MUSK-TARGETING OLIGONUCLEOTIDES CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Provisional Application No. 63/301,416, filed January 20, 2022, the contents of which is hereby incorporated by reference in its entirety. BACKGROUND [0002] Neurodegenerative diseases represent a major public health challenge, expected to impact one in five people in their lifetimes. Alzheimer’s disease (AD) is the most common cause of age-related dementia. There is a critical and urgent need for therapeutics to prevent and treat AD and other neurodegenerative conditions. [0003] Skeletal muscle has the ability to regenerate after injury. Muscle regeneration is dependent upon resident stem cells, referred to as muscle satellite cells. In mature muscle tissue, satellite cells constitute a small, scattered population of mitotically and physiologically quiescent cells. Satellite cells are also implicated in normal muscle growth and maintenance throughout life, indicating that they could be exploited to treat muscle wasting conditions. [0004] Skeletal muscle makes up about 35% of body weight and is essential for metabolism, locomotion, and breathing, which highlights its importance in human health. Muscle wasting reduces mobility, metabolism, and quality of life for the majority of cancer patients, elderly patients, and many others with no history of neuromuscular dysfunction. In addition, muscular dystrophies are an often fatal group of genetic diseases leading to severe muscle loss, including Duchenne Muscular Dystrophy which affects children. [0005] Neurogenesis and muscle regeneration are dependent on neural stem cells (NSCs) and muscle satellite cells. A roadblock to development of treatments of neurodegeneration and muscle wasting is that the signaling that regulates neural stem cells and satellite cells and their regeneration is poorly understood. Accordingly, there is a need for compositions and methods for promoting neurogenesis and muscle regeneration. SUMMARY [0006] Among other things, the present disclosure provides an insight that presence and/or activity of a particular form(s) of the muscle-specific tyrosine kinase (MuSK) protein, specifically lacking a functional Ig3 domain, may achieve or contribute to beneficial biological events including, for example, neurogenesis and/or muscle regeneration. [0007] The present disclosure provides certain technologies for enhancing neurogenesis, including in particular in adult humans. In some embodiments, technologies provided herein may be useful in medicine, including specifically treatment of diseases, disorders or conditions associated with neurodegeneration, or otherwise with low or reduced neuronal activity (e.g., neuronal activity in an adult hippocampus and/or in subventricular zone(s)). For example, in some embodiments, technologies provided herein may be useful in the treatment of one or more of Alzheimer’s Disease (AD), Parkinson’s disease, dementia (e.g., Frontotemporal dementia), stroke, Major Depressive Disorder (MDD), bipolar disorder, Schizophrenia, Post-Traumatic Stress Disorder (PTSD), substance-related and addictive disorders (e.g., chronic cocaine use and lifelong cigarette smoking), Temporal-Lobe Epilepsy, Hippocampal Sclerosis, Niemann Pick Type C, Diabetes-mediated hippocampal neuronal loss, brain injury (e.g., traumatic and/or anoxic brain injury), and Huntington’s disease. [0008] Bone morphogenetic protein (BMP) signaling regulates at least two important NSC decision points: 1) quiescence, where proliferating stem cells exit the cell cycle and return to replenish a reserve pool that can supply fresh stem cells; and; 2) differentiation into mature progeny (Mira et al., 2010). The present disclosure contemplates that manipulating the BMP pathway in NSCs is an attractive target for regulating neurogenesis in the adult brain. Additionally, BMP signaling regulates skeletal muscle stem cell activity in both normal and pathological states. The present disclosure provides technologies for increasing level and/or activity of MuSK form(s) that functionally participate in neurogenesis and/or muscle regeneration, including, in some embodiments, by reducing alternative splicing that would otherwise generate MuSK form(s) that do not so participate. In some embodiments, such increase is in a relevant tissue such as muscle. Alternatively or additionally, in some embodiments, such increase is in a tissues such as a brain tissue (e.g., hippocampal and/or subventricular) and/or lung tissue. [0009] Among other things, the present disclosure provides an insight that presence and/or activity of a particular form(s) of the muscle-specific tyrosine kinase (MuSK) protein, specifically lacking a functional Ig3 domain, may achieve or contribute to neurogenesis in adult humans, or otherwise provide neurological benefit(s). The MuSK transcript can be alternatively spliced, including to generate at least one form (i.e., ΔIg3-MuSK) that lacks the Ig3 domain. The present disclosure appreciates that increasing presence and/or level of ΔIg3- MuSK, and/or of other functional form(s) in which its Ig3 domain is altered (e.g., mutated, blocked, etc.) or removed, may provide benefits as described herein. [0010] In some embodiments, the present disclosure provides technologies for increasing level and/or activity of one or more forms of MuSK whose Ig3 domain is altered (e.g., mutated, blocked, removed, etc.) for example so that it fails to effectively participate in interaction(s) with BMP. In some embodiments, the present disclosure provides technologies for reducing Ig3 ⁺ MuSK, for example by reducing level and/or activity of one or more forms of MuSK whose Ig3 domain effectively participates in interaction(s) with BMP. [0011] In some embodiments, an agent that targets the MuSK Ig3 domain, as described herein (e.g., a MuSK-targeting oligonucleotide), so that level and/or activity of a MuSK/BMP complex is reduced is useful in contexts of neurogenesis and/or muscle regeneration and/or of muscle growth. [0012] In some embodiments, provided agent(s) may enhance muscle growth. In some embodiments, muscle growth occurs in uninjured tissue. In some embodiments, muscle growth occurs in injured tissue. In some embodiments, enhanced and/or increased muscle growth is determined by a decrease in satellite cell number and/or increase in muscle fiber size. In this regard, muscle growth can be characterized by a decrease in satellite cell number and/or increase in muscle fiber size, which is indicative of satellite cells differentiating and fusing into/augmenting existing muscle fibers and forming new muscle fibers. [0013] Embodiments of the present invention provide methods of enhancing neurogenesis and/or muscle regeneration and/or growth, for example in a subject in need thereof, by administering a composition that downregulates MuSK Ig3 domain protein expression, MuSK Ig3 domain gene expression, and/or MuSK Ig3 activation of BMP signaling, thereby upregulating muscle satellite cells which results in enhancement of muscle regeneration and/or growth. In some embodiments, such a composition can comprise and/or deliver a MuSK-targeting oligonucleotide (e.g., a MuSK Ig3-targeting exon-skipping oligonucleotide). [0014] In some embodiments, enhancing neurogenesis is used in the context of treating a disease or disorder associated with reduced Adult Hippocampal Neurogenesis (AHN). As AHN occurs throughout life in humans and is dramatically reduced in AD (Moreno-Jimenez et al., 2019; Steiner et al., 2019), the present disclosure provides compositions and methods for promoting AHN, enhancing cognitive function and combating neurodegeneration (e.g., Alzheimer’s disease). [0015] In some embodiments, enhancing neurogenesis is used in the context of treating a disease or disorder associated with reduced Subventricular Zone Neurogenesis. As NSCs reside in the subventricular zone (SVZ) lining the lateral ventricles and generate astrocytes and oligodendrocytes that support the existing circuitry as well as neurons in the olfactory bulb that are critical for olfactory discrimination. The present disclosure provides compositions and methods for compensating for the degeneration of neurons in the SVZ through enhancing endogenous neurogenesis. In some embodiments, the present disclosure provides compositions and methods for treating diseases specifically associated with striatal neurogenesis such as Parkinson’s disease (which could benefit both from increasing AHN and striatal neurogenesis in the SVZ; Pitcher et al.2012; Sterling et al.2013) and Huntington’s disease (Sassone et al., 2018). In some embodiments, the present disclosure provides compositions and methods for treating other diseases including addiction (e.g., chronic cocaine use and lifelong cigarette smoking). [0016] In some embodiments, a subject of interest can be at risk of, or afflicted with, a disease or disorder including, but not limited to, neuromuscular dysfunction, neurodegenerative disorder, cardiac disorder (e.g., myocardial infarction, cardiomyopathy), or genetic diseases characterized by muscle wasting. Alternatively or additionally, in some embodiments, a subject of interest can be at risk of, or afflicted with a disease or disorder associated with lung damage, including, for example, idiopathic pulmonary fibrosis (IPF), acute respiratory distress syndrome (ARDS), pneumonia, and/or certain infections, including viral infections including coronaviral infections such as COVID19. [0017] Exemplary neuromuscular dysfunctions or disorders that can be treated by technologies of the present invention include, but are not limited to, Becker muscular dystrophy, Congenital muscular dystrophy, Distal muscular dystrophy, Duchenne muscular dystrophy, Emery-Dreifuss muscular dystrophy, Facioscapulohumeral muscular dystrophy, Limb-girdle muscular dystrophy, Myotonic muscular dystrophy, and Oculo-pharyngeal muscular dystrophy. [0018] In some embodiments, enhancing muscle growth is used in the context of treating a disease or disorder associated with muscle atrophy or muscle wasting. Muscle atrophy or muscle wasting may be observed in connection with various diseases and conditions described herein, such as neuromuscular disorders, or direct or indirectly caused by prolonged inactivity, bed rest, hospitalization, aging, malnutrition, cancer cachexia, chronic inflammatory diseases, etc.. Example chronic inflammatory diseases include rheumatoid arthritis, chronic heart failure, and chronic obstructive pulmonary disease (COPD). [0019] Duration of hospitalization and type and severity of the illness can affect the extent of muscle wasting in a subject, and muscle wasting is common in patients suffering from sepsis, organ failure, hyperglycemia, and diseases associated with chronic and systemic inflammation or oxidative stress. Additionally, hospitalization requiring complete immobilization/bed rest contributes significantly to muscle wasting. [0020] Additional disorders associated with muscle atrophy/wasting include disorders associate with decreased mobility, such as rheumatoid arthritis, osteoarthritis, and injury. (2016 Powers, Scott K., et al. Medicine and science in sports and exercise 48(11): 2307). Thus, in some embodiments, the present disclosure provides therapies for preventing/treating muscle wasting or muscle atrophy related to or as a result of a number of diseases or conditions described herein. [0021] In some embodiments, methods of the present invention can also be used when a subject is in need of enhanced muscle regeneration and muscle growth following surgery, trauma and/or prolonged immobilization (e.g., from bed-rest or casting). As muscle stem cell activity is known to decrease with age, methods of the present invention can also be used to prevent or reverse sarcopenia in patients that are otherwise healthy and could lead to significant improvements in quality of life and autonomy. [0022] Embodiments of the present invention also provide methods of preventing or treating neurodegenerative diseases (e.g., AD) and/or muscle fibrosis, e.g., in a subject in need thereof, by administering a composition that downregulates the MuSK Ig3 domain protein expression, the MuSK Ig3 domain gene expression, and/or the MuSK Ig3 activation of BMP signaling. The composition can comprise, e.g., a MuSK-targeting oligonucleotide (e.g., a MuSK Ig3-targeting exon- skipping oligonucleotide). The subject can be at risk of, or afflicted with, various neurodegenerative diseases, such as Alzheimer’s Disease (AD), Parkinson’s disease, dementia (e.g., Frontotemporal dementia), stroke, Major Depressive Disorder (MDD), bipolar disorder, Schizophrenia, Post-Traumatic Stress Disorder (PTSD), substance-related and addictive disorders (e.g., chronic cocaine use and lifelong cigarette smoking), Temporal-Lobe Epilepsy, Hippocampal Sclerosis, Niemann Pick Type C, Diabetes-mediated hippocampal neuronal loss, brain injury (e.g., traumatic and/or anoxic brain injury), and Huntington’s disease or muscle fibrosis resulting from a disease or condition including, but not limited to, trauma, heritable disease, muscle disorder and aging. The trauma can result from, for example, radiation treatment, crush injury, laceration, and amputation. The heritable disease or muscle disorder include, but are not limited to, Congenital Muscular Dystrophy, Duchenne Muscular Dystrophy, Becker’s Muscular Dystrophy; Amyotrophic Lateral Sclerosis (ALS), and age-associate sarcopenia. [0023] The present invention features, inter alia, an oligonucleotide composition comprising plurality of oligonucleotides, the oligonucleotide composition being characterized in that, when it is contacted with a MuSK transcript in a transcript splicing system, relative amounts of transcripts that do and do not include Ig3 domain-encoding sequences are altered as compared with such relative amounts observed under reference conditions selected from the group consisting of absence of the composition, presence of a reference composition, and combinations thereof. [0024] In some embodiments, the oligonucleotides mediate skipping of at least one exon of the MuSK gene. In some embodiments, the exon skipping lowers levels of mRNAs encoding MuSK protein form that participate in BMP signaling compared with levels observed absent the exon skipping. In some embodiments, the MuSK protein form participating in BMP signaling is or comprises a MuSK protein form that forms a MuSK/BMP complex. [0025] In some embodiments, the exon skipping reduces the level and/or activity of a MuSK/BMP complex. In some embodiments, at least one skipped exon is selected from the group consisting of exons 3, 4, 6, and 7. In some embodiments, the relative amounts are amounts of transcripts including exons 6 and 7 relative to those lacking exons 6 and 7. In some embodiments, relative amounts are amounts of transcripts including exons 3 and 4 relative to those lacking exons 6 and 7. [0026] In some embodiments, the alteration comprises skipping one or more of exons 6 and 7 of MuSK. In some embodiments, the alteration comprises skipping one or more of exons 3 and 4 of MuSK. In some embodiments, the alteration comprises skipping one or more of exons 6 and 7 of MuSK, but skipping none of exons 3 and 4 of MuSK. [0027] In some embodiments, MuSK splicing is altered in that level of MuSK transcripts including exons 6 and 7 is decreased or level of MuSK protein forms including sequences encoded by exons 6 and 7 is decreased, or both. In some embodiments, MuSK splicing is altered in that level of MuSK transcripts including exons 3 and 4 is decreased or level of MuSK protein forms including sequences encoded by exons 3 and 4 is decreased, or both. In some embodiments, MuSK splicing is altered in that level of MuSK transcripts including exons 6 and 7 is increased or level of MuSK protein forms including sequences encoded by exons 6 and 7 is increased, or both. In some embodiments, MuSK splicing is altered in that level of MuSK transcripts including exons 3 and 4 is increased or level of MuSK protein forms including sequences encoded by exons 3 and 4 is increased, or both. In some embodiments, MuSK splicing is altered in that level of MuSK transcripts including exons 3 and 4 remains substantially unchanged and level of MuSK transcripts including exons 6 and 7 is decreased. In some embodiments, MuSK splicing is altered in that level of MuSK protein forms including sequences encoded by exons 3 and 4 remains substantially unchanged and l level of MuSK protein forms including sequences encoded by exons 6 and 7 is decreased. In some embodiments, MuSK splicing is altered in that total level of MuSK transcripts remained substantially unchanged and level of MuSK transcripts including exons 6 and 7 is decreased. [0028] In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 10%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 50%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 80%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 100%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 