MULTIPLEX MICROFLUIDIC DEVICE FOR SELECTING NUCLEIC ACID APTAMERS, AND HIGH THROUGHPUT SELECTION METHOD FOR NUCLEIC ACID APTAMERS USING SAME

WIPO Patent Application WO/2012/047015

A2

The present invention relates to a multiplex microfluidic device for selecting nucleic acid aptamers, and a high throughput selection method for nucleic acid aptamers using the same, and more specifically, to a multiplex microfluidic device (SELEX lap-on-a-chip) in which a conventional aptamer development method for a single target is converted into an improved multiplex platform, and a high throughput selection method for nucleic acid aptamers in which the method is linked with high throughput sequencing. According to the present invention, the multiplex microfluidic device can simultaneously detect each aptamer for a plurality of targets and remarkably reduces the processing amount and processing time compared with a conventional multiplex method. In particular, the target coupling/separation/amplification process round can be greatly reduced and an automated process can carry out a selection process of aptamers by linking the device of the present invention with high throughput sequencing, and thus the device is very useful.

KIM SO YOUN (KR)
AHN JI-YOUNG (KR)
JO MINJOUNG (KR)
KIM TAE KYUNG (KR)

PCT/KR2011/007367

April 12, 2012

October 05, 2011

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PCL INC (KR)
UNIV DONGGUK IND ACAD COOP (KR)
KIM SO YOUN (KR)
AHN JI-YOUNG (KR)
JO MINJOUNG (KR)
KIM TAE KYUNG (KR)

C12Q1/68; C12M1/34; C12N15/115; G01N33/53

WO2010019969A1

2010-02-18

US20040248167A1	2004-12-09
US20050064465A1	2005-03-24
US5607646A	1997-03-04

LEE, Cheo Young (KR)
이처영 (KR)

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