Title:
MULTIMERIC AND MULTIVALENT POLYMER COMPRISING HYDROPHOBIC TAIL DOMAIN OF HAGFISH-DERIVED VLRB PROTEIN
Document Type and Number:
WIPO Patent Application WO/2018/124398
Kind Code:
A1
Abstract:
The present invention relates to a multimeric and multivalent polymer comprising a hydrophobic tail domain of a hagfish-derived VLRB protein. A multivalent polymer comprising a hydrophobic tail domain of a hagfish-derived VLRB protein is produced, wherein the multivalent polymer exhibits a probe effect by forming a nano-sized spherical shape by means of self-assembly, thereby being usable in the development of a highly sensitive protein nanochip and the development of a diagnostic kit.
Inventors:
JUNG TAE SUNG (KR)
LEE JUNG SUK (KR)
IM SE PYUNG (KR)
KIM JAE-SUNG (KR)
KIM YOUNG RIM (KR)
LEE JUNG SUK (KR)
IM SE PYUNG (KR)
KIM JAE-SUNG (KR)
KIM YOUNG RIM (KR)
Application Number:
PCT/KR2017/003937
Publication Date:
July 05, 2018
Filing Date:
April 12, 2017
Export Citation:
Assignee:
NAT UNIV GYEONGSANG IACF (KR)
International Classes:
C07K14/705; C07K14/46; G01N33/543; G01N33/68; B82Y5/00
Foreign References:
| US20110165584A1 | 2011-07-07 | |||
| KR101220162B1 | 2013-01-14 | |||
| US20140088292A1 | 2014-03-27 |
Other References:
FLAJNIK: "Origin and evolution of the adaptive immune system: genetic events and selective pressures", NATURE REVIEWS GENETICS, vol. 11, 8 December 2009 (2009-12-08), pages 47 - 59, XP055612913
PANCER: "Variable lymphocyte receptors in hagfish", PNAS, vol. 102, no. 26, 28 June 2005 (2005-06-28), pages 9224 - 9229, XP008103115
KIM: "Multimerized variable lymphocyte receptors B of hagfish induced by hydrophobic clustering", vol. 56, no. 3, October 2016 (2016-10-01), pages 47
KIM: "Globular-shaped variable lymphocyte receptors (VLRs) of hagfish : a primordial antibody in vertebrates", ANTIBODY ENGINEERING & THERAPEUTICS, 11 December 2016 (2016-12-11)
PANCER: "Variable lymphocyte receptors in hagfish", PNAS, vol. 102, no. 26, 28 June 2005 (2005-06-28), pages 9224 - 9229, XP008103115
KIM: "Multimerized variable lymphocyte receptors B of hagfish induced by hydrophobic clustering", vol. 56, no. 3, October 2016 (2016-10-01), pages 47
KIM: "Globular-shaped variable lymphocyte receptors (VLRs) of hagfish : a primordial antibody in vertebrates", ANTIBODY ENGINEERING & THERAPEUTICS, 11 December 2016 (2016-12-11)
Attorney, Agent or Firm:
CHOI, Kyu Whan (KR)
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