Title:
MULTIFUNCTIONAL NANOMATERIALS FOR THE TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2013/112856
Kind Code:
A3
Abstract:
The invention relates to a multifunctional nanomaterial comprising a nanorod comprising 1) a noble metal, wherein the nanorod exhibits surface plasmon resonance absorption in the near-infrared spectrum; 2) an up-conversion phosphor that absorbs infrared light and emits visible luminescence; and optionally 3) a biomolecule targeting moiety. The invention further relates to methods of detecting and treating cancer using the multifunctional nanomaterials of the invention.
Inventors:
PARK WOUNJHANG (US)
FLAIG THOMAS (US)
YANG XIAOPING (US)
SU LIH-JEN SHIH (US)
EMOTO KAZUNORI (US)
FLAIG THOMAS (US)
YANG XIAOPING (US)
SU LIH-JEN SHIH (US)
EMOTO KAZUNORI (US)
Application Number:
PCT/US2013/023174
Publication Date:
September 19, 2013
Filing Date:
January 25, 2013
Export Citation:
Assignee:
UNIV COLORADO REGENTS (US)
International Classes:
B82B1/00; A61K33/242; A61K33/243; A61K33/244; A61K39/395; A61P35/00; C01G5/00; C01G7/00; C09K11/00
Foreign References:
| US20110263920A1 | 2011-10-27 |
Other References:
JAIN P. K. ET AL.: "Noble metals on the nanoseale: Optical and photothermal properties and some applications in imaging, sensing, biology, and medicine", ACC. CHEM. RES., vol. 41, no. 12, December 2008 (2008-12-01), pages 1578 - 86, XP055160359
SUDHEENDRA L. ET AL.: "Plasmonic enhanced emissions from cubic NaYF4:Yb: Er/Tm nanophosphors.", CHEM. MATER., vol. 23, no. 11, 14 June 2011 (2011-06-14), pages 2987 - 2993, XP055160364
GLAZER EVAN S. ET AL.: "Noninvasive radiofrequency field destruction of pancreatic adenocarcinoma xenografts treated with targeted gold nanoparticles.", CLIN. CANCER RES., vol. 16, no. 23, 1 December 2010 (2010-12-01), pages 5712 - 21, XP055160367
SUDHEENDRA L. ET AL.: "Plasmonic enhanced emissions from cubic NaYF4:Yb: Er/Tm nanophosphors.", CHEM. MATER., vol. 23, no. 11, 14 June 2011 (2011-06-14), pages 2987 - 2993, XP055160364
GLAZER EVAN S. ET AL.: "Noninvasive radiofrequency field destruction of pancreatic adenocarcinoma xenografts treated with targeted gold nanoparticles.", CLIN. CANCER RES., vol. 16, no. 23, 1 December 2010 (2010-12-01), pages 5712 - 21, XP055160367
Attorney, Agent or Firm:
NEVRIVY, Daniel, J. (1055 Thomas Jefferson Street NW,Suite M-10, Washington DC, US)
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