120%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 150%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 180%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 200%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 250%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 300%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 350%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 400%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 450%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 500%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 600%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 700%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 800%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 900%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by about 1000%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is increased by at least 1000%. [0029] In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 10%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 50%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 80%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 100%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 120%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 150%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 180%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 200%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 250%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 300%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 350%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 400%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 450%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 500%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 600%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 700%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 800%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 900%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by about 1000%. In some embodiments, MuSK splicing is altered in that ratio of MuSK transcripts including exons 3 and 4 to MuSK transcripts including exons 6 and 7 is decreased by at least 1000%. [0030] In some embodiments, prior to contact with one or more exon-skipping oligonucleotides as described herein, ratio of MuSK transcripts including exons 3 and 4 (i.e., total MuSK transcripts) to MuSK transcripts in a cell or system including exons 6 and 7 is between about 1:1 and 1:0.1. In some embodiments, prior to contact with one or more exon- skipping oligonucleotides as described herein, ratio of MuSK transcripts including exons 3 and 4 (i.e., total MuSK transcripts) to MuSK transcripts in a cell or system including exons 6 and 7 is about 1:1, 1:0.9, 1:0.8, 1:0.7, 1:0.6, 1:0.5, 1:0.4, 1:0.3, 1:0.2, or 1:0.1. In some embodiments, prior to contact with one or more exon-skipping oligonucleotides as described herein, ratio of MuSK transcripts including exons 3 and 4 (i.e., total MuSK transcripts) to MuSK transcripts in a cell or system including exons 6 and 7 is about 1:0.8. [0031] In some embodiments, after contact with one or more exon-skipping oligonucleotides as described herein, ratio of MuSK transcripts including exons 3 and 4 (i.e., total MuSK transcripts) to MuSK transcripts in a cell or system including exons 6 and 7 is between about 1:0.9 and 1:0.0001. In some embodiments, after contact with one or more exon-skipping oligonucleotides as described herein, ratio of MuSK transcripts including exons 3 and 4 (i.e., total MuSK transcripts) to MuSK transcripts in a cell or system including exons 6 and 7 is about 1:0.9, 1:0.8, 1:0.7, 1:0.6, 1:0.5, 1:0.4, 1:0.3, 1:0.2, or 1:0.1, 1:0.05, 1:0.01, 1:0.001, or 1:0001. In some embodiments, after contact with one or more exon- skipping oligonucleotides as described herein, ratio of MuSK transcripts including exons 3 and 4 (i.e., total MuSK transcripts) to MuSK transcripts in a cell or system including exons 6 and 7 is between about 1:0.9 and 1:0.8, 1:08 and 1:0.7, 1:0.7 and 1:0.6, 1:0.6 and 1:0.5, 1:0.5 and 1:0.4, 1:0.4 and 1:0.3, 1:0.3 and 1:0.2, 1:0.2 and 1:0.1, 1:0.1 and 1:0.05, 1:0.05 and 1:0.01, 1:0.01 and 1:0.001, or 1:0.001 and 1:0001. In some embodiments, after contact with one or more exon-skipping oligonucleotides as described herein, ratio of MuSK transcripts including exons 3 and 4 (i.e., total MuSK transcripts) to MuSK transcripts in a cell or system including exons 6 and 7 is between about 1:0.9 and 1:0.5. [0032] In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases at a level at least 2 fold greater than the decrease observed for the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both. [0033] In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases at a level at least 3 fold greater than the decrease observed for the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both. In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases at a level at least 4 fold greater than the decrease observed for the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both. [0034] In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases at a level at least 5 fold greater than the decrease observed for the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both. In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases at a level at least 10 fold greater than the decrease observed for the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both. [0035] In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 60% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 40%. [0036] In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 70% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 40%. [0037] In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 80% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 40%. [0038] In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 90% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 40%. [0039] In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 60% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 30%. [0040] In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 60% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 20%. In some embodiments, the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 60% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 10%. In some embodiments, the base sequence of the oligonucleotide comprises a sequence having no more than 5 mismatches from a 18-25 base long portion of the MuSK gene or its complement. [0041] In some embodiments, the oligonucleotides correspond to positions 83776- 83800 and on 83854-83878 of the MuSK gene sequence represented in SEQ ID NO: 77. [0042] In some embodiments, the oligonucleotides described herein target a region on the MuSK genomic sequence within a region defined by nucleotides 83841-83905 and 83962-84032 on the MuSK gene sequence represented in SEQ ID NO: 77. [0043] In some embodiments, oligonucleotides target a region on the MuSK genomic sequence within or comprising at least a portion of sequence ACTCTGTCAGGTTTCTTCTGGGTCCATTCAAGAGAGTGTGAAAGACCGAGTGATT GACTCAAGAC (region 1, SEQ ID: 126). In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50% identical to region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to at least 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to no more than 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MUSK transcript comprising a sequence that is identical to at least 15 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 15-30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MUSK transcript comprising a sequence that is identical to 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 15 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 16 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 17 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 18 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 19 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 20 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 21 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 22 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 23 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 24 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 25 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 26 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 27 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 28 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 29 consecutive bases of region 1, SEQ ID: 126. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 30 consecutive bases of region 1, SEQ ID: 126. [0044] In some embodiments, oligonucleotides target a region on the MuSK genomic sequence within or comprising at least a portion of sequence GGGGAGAAGTTCAGTACTGCCAAGGCTGCAGCCACCATCAGCATAGCAGGTAGG ATGCCCCTTCACATTTG (region 2, SEQ ID 211). In some embodiments, oligonucleotides target a portion of MUSK transcript comprising a sequence that is at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50% identical to region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MUSK transcript comprising a sequence that is identical to at least 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MUSK transcript comprising a sequence that is identical to no more than 30 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MUSK transcript comprising a sequence that is identical to at least 15 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MUSK transcript comprising a sequence that is identical to 15-30 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MUSK transcript comprising a sequence that is identical to 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 15 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 16 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 17 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 18 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 19 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 20 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 21 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 22 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 23 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 24 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 25 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 26 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 27 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 28 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 29 consecutive bases of region 2, SEQ ID: 211. In some embodiments, oligonucleotides target a portion of MuSK transcript comprising a sequence that is identical to 30 consecutive bases of region 2, SEQ ID: 211. [0045] In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to a sequence within or comprising at least a portion of ACTCTGTCAGGTTTCTTCTGGGTCCATTCAAGAGAGTGTGAAAGACCGAGTGATT GACTCAAGAC (region 1, SEQ ID: 126). In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to a sequence that is at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50% identical to region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 95% identical to a portion of region 1 (SEQ ID: 126) that includes at least 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 10 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 11 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 12 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 13 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 14 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 15 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 16 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 17 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 18 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 19 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 20 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 21 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 22 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 23 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 24 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 25 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 26 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 27 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 28 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 29 consecutive bases of region 1 (SEQ ID: 126). In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of region 1 (SEQ ID: 126) that includes at least 30 consecutive bases of region 1 (SEQ ID: 126). [0046] In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to no more than 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 15-30 consecutive bases of region 1, SEQ ID: 126. [0047] In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 15 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 16 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 17 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 18 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 19 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 20 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 21 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 22 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 23 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 24 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 25 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 26 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 27 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 28 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 29 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 30 consecutive bases of region 1, SEQ ID: 126. [0048] In some embodiments, an oligonucleotide has a length of 30 bases. In some embodiments, an oligonucleotide has a length of 29 bases. In some embodiments, an oligonucleotide has a length of 28 bases. In some embodiments, an oligonucleotide has a length of 27 bases. In some embodiments, an oligonucleotide has a length of 26 bases. In some embodiments, the oligonucleotide has a length of 25 bases. In some embodiments, the oligonucleotide has a length of 24 bases. In some embodiments, the oligonucleotide has a length of 23 bases. In some embodiments, the oligonucleotide has a length of 22 bases. In some embodiments, the oligonucleotide has a length of 21 bases. In some embodiments, the oligonucleotide has a length of 20 bases. In some embodiments, the oligonucleotide has a length of 19 bases. In some embodiments, the oligonucleotide has a length of 18 bases. In some embodiments, the oligonucleotide has a length of 17 bases. In some embodiments, the oligonucleotide has a length of 16 bases. In some embodiments, the oligonucleotide has a length of 15 bases. [0049] In some embodiments, the oligonucleotide has a length of less than about 50 bases. In some embodiments, the oligonucleotide has a length of less than about 40 bases. In some embodiments, the oligonucleotide has a length of less than about 30 bases. In some embodiments, the oligonucleotide has a length of more than about 10 bases. In some embodiments, the oligonucleotide has a length of more than about 15 bases. In some embodiments, the oligonucleotide has a length of more than about 20 bases. In some embodiments, the base sequence of the oligonucleotide comprises from 5’ to 3’:

