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Title:
MULTIDRUG RESISTANCE (MDR) EFFLUX PUMP POLYPEPTIDES
Document Type and Number:
WIPO Patent Application WO2001079257
Kind Code:
A3
Abstract:
The invention features methods of determining whether a nucleotide sequence encodes an MDR efflux pump, methods for deleting a desired region of DNA in a bacterial cell, methods for determining whether a test substance inhibits the growth or metabolism of cells of a strain of E. faecalis bacteria having a disruptive mutation in a gene encoding a MDR efflux pump, methods for determining whether a test substance includes a compound that blocks efflux of an antibacterial agent from a cell, and methods for identifying an inhibitor of an MDR pump.

Inventors:
DAVIS DEBORAH VANRIET
ROGERS BRUCE LEE
WHITE ABIGAIL COFFIN
Application Number:
PCT/US2001/012230
Publication Date:
March 21, 2002
Filing Date:
April 12, 2001
Export Citation:
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Assignee:
PHYTERA INC (US)
International Classes:
C07K14/315; C12N15/74; (IPC1-7): G06F19/00
Domestic Patent References:
WO1998014784A11998-04-09
WO1998050555A21998-11-12
WO2001007034A12001-02-01
WO1997040160A11997-10-30
Foreign References:
US5989832A1999-11-23
US5885786A1999-03-23
US5866699A1999-02-02
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