Title:
MULTIFUNCTIONAL LIGAND FOR USE AS A DIAGNOSTIC OR THERAPEUTIC PHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO1995029669
Kind Code:
A3
Abstract:
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from the phosphorous or germanium core.
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Inventors:
KATTI KATTESH V
VOLKERT WYNN A
KETRING ALAN
SINGH PRAHLAD R
VOLKERT WYNN A
KETRING ALAN
SINGH PRAHLAD R
Application Number:
PCT/US1995/003629
Publication Date:
February 14, 2002
Filing Date:
March 27, 1995
Export Citation:
Assignee:
UNIV MISSOURI (US)
International Classes:
A61K31/047; A61K31/28; A61K31/66; A61K31/675; A61K31/695; A61K39/395; A61K49/00; A61K49/06; A61K49/08; A61K51/00; A61K51/04; A61P35/00; A61P43/00; C07B59/00; C07F7/00; C07F7/30; A61K38/00; C07F9/06; C07F9/22; C07F9/24; C07F9/44; C07F9/535; C07F13/00; C07F15/00; C07F15/06; C07F19/00; (IPC1-7): A61K31/15; A61K31/19; A61K31/66; A61K31/135; A61K31/165; A61K31/235; A61K31/675; A61K31/695; C07D241/04; C07F7/10; C07F7/30; C07F9/50; C07F9/53; C07F13/00; C07F15/02; C07F15/06
Other References:
MAJORAL J.P. ET AL.: "Heterocycles contenant du phosphore - XXIX", TETRAHEDRON, vol. 32, 1976, pages 2633 - 2644
NOTH H. ET AL.: "Die Stabilisierung von Tris (hydrazino)phosphan durch Kemplexbildung", Z. NATURFORSCH., vol. 36B, 1981, pages 659 - 661
MAISCH H.: "Die Stabilisierung von Phosphanen P(nhx)3 durch Ligandenreaktionene am Pentacarbonyl(trichlorophosphan) molybdan(O)", Z. NATURFORSCH., vol. 34B, 1979, pages 784 - 789
CATES L.A. ET AL.: "Phosphorus-nitrogen compounds XVIII: Hydrazides and thiosemicarbazides", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 63, no. 11, November 1974 (1974-11-01), pages 1736 - 1737
HORN H. ET AL.: "Datstellung von thiophosphoryltrihydrazid und 1-phenyl-2-difluorthiophosphoryl-hydrazin", CHEMISCHE BERICHTE, vol. 100, no. 7, 1967, pages 2258 - 2260
MAJORAL J.P. ET AL.: "Heterocyclic compounds containing phosphorus. Part 30. Synthesis of mixed phosphorohydrazides and of some new mono-, bi- and tri-cyclic derivatives", JOURNAL OF THE CHEMICAL SOCIETY, PERKINS TRANSACTIONS 1, 1976, pages 2093 - 2098
CHEMICAL ABSTRACTS, vol. 105, no. 5, 1986, Columbus, Ohio, US; abstract no. 52955G, AL-RAWI ET AL.: "Carbon-13 chemical shift assignment of some organophosphorus compounds. VI. Aryl, aryloxy, phenylhydrazino and alkylamino substituted thiophosphoric hydrazines and cyclic analogs"
CHEMICAL ABSTRACTS, vol. 99, no. 25, 1983, Columbus, Ohio, US; abstract no. 212591N, BAKHTIYAROVA F.A. ET AL.: "Reaction of monochloroacetic acid with diamides, hydrazides and dihydrazides of phosphorous acids in the presence of ammonium thiocyanate"
CHEMICAL ABSTRACTS, vol. 93, no. 11, 1980, Columbus, Ohio, US; abstract no. 114466G, MAJORAL J.P.: "Heterocyclic compounds containing phosphorus. Part 35. New reactions of phosphorohydrazidic derivatives with aldehydes; production of macropolycyclic compounds"
CHEMICAL ABSTRACTS, vol. 88, no. 7, 1978, Columbus, Ohio, US; abstract no. 50967H, MAJORAL J.P. ET AL.: "Heterocycles containing phosphorus. XXXII. Study of the reaction of phosphorus hydrazides with ortho esters, acetic anhydride and formic acid"
CHEMICAL ABSTRACTS, vol. 87, no. 19, 1977, Columbus, Ohio, US; abstract no. 152323S, GRAPOV A.F. ET AL.: "Some reactions of phosphorus thio acid dihydrazides"
CHEMICAL ABSTRACTS, vol. 85, no. 18, 1976, Columbus, Ohio, US; abstract no. 136429J, AGGARWAL R.C. ET AL.: "Complexes of germanium (IV) and tin(IV) chlorides with N-salicyloylhydrazine, N-acetyl-N'-salicyloylhydrazine and N-benzoyl-N'-salicyloylhydrazine"