[0050] In some embodiments, the oligonucleotide is complementary to a nucleotide sequence that is at least 90% identical to any one of SEQ ID NOs: 39-76 and and 212-253. [0051] In some embodiments, the oligonucleotides comprise one or more types of base modifications, sugar modification, and internucleotidic linkage modifications. In some embodiments, the oligonucleotides comprise non-natural sugar moieties, or non-natural internucleotidic linkages, or both. [0052] In some embodiments, the oligonucleotides comprise internucleotidic linkage modifications. In some embodiments, the internucleotidic linkages of the oligonucleotide comprises natural phosphate, phosphorothioate, or phosphodithioate linkages. In some embodiments, each internucleotidic linkages of the oligonucleotide is a phosphorothioate linkage. In some embodiments, each internucleotidic linkage of the oligonucleotide is a natural phosphate linkage. In some embodiments, oligonucleotide comprises at least one natural phosphate linkage and at least one phosphodithioate linkage. In some embodiments, at least 50%, 60%, 70%, 80%, 90%, 94%, or 95% of internucleotidic linkages of an oligonucleotide are phosphodithioate linkages. In some embodiments, at least 50%, 60%, 70%, 80%, 90%, 94%, or 95% of internucleotidic linkages of an oligonucleotide are natural phosphate linkages. [0053] In some embodiments, the oligonucleotides comprise sugar modification. In some embodiments, the modified sugar moiety has a 2’-modification. In some embodiments, the modified sugar moiety comprises a bicyclic sugar modification. In some embodiments, the modified sugar moiety comprises a 2’-modification, wherein a 2’-modification is 2’-OR ¹ , wherein R ¹ is optionally substituted C _1-6 alkyl. In some embodiments, the modified sugar moiety comprises a 2’-modification, wherein a 2’-modification is 2’-MOE. In some embodiments, the modified sugar moiety comprises a 2’-modification, wherein a 2’- modification is 2’-OMe. In some embodiments, each sugar of the oligonucleotide is a 2’- MOE modified sugar. In some embodiments, an oligonucleotide comprises 2’-OH sugar (RNA sugar). In some embodiments, an oligonucleotide comprise 2’-H sugar (DNA sugar). In some embodiments, an oligonucleotide comprises 2’-MOE sugar. In some embodiments, an oligonucleotide comprises 2’-OMe sugar. In some embodiments, an oligonucleotide comprises 2’-MOE, 2’-OMe, 2’-OH, 2’-H sugar, or any combination thereof. In some embodiments, an oligonucleotide comprises at least one 2’-MOE sugar and at least one 2’- OH sugar (RNA sugar). In some embodiments, an oligonucleotide comprises at least one 2’- MOE sugar and at least one 2’-H sugar (DNA sugar). [0054] In some embodiments, the oligonucleotide has the structure from 5’ to 3’of: wherein * represents a phosphorothioate linkage, and each sugar of the oligonucleotides is a 2’-MOE modified sugar. [0055] In some embodiments, an oligonucleotide composition comprising a mixture of two or more oligonucleotides according to any one of the embodiments. [0056] In some embodiments, the composition comprises oligonucleotides that targets regions of the MuSK gene that correspond to positions 83776-83800 and on 83854-83878 of SEQ ID NO: 77. [0057] In some embodiments, a pharmaceutical composition comprises a therapeutically effective amount of an oligonucleotide, and at least one pharmaceutically acceptable inactive ingredient selected from pharmaceutically acceptable diluents, pharmaceutically acceptable excipients, and pharmaceutically acceptable carriers, wherein the oligonucleotide is an oligonucleotide of any one of the embodiments. [0058] In some embodiments, the oligonucleotides are formulated a nanocarrier. In some embodiments, the oligonucleotides are formulated in lipid nano-particles (LNPs). In some embodiments, the oligonucleotides are covalently conjugated to an additional moiety selected from lipids (for example, cholesterol), peptides, aptamers, antibodies, and sugars (for example, N-acetylgalactosamine (GalNAc). In some embodiments, the oligonucleotides are covalently conjugated to N-acetylgalactosamine (GalNAc). [0059] In another aspect, the disclosure features, a method of altering relative amounts of MuSK spliced transcripts, the method comprising a step of administering to a subject a pharmaceutical composition that comprises or delivers a composition of any one of previous embodiments. [0060] In some embodiments, the disclosure features the alteration of MuSK spliced transcripts being characterized in that, the ratio of MuSK transcripts containing Ig3 domain- encoding sequences to MuSK transcription containing no Ig3 domain-encoding sequences is increased. In some embodiments, the alteration of MuSK spliced transcripts being characterized in that, the ratio of MuSK transcripts containing Ig3 domain-encoding sequences to MuSK transcription containing no Ig3 domain-encoding sequences decreases. In some embodiments, the alteration of MuSK spliced transcripts being characterized in that, MuSK transcripts containing Ig3 domain-encoding sequences decreases and level of total MuSK transcripts remains substantially the same. [0061] In some embodiments, the alteration of MuSK spliced transcripts is characterized in that, the level of MuSK transcripts including exons 6 and 7 decreases or level of MuSK protein forms including sequences encoded by exons 6 and 7 decreases, or both. [0062] In some embodiments, the alteration of MuSK spliced transcripts being characterized in that, level of MuSK transcripts including exons 6 and 7 is increased or level of MuSK protein forms including sequences encoded by exons 6 and 7 is increased, or both. In some embodiments, the alteration of MuSK spliced transcripts is characterized in that, the level of MuSK transcripts including exons 3 and 4 decreases or level of MuSK protein forms including sequences encoded by exons 3 and 4 decreases, or both. In some embodiments, the alteration of MuSK spliced transcripts is characterized in that, the level of MuSK transcripts including exons 3 and 4 is increased or level of MuSK protein forms including sequences encoded by exons 3 and 4 is increased, or both. [0063] In some embodiments, the alteration of MuSK spliced transcripts being characterized in that, the level of MuSK transcripts including exons 3 and 4 remains substantially the same, or level of MuSK protein forms including sequences encoded by exons 3 and 4 remains substantially the same, or both. In some embodiments, the alteration of MuSK spliced transcripts is characterized that, the level of MuSK transcripts including exons 3 and 4 remains substantially the same, or level of MuSK protein forms including sequences encoded by exons 3 and 4 remains substantially the same, or both; and level of MuSK transcripts including exons 6 and 7 decreases or level of MuSK protein forms including sequences encoded by exons 6 and 7 decreases, or both. [0064] In another aspect, the disclosure features, a method of treating a subject suffering from one or more features of neurodegenerative diseases, the method comprising a step of administering to a subject a pharmaceutical composition that comprises or delivers a composition of any one of the previous embodiments. [0065] In another aspect, the disclosure features, a method of increasing neurogenesis, the method comprising a step of administering to a subject a pharmaceutical composition that comprises or delivers a composition of any one of the previous embodiments. [0066] In another aspect, the disclosure features, a method of treating a subject suffering from one or more features of neuromuscular dysfunction or a muscular dystrophy, the method comprising a step of administering to a subject a pharmaceutical composition that comprises or delivers a composition of any one of the previous embodiments. [0067] In another aspect, the disclosure features, a method of increasing muscle regeneration and/or muscle growth, the method comprising a step of administering to a subject a pharmaceutical composition that comprises or delivers a composition of any one of the previous embodiments. [0068] In another aspect, the disclosure features, a method of treating muscle fibrosis, the method comprising a step of administering to a subject a pharmaceutical composition that comprises or delivers a composition of any one of the previous embodiments. [0069] In some embodiments, the subject is at risk of, or afflicted with, a disease or disorder selected from the group consisting of: neuromuscular dysfunction, neurodegenerative disorder, cardiac disorder, and diseases characterized by muscle wasting. In some embodiments, the neurodegenerative disorder is selected from the group consisting of Alzheimer’s Disease (AD), Parkinson’s disease, dementia (e.g., Frontotemporal dementia), stroke, Major Depressive Disorder (MDD), bipolar disorder, Schizophrenia, Post-Traumatic Stress Disorder (PTSD), substance-related and addictive disorders (e.g., chronic cocaine use and lifelong cigarette smoking), Temporal-Lobe Epilepsy, Hippocampal Sclerosis, Niemann Pick Type C, Diabetes-mediated hippocampal neuronal loss, brain injury (e.g., traumatic and/or anoxic brain injury), and Huntington’s disease. In some embodiments, the neurodegenerative disease is Alzheimer’s Disease (AD). [0070] In some embodiments, the neuromuscular dysfunction is a muscular dystrophy selected from the group consisting of: Becker, Congenital, Distal, Duchenne, Emery- Dreifuss, Facioscapulohumeral, Limb-girdle, Myotonic, and Oculo-pharyngeal muscular dystrophy. In another aspect, the disclosure features, [0071] In some embodiments, the cardiac disorder is myocardial infarction or cardiomyopathy. In some embodiments, the subject is in need of enhanced muscle regeneration and/or growth following a condition selected from the group consisting of: surgery, trauma and prolonged immobilization. In some embodiments, the prolonged immobilization results from bed-rest or casting. In some embodiments, the subject is at risk of, or afflicted with, sarcopenia. In some embodiments, the subject is at risk of, or afflicted with, muscle fibrosis resulting from a disease or condition selected from the group consisting of: trauma, heritable disease, muscle disorder, and aging. In some embodiments, the trauma is the result of a condition selected from the group consisting of: radiation treatment, crush injury, laceration, and amputation. [0072] In some embodiments, the heritable disease or muscle disorder selected from the group consisting of: Congenital Muscular Dystrophy, Duchenne Muscular Dystrophy, Becker’s Muscular Dystrophy; Amyotrophic Lateral Sclerosis (ALS), and age-associate sarcopenia. [0073] In some embodiments, the composition is delivered to the CNS. In some embodiments, the composition is delivered to the cerebrospinal fluid. In some embodiments, the composition is delivered to the muscle. In some embodiments, the composition is delivered to the liver. In some embodiments, the composition can be formulated for systemic or localized administration. In some embodiments, the composition is formulated for delivery by a route selected from intravenous injection, intravenous infusion, intramuscular injection, intrathecal administration, oral administration, buccal administration, inhalation, nasal administration, topical administration, ophthalmic administration or otic administration. [0074] In some embodiments, the composition is formulated for delivery by intramuscular administration. In some embodiments, the composition is formulated for delivery by intravenous administration. In some embodiments, the composition is formulated for delivery by oral administration. BRIEF DESCRIPTION OF THE DRAWING [0075] For the purpose of illustration, certain embodiments of the present invention are shown in the drawings described below. Like numerals in the drawings indicate like elements throughout. It should be understood, however, that the invention is not limited to the precise arrangements, dimensions, and instruments shown. In the drawings: [0076] FIG.1 is a schematic representation of an interaction between BMP and Ig3 domain of MuSK and its implications in BMP signaling and neurogenesis and cognition. [0077] FIG.2 is a schematic representation of the full-length and MuSKΔIg3 transcripts and encoded proteins and exemplary primer design to selectively detect total MuSK and full-length MuSK transcripts. [0078] FIG.3 shows relative MuSK expression measured by qPCR using Taqman or SYBR green technology in LHCN-M2 cells. [0079] FIG.4 is a schematic representation of “region 1” and “region 2” of exon 7 of MuSK transcript. [0080] FIG.5 shows an alignment of the ASOs Bld1-Bld18 on the genetic sequence of MuSK. [0081] FIG.6 shows microscopic acquisitions of LHCN-M224h after being transfected with the ASOs Bld1-Bld4, Bld6, Bld7, Bld9, Bld11, Bld12, Bld13, Bld14, Bld15, Bld16, Bld17, and untreated control at 100nM (scale 100nm). [0082] FIG.7 shows relative MuSK expression measured by qPCR of LHCN-M2 cells transfected with ASOs Bld1-Bld18 at 50 and 100 nM. Panel A shows total MuSK expression (i.e., of MuSK34, a primer spanning exon/exon junction 3-4) and Panel B shows expression of MuSK exons 6-7 (i.e., using MuSK67, a primer spanning exon/exon junction 6- 7). All samples are normalized to the housekeeping genes GAPDH and YWHAZ and to controls. [0083] FIG.8 shows alignment of the ASOs Bld1-Bld18 on the genetic sequence of MuSK and their effect on MuSK expression. Green: no effect or increase in MuSK expression (MuSK expression comprised between 90 and 300% of the untreated condition). Orange: moderate decrease in MuSK expression (MuSK expression comprised between 40 and 70% of the untreated condition). Red: high decrease in MuSK expression (MuSK expression below 40% of the untreated condition). Red areas indicate regions important for the expression of MuSK where ASOs induced a decrease of MuSK67 >80%. [0084] FIG.9 shows an alignment of the ASOs Bld19-Bld38 on the genetic sequence of MuSK. [0085] FIG.10 shows microscopic acquisitions of LHCN-M224 h after being transfected with the ASOs Bld 19-22, Bld29-34, and untreated control at 100 nM (scale 100nm). [0086] FIG.11 shows relative MuSK expression measured by qPCR of LHCN-M2 cells transfected with ASOs (control, Bld19-Bld28) at 50 and 100 nM. Panel A shows MuSK34 expression and panel B shows MuSK67 expression. All samples are normalized to the housekeeping genes GAPDH and YWHAZ and to controls. [0087] FIG.12 shows the alignment of the ASOs Bld19-Bld38 on the genetic sequences and their effect on MuSK expression. Green: no effect or increase in MuSK expression (MuSK expression comprised between 90 and 300% of the untreated condition). Orange: moderate decrease in MuSK expression (MuSK expression comprised between 40 and 70% of the untreated condition). Red: high decrease in MuSK expression (MuSK expression below 40% of the untreated condition). Red areas indicate regions important for the expression of MuSK where ASOs induced a decrease of MuSK67 >80%. Purple areas indicate regions that can be targeted to selectively inhibit MuSK67 expression (with lower effect on other exons). [0088] FIG.13 shows relative MuSK expression in response to various doses of ASOs (Bld25 (panel A), Bld26 (panel B), Bld27 (panel C), Bld28 (panel D), Bld35 (panel E), Bld38 (panel F)). MuSK34 (in blue) and MuSK67 (in red) expressions were measured by qPCR and normalized to housekeeping genes and to the controls. The estimated IC is indicated on each graph. The 5 tested doses were 2.5, 5, 25, 125, and 400 nM. [0089] FIG.14 shows relative MuSK expression in response to various doses of ASOs (Bld25 (panel A), Bld26 (panel B)). MuSK34 (in blue) and MuSK67 (in red) expressions were measured by qPCR and normalized to housekeeping genes and to the controls. The 4 tested doses were 5, 7.5, 12.5 and 25 nM. [0090] FIG.15 shows relative MuSK expression in response to combination of ASOs Bld25 and Bld26 at 12.5 nM final concentration compared to an untreated control. MuSK34 (in blue) and MuSK67 (in red) expressions were measured by qPCR and normalized to housekeeping genes and to controls. [0091] FIG.16 shows migration of PCR products from exon 3 to exon 9 on gel electrophoresis. cDNA of ASO-treated cells (Bld25, i.e., “hu7-10 or Bld26, i.e., “hu73”) was amplified by PCR and deposited on gel electrophoresis to be migrated (panel A). Predicted products are presented in panel B and panel B’. [0092] FIG.17 shows an alignment of sequences of various target portion of “region 1”. ASOs Bld25, Bld26, and Bld51-Bld66 target various portions of “region 1.” [0093] FIG.18 shows the relative change of gene expression of total MuSK (MuSK34) and MuSK containing Ig3 domain (MuSK67) for ASOs Bld51-Bld66 at a concentration of 12.5 nM (Panel A) and at a concentration of 100 nM (Panel B). [0094] FIG.19 shows an alignment of ASOs Bld25-1, Bld25-2, Bld25, Bld25-3, Bld25-4, BLd25-5, Bld26-1, Bld26-2, Bld26, Bld26-3, Bld26-4, Bld27, Bld28, Bld35, Bld 38 on various target portions of “region 1” and “region 2” of exon 7 of human MuSK. [0095] FIG.20 shows MuSK gene expression analyzed in qPCR. Panel A shows relative gene expression of MuSKIg3 (MuSK67) and Panel B shows relative gene expression of total MuSK (MuSK34). [0096] FIG.21 shows MuSK gene expression from only the ASOs which showed relative expression of MuSK67 of less than 50% and total MuSK (MuSK34) of greater than 60% compared to the control. Panel A shows relative gene expression of MuSKIg3 (MuSK67) and Panel B shows relative gene expression of total MuSK (MuSK34). [0097] FIG.22 shows a comparison of Bld25-5 to Bld25 after transfection with ASO for 24 hours (Panels A and B) and 48 hours (Panels C and D). [0098] FIG.23 shows an alignment of ASOs Bld25, Bld25-A, Bld25-B, Bld25-C, Bld25-D, Bld25-E, Bld25-5, Bld25-5-A, Bld25-5-B, Bld25-5-C, Bld25-5-D, Bld25-5-E, Bld26-2, Bld26-2-A, Bld26-2-B, Bld26-2-C, Bld26-2-D, Bld26, Bld26-B, Bld26-C, Bld26-D, on various target portions of “region 1” of exon 7 of human MuSK. [0099] FIG.24 shows relative gene expression (MuSK34 and MuSK67) for ASOs Bld25-A, Bld25-B, Bld25-C, Bld25-D, and Bld25-E. [0100] FIG.25 shows relative gene expression (MuSK34 and MuSK67) for ASOs Bld25-5-A, Bld25-5-B, Bld25-5-C, Bld25-5-D, and Bld25-5-E. [0101] FIG.26 shows a graphical representation of the 3 variants of MuSK RNA. Full length and ΔIg3 indicate the lengths of the full-length sequence and the sequence comprising a deletion of exon 6, 7, respectively, amplified by PCR from exon 3 to exon 9. [0102] FIG.27 shows the gel migration of pcr products from cells treated with Bld25 and Bld25-5 and intensity of bands from Bld25 and Bld25-5 products. [0103] FIG.28 shows that the sequence of the band lower band positioned, where Δ6,7 