/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

HIPP SUSANNE (DE)
ADAM PAUL (DE)
DZIEGELEWSKI MICHAEL (US)
GANESAN RAJKUMAR (US)
GORMAN PHILIP NICHOLAS (US)
GUPTA PANKAJ (US)
GUPTA PRIYANKA (US)
LASARO MARCIO (US)
SCHEER JUSTIN M (US)
VOYNOV VLADIMIR H (US)

PCT/EP2020/077586

May 14, 2021

October 01, 2020

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BOEHRINGER INGELHEIM INT (DE)

C07K16/28; A61P35/00

WO2017181001A1	2017-10-19
WO2013169691A1	2013-11-14
WO2012162067A2	2012-11-29

ANONYMOUS: "mab10162: Human/Cynomolgus Monkey B7-H6 Antibody", R&D SYSTEMS PRODUCT CATALOG, 28 May 2019 (2019-05-28), pages 1 - 2, XP055683034, Retrieved from the Internet [retrieved on 20200406]
CAMERON S. BRANDT ET AL: "IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 163, no. 7, 15 June 2009 (2009-06-15), US, pages 4041 - 1503, XP055276540, ISSN: 0022-1007, DOI: 10.1084/jem.20090681

SIMON, Elke Anna Maria et al. (DE)

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