Title:
MULTIPLE GENE DIAGNOSTIC PROBES AND ASSAY KITS AND METHOD FOR THE ASSESSMENT OF MULTIPLE MARKERS FOR BREAST CANCER PROGNOSIS
Document Type and Number:
WIPO Patent Application WO2004025246
Kind Code:
A3
Abstract:
The problem of inadequate broad-range prognostic factors for breast cancer is solved by providing a multi-gene probe for a single-step determination of disease outcome. The 5-genes chosen (HER2, Topo IIalpha, NuMu23Eta1 Eta1, CK 19) are known to show altered expression in different breast tumors. The altered expression of any one of them has a similar prognostic significance, with respect to disease-free survival or overall survival. The multi-gene probe is labeled and used to screen a tumor specimen. The signal generated after the assay provides information that has prognostic significance. Since five prognostic markers are simultaneously assessed, a wider variety of breast cancers are covered and disease outcome prediction is improved in a winder population.
Inventors:
SOMIARI RICHARD I
SOMIARI STELLA B
JACOBS F NICHOLAS
JORDAN RICK
SOMIARI STELLA B
JACOBS F NICHOLAS
JORDAN RICK
Application Number:
PCT/US2003/021418
Publication Date:
August 12, 2004
Filing Date:
July 10, 2003
Export Citation:
Assignee:
WINDBER RES INST (US)
International Classes:
C12Q1/68; (IPC1-7): C12Q1/68; C12P19/34; C07H21/02; C07H21/04
Foreign References:
| US6413228B1 | 2002-07-02 |
Other References:
JARVINEN ET AL: "Characterization of topoisomerase IIalpha gene amplification and deletion in breast cancer", GENES, CHROMOSOMES & CANCER, vol. 26, July 1999 (1999-07-01), pages 142 - 150, XP002978464
MITAS ET AL: "Quantitative real-time RT-PCR detection of breast cancer micrometastasis using a multigene marker panel", INTERNATIONAL JOURNAL OF CANCER, vol. 93, 2001, pages 162 - 171, XP002235531
MITAS ET AL: "Quantitative real-time RT-PCR detection of breast cancer micrometastasis using a multigene marker panel", INTERNATIONAL JOURNAL OF CANCER, vol. 93, 2001, pages 162 - 171, XP002235531
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