variant 1 (687 bases) was expected, was indeed the sequence of this splice variant. [0104] FIG.29 shows images of HCN-M2 cells being treated for 48h with 10nM of siRNA against MuSK and were then stained for MuSK protein on days 2, 3, 4, and 5 following siRNA treatment. DEFINITIONS [0105] For convenience, the meaning of some terms and phrases used in the specification, examples, and appended claims, are provided below. Unless stated otherwise, or implicit from context, the following terms and phrases include the meanings provided below. [0106] These definitions are provided to aid in describing particular embodiments, and are not intended to limit the claimed invention, because the scope of the invention is limited only by the claims. [0107] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. If there is an apparent discrepancy between the usage of a term in the art and its definition provided herein, the definition provided within the specification shall prevail. [0108] About or Approximately: The term “about” or “approximately”, when used herein in reference to a value, refers to a value that is similar, in context to the referenced value. In general, those skilled in the art, familiar with the context, will appreciate the relevant degree of variance encompassed by “about” in that context. For example, in some embodiments, the term “about” may encompass a range of values that within 25%, 20%, 19%, 18%, 17%, 16%, 15%, 14%, 13%, 12%, 11%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, or less of the referred value. [0109] Administration: As used herein, the term “administration” typically refers to the administration of a composition to a subject or system, for example to achieve delivery of an agent (e.g., an agonizing agent) that is, or is included in or otherwise delivered by, the composition. Those of ordinary skill in the art will be aware of a variety of routes that may, in appropriate circumstances, be utilized for administration to a subject, for example a human. For example, in some embodiments, administration may be ocular, oral, buccal, dermal (which may be or comprise, for example, one or more of topical to the dermis, intradermal, interdermal, transdermal, etc), enteral, intra-arterial, intradermal, intragastric, intramedullary, intramuscular, intranasal, intraperitoneal, intrathecal, intravenous, intraventricular, within a specific organ (e.g., intrahepatic), mucosal, nasal, oral, rectal, subcutaneous, sublingual, topical, tracheal (e.g., by intratracheal instillation), vaginal, vitreal, etc. In some embodiments, an agent (e.g., an agonizing agent) is delivered to the central nervous system (CNS), e.g., delivered via intracerebroventricular administration. In some embodiments, administration may involve only a single dose. In some embodiments, administration may involve application of a fixed number of doses. In some embodiments, administration may involve dosing that is intermittent (e.g., a plurality of doses separated in time) and/or periodic (e.g., individual doses separated by a common period of time) dosing. In some embodiments, administration may involve continuous dosing (e.g., perfusion) for at least a selected period of time. [0110] Agent: In general, the term “agent”, as used herein, may be used to refer to a compound or entity of any chemical class including, for example, a polypeptide, nucleic acid, saccharide, lipid, small molecule, metal, or combination or complex thereof. In appropriate circumstances, as will be clear from context to those skilled in the art, the term may be utilized to refer to an entity that is or comprises a cell or organism, or a fraction, extract, or component thereof. Alternatively or additionally, as context will make clear, the term may be used to refer to a natural product in that it is found in and/or is obtained from nature. In some instances, again as will be clear from context, the term may be used to refer to one or more entities that is man-made in that it is designed, engineered, and/or produced through action of the hand of man and/or is not found in nature. In some embodiments, an agent may be utilized in isolated or pure form; in some embodiments, an agent may be utilized in crude form. In some embodiments, potential agents may be provided as collections or libraries, for example that may be screened to identify or characterize active agents within them. In some cases, the term “agent” may refer to a compound or entity that is or comprises a polymer; in some cases, the term may refer to a compound or entity that comprises one or more polymeric moieties. In some embodiments, the term “agent” may refer to a compound or entity that is not a polymer and/or is substantially free of any polymer and/or of one or more particular polymeric moieties. In some embodiments, the term may refer to a compound or entity that lacks or is substantially free of any polymeric moiety. [0111] Agonist: Those skilled in the art will appreciate that the term “agonist” may be used to refer to an agent (i.e., an “agonizing agent”), condition, or event whose presence, level, degree, type, or form correlates with increased level or activity of another agent (i.e., the agonized agent or the target agent). In general, an agonist may be or include an agent of any chemical class including, for example, small molecules, polypeptides, nucleic acids, carbohydrates, lipids, metals, and/or any other entity that shows the relevant activating activity. In some embodiments, an agonist may be direct (in which case it exerts its influence directly upon its target); in some embodiments, an agonist may be indirect (in which case it exerts its influence by other than binding to its target; e.g., by interacting with a regulator of the target, so that level or activity of the target is altered). In some embodiments, an agonist is a binding agent that is a protein (e.g., an antibody) or a nucleic acid (e.g., an antisense oligonucleotide) that binds a target (e.g., a protein or nucleic acid) so that level, form, and/or or activity of the target is altered. In some embodiments, the altered level, form and/or activity is an increased level of altered protein expressed from the target nucleic acid sequence. Those skilled in the art, reading the present disclosure, will appreciate that, in some embodiments, an agonizing agent may bind to (and potentially agonize) a binding target, which binding causes an increase in level or activity of a further agonized target. To give a specific example, in some embodiments, an agonizing agent that binds to a nucleic acid target may alter level and/or activity of that target, and in some specific embodiments may agonize an activity of that nucleic acid target (e.g., by increasing its modification, splicing, 5’ cap formation, and/or 3’ end formation, transport, and/or translation, etc, so that a level of a desired product – e.g., mRNA, is increased) and/or may agonize a downstream target, such as a polypeptide encoded by such nucleic acid target. To give one particular such example, in some embodiments, an agonizing agent may be or comprise an oligonucleotide that binds to a primary transcript and alters its splicing pattern so that level and/or activity of a particular spliced form (e.g., mature mRNA) is increased, which may, in turn achieved increased level of a product (e.g., a polypeptide) that is or is encoded by such particular spliced form. [0112] Antagonist: Those skilled in the art will appreciate that the term “antagonist”, as used herein, may be used to refer to an agent (i.e., an “antagonizing agent”), condition, or event whose presence, level, degree, type, or form correlates with decreased level or activity of another agent (i.e., the inhibited agent, or target). In general, an antagonist may be or include an agent of any chemical class including, for example, small molecules, polypeptides, nucleic acids, carbohydrates, lipids, metals, and/or any other entity that shows the relevant inhibitory activity. In some embodiments, an antagonist may be direct (in which case it exerts its influence directly upon its target); in some embodiments, an antagonist may be indirect (in which case it exerts its influence by other than binding to its target; e.g., by interacting with a regulator of the target, so that level or activity of the target is altered). In some embodiments, an antagonist is binding agent that is a protein (e.g., an antibody) or a nucleic acid (e.g., an antisense oligonucleotide) that binds a target (e.g., a protein or nucleic acid) so that the level, form, and/or activity of the target is altered. In some embodiments, the altered level, form and/or activity is a decreased level of altered protein expressed from the target nucleic acid sequence. Those skilled in the art, reading the present disclosure, will appreciate that, in some embodiments, an antagonizing agent may bind to (and potentially antagonize) a binding target, which binding causes a decrease in level or activity of a further antagonized target. To give a specific example, in some embodiments, an antagonizing agent that binds to a nucleic acid target may alter level and/or activity of that target, and in some specific embodiments may antagonize an activity of that nucleic acid target (e.g., by decreasing its modification, splicing, 5’ cap formation, and/or 3’ end formation, transport, and/or translation, etc, so that a level of an undesired product – e.g., mRNA, is suppressed) and/or may antagonize a downstream target, such as a polypeptide encoded by such nucleic acid target. To give one particular such example, in some embodiment, an antagonizing agent may be or comprise an oligonucleotide that binds to a primary transcript and alters its splicing pattern so that level and/or activity of a particular spliced form (e.g., mature mRNA) is suppressed, which may, in turn achieved decreased level of a product (e.g., a polypeptide) that is or is encoded by such particular spliced form. [0113] Antibody agent: As used herein, the term “antibody agent” refers to an agent that specifically binds to a particular antigen (e.g., that may be or comprise an epitope of a protein of interest - e.g., a MuSK protein). In some embodiments, the term encompasses any polypeptide or polypeptide complex that includes immunoglobulin structural elements sufficient to confer specific binding. Exemplary antibody agents include, but are not limited to monoclonal antibodies or polyclonal antibodies. In some embodiments, an antibody agent may include one or more constant region sequences that are characteristic of mouse, rabbit, primate, or human antibodies. In some embodiments, an antibody agent may include one or more sequence elements are humanized, primatized, chimeric, etc, as is known in the art. In many embodiments, the term “antibody agent” is used to refer to one or more of the art- known or developed constructs or formats for utilizing antibody structural and functional features in alternative presentation. For example, embodiments, an antibody agent utilized in accordance with the present invention is in a format selected from, but not limited to, intact IgA, IgG, IgE or IgM antibodies; bi- or multi- specific antibodies (e.g., Zybodies®, etc); antibody fragments such as Fab fragments, Fab’ fragments, F(ab’)2 fragments, Fd’ fragments, Fd fragments, and isolated CDRs or sets thereof; single chain Fvs; polypeptide-Fc fusions; single domain antibodies (e.g., shark single domain antibodies such as IgNAR or fragments thereof); cameloid antibodies; masked antibodies (e.g., Probodies®); Small Modular ImmunoPharmaceuticals (“SMIPs ^TM” ); single chain or Tandem diabodies (TandAb®); VHHs; Anticalins®; Nanobodies® minibodies; BiTE®s; ankyrin repeat proteins or DARPINs®; Avimers®; DARTs; TCR-like antibodies;, Adnectins®; Affilins®; Trans- bodies®; Affibodies®; TrimerX®; MicroProteins; Fynomers®, Centyrins®; and KALBITOR®s. In some embodiments, an antibody may lack a covalent modification (e.g., attachment of a glycan) that it would have if produced naturally. In some embodiments, an antibody may contain a covalent modification (e.g., attachment of a glycan, a payload [e.g., a detectable moiety, a therapeutic moiety, a catalytic moiety, etc], or other pendant group [e.g., poly-ethylene glycol, etc.]. In many embodiments, an antibody agent is or comprises a polypeptide whose amino acid sequence includes one or more structural elements recognized by those skilled in the art as a complementarity determining region (CDR); in some embodiments an antibody agent is or comprises a polypeptide whose amino acid sequence includes at least one CDR (e.g., at least one heavy chain CDR and/or at least one light chain CDR) that is substantially identical to one found in a reference antibody. In some embodiments an included CDR is substantially identical to a reference CDR in that it is either identical in sequence or contains between 1-5 amino acid substitutions as compared with the reference CDR. In some embodiments an included CDR is substantially identical to a reference CDR in that it shows at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity with the reference CDR. In some embodiments an included CDR is substantially identical to a reference CDR in that it shows at least 96%, 96%, 97%, 98%, 99%, or 100% sequence identity with the reference CDR. In some embodiments an included CDR is substantially identical to a reference CDR in that at least one amino acid within the included CDR is deleted, added, or substituted as compared with the reference CDR but the included CDR has an amino acid sequence that is otherwise identical with that of the reference CDR. In some embodiments an included CDR is substantially identical to a reference CDR in that 1-5 amino acids within the included CDR are deleted, added, or substituted as compared with the reference CDR but the included CDR has an amino acid sequence that is otherwise identical to the reference CDR. In some embodiments an included CDR is substantially identical to a reference CDR in that at least one amino acid within the included CDR is substituted as compared with the reference CDR but the included CDR has an amino acid sequence that is otherwise identical with that of the reference CDR. In some embodiments an included CDR is substantially identical to a reference CDR in that 1-5 amino acids within the included CDR are deleted, added, or substituted as compared with the reference CDR but the included CDR has an amino acid sequence that is otherwise identical to the reference CDR. In some embodiments, an antibody agent is or comprises a polypeptide whose amino acid sequence includes structural elements recognized by those skilled in the art as an immunoglobulin variable domain. In some embodiments, an antibody agent is a polypeptide protein having a binding domain which is homologous or largely homologous to an immunoglobulin-binding domain. [0114] Antibody: As used herein, the term “antibody” refers to an immunoglobulin or a derivative thereof containing an immunoglobulin domain capable of binding to an antigen (e.g., that may be or comprise an epitope of a protein of interest - e.g., a MuSK protein). The antibody can be of any species, e.g., human, rodent, rabbit, goat, chicken, etc. The antibody may be a member of any immunoglobulin class, including any of the human classes: IgG, IgM, IgA, IgD, and IgE, or subclasses thereof such as IgG1, IgG2, etc. In various embodiments of the invention the antibody is a fragment such as an Fab’, F(ab’) ₂ , scFv (single-chain variable) or other fragment that retains an antigen binding site, or a recombinantly produced scFv fragment, including recombinantly produced fragments. See, e.g., Allen, T., Nature Reviews Cancer, Vol.2, 750-765, 2002, and references therein. The antibody can be monovalent, bivalent or multivalent. The antibody may be a chimeric or “humanized” antibody in which, for example, a variable domain of rodent origin is fused to a constant domain of human origin, thus retaining the specificity of the rodent antibody. The domain of human origin need not originate directly from a human in the sense that it is first synthesized in a human being. Instead, “human” domains may be generated in rodents whose genome incorporates human immunoglobulin genes. See, e.g., Vaughan, et al., (1998), Nature Biotechnology, 16: 535-539. The antibody may be partially or completely humanized. An antibody may be polyclonal or monoclonal, though for purposes of the present invention monoclonal antibodies are generally preferred. Methods for producing antibodies that specifically bind to virtually any molecule of interest are known in the art. For example, monoclonal or polyclonal antibodies can be purified from blood or ascites fluid of an animal that produces the antibody (e.g., following natural exposure to or immunization with the molecule or an antigenic fragment thereof), can be produced using recombinant techniques in cell culture or transgenic organisms, or can be made at least in part by chemical synthesis. In some embodiments, the antibody can act as an antagonist, e.g., by binding to a target antigen, resulting in a decreased level or activity of said antigen. In some embodiments, the antibody can act as an agonist, e.g., by binding to a target antigen, resulting in an increased level or activity of said antigen. [0115] Antisense: The term “antisense” is used herein to refer to a nucleic acid whose nucleotide sequence is complementary to part or all of a sequence found in a coding strand nucleic acid. Typically, a “coding strand” nucleic acid is one whose sequence includes part or all of an open reading frame or other stretch of residues that encodes part or all of a polypeptide. In some embodiments, the term “antisense” may particularly be used herein in reference to an oligonucleotide that binds specifically to a coding strand (i.e., to a target sequence within such coding strand). In some embodiments, a coding strand may include both coding and non-coding sequences (e.g., to give but one example, may be a transcript, such as a primary transcript. that includes both intron and exon sequences). Those skilled in the art, reading the present disclosure, will appreciate that, in some embodiments, an oligonucleotide may be considered or referred to as an “antisense” oligonucleotide when some or all of its sequence is complementary to non-coding portion(s) of its target strand. In some embodiments, an antisense oligonucleotide binds to coding sequences in a target sense strand; in some embodiments, an antisense oligonucleotide binds to non-coding sequences in a target coding strand. In some embodiments, an antisense oligonucleotide binds to both coding and non-coding sequences in a target coding strand. In some embodiments, an antisense oligonucleotide is characterized in that, when bound to its target sequence in a coding strand (e.g., a transcript), it alters post-transcriptional processing (e.g., one or more of modification, splicing, 5’ cap formation, and/or 3’ end formation, 5’ cap formation, and/or 3’ end formation, transport, and/or translation) of such coding strand. In some particular embodiments, an antisense oligonucleotide alters splicing of its target coding strand, Alternatively or additionally, in some embodiments, an antisense-coding strand complex is or can be degraded, e.g., by RNase H. [0116] Approximately: As used herein, the terms “approximately” or “about” in reference to a number are generally taken to include numbers that fall within a range of 5%, 10%, 15%, or 20% in either direction (greater than or less than) of the number unless otherwise stated or otherwise evident from the context (except where such number would be less than 0% or exceed 100% of a possible value). [0117] Binding agent: In general, the term “binding agent” is used herein to refer to any entity that binds to a target of interest as described herein. In many embodiments, a binding agent of interest is one that binds specifically with its target in that it discriminates its target from other potential binding partners in a particular interaction context. In general, a binding agent may be or comprise an entity of any chemical class (e.g., polymer, non- polymer, small molecule, polypeptide, carbohydrate, lipid, nucleic acid, etc). In some embodiments, a binding agent is a single chemical entity. In some embodiments, a binding agent is a complex of two or more discrete chemical entities associated with one another under relevant conditions by non-covalent interactions. For example, those skilled in the art will appreciate that in some embodiments, a binding agent may comprise a “generic” binding moiety (e.g., one of biotin/avidin/streptavidin and/or a class-specific antibody) and a “specific” binding moiety (e.g., an antibody or aptamers with a particular molecular target) that is linked to the partner of the generic biding moiety. In some embodiments, such an approach can permit modular assembly of multiple binding agents through linkage of different specific binding moieties with the same generic binding poiety partner. In some embodiments, binding agents are or comprise polypeptides (including, e.g., antibodies or antibody fragments). In some embodiments, binding agents are or comprise small molecules. In some embodiments, binding agents are or comprise nucleic acids (e.g., antisense oligonucleotides). In some embodiments, binding agents are aptamers. In some embodiments, binding agents are polymers; in some embodiments, binding agents are not polymers. In some embodiments, binding agents are non-polymeric in that they lack polymeric moieties. In some embodiments, binding agents are or comprise carbohydrates. In some embodiments, binding agents are or comprise lectins. In some embodiments, binding agents are or comprise peptidomimetics. In some embodiments, binding agents are or comprise scaffold proteins. In some embodiments, binding agents are or comprise mimeotopes. In some embodiments, binding agents are or comprise stapled peptides. In certain embodiments, binding agents are or comprise nucleic acids, such as DNA or RNA (e.g., antisense oligonucleotides). [0118] Complementary: As used herein, in accordance with its art-accepted meaning, “complementary” refers to the capacity for precise pairing between particular bases, nucleosides, nucleotides or nucleic acids. For example, adenine (A) and uridine (U) are complementary; adenine (A) and thymidine (T) are complementary; and guanine (G) and cytosine (C), are complementary and are referred to in the art as Watson-Crick base pairings. If a nucleotide at a certain position of a first nucleic acid sequence is complementary to a nucleotide located opposite in a second nucleic acid sequence when the strands are aligned in anti-parallel orientation, the nucleotides form a complementary base pair, and the nucleic acids are complementary at that position. The percent complementarity of a first nucleic acid to a second nucleic acid may be evaluated by aligning them in antiparallel orientation for maximum complementarity over a window of evaluation, determining the total number of nt in both strands that form complementary base pairs within the window, dividing by the total number of nt within the window, and multiplying by 100. For example, AAAAAAAA and TTTGTTAT are 75% complementary since there are 12 nt in complementary base pairs out of a total of 16 nt. When computing the number of complementary nt needed to achieve a particular % complementarity, fractions are rounded to the nearest whole number. A position occupied by non-complementary nucleotides constitutes a mismatch, i.e., the position is occupied by a non-complementary base pair. In certain embodiments a window of evaluation has the length described herein for duplex portions or target portions. Complementary sequences include base-pairing of a polynucleotide comprising a first nucleotide sequence to a polynucleotide comprising a second nucleotide sequence over the entire length of both nucleotide sequences (if the same length) or over the entire length of the shorter sequence (if different lengths). Such sequences can be referred to as “perfectly complementary” (100% complementarity) with respect to each other herein. Nucleic acids that are at least 70% complementary over a window of evaluation are considered “substantially complementary” over that window. In certain embodiments complementary nucleic acids are at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% complementary over the window of evaluation. Where a first sequence is referred to as "substantially complementary" with respect to a second sequence herein, the two sequences may be perfectly complementary or they may comprise one or more unmatched bases upon hybridization, e.g., up to about 5%, 10%, 15%, 20%, or 25% unmatched bases upon hybridization, e.g., 1, 2, 3, 4, 5, or 6 mismatched base pairs upon hybridization for a duplex up to 30 base pairs, while retaining the ability to hybridize under the conditions most relevant to their intended use. It should be understood that where two oligonucleotides are designed to form, upon hybridization, one or more single stranded overhangs, such overhangs are not regarded as mismatches or unpaired nucleotides with regard to the determination of percent complementarity. For example, the two strands of a dsRNA comprising one oligonucleotide 21 nucleotides in length and another oligonucleotide 23 nucleotides in length, wherein the longer oligonucleotide comprises a sequence of 21 nucleotides that is perfectly complementary to the shorter oligonucleotide and a 2 nucleotide overhang, may be referred to as “perfectly complementary” herein. “Complementary” sequences, as used herein may include one or more non-Watson-Crick base pairs and/or base pairs formed from non-natural and other modified nucleotides, in so far as the requirements with respect to their ability to hybridize are fulfilled. Such non- Watson-Crick base pairs include, but are not limited to, G:U Wobble or Hoogsteen base pairing. Those of ordinary skill in the art are aware that guanine, cytosine, adenine, and uracil can be replaced by other bases without substantially altering the base pairing properties of a polynucleotide comprising a nucleotide bearing such bases, according to the so-called “wobble” rules (see, e.g., Murphy, FV IV & V Ramakrishnan, V., Nature Structural and Molecular Biology 11: 1251 - 1252 (2004)). For example, a nucleotide comprising inosine as its base can base pair with nucleotides containing adenine, cytosine, or uracil. Thus, nucleotides containing uracil, guanine, or adenine can be replaced in the nucleotide sequences of an Inhibitory RNA described herein by a nucleotide containing, for example, inosine. It will be understood that the terms "complementary”, “perfectly complementary”, and “substantially complementary” can be used with respect to the base matching between any two nucleic acids, e.g., the base matching between the sense strand and the antisense strand of a double stranded nucleic acid, or portion thereof. “Hybridize”, as used herein, refers to the interaction between two nucleic acid sequences (which in some embodiments may be part of the same nucleic acid molecule and in other embodiments may be or include part(s) of different nucleic acid molecules) comprising or consisting of complementary portions such that a duplex structure (i.e., an intramolecular or intermolecular duplex) is formed that is stable under the particular conditions of interest, as will be understood by the ordinary skilled artisan. [0119] Comprising: The term "comprising" means that other elements can also be present in addition to the defined elements presented. The use of "comprising" indicates inclusion rather than limitation. [0120] Consisting of: The term "consisting of" refers to compositions, methods, and respective components thereof as described herein, which are exclusive of any element not recited in that description of the embodiment. As used herein the term "consisting essentially of" refers to those elements required for a given embodiment. The term permits the presence of additional elements that do not materially affect the basic and novel or functional characteristic(s) of that embodiment of the invention. [0121] Combination therapy: As used herein, the term “combination therapy” refers to those situations in which a subject is simultaneously exposed to two or more therapeutic regimens (e.g., two or more therapeutic agents). In some embodiments, the two or more regimens may be administered simultaneously; in some embodiments, such regimens may be administered sequentially (e.g., all “doses” of a first regimen are administered prior to administration of any doses of a second regimen); in some embodiments, such agents are administered in overlapping dosing regimens. In some embodiments, “administration” of combination therapy may involve administration of one or more agent(s) or modality(ies) to a subject receiving the other agent(s) or modality(ies) in the combination. For clarity, combination therapy does not require that individual agents be administered together in a single composition (or even necessarily at the same time), although in some embodiments, two or more agents, or active moieties thereof, may be administered together in a combination composition, or even in a combination compound (e.g., as part of a single chemical complex or covalent entity). [0122] Comparable: As used herein, the term “comparable” refers to two or more agents, entities, situations, sets of conditions, etc., that may not be identical to one another but that are sufficiently similar to permit comparison there between so that one skilled in the art will appreciate that conclusions may reasonably be drawn based on differences or similarities observed. In some embodiments, comparable sets of conditions, circumstances, individuals, or populations are characterized by a plurality of substantially identical features and one or a small number of varied features. Those of ordinary skill in the art will understand, in context, what degree of identity is required in any given circumstance for two or more such agents, entities, situations, sets of conditions, etc to be considered comparable. For example, those of ordinary skill in the art will appreciate that sets of circumstances, individuals, or populations are comparable to one another when characterized by a sufficient number and type of substantially identical features to warrant a reasonable conclusion that differences in results obtained or phenomena observed under or with different sets of circumstances, individuals, or populations are caused by or indicative of the variation in those features that are varied. [0123] Domain: The term “domain” as used herein refers to a section or portion of an entity. In some embodiments, a “domain” is associated with a particular structural and/or functional feature of the entity so that, when the domain is physically separated from the rest of its parent entity, it substantially or entirely retains the particular structural and/or functional feature. Alternatively or additionally, a domain may be or include a portion of an entity that, when separated from that (parent) entity and linked with a different (recipient) entity, substantially retains and/or imparts on the recipient entity one or more structural and/or functional features that characterized it in the parent entity. In some embodiments, a domain is a section or portion of a molecule (e.g., a small molecule, carbohydrate, lipid, nucleic acid, or polypeptide). In some embodiments, a domain is a section of a polypeptide (e.g., the Ig3 domain of a MuSK protein); in some such embodiments, a domain is characterized by a particular structural element (e.g., a particular amino acid sequence or sequence motif, a-helix character, b-sheet character, coiled-coil character, random coil character, etc.), and/or by a particular functional feature (e.g., binding activity, enzymatic activity, folding activity, signaling activity, etc.). [0124] Dosing regimen: Those skilled in the art will appreciate that the term “dosing regimen” may be used to refer to a set of unit doses (typically more than one) that are administered individually to a subject, typically separated by periods of time. In some embodiments, a given therapeutic agent has a recommended dosing regimen, which may involve one or more doses. In some embodiments, a dosing regimen comprises a plurality of doses each of which is separated in time from other doses. In some embodiments, individual doses are separated from one another by a time period of the same length; in some embodiments, a dosing regimen comprises a plurality of doses and at least two different time periods separating individual doses. In some embodiments, all doses within a dosing regimen are of the same unit dose amount. In some embodiments, different doses within a dosing regimen are of different amounts. In some embodiments, a dosing regimen comprises a first dose in a first dose amount, followed by one or more additional doses in a second dose amount different from the first dose amount. In some embodiments, a dosing regimen comprises a first dose in a first dose amount, followed by one or more additional doses in a second dose amount same as the first dose amount. In some embodiments, a dosing regimen is correlated with a desired or beneficial outcome when administered across a relevant population (i.e., is a therapeutic dosing regimen). [0125] Expression: As used herein, “expression” of a nucleic acid sequence refers to one or more of the following events: (1) production of an RNA template from a DNA sequence (e.g., by transcription); (2) processing of an RNA transcript (e.g., by splicing, editing, 5’ cap formation, and/or 3’ end formation); (3) transport of an RNA transcript (e.g., from nucleus to cytoplasm; and/or (4) translation of an RNA into a polypeptide or protein; and/or (4) post-translational modification of a polypeptide or protein. [0126] Isolated or Partially Purified: The term “isolated” or “partially purified” as used herein refers, in the case of a nucleic acid or polypeptide, to a nucleic acid or polypeptide separated from at least one other component (e.g., nucleic acid or polypeptide) that is present with the nucleic acid or polypeptide as found in its natural source and/or that would be present with the nucleic acid or polypeptide when expressed by a cell, or secreted in the case of secreted polypeptides. A chemically synthesized nucleic acid or polypeptide or one synthesized using in vitro transcription/translation is considered “isolated.” The terms “purified” or “substantially purified” refer to an isolated nucleic acid or polypeptide that is at least 95% by weight the subject nucleic acid or polypeptide, including, for example, at least 96%, at least 97%, at least 98%, at least 99% or more. In some embodiments, the antibody, antigen-binding portion thereof, or chimeric antigen receptor (CAR) described herein is isolated. In some embodiments, the antibody, antibody reagent, antigen- binding portion thereof, or CAR described herein is purified. [0127] Engineered: As used herein, “engineered” refers to the aspect of having been manipulated by the hand of man. For example, an antibody, antibody reagent, antigen- binding portion thereof, CAR or bispecific antibody is considered to be “engineered” when the sequence of the antibody, antibody reagent, antigen-binding portion thereof, CAR or bispecific antibody is manipulated by the hand of man to differ from the sequence of an antibody as it exists in nature. As is common practice and is understood by those in the art, progeny and copies of an engineered polynucleotide and/or polypeptide are typically still referred to as “engineered” even though the actual manipulation was performed on a prior entity. [0128] Fragment: A “fragment” of a material or entity as described herein has a structure that includes a discrete portion of the whole, but lacks one or more moieties found in the whole. In some embodiments, a fragment consists of such a discrete portion. In some embodiments, a fragment consists of or comprises a characteristic structural element or moiety found in the whole. In some embodiments, a polymer fragment comprises or consists of at least 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500 or more monomeric units (e.g., residues) as found in the whole polymer. In some embodiments, a polymer fragment comprises or consists of at least about 5%, 10%, 15%, 20%, 25%, 30%, 25%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or more of the monomeric units (e.g., residues) found in the whole polymer. The whole material or entity may in some embodiments be referred to as the “parent” of the fragment. [0129] Gene: As used herein, the term “gene” refers to a DNA sequence in a chromosome that codes for a product (e.g., an RNA product and/or a polypeptide product). In some embodiments, a gene includes coding sequence (i.e., sequence that encodes a particular product); in some embodiments, a gene includes non-coding sequence. In some particular embodiments, a gene may include both coding (e.g., exonic) and non-coding (e.g., intronic) sequences. In some embodiments, a gene may include one or more regulatory elements that, for example, may control or impact one or more aspects of gene expression (e.g., cell-type-specific expression, inducible expression, etc.). [0130] Gene product or expression product: As used herein, the term “gene product” or “expression product” generally refers to an RNA transcribed from the gene (pre-and/or post-processing) or a polypeptide (pre- and/or post-modification) encoded by an RNA transcribed from the gene. In some embodiments, a gene product may be or comprise a particular processed form of an RNA transcript (e.g., a particular edited form, a particular splice form, a particular capped form, etc). [0131] Homology: As used herein, the term “homology” refers to the overall relatedness between polymeric molecules, e.g., between nucleic acid molecules (e.g., DNA molecules and/or RNA molecules) and/or between polypeptide molecules. In some embodiments, polymeric molecules are considered to be “homologous” to one another if their sequences are at least 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% identical. In some embodiments, polymeric molecules are considered to be “homologous” to one another if their sequences are at least 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% similar. [0132] Identity: As used herein, the term “identity” refers to the overall relatedness between polymeric molecules, e.g., between nucleic acid molecules (e.g., DNA molecules and/or RNA molecules) and/or between polypeptide molecules. In some embodiments, polymeric molecules are considered to be “substantially identical” to one another if their sequences are at least 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% identical. Calculation of the percent identity of two nucleic acid or polypeptide sequences, for example, can be performed by aligning the two sequences for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second sequences for optimal alignment and non-identical sequences can be disregarded for comparison purposes). In certain embodiments, the length of a sequence aligned for comparison purposes is at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95%, or substantially 100% of the length of a reference sequence. The nucleotides at corresponding positions are then compared. When a position in the first sequence is occupied by the same residue (e.g., nucleotide or amino acid) as the corresponding position in the second sequence, then the molecules are identical at that position. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which needs to be introduced for optimal alignment of the two sequences. The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. For example, the percent identity between two nucleotide sequences can be determined using the algorithm of Meyers and Miller (CABIOS, 1989, 4: 11-17), which has been incorporated into the ALIGN program (version 2.0). In some exemplary embodiments, nucleic acid sequence comparisons made with the ALIGN program use a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4. The percent identity between two nucleotide sequences can, alternatively, be determined using the GAP program in the GCG software package using an NWSgapdna.CMP matrix. [0133] Improve, “increase”, “inhibit” or “reduce”: As used herein, the terms “improve”, “increase”, “inhibit’, “reduce”, or grammatical equivalents thereof, indicate values that are relative to a baseline or other reference measurement. In some embodiments, an appropriate reference measurement may be or comprise a measurement in a particular system (e.g., in a single individual, a single cell, or cell population) under otherwise comparable conditions absent presence of (e.g., prior to and/or after) a particular agent or treatment, or in presence of an appropriate reference agent (e.g., a positive control agent or a negative control agent). In some embodiments, an appropriate reference measurement may be or comprise a measurement in comparable system known or expected to respond in a particular way, in presence of the relevant agent or treatment. Those skilled in the art will appreciate that an “improvement”, “increase”, “reduction”, etc typically refers to a statistically significant change. Moreover, those skilled in the art will understand from context what magnitude of change may be relevant. For example, in some embodiments, a change may be a “fold” change – i.e., so that a “changed” value represents a 1.1, 1.2, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 30, 40, 50 or more (e.g., 500, 1000 times) (including all integers and decimal points in between and above 1), e.g., 1.5, 1.6, 1.7.1.8, etc.)-fold difference relative to the relevant reference. Alternatively or additionally, in some embodiments, a “change” may be a “percentage” change, so that a “changed” value represents a1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 100% increase or decrease, including all integers and decimal points in between), relative to the relevant reference. [0134] Linked: As used herein, the term “linked”, when used with respect to two or more moieties, means that the moieties are physically associated or connected with one another to form a molecular structure that is sufficiently stable so that the moieties remain associated under the conditions in which the linkage is formed and, preferably, under the conditions in which the new molecular structure is used, e.g., physiological conditions. In certain preferred embodiments of the invention the linkage is a covalent linkage. In other embodiments the linkage is noncovalent. Moieties may be linked either directly or indirectly. When two moieties are directly linked, they are either covalently bonded to one another or are in sufficiently close proximity such that intermolecular forces between the two moieties maintain their association. When two moieties are indirectly linked, they are each linked either covalently or noncovalently to a third moiety, which maintains the association between the two moieties. In general, when two moieties are referred to as being linked by a “linker” or “linking moiety” or “linking portion”, the linkage between the two linked moieties is indirect, and typically each of the linked moieties is covalently bonded to the linker. The linker can be any suitable moiety that reacts with the two moieties to be linked within a reasonable period of time, under conditions consistent with stability of the moieties (which may be protected as appropriate, depending upon the conditions), and in sufficient amount, to produce a reasonable yield. [0135] Internucleotidic linkage: As used herein, the phrase “internucleotidic linkage” refers generally to the phosphorus-containing linkage between nucleotide units of an oligonucleotide, and is interchangeable with “inter-sugar linkage” and “phosphorus atom bridge,” as used above and herein. In some embodiments, an internucleotidic linkage is a phosphodiester linkage, as found in naturally occurring DNA and RNA molecules. In some embodiments, an internucleotidic linkage is a “modified internucleotidic linkage” wherein each oxygen atom of the phosphodiester linkage is optionally and independently replaced by an organic or inorganic moiety. In some embodiments, such an organic or inorganic moiety is selected from but not limited to =S, =Se, =NR’, –SR’, –SeR’, –N(R’) ₂ , B(R’) _3, –S–, –Se–, and –N(R’)–, wherein each R’ is independently as defined and described below. In some embodiments, an internucleotidic linkage is a phosphotriester linkage, phosphorothioate diester linkage ( ), or modified phosphorothioate triester linkage. It is understood by a person of ordinary skill in the art that the internucleotidic linkage may exist as an anion or cation at a given pH due to the existence of acid or base moieties in the linkage. In some embodiments, an internucleotide linkage may be a chiral linkage. [0136] Long-term Administration: As used herein, the term "long-term" administration means that the therapeutic agent or drug is administered for a period of at least 12 weeks. This includes that the therapeutic agent or drug is administered such that it is effective over, or for, a period of at least 12 weeks and does not necessarily imply that the administration itself takes place for 12 weeks, e.g., if sustained release compositions or long acting therapeutic agent or drug is used. Thus, the subject is treated for a period of at least 12 weeks. In many cases, long-term administration is for at least 4, 5, 6, 7, 8, 9 months or more, or for at least 1, 2, 3, 5, 7 or 10 years, or more. [0137] Moiety: Those skilled in the art will appreciate that a “moiety” is a defined chemical group or entity with a particular structure and/or or activity, as described herein. [0138] Nanoparticle: As used herein, the term “nanoparticle” refers to a particle having a diameter of less than 1000 nanometers (nm). In some embodiments, a nanoparticle has a diameter of less than 300 nm, as defined by the National Science Foundation. In some embodiments, a nanoparticle has a diameter of less than 100 nm as defined by the National Institutes of Health. In some embodiments, nanoparticles are micelles in that they comprise an enclosed compartment, separated from the bulk solution by a micellar membrane, typically comprised of amphiphilic entities which surround and enclose a space or compartment (e.g., to define a lumen). In some embodiments, a micellar membrane is comprised of at least one polymer, such as for example a biocompatible and/or biodegradable polymer. [0139] Nucleic acid: As used herein, in its broadest sense, refers to any compound and/or substance that is or can be incorporated into an oligonucleotide chain. In some embodiments, a nucleic acid is a compound and/or substance that is or can be incorporated into an oligonucleotide chain via a phosphodiester linkage. As will be clear from context, in some embodiments, "nucleic acid" refers to an individual nucleic acid residue (e.g., a nucleotide and/or nucleoside); in some embodiments, "nucleic acid" refers to an oligonucleotide chain comprising individual nucleic acid residues. In some embodiments, a "nucleic acid" is or comprises RNA; in some embodiments, a "nucleic acid" is or comprises DNA. In some embodiments, a nucleic acid is, comprises, or consists of one or more natural nucleic acid residues. In some embodiments, a nucleic acid is, comprises, or consists of one or more nucleic acid analogs. In some embodiments, a nucleic acid analog differs from a nucleic acid in that it does not utilize a phosphodiester backbone. For example, in some embodiments, a nucleic acid is, comprises, or consists of one or more "peptide nucleic acids", which are known in the art and have peptide bonds instead of phosphodiester bonds in the backbone, are considered within the scope of the present invention. Alternatively or additionally, in some embodiments, a nucleic acid has one or more phosphorothioate and/or 5'-N-phosphoramidite linkages rather than phosphodiester bonds. In some embodiments, a nucleic acid is, comprises, or consists of one or more natural nucleosides (e.g., adenosine, thymidine, guanosine, cytidine, uridine, deoxyadenosine, deoxythymidine, deoxy guanosine, and deoxycytidine). In some embodiments, a nucleic acid is, comprises, or consists of one or more nucleoside analogs (e.g., 2-aminoadenosine, 2-thiothymidine, inosine, pyrrolo- pyrimidine, 3 -methyl adenosine, 5-methylcytidine, C-5 propynyl-cytidine, C-5 propynyl- uridine, 2-aminoadenosine, C5-bromouridine, C5-fluorouridine, C5-iodouridine, C5- propynyl-uridine, C5 -propynyl-cytidine, C5-methylcytidine, 2-aminoadenosine, 7- deazaadenosine, 7-deazaguanosine, 8-oxoadenosine, 8-oxoguanosine, 0(6)-methylguanine, 2- thiocytidine, methylated bases, intercalated bases, and combinations thereof). In some embodiments, a nucleic acid comprises one or more modified sugars (e.g., 2'-fluororibose, ribose, 2'-deoxyribose, arabinose, and hexose) as compared with those in natural nucleic acids. In some embodiments, a nucleic acid has a nucleotide sequence that encodes a functional gene product such as an RNA or protein. In some embodiments, a nucleic acid includes one or more introns. In some embodiments, nucleic acids are prepared by one or more of isolation from a natural source, enzymatic synthesis by polymerization based on a complementary template (in vivo or in vitro), reproduction in a recombinant cell or system, and chemical synthesis. In some embodiments, a nucleic acid is at least 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 20, 225, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500, 600, 700, 800, 900, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000 or more residues long. In some embodiments, a nucleic acid is partly or wholly single stranded; in some embodiments, a nucleic acid is partly or wholly double stranded. In some embodiments a nucleic acid has a nucleotide sequence comprising at least one element that encodes, or is the complement of a sequence that encodes, a polypeptide. In some embodiments, a nucleic acid has enzymatic activity. [0140] Oligonucleotide: As used herein, the term “oligonucleotide” refers to a polymer or oligomer of nucleotide monomers, containing any combination of nucleobases, modified nucleobases, sugars, modified sugars, phosphate bridges, or modified phosphorus atom bridges (also referred to herein as “internucleotidic linkage”, defined further herein). Oligonucleotides can be single-stranded or double-stranded. A single-stranded oligonucleotide can have double-stranded regions and a double-stranded oligonucleotide can have single-stranded regions. Example oligonucleotides include, but are not limited to structural genes, genes including control and termination regions, self-replicating systems such as viral or plasmid DNA, single-stranded and double-stranded siRNAs and other RNA interference reagents (RNAi agents or