CHEMICAL ABSTRACTS, vol. 76, no. 20, 1972, Columbus, Ohio, US; abstract no. 113579H, HUANG Y. ET AL.: "Polymers containing phosphorus. X. Polyaddition of diisocyanates and diisothiocyanates to phosphorous-containing dihydrazides"
CHEMICAL ABSTRACTS, vol. 74, no. 22, 1970, Columbus, Ohio, US; abstract no. 118424X, SMALL F.E.: "Recording sheet, suitable for thermographic reproduction"
CHEMICAL ABSTRACTS, vol. 69, no. 25, 1968, Columbus, Ohio, US; abstract no. 106808J, SCOLA D.A. ET AL.: "N,N'-disubstituted P-phenylphosphonothioic diamides"
NOTH H. ET AL.: "Die Stabilisierung von Tris (hydrazino)phosphan durch Kemplexbildung", Z. NATURFORSCH., vol. 36B, 1981, pages 659 - 661
MAISCH H.: "Die Stabilisierung von Phosphanen P(nhx)3 durch Ligandenreaktionene am Pentacarbonyl(trichlorophosphan) molybdan(O)", Z. NATURFORSCH., vol. 34B, 1979, pages 784 - 789
CATES L.A. ET AL.: "Phosphorus-nitrogen compounds XVIII: Hydrazides and thiosemicarbazides", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 63, no. 11, November 1974 (1974-11-01), pages 1736 - 1737
HORN H. ET AL.: "Datstellung von thiophosphoryltrihydrazid und 1-phenyl-2-difluorthiophosphoryl-hydrazin", CHEMISCHE BERICHTE, vol. 100, no. 7, 1967, pages 2258 - 2260
MAJORAL J.P. ET AL.: "Heterocyclic compounds containing phosphorus. Part 30. Synthesis of mixed phosphorohydrazides and of some new mono-, bi- and tri-cyclic derivatives", JOURNAL OF THE CHEMICAL SOCIETY, PERKINS TRANSACTIONS 1, 1976, pages 2093 - 2098
CHEMICAL ABSTRACTS, vol. 105, no. 5, 1986, Columbus, Ohio, US; abstract no. 52955G, AL-RAWI ET AL.: "Carbon-13 chemical shift assignment of some organophosphorus compounds. VI. Aryl, aryloxy, phenylhydrazino and alkylamino substituted thiophosphoric hydrazines and cyclic analogs"
CHEMICAL ABSTRACTS, vol. 99, no. 25, 1983, Columbus, Ohio, US; abstract no. 212591N, BAKHTIYAROVA F.A. ET AL.: "Reaction of monochloroacetic acid with diamides, hydrazides and dihydrazides of phosphorous acids in the presence of ammonium thiocyanate"
CHEMICAL ABSTRACTS, vol. 93, no. 11, 1980, Columbus, Ohio, US; abstract no. 114466G, MAJORAL J.P.: "Heterocyclic compounds containing phosphorus. Part 35. New reactions of phosphorohydrazidic derivatives with aldehydes; production of macropolycyclic compounds"
CHEMICAL ABSTRACTS, vol. 88, no. 7, 1978, Columbus, Ohio, US; abstract no. 50967H, MAJORAL J.P. ET AL.: "Heterocycles containing phosphorus. XXXII. Study of the reaction of phosphorus hydrazides with ortho esters, acetic anhydride and formic acid"
CHEMICAL ABSTRACTS, vol. 87, no. 19, 1977, Columbus, Ohio, US; abstract no. 152323S, GRAPOV A.F. ET AL.: "Some reactions of phosphorus thio acid dihydrazides"
CHEMICAL ABSTRACTS, vol. 85, no. 18, 1976, Columbus, Ohio, US; abstract no. 136429J, AGGARWAL R.C. ET AL.: "Complexes of germanium (IV) and tin(IV) chlorides with N-salicyloylhydrazine, N-acetyl-N'-salicyloylhydrazine and N-benzoyl-N'-salicyloylhydrazine"
CHEMICAL ABSTRACTS, vol. 76, no. 20, 1972, Columbus, Ohio, US; abstract no. 113579H, HUANG Y. ET AL.: "Polymers containing phosphorus. X. Polyaddition of diisocyanates and diisothiocyanates to phosphorous-containing dihydrazides"
CHEMICAL ABSTRACTS, vol. 74, no. 22, 1970, Columbus, Ohio, US; abstract no. 118424X, SMALL F.E.: "Recording sheet, suitable for thermographic reproduction"
CHEMICAL ABSTRACTS, vol. 69, no. 25, 1968, Columbus, Ohio, US; abstract no. 106808J, SCOLA D.A. ET AL.: "N,N'-disubstituted P-phenylphosphonothioic diamides"
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