MULTICYCLIC COMPOUNDS AND METHODS OF USING SAME

Title:

MULTICYCLIC COMPOUNDS AND METHODS OF USING SAME

Document Type and Number:

WIPO Patent Application WO/2015/042414

Kind Code:

A8

Abstract:

The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

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Inventors:

BALOGLU ERKAN (US)
SHACHAM SHARON (US)
SENAPEDIS WILLIAM (US)
MCCAULEY DILARA (US)
LANDESMAN YOSEF (US)
GOLAN GALI (IL)
KALID ORI (IL)
SHECHTER SHARON (US)

Application Number:

PCT/US2014/056580

Publication Date:

August 06, 2015

Filing Date:

September 19, 2014

Export Citation:

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Assignee:

KARYOPHARM THERAPEUTICS INC (US)

International Classes:

C07D401/14; A61K31/433; A61P35/00; C07D213/73; C07D401/12; C07D413/12; C07D417/12; C07D419/12

Attorney, Agent or Firm:

ABELLEIRA, Susan, M. et al. (Brook Smith & Reynolds, P.C.,530 Virginia Rd, P.O. Box 913, Concord MA, US)

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