Title:
MULTISTEP PROCESS FOR THE PHYSICAL DEPOLYMERIZATION OF HEPARIN AND PRODUCTS OBTAINED THEREFROM
Document Type and Number:
WIPO Patent Application WO2005035587
Kind Code:
A3
Abstract:
The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two gamma-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.
Inventors:
DE AMBROSI LUIGI (IT)
GONELLA SERGIO (IT)
BENSI DONATA (IT)
TORRI GIANGIACOMO (IT)
BISIO ANTONELLA (IT)
VISMARA ELENA (IT)
GONELLA SERGIO (IT)
BENSI DONATA (IT)
TORRI GIANGIACOMO (IT)
BISIO ANTONELLA (IT)
VISMARA ELENA (IT)
Application Number:
PCT/EP2004/052531
Publication Date:
June 16, 2005
Filing Date:
October 13, 2004
Export Citation:
Assignee:
DERIVATI ORGANICI LAB (IT)
DE AMBROSI LUIGI (IT)
GONELLA SERGIO (IT)
BENSI DONATA (IT)
TORRI GIANGIACOMO (IT)
BISIO ANTONELLA (IT)
VISMARA ELENA (IT)
DE AMBROSI LUIGI (IT)
GONELLA SERGIO (IT)
BENSI DONATA (IT)
TORRI GIANGIACOMO (IT)
BISIO ANTONELLA (IT)
VISMARA ELENA (IT)
International Classes:
C08B37/00; C08B37/10; (IPC1-7): C08B37/10; C08B37/00
Domestic Patent References:
| WO2000069444A1 | 2000-11-23 | |||
| WO2003076474A1 | 2003-09-18 |
Foreign References:
| EP0269937A2 | 1988-06-08 |
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