Title:
PREVENTIVES/REMEDIES FOR MULTIPLE ORGAN FAILURE
Document Type and Number:
WIPO Patent Application WO/2000/013707
Kind Code:
A1
Abstract:
Preventives/remedies for syndrome caused by the worsening of sepsis, hyperchemokinemia and hepatic diseases which contain as the active ingredient an antithrombin agent and/or a thrombin synthesis inhibitor. Because of being usable in preventing or treating diseases including sepsis, severe sepsis, septic shock and multiorgan failure, these drugs are useful in the treatment of trauma, burn, heat attack, severe infection, etc. caused by, in particular, traffic accidents in the field of emergency care. These drugs are also useful in preventing and treating hyperchemokinemia and hepatic diseases.
Inventors:
HARA TSUYOSHI (JP)
FUJIWARA KAZUKO (JP)
FUJIWARA KAZUKO (JP)
Application Number:
PCT/JP1999/004783
Publication Date:
March 16, 2000
Filing Date:
September 03, 1999
Export Citation:
Assignee:
DAIICHI SEIYAKU CO (JP)
HARA TSUYOSHI (JP)
FUJIWARA KAZUKO (JP)
HARA TSUYOSHI (JP)
FUJIWARA KAZUKO (JP)
International Classes:
A61K31/155; A61K31/34; A61K31/38; A61K31/381; A61K31/40; A61K31/415; A61K31/42; A61K31/425; A61K31/428; A61K31/4433; A61K31/445; A61K38/57; A61K45/00; A61P1/16; A61P7/00; A61P31/04; A61P43/00; C07D333/60; C07D207/12; C07D211/46; C07D277/64; C07D403/12; C07D409/12; (IPC1-7): A61K45/00; A61K31/40; A61K31/445; C07D207/12; C07D211/46; C07D403/12; C07D401/12; C07D409/12
Foreign References:
| EP0540051A1 | 1993-05-05 |
Other References:
MAMMENN EBERHARD F. ET AL.: "The haematological manifestation of sepsis", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 41, January 1998 (1998-01-01), pages 17 - 24, SUPPL. A, XP002926520
EISELE BERND ET AL.: "Clinical Experience with Antithrombin III Concentrates in Critically I11 Patients with Sepsis and Multiple Organ Failure", SEMINARS IN THROMBOSIS AND HEMOSTASIS, vol. 24, no. 1, 1998, pages 71 - 80, XP002926521
DICKNEITE GERHARD: "Antithrombin III on Animal Models of Sepsis and Organ Failure", SEMINARS IN THROMBOSIS AND HEMOSTASIS, vol. 24, no. 1, 1998, pages 61 - 69, XP002926522
CHEMICAL ABSTRACTS, vol. 127, 1997, Columbus, Ohio, US; abstract no. 103799N, SIEBECK M.: "Thrombin inhibition" XP002923688
HOWARD MAUREEN ET AL: "Interleukin 10 Protects Mice from Lethal Endotoxemia", J. EXP. MED., vol. 177, no. 4, 1993, pages 1205 - 1208, XP002926524
IRATA KAZUO ET AL: "The Limiting Effect of Dichloroacetate on Endotoxin-Induced Liver Damage in Starved Rats", J. OF SURGICAL RESEARCH, vol. 56, 1994, pages 216 - 220, XP002926525
See also references of EP 1110556A4
EISELE BERND ET AL.: "Clinical Experience with Antithrombin III Concentrates in Critically I11 Patients with Sepsis and Multiple Organ Failure", SEMINARS IN THROMBOSIS AND HEMOSTASIS, vol. 24, no. 1, 1998, pages 71 - 80, XP002926521
DICKNEITE GERHARD: "Antithrombin III on Animal Models of Sepsis and Organ Failure", SEMINARS IN THROMBOSIS AND HEMOSTASIS, vol. 24, no. 1, 1998, pages 61 - 69, XP002926522
CHEMICAL ABSTRACTS, vol. 127, 1997, Columbus, Ohio, US; abstract no. 103799N, SIEBECK M.: "Thrombin inhibition" XP002923688
HOWARD MAUREEN ET AL: "Interleukin 10 Protects Mice from Lethal Endotoxemia", J. EXP. MED., vol. 177, no. 4, 1993, pages 1205 - 1208, XP002926524
IRATA KAZUO ET AL: "The Limiting Effect of Dichloroacetate on Endotoxin-Induced Liver Damage in Starved Rats", J. OF SURGICAL RESEARCH, vol. 56, 1994, pages 216 - 220, XP002926525
See also references of EP 1110556A4
Attorney, Agent or Firm:
Aruga, Mitsuyuki (Nihonbashiningyocho 1-chome Chuo-ku, Tokyo, JP)
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