Title:
MULTISPECIFIC POLYNUCLEOTIDE NANOSTRUCTURES FOR CANCER DETECTION AND THERAPY
Document Type and Number:
WIPO Patent Application WO/2023/076614
Kind Code:
A3
Abstract:
Disclosed herein are multispecific polynucleotide nanostructures and techniques that use multispecific polynucleotide nanostructures as multimolecular recognition entities for the detection of antigens. For example, an artificial biopolymer complex can include a network of polynucleotides, a first set of binders attached at uniquely addressable loci on a first surface of the network of polynucleotides, and a second set of binders attached at uniquely addressable loci on a second surface of the network of polynucleotides. The first set of binders bind to antigens of a target analyte and the second set of binders bind to biomarkers of immune cells. The first and second set of binders are attached at the uniquely addressable loci on the network of polynucleotides separated by predetermined inter-binder and/or intra-binder distances that match intermolecular spacing and/or intramolecular spacing of antigens on a surface of the target analyte and biomarkers on a surface of the immune cells, respectively.
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Inventors:
FRIEDMAN ADAM (US)
YAO SHERWOOD (US)
YAO SHERWOOD (US)
Application Number:
PCT/US2022/048248
Publication Date:
July 06, 2023
Filing Date:
October 28, 2022
Export Citation:
Assignee:
ATOM BIOWORKS INC (US)
International Classes:
C12Q1/6816; A61K31/7088; A61K39/00; B82Y5/00; C12N15/11; G01N33/483
Other References:
KWON PAUL S.; REN SHAOKANG; KWON SEOK-JOON; KIZER MEGAN E.; KUO LILI; XIE MO; ZHU DAN; ZHOU FENG; ZHANG FUMING; KIM DOMYOUNG; FRAS: "Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition", NATURE CHEMISTRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 12, no. 1, 25 November 2019 (2019-11-25), London, pages 26 - 35, XP037660301, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0369-8
CHEN, X. ET AL.: "Fusion Protein Linkers: Property, Design and Functionalit y", ADVANCED DRUG DELIVERY REV., 15 October 2013 (2013-10-15), pages 1 - 32, XP055341428, DOI: 10.1016/j.addr. 2012.09.03 9
ANONYMOUS: "DNA Star Platform; Designer DNA Material; PROGRAMMABLE BINDING AFFINITY", ATOM BIOWORKS, 1 January 2021 (2021-01-01), XP093078355, Retrieved from the Internet [retrieved on 20230904]
CHEN, X. ET AL.: "Fusion Protein Linkers: Property, Design and Functionalit y", ADVANCED DRUG DELIVERY REV., 15 October 2013 (2013-10-15), pages 1 - 32, XP055341428, DOI: 10.1016/j.addr. 2012.09.03 9
ANONYMOUS: "DNA Star Platform; Designer DNA Material; PROGRAMMABLE BINDING AFFINITY", ATOM BIOWORKS, 1 January 2021 (2021-01-01), XP093078355, Retrieved from the Internet
Attorney, Agent or Firm:
MAO, Yifan et al. (US)
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