Title:
MUSCULAR ATROPHY INHIBITOR AND METHOD FOR INHIBITING MUSCULAR ATROPHY
Document Type and Number:
WIPO Patent Application WO/2022/145439
Kind Code:
A1
Abstract:
This muscular atrophy inhibitor contains a pyrimidine nucleotide or a precursor thereof as an active ingredient. This method is for inhibiting muscular atrophy through administration of a pyrimidine nucleotide or a precursor thereof.
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Inventors:
NAKAGAWARA KOSUKE (JP)
TAKEUCHI CHIERI (JP)
ISHIGE KAZUYA (JP)
TAKEUCHI CHIERI (JP)
ISHIGE KAZUYA (JP)
Application Number:
PCT/JP2021/048703
Publication Date:
July 07, 2022
Filing Date:
December 27, 2021
Export Citation:
Assignee:
YAMASA CORP (JP)
International Classes:
A61K31/7072; A23L33/13; A61K31/7068; A61P21/00; A61P43/00
Foreign References:
| JP2018521993A | 2018-08-09 | |||
| JP2010248161A | 2010-11-04 | |||
| JP2017061466A | 2017-03-30 | |||
| JP2016160183A | 2016-09-05 | |||
| JP2018105550A | 2018-07-05 | |||
| JPH10203989A | 1998-08-04 | |||
| JP2010248161A | 2010-11-04 | |||
| JP2017061466A | 2017-03-30 |
Other References:
L V KUZNETSOVA, V M AVAKUMOV: "[Effect of potassium orotate and the sodium salt of uridine monophosphate on the development of experimental adrenaline myocardial dystrophy]", FARMAKOLOGIYA I TOKSIKOLOGIYA, vol. 44, no. 2, 1 January 1981 (1981-01-01), RU , pages 170 - 173, XP009537942, ISSN: 0014-8318
W KING ENGEL: "PP537 Uridine as a Possible Treatment for Amyotrophic Lateral Sclerosis (ALS): Hypothesis and Phase-I- Study Demonstrating Safety. Neurology", NEUROLOGY, vol. 38, no. 3 Supplement 1, 1 March 1988 (1988-03-01), US, pages 326 - 326, XP002041332, ISSN: 0028-3878
WANG DELONG, CHEN WEIQIAO, BI QIANYU, ZONG XIN, RUAN JIAZHAO, YIN XIANGJUN, WANG JIXIN, ZHANG HONGHUA, JI XUMING: "Baoyuan Jiedu Decoction Alleviates Cancer-Induced Myotube Atrophy by Regulating Mitochondrial Dynamics Through p38 MAPK/PGC-1α Signaling Pathway", FRONTIERS IN ONCOLOGY, vol. 10, 1 January 2020 (2020-01-01), pages 1 - 14, XP055947015, DOI: 10.3389/fonc.2020.523577
STEWART H. LECKER ET AL.: "Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression", FASEB J., vol. 18, 2004, pages 39 - 51
MICHAEL MENCONI ET AL.: "Dexamethasone and corticosterone include similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes", J CELL. BIOCHEM., vol. 105, 2008, pages 353 - 364, XP055177363, DOI: 10.1002/jcb.21833
CAS, no. 63-37-6
CAS, no. 58-97-9
ISAO MATSUOKA: "Ectonucleotidases in Nervous System", CLINICAL CHEMISTRY, vol. 33, 2004, pages 11 - 18
A ORENGO: "Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor", J BIOL CHEM., vol. 244, no. 8, 25 April 1969 (1969-04-25), pages 2204 - 9
W KING ENGEL: "PP537 Uridine as a Possible Treatment for Amyotrophic Lateral Sclerosis (ALS): Hypothesis and Phase-I- Study Demonstrating Safety. Neurology", NEUROLOGY, vol. 38, no. 3 Supplement 1, 1 March 1988 (1988-03-01), US, pages 326 - 326, XP002041332, ISSN: 0028-3878
WANG DELONG, CHEN WEIQIAO, BI QIANYU, ZONG XIN, RUAN JIAZHAO, YIN XIANGJUN, WANG JIXIN, ZHANG HONGHUA, JI XUMING: "Baoyuan Jiedu Decoction Alleviates Cancer-Induced Myotube Atrophy by Regulating Mitochondrial Dynamics Through p38 MAPK/PGC-1α Signaling Pathway", FRONTIERS IN ONCOLOGY, vol. 10, 1 January 2020 (2020-01-01), pages 1 - 14, XP055947015, DOI: 10.3389/fonc.2020.523577
STEWART H. LECKER ET AL.: "Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression", FASEB J., vol. 18, 2004, pages 39 - 51
MICHAEL MENCONI ET AL.: "Dexamethasone and corticosterone include similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes", J CELL. BIOCHEM., vol. 105, 2008, pages 353 - 364, XP055177363, DOI: 10.1002/jcb.21833
CAS, no. 63-37-6
CAS, no. 58-97-9
ISAO MATSUOKA: "Ectonucleotidases in Nervous System", CLINICAL CHEMISTRY, vol. 33, 2004, pages 11 - 18
A ORENGO: "Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor", J BIOL CHEM., vol. 244, no. 8, 25 April 1969 (1969-04-25), pages 2204 - 9
Attorney, Agent or Firm:
AXIS PATENT INTERNATIONAL (JP)
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