Title:
MULTIFUNCTIONAL PROTEIN
Document Type and Number:
WIPO Patent Application WO/2018/121605
Kind Code:
A1
Abstract:
A multifunctional polypeptide chain or a protein. A polypeptide chain X, comprising an antigen 1 binding domain R1, an auxiliary peptide chain linking domain R2 and an antigen 2 binding domain R3. The auxiliary peptide chain linking domain R2 is a cytokine or a cytokine binding domain in a cytokine receptor. A protein, which is a heterodimer composed of the polypeptide chain X as a main peptide chain and an auxiliary peptide chain Y. The auxiliary peptide chain Y comprises an antigen 3 binding domain R4 and a main peptide chain X linking domain R5, or the auxiliary peptide chain Y is the main peptide chain linking domain R5. The multifunctional protein mediates specific cell killing by binding to different tumor antigens with the two antigen binding domains of tumor-associated antigens therein. The multifunctional protein can function as a cytokine by introducing a cytokine or a cytokine receptor complex.
Inventors:
ZHANG FENGYU (CN)
GAO BIN (CN)
WANG LEI (CN)
WU YASONG (CN)
WEI QING (CN)
GAO BIN (CN)
WANG LEI (CN)
WU YASONG (CN)
WEI QING (CN)
Application Number:
PCT/CN2017/118984
Publication Date:
July 05, 2018
Filing Date:
December 27, 2017
Export Citation:
Assignee:
TIMMUNE BIOTECH INC (CN)
International Classes:
C07K16/30; A61P35/00; C07K16/18; C07K19/00
Domestic Patent References:
| WO2015103928A1 | 2015-07-16 |
Foreign References:
| CN102573922A | 2012-07-11 | |||
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Other References:
MAY, M.B. ET AL.: "Blinatumomab: A Novel, Bispecific, T- cell Engaging Antibody", AM J HEALTH-SYST PHARM., vol. 73, no. 1, 1 January 2016 (2016-01-01), pages e6 - e13, XP055613324, DOI: 10.2146/ajhp150134
See also references of EP 3578570A4
See also references of EP 3578570A4
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
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