iRNA agents), shRNA, antisense oligonucleotides, ribozymes, microRNAs, microRNA mimics, supermirs, aptamers, antimirs, antagomirs, Ul adaptors, triplex-forming oligonucleotides, G-quadruplex oligonucleotides, RNA activators, immuno-stimulatory oligonucleotides, and decoy oligonucleotides. Double-stranded and single-stranded oligonucleotides that are effective in inducing RNA interference are also referred to as siRNA, RNAi agent, or iRNA agent, herein. In some embodiments, these RNA interference inducing oligonucleotides associate with a cytoplasmic multi-protein complex known as RNAi-induced silencing complex (RISC). In many embodiments, single-stranded and double-stranded RNAi agents are sufficiently long that they can be cleaved by an endogenous molecule, e.g., by Dicer, to produce smaller oligonucleotides that can enter the RISC machinery and participate in RISC mediated cleavage of a target sequence, e.g. a target mRNA. [0141] Operably linked: As used herein, the term “operably linked” refers to a juxtaposition wherein the components described are in a relationship permitting them to function in their intended manner. A control element “operably linked” to a functional element is associated in such a way that expression and/or activity of the functional element is achieved under conditions compatible with the control element. In some embodiments, “operably linked” control elements (e.g., promoters, enhancers, etc.) are contiguous (e.g., covalently linked) with the coding elements of interest; in some embodiments, control elements act in trans- or cis- with the coding functional element of interest. [0142] Patient: As used herein, the term “patient” refers to any organism to which a provided composition (e.g., an agonizing agent such as an ASO) is or may be administered, e.g., for experimental, diagnostic, prophylactic, cosmetic, and/or therapeutic purposes. Typical patients include animals (e.g., mammals such as mice, rats, rabbits, non-human primates, and/or humans). In some embodiments, a patient is a human. In some embodiments, a patient is suffering from or susceptible to one or more disorders or conditions. In some embodiments, a patient displays one or more symptoms of a disorder or condition. In some embodiments, a patient has been diagnosed with one or more disorders or conditions. In some embodiments, the disorder or condition is Alzheimer’s disease or other disease characterized by neurodegeneration. In some embodiments, the disorder or condition is muscular dystrophy or other disease characterized by neuromuscular dysfunction. In some embodiments, the patient is receiving or has received certain therapy to diagnose and/or to treat a disease, disorder, or condition. [0143] Pharmaceutical composition: As used herein, the term “pharmaceutical composition” refers to an active agent (e.g., MuSK-targeting oligonucleotide), formulated together with one or more pharmaceutically acceptable carriers. In some embodiments, active agent is present in unit dose amount appropriate for administration in a therapeutic regimen that shows a statistically significant probability of achieving a predetermined therapeutic effect when administered to a relevant population. In some embodiments, pharmaceutical compositions may be specially formulated for administration in solid or liquid form, including those adapted for the following: oral administration, for example, drenches (aqueous or non-aqueous solutions or suspensions), tablets, e.g., those targeted for buccal, sublingual, and systemic absorption, boluses, powders, granules, pastes for application to the tongue; parenteral administration, for example, by subcutaneous, intramuscular, intravenous, intraperitoneal, intrathecal, intravenous, intraventricular or epidural injection as, for example, a sterile solution or suspension, or sustained-release formulation; topical application, for example, as a cream, ointment, or a controlled-release patch or spray applied to the skin, lungs, or oral cavity; intravaginally or intrarectally, for example, as a pessary, cream, or foam; sublingually; ocularly; transdermally; or nasally, pulmonary, and to other mucosal surfaces. [0144] Pharmaceutically acceptable: As used herein, the phrase “pharmaceutically acceptable” refers to those compounds, materials, compositions and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio. [0145] Pharmaceutically acceptable carrier: As used herein, the term “pharmaceutically acceptable carrier” means a pharmaceutically-acceptable material, composition or vehicle, such as a liquid or solid filler, diluent, excipient, or solvent encapsulating material, involved in carrying or transporting the subject compound from one organ, or portion of the body, to another organ, or portion of the body. Each carrier must be “acceptable” in the sense of being compatible with the other ingredients of the formulation and not injurious to the patient. Some examples of materials which can serve as pharmaceutically-acceptable carriers include: sugars, such as lactose, glucose and sucrose; starches, such as corn starch and potato starch; cellulose, and its derivatives, such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt; gelatin; talc; excipients, such as cocoa butter and suppository waxes; oils, such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; glycols, such as propylene glycol; polyols, such as glycerin, sorbitol, mannitol and polyethylene glycol; esters, such as ethyl oleate and ethyl laurate; agar; buffering agents, such as magnesium hydroxide and aluminum hydroxide; alginic acid; pyrogen-free water; isotonic saline; Ringer’s solution; ethyl alcohol; pH buffered solutions; polyesters, polycarbonates and/or polyanhydrides; and other non-toxic compatible substances employed in pharmaceutical formulations. [0146] Pharmaceutically acceptable salt: The term “pharmaceutically acceptable salt”, as used herein, refers to salts of such compounds that are appropriate for use in pharmaceutical contexts, i.e., salts which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response and the like, and are commensurate with a reasonable benefit/risk ratio. Pharmaceutically acceptable salts are well known in the art. For example, S. M. Berge, et al. describes pharmaceutically acceptable salts in detail in J. Pharmaceutical Sciences, 66: 1-19 (1977). In some embodiments, pharmaceutically acceptable salt include, but are not limited to, nontoxic acid addition salts, which are salts of an amino group formed with inorganic acids such as hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid and perchloric acid or with organic acids such as acetic acid, maleic acid, tartaric acid, citric acid, succinic acid or malonic acid or by using other methods used in the art such as ion exchange. In some embodiments, pharmaceutically acceptable salts include, but are not limited to, adipate, alginate, ascorbate, aspartate, benzenesulfonate, benzoate, bisulfate, borate, butyrate, camphorate, camphorsulfonate, citrate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, formate, fumarate, glucoheptonate, glycerophosphate, gluconate, hemisulfate, heptanoate, hexanoate, hydroiodide, 2-hydroxy-ethanesulfonate, lactobionate, lactate, laurate, lauryl sulfate, malate, maleate, malonate, methanesulfonate, 2- naphthalenesulfonate, nicotinate, nitrate, oleate, oxalate, palmitate, pamoate, pectinate, persulfate, 3-phenylpropionate, phosphate, picrate, pivalate, propionate, stearate, succinate, sulfate, tartrate, thiocyanate, p-toluenesulfonate, undecanoate, valerate salts, and the like. In some embodiments, a provided compound comprises one or more acidic groups, e.g., an oligonucleotide, and a pharmaceutically acceptable salt is an alkali, alkaline earth metal, or ammonium (e.g., an ammonium salt of N(R) ₃ , wherein each R is independently defined and described in the present disclosure) salt. Representative alkali or alkaline earth metal salts include sodium, lithium, potassium, calcium, magnesium, and the like. In some embodiments, a pharmaceutically acceptable salt is a sodium salt. In some embodiments, a pharmaceutically acceptable salt is a potassium salt. In some embodiments, a pharmaceutically acceptable salt is a calcium salt. In some embodiments, pharmaceutically acceptable salts include, when appropriate, nontoxic ammonium, quaternary ammonium, and amine cations formed using counterions such as halide, hydroxide, carboxylate, sulfate, phosphate, nitrate, alkyl having from 1 to 6 carbon atoms, sulfonate and aryl sulfonate. In some embodiments, a provided compound comprises more than one acid groups, for example, an oligonucleotide may comprise two or more acidic groups (e.g., in natural phosphate linkages and/or modified internucleotidic linkages). In some embodiments, a pharmaceutically acceptable salt, or generally a salt, of such a compound comprises two or more cations, which can be the same or different. In some embodiments, in a pharmaceutically acceptable salt (or generally, a salt), all ionizable hydrogen (e.g., in an aqueous solution with a pKa no more than about 11, 10, 9, 8, 7, 6, 5, 4, 3, or 2; in some embodiments, no more than about 7; in some embodiments, no more than about 6; in some embodiments, no more than about 5; in some embodiments, no more than about 4; in some embodiments, no more than about 3) in the acidic groups are replaced with cations. In some embodiments, each internucleotidic linkage, e.g., phosphate group, independently exists in its salt form (e.g., if sodium salt, −O−P(O)(ONa)−O−). In some embodiments, a pharmaceutically acceptable salt is a sodium salt of an oligonucleotide. In some embodiments, a pharmaceutically acceptable salt is a sodium salt of an oligonucleotide, wherein each acidic phosphate and modified phosphate group, if any, exists as a salt form (all sodium salt). [0147] Polypeptide: As used herein, the term “polypeptide,” which is interchangeably used herein with the term “protein,” refers to a polymer of at least three amino acid residues. In some embodiments, a polypeptide comprises one or more, or all, natural amino acids. In some embodiments, a polypeptide comprises one or more, or all non- natural amino acids. In some embodiments, a polypeptide comprises one or more, or all, D- amino acids. In some embodiments, a polypeptide comprises one or more, or all, L-amino acids. In some embodiments, a polypeptide comprises one or more pendant groups or other modifications, e.g., modifying or attached to one or more amino acid side chains, at the polypeptide’s N-terminus, at the polypeptide’s C-terminus, or any combination thereof. In some embodiments, a polypeptide comprises one or more modifications such as acetylation, amidation, aminoethylation, biotinylation, carbamylation, carbonylation, citrullination, deamidation, deimination, eliminylation, glycosylation, lipidation, methylation, pegylation, phosphorylation, sumoylation, or combinations thereof. In some embodiments, a polypeptide may participate in one or more intra- or inter-molecular disulfide bonds. In some embodiments, a polypeptide may be cyclic, and/or may comprise a cyclic portion. In some embodiments, a polypeptide is not cyclic and/or does not comprise any cyclic portion. In some embodiments, a polypeptide is linear. In some embodiments, a polypeptide may comprise a stapled polypeptide. In some embodiments, a polypeptide participates in non- covalent complex formation by non-covalent or covalent association with one or more other polypeptides (e.g., as in an antibody). In some embodiments, a polypeptide has an amino acid sequence that occurs in nature. In some embodiments, a polypeptide has an amino acid sequence that does not occur in nature. In some embodiments, a polypeptide has an amino acid sequence that is engineered in that it is designed and/or produced through action of the hand of man. In some embodiments, the term “polypeptide” may be appended to a name of a reference polypeptide, activity, or structure; in such instances it is used herein to refer to polypeptides that share the relevant activity or structure and thus can be considered to be members of the same class or family of polypeptides. For each such class, the present specification provides and/or those skilled in the art will be aware of exemplary polypeptides within the class whose amino acid sequences and/or functions are known; in some embodiments, such exemplary polypeptides are reference polypeptides for the polypeptide class or family. In some embodiments, a member of a polypeptide class or family shows significant sequence homology or identity with, shares a common sequence motif (e.g., a characteristic sequence element) with, and/or shares a common activity (in some embodiments at a comparable level or within a designated range) with a reference polypeptide of the class; in some embodiments with all polypeptides within the class). For example, in some embodiments, a member polypeptide shows an overall degree of sequence homology or identity with a reference polypeptide that is at least about 30-40%, and is often greater than about 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more and/or includes at least one region (e.g., a conserved region that may in some embodiments comprise a characteristic sequence element) that shows very high sequence identity, often greater than 90% or even 95%, 96%, 97%, 98%, or 99%. Such a conserved region usually encompasses at least 3-4 and often up to 20 or more amino acids; in some embodiments, a conserved region encompasses at least one stretch of at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or more contiguous amino acids. In some embodiments, a useful polypeptide may comprise a fragment of a parent polypeptide. In some embodiments, a useful polypeptide as may comprise a plurality of fragments, each of which is found in the same parent polypeptide in a different spatial arrangement relative to one another than is found in the polypeptide of interest (e.g., fragments that are directly linked in the parent may be spatially separated in the polypeptide of interest or vice versa, and/or fragments may be present in a different order in the polypeptide of interest than in the parent), so that the polypeptide of interest is a derivative of its parent polypeptide. In some embodiments, the polypeptide described herein (or a nucleic acid encoding such a polypeptide) can be a functional fragment of one of the amino acid sequences described herein. As used herein, a “functional fragment” is a fragment or segment of a peptide which retains at least 50% of the wildtype reference polypeptide’s activity according to the assays described below herein. A functional fragment can comprise conservative substitutions of the sequences disclosed herein. In some embodiments, the polypeptide described herein can be a variant of a sequence described herein. In some embodiments, the variant is a conservatively modified variant. Conservative substitution variants can be obtained by mutations of native nucleotide sequences, for example. A “variant," as referred to herein, is a polypeptide substantially homologous to a native or reference polypeptide, but which has an amino acid sequence different from that of the native or reference polypeptide because of one or a plurality of deletions, insertions or substitutions. Variant polypeptide-encoding DNA sequences encompass sequences that comprise one or more additions, deletions, or substitutions of nucleotides when compared to a native or reference DNA sequence, but that encode a variant protein or fragment thereof that retains activity. A wide variety of PCR-based site-specific mutagenesis approaches are known in the art and can be applied by the ordinarily skilled artisan. In the various embodiments described herein, it is further contemplated that variants (naturally occurring or otherwise), alleles, homologs, conservatively modified variants, and/or conservative substitution variants of any of the particular polypeptides described are encompassed. As to amino acid sequences, one of skill will recognize that individual substitutions, deletions or additions to a nucleic acid, peptide, polypeptide, or protein sequence which alters a single amino acid or a small percentage of amino acids in the encoded sequence is a “conservatively modified variant" where the alteration results in the substitution of an amino acid with a chemically similar amino acid and retains the desired activity of the polypeptide. Such conservatively modified variants are in addition to and do not exclude polymorphic variants, interspecies homologs, and alleles consistent with the disclosure. [0148] Prevent or prevention: as used herein when used in connection with the occurrence of a disease, disorder, and/or condition, refers to reducing the risk of developing the disease, disorder and/or condition and/or to delaying onset of one or more characteristics or symptoms of the disease, disorder or condition. Prevention may be considered complete when onset of a disease, disorder or condition has been delayed