Title:
MULTI-SUBSTITUTED THIAZOLE DERIVATIVE AND APPLICATION THEREOF IN DISEASE TREATMENT
Document Type and Number:
WIPO Patent Application WO/2023/011312
Kind Code:
A1
Abstract:
The present application belongs to the field of medicine, and discloses a multi-substituted thiazole derivative and an application thereof in disease treatment. Specifically, disclosed are a compound represented by formula I or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound represented by formula I or the pharmaceutically acceptable salt thereof, and an application thereof in the treatment or prevention of dihydroorotate dehydrogenase-mediated diseases, including tumors, viral infections, and immune diseases.
Inventors:
DUAN SHUDONG (CN)
QIN JIHONG (CN)
QIN JIHONG (CN)
Application Number:
PCT/CN2022/108625
Publication Date:
February 09, 2023
Filing Date:
July 28, 2022
Export Citation:
Assignee:
SHANGHAI HUILUN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D277/50; A61K31/426; A61K31/433; A61P31/12; A61P35/00; A61P37/00; C07D285/135
Domestic Patent References:
| WO2018192535A1 | 2018-10-25 | |||
| WO2017198178A1 | 2017-11-23 | |||
| WO2017206955A1 | 2017-12-07 | |||
| WO2013056684A2 | 2013-04-25 |
Foreign References:
| CN113813258A | 2021-12-21 | |||
| US4319026A | 1982-03-09 | |||
| CN106892878A | 2017-06-27 | |||
| CN112707874A | 2021-04-27 |
Other References:
SONG, WENLIN ET AL.: "Structure-based design of potent human dihydroorotate dehydrogenase inhibitors as anticancer agents", MED. CHEM. COMMUN., vol. 7, no. 7, 13 June 2016 (2016-06-13), XP055625552, ISSN: 2040-2503, DOI: 10.1039/C6MD00179C
RUI XIONG, ZHANG LEIKE, LI SHILIANG, SUN YUAN, DING MINYI, WANG YONG, ZHAO YONGLIANG, WU YAN, SHANG WEIJUAN, JIANG XIAMING, SHAN J: "Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2", BIORXIV, 12 March 2020 (2020-03-12), XP055740305, Retrieved from the Internet [retrieved on 20201015], DOI: 10.1101/2020.03.11.983056
SHAN JI-WEI, TIAN-TIAN QI, LI HONG-LIN, ZHU LI-LI, ZHAO ZHEN-JIANG: "Synthesis, stability and activity of the prodrugs of dihydroorotate dehydrogenase inhibitors", ACTA PHARMACEUTICA SINICA, YAOXUE XUEBAO, CN, vol. 53, no. 3, 2 March 2018 (2018-03-02), CN , pages 410 - 415, XP093031774, ISSN: 0513-4870, DOI: 10.16438/j.0513-4870.2017-0992
DATABASE REGISTRY ANONYMOUS : "Thiazole, 4-(2-chlorophenyl)-2-(1-methylhydrazinyl)- (CA INDEX NAME)", XP093031776, retrieved from STN
RUI XIONG, ZHANG LEIKE, LI SHILIANG, SUN YUAN, DING MINYI, WANG YONG, ZHAO YONGLIANG, WU YAN, SHANG WEIJUAN, JIANG XIAMING, SHAN J: "Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2", BIORXIV, 12 March 2020 (2020-03-12), XP055740305, Retrieved from the Internet
SHAN JI-WEI, TIAN-TIAN QI, LI HONG-LIN, ZHU LI-LI, ZHAO ZHEN-JIANG: "Synthesis, stability and activity of the prodrugs of dihydroorotate dehydrogenase inhibitors", ACTA PHARMACEUTICA SINICA, YAOXUE XUEBAO, CN, vol. 53, no. 3, 2 March 2018 (2018-03-02), CN , pages 410 - 415, XP093031774, ISSN: 0513-4870, DOI: 10.16438/j.0513-4870.2017-0992
DATABASE REGISTRY ANONYMOUS : "Thiazole, 4-(2-chlorophenyl)-2-(1-methylhydrazinyl)- (CA INDEX NAME)", XP093031776, retrieved from STN
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
Download PDF: