Title:
MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR MODULATION OF MILCK1
Document Type and Number:
WIPO Patent Application WO/2021/142217
Kind Code:
A1
Abstract:
Aspects of the disclosure relate to molecular payloads that modulate the expression or activity of MLCK1 and complexes comprising a muscle-targeting agent covalently linked to the molecular payloads. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on a muscle cell (e.g., a smooth muscle cell). In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.
Inventors:
SUBRAMANIAN ROMESH R (US)
QATANANI MOHAMMED T (US)
WEEDEN TIMOTHY (US)
DESJARDINS CODY A (US)
QUINN BRENDAN (US)
QATANANI MOHAMMED T (US)
WEEDEN TIMOTHY (US)
DESJARDINS CODY A (US)
QUINN BRENDAN (US)
Application Number:
PCT/US2021/012637
Publication Date:
July 15, 2021
Filing Date:
January 08, 2021
Export Citation:
Assignee:
DYNE THEREAPEUTICS INC (US)
International Classes:
A61K31/7088; A61K31/7105; A61K39/395; A61K47/66; A61K47/68; C07K16/28
Domestic Patent References:
| WO2020028842A1 | 2020-02-06 | |||
| WO2020028861A1 | 2020-02-06 |
Foreign References:
| US20190298847A1 | 2019-10-03 | |||
| US20130084261A1 | 2013-04-04 | |||
| US20100260773A1 | 2010-10-14 |
Attorney, Agent or Firm:
GE, Zhiyun et al. (US)
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