for a predefined period of time. [0149] Recombinant: As used herein, the term “recombinant” is intended to refer to polypeptides that are designed, engineered, prepared, expressed, created, manufactured, and/or or isolated by recombinant means, such as polypeptides expressed using a recombinant expression vector transfected into a host cell; polypeptides isolated from a recombinant, combinatorial human polypeptide library; polypeptides isolated from an animal (e.g., a mouse, rabbit, sheep, fish, etc.) that is transgenic for or otherwise has been manipulated to express a gene or genes, or gene components that encode and/or direct expression of the polypeptide or one or more component(s), portion(s), element(s), or domain(s) thereof; and/or polypeptides prepared, expressed, created or isolated by any other means that involves splicing or ligating selected nucleic acid sequence elements to one another, chemically synthesizing selected sequence elements, and/or otherwise generating a nucleic acid that encodes and/or directs expression of the polypeptide or one or more component(s), portion(s), element(s), or domain(s) thereof. In some embodiments, one or more of such selected sequence elements is found in nature. In some embodiments, one or more of such selected sequence elements is designed in silico. In some embodiments, one or more such selected sequence elements results from mutagenesis (e.g., in vivo or in vitro) of a known sequence element, e.g., from a natural or synthetic source such as, for example, in the germline of a source organism of interest (e.g., of a human, a mouse, etc.). [0150] Small molecule: As used herein, the term “small molecule” means a low molecular weight organic and/or inorganic compound. In general, a “small molecule” is a molecule that is less than about 5 kilodaltons (kD) in size. In some embodiments, a small molecule is less than about 4 kD, 3 kD, about 2 kD, or about 1 kD. In some embodiments, the small molecule is less than about 800 daltons (D), about 600 D, about 500 D, about 400 D, about 300 D, about 200 D, or about 100 D. In some embodiments, a small molecule is less than about 2000 g/mol, less than about 1500 g/mol, less than about 1000 g/mol, less than about 800 g/mol, or less than about 500 g/mol. In some embodiments, a small molecule is not a polymer. In some embodiments, a small molecule does not include a polymeric moiety. In some embodiments, a small molecule is not and/or does not comprise a protein or polypeptide (e.g., is not an oligopeptide or peptide). In some embodiments, a small molecule is not and/or does not comprise a polynucleotide (e.g., is not an oligonucleotide). In some embodiments, a small molecule is not and/or does not comprise a polysaccharide; for example, in some embodiments, a small molecule is not a glycoprotein, proteoglycan, glycolipid, etc.). In some embodiments, a small molecule is not a lipid. In some embodiments, a small molecule is a modulating agent (e.g., is an inhibiting agent or an activating agent). In some embodiments, a small molecule is biologically active. In some embodiments, a small molecule is detectable (e.g., comprises at least one detectable moiety). In some embodiments, a small molecule is a therapeutic agent. Those of ordinary skill in the art, reading the present disclosure, will appreciate that certain small molecule compounds described herein may be provided and/or utilized in any of a variety of forms such as, for example, crystal forms, salt forms, protected forms, pro-drug forms, ester forms, isomeric forms (e.g., optical and/or structural isomers), isotopic forms, etc. Those of skill in the art will appreciate that certain small molecule compounds have structures that can exist in one or more steroisomeric forms. In some embodiments, such a small molecule may be utilized in accordance with the present disclosure in the form of an individual enantiomer, diastereomer or geometric isomer, or may be in the form of a mixture of stereoisomers; in some embodiments, such a small molecule may be utilized in accordance with the present disclosure in a racemic mixture form. Those of skill in the art will appreciate that certain small molecule compounds have structures that can exist in one or more tautomeric forms. In some embodiments, such a small molecule may be utilized in accordance with the present disclosure in the form of an individual tautomer, or in a form that interconverts between tautomeric forms. Those of skill in the art will appreciate that certain small molecule compounds have structures that permit isotopic substitution (e.g., ² H or ³ H for H;, ¹¹ C, ¹³ C or ¹⁴ C for 12C; , ¹³ N or ¹⁵ N for 14N; ¹⁷ O or ¹⁸ O for 16O; ³⁶ Cl for XXC; ¹⁸ F for XXF; 131I for XXXI; etc). In some embodiments, such a small molecule may be utilized in accordance with the present disclosure in one or more isotopically modified forms, or mixtures thereof. In some embodiments, reference to a particular small molecule compound may relate to a specific form of that compound. In some embodiments, a particular small molecule compound may be provided and/or utilized in a salt form (e.g., in an acid-addition or base- addition salt form, depending on the compound); in some such embodiments, the salt form may be a pharmaceutically acceptable salt form. In some embodiments, where a small molecule compound is one that exists or is found in nature, that compound may be provided and/or utilized in accordance in the present disclosure in a form different from that in which it exists or is found in nature. Those of ordinary skill in the art will appreciate that, in some embodiments, a preparation of a particular small molecule compound that contains an absolute or relative amount of the compound, or of a particular form thereof, that is different from the absolute or relative (with respect to another component of the preparation including, for example, another form of the compound) amount of the compound or form that is present in a reference preparation of interest (e.g., in a primary sample from a source of interest such as a biological or environmental source) is distinct from the compound as it exists in the reference preparation or source. Thus, in some embodiments, for example, a preparation of a single stereoisomer of a small molecule compound may be considered to be a different form of the compound than a racemic mixture of the compound; a particular salt of a small molecule compound may be considered to be a different form from another salt form of the compound; a preparation that contains only a form of the compound that contains one conformational isomer ((Z) or (E)) of a double bond may be considered to be a different form of the compound from one that contains the other conformational isomer ((E) or (Z)) of the double bond; a preparation in which one or more atoms is a different isotope than is present in a reference preparation may be considered to be a different form; etc. [0151] Specific binding: As used herein, the term “specific binding” refers to an ability to discriminate between possible binding partners in the environment in which binding is to occur. A binding agent that interacts with one particular target when other potential targets are present is said to "bind specifically" to the target (e.g., a target amino acid or nucleic acid sequence on a target protein/gene of interest) with which it interacts. In some embodiments, specific binding is assessed by detecting or determining degree of association between the binding agent and its partner; in some embodiments, specific binding is assessed by detecting or determining degree of dissociation of a binding agent-partner complex; in some embodiments, specific binding is assessed by detecting or determining ability of the binding agent to compete an alternative interaction between its partner and another entity. In some embodiments, specific binding is assessed by performing such detections or determinations across a range of concentrations. [0152] Specificity: As is known in the art, “specificity” is a measure of the ability of a particular ligand to distinguish its binding partner from other potential binding partners. [0153] Subject: As used herein, the term “subject” refers an organism, typically a mammal (e.g., a human, in some embodiments including prenatal human forms). In some embodiments, a subject is suffering from a relevant disease, disorder or condition (e.g., Alzheimer’s disease (AD), muscular dystrophy or other disease characterized by neurodegeneration or neuromuscular dysfunction). In some embodiments, a subject is susceptible to a disease, disorder, or condition. In some embodiments, a subject displays one or more symptoms or characteristics of a disease, disorder or condition. In some embodiments, a subject does not display any symptom or characteristic of a disease, disorder, or condition. In some embodiments, a subject is someone with one or more features characteristic of susceptibility to or risk of a disease, disorder, or condition. In some embodiments, a subject is a patient. In some embodiments, a subject is an individual to whom diagnosis and/or therapy is and/or has been administered. [0154] Substantially: As used herein, the term “substantially” refers to the qualitative condition of exhibiting total or near-total extent or degree of a characteristic or property of interest. One of ordinary skill in the biological arts will understand that biological and chemical phenomena rarely, if ever, go to completion and/or proceed to completeness or achieve or avoid an absolute result. The term “substantially” is therefore used herein to capture the potential lack of completeness inherent in many biological and chemical phenomena. [0155] Substantial identity: as used herein refers to a comparison between amino acid or nucleic acid sequences. As will be appreciated by those of ordinary skill in the art, two sequences are generally considered to be "substantially identical" if they contain identical residues in corresponding positions. As is well known in this art, amino acid or nucleic acid sequences may be compared using any of a variety of algorithms, including those available in commercial computer programs such as BLASTN for nucleotide sequences and BLASTP, gapped BLAST, and PSI-BLAST for amino acid sequences. Exemplary such programs are described in Altschul et al., Basic local alignment search tool, J. Mol. Biol., 215(3): 403-410, 1990; Altschul et al., Methods in Enzymology; Altschul et al., Nucleic Acids Res.25:3389- 3402, 1997; Baxevanis et al., Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, Wiley, 1998; and Misener, et al, (eds.), Bioinformatics Methods and Protocols (Methods in Molecular Biology, Vol.132), Humana Press, 1999. In addition to identifying identical sequences, the programs mentioned above typically provide an indication of the degree of identity. In some embodiments, two sequences are considered to be substantially identical if at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more of their corresponding residues are identical over a relevant stretch of residues. In some embodiments, the relevant stretch is a complete sequence. In some embodiments, the relevant stretch is at least 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 125, 150, 175, 200, 225, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500 or more residues. [0156] Suffering from: An individual who is “suffering from” a disease, disorder, and/or condition (e.g., muscular dystrophy or other disease characterized by neuromuscular dysfunction) has been diagnosed with and/or displays one or more symptoms of a disease, disorder, and/or condition. [0157] Susceptible to: An individual who is “susceptible to” a disease, disorder, and/or condition (e.g., Alzheimer’s disease (AD), muscular dystrophy or other disease characterized by neurodegeneration or neuromuscular dysfunction) is one who has a higher risk of developing the disease, disorder, and/or condition than does a member of the general public. In some embodiments, an individual who is susceptible to a disease, disorder and/or condition may not have been diagnosed with the disease, disorder, and/or condition. In some embodiments, an individual who is susceptible to a disease, disorder, and/or condition may exhibit symptoms of the disease, disorder, and/or condition. In some embodiments, an individual who is susceptible to a disease, disorder, and/or condition may not exhibit symptoms of the disease, disorder, and/or condition. In some embodiments, an individual who is susceptible to a disease, disorder, and/or condition will develop the disease, disorder, and/or condition. In some embodiments, an individual who is susceptible to a disease, disorder, and/or condition will not develop the disease, disorder, and/or condition. [0158] Symptoms are reduced: According to the present invention, “symptoms are reduced” when one or more symptoms of a particular disease, disorder or condition (e.g., Alzheimer’s disease (AD), muscular dystrophy or other disease characterized by neurodegeneration or neuromuscular dysfunction) is reduced in magnitude (e.g., intensity, severity, etc.) and/or frequency. For purposes of clarity, a delay in the onset of a particular symptom is considered one form of reducing the frequency of that symptom. [0159] Target gene: A “target gene”, as used herein, refers to a gene whose expression is to be modulated, e.g., through modifying splice activity (e.g., by inducing exon- skipping). As used herein, the term “target portion” or “target region” refers to a contiguous portion of the nucleotide sequence of a target gene. In some embodiments, a target portion or target region is one or more exons within the target gene sequence. A target portion may be from about 8-36 nucleotides in length, e.g., about 10-20 or about 15-30 nucleotides in length. A target portion length may have specific value or subrange within the afore-mentioned ranges. For example, in certain embodiments a target portion may be between about 15-29, 15-28, 15-27, 15-26, 15-25, 15-24, 15-23, 15-22, 15-21, 15-20, 15-19, 15-18, 15-17, 18-30, 18-29, 18-28, 18-27, 18-26, 18-25, 18-24, 18-23, 18-22, 18-21, 18-20, 19-30, 19-29, 19- 28, 19-27, 19-26, 19-25, 19-24, 19-23, 19-22, 19-21, 19-20, 20-30, 20-29, 20-28, 20-27, 20- 26, 20-25, 20-24, 20-23, 20-22, 20-21, 21-30, 21-29, 21-28, 21-27, 21-26, 21-25, 21-24, 21-23, or 21-22 nucleotides in length. [0160] Therapeutic agent: As used herein, the phrase “therapeutic agent” refers to any agent that, when administered to a subject, has a therapeutic effect and/or elicits a desired biological and/or pharmacological effect. In some embodiments, a therapeutic agent is any substance that can be used to alleviate, ameliorate, relieve, inhibit, prevent, delay onset of, reduce severity of, and/or reduce incidence of one or more symptoms or features of a disease, disorder, and/or condition (e.g., one or more symptoms or features of Alzheimer’s disease (AD), muscular dystrophy or other disease characterized by neurodegeneration or neuromuscular dysfunction). [0161] Therapeutically effective amount: As used herein, the term “therapeutically effective amount” means an amount of a substance (e.g., a therapeutic agent, composition, and/or formulation) that elicits a desired biological response when administered as part of a therapeutic dosing regimen. In some embodiments, a therapeutically effective amount of a substance is an amount that is sufficient, when administered to a subject suffering from or susceptible to a disease, disorder, and/or condition, to treat, diagnose, prevent, and/or delay the onset of the disease, disorder, and/or condition. As will be appreciated by those of ordinary skill in this art, the effective amount of a substance may vary depending on such factors as the desired biological endpoint, the substance to be delivered, the target cell or tissue, etc. It will be appreciated that there will be many ways known in the art to determine the effective amount for a given application. For example, the pharmacological methods for dosage determination may be used in the therapeutic context. In the context of therapeutic or prophylactic applications, the amount of a composition administered to the subject will depend on the type and severity of the disease and on the characteristics of the individual, such as general health, age, sex, body weight and tolerance to drugs. It will also depend on the degree, severity and type of disease. The skilled artisan will be able to determine appropriate dosages depending on these and other factors. For example, the effective amount of compound in a formulation to treat a disease, disorder, and/or condition is the amount that alleviates, ameliorates, relieves, inhibits, prevents, delays onset of, reduces severity of and/or reduces incidence of one or more symptoms or features of the disease, disorder, and/or condition. As used herein, the terms "effective amount" and “therapeutically-effective amount” include an amount sufficient to prevent or ameliorate a manