Title:
MULTIMERIC POLYPEPTIDES OF HLA-G INCLUDING AT LEAST TWO ALPHA3 DOMAINS AND PHARMACEUTICAL USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/150233
Kind Code:
A3
Abstract:
Multimeric polypeptides and pharmaceutical uses thereof; multimers comprising alpha3 peptides of an HLA-G antigen and methods of producing such multimers, pharmaceutical compositions comprising the same, as well as their uses for treating various diseases including organ/tissue rejection. Said multimers comprise at least two monomers, each of said monomers being selected in the group consisting of a peptide Pl of formula X1 -X2, wherein X1 represents a peptidic linker including a cysteine amino acid and X2 represents an alpha3 domain of HLA-G.
Inventors:
LE MAOULT JOEL (FR)
CAROSELLA EDGARDO DELFINO (FR)
CAROSELLA EDGARDO DELFINO (FR)
Application Number:
PCT/IB2010/052917
Publication Date:
May 12, 2011
Filing Date:
June 25, 2010
Export Citation:
Assignee:
COMMISSARIAT ENERGIE ATOMIQUE (FR)
LE MAOULT JOEL (FR)
CAROSELLA EDGARDO DELFINO (FR)
LE MAOULT JOEL (FR)
CAROSELLA EDGARDO DELFINO (FR)
International Classes:
A61K39/00; C07K14/705; A61P37/06
Domestic Patent References:
| WO2010052228A1 | 2010-05-14 | |||
| WO2007011044A1 | 2007-01-25 | |||
| WO2010150235A1 | 2010-12-29 |
Other References:
CLEMENTS CRAIG S ET AL: "Structural studies on HLA-G: implications for ligand and receptor binding.", HUMAN IMMUNOLOGY APR 2007 LNKD- PUBMED:17400055, vol. 68, no. 4, April 2007 (2007-04-01), pages 220 - 226, XP002623221, ISSN: 0198-8859
LI CHANGLIN ET AL: "HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 106, no. 14, April 2009 (2009-04-01), pages 5767 - 5772, XP002623222, ISSN: 0027-8424
LI CHANGLIN ET AL: "HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 106, no. 14, April 2009 (2009-04-01), pages 5767 - 5772, XP002623222, ISSN: 0027-8424
Attorney, Agent or Firm:
CABINET ORES (Paris, FR)
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