Title:
MULTI-SUBSTITUTED BENZENE COMPOUND HAVING BIOLOGICAL ACTIVITY, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/153954
Kind Code:
A1
Abstract:
Disclosed are a multi-substituted benzene compound having biological activity, a preparation method therefor, and an application thereof. The compound of the present invention has good biological activity and the activity of inhibiting tumor cell proliferation, and can be used as a lead compound for the research and development of novel drugs and for the preparation of anti-tumor drugs, such as drugs for the treatment of gastric cancer, ovarian cancer, lung cancer, or prostate cancer. The synthesis method of the present invention has wide availability of raw materials, ease of operation, short route, mild reaction conditions, low costs, and a potential value for industrialization.
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Inventors:
ZHU SHIFA (CN)
CAO TONGXIANG (CN)
WANG YONGDONG (CN)
HUANG ZHIPENG (CN)
CAO TONGXIANG (CN)
WANG YONGDONG (CN)
HUANG ZHIPENG (CN)
Application Number:
PCT/CN2018/125074
Publication Date:
August 15, 2019
Filing Date:
December 28, 2018
Export Citation:
Assignee:
GENIFARM LABORATORIES INC (CN)
UNIV SOUTH CHINA TECH (CN)
UNIV SOUTH CHINA TECH (CN)
International Classes:
C07D307/88; A61P35/00; C07C13/36; C07C47/57; C07D333/72
Foreign References:
| CN101928270A | 2010-12-29 | |||
| US4500543A | 1985-02-19 |
Other References:
W. R. ALLISONW ET AL.: "875.Phthalans. Part II. Ultraviolet and Infrared Spectra", JOURNAL OF THE CHEMICAL SOCIETY, 1958, pages 4311 - 4314, XP055630850, ISSN: 0368-1769
CHANDRASEKARAN PRAVEEN ET AL.: "Regioselective synthesis of phthalans via Cu(OTf)2-catalyzed 5-exo-dig intramolecular hydroalkoxylation of 2- (ethynyl)benzyl alcohols", TETRAHEDRON LETTERS, vol. 51, no. 36, 8 July 2010 (2010-07-08), pages 4767 - 4771, XP027192652, ISSN: 0040-4039
See also references of EP 3753931A4
CHANDRASEKARAN PRAVEEN ET AL.: "Regioselective synthesis of phthalans via Cu(OTf)2-catalyzed 5-exo-dig intramolecular hydroalkoxylation of 2- (ethynyl)benzyl alcohols", TETRAHEDRON LETTERS, vol. 51, no. 36, 8 July 2010 (2010-07-08), pages 4767 - 4771, XP027192652, ISSN: 0040-4039
See also references of EP 3753931A4
Attorney, Agent or Firm:
YOGO PATENT & TRADEMARK AGENCY LIMITED COMPANY (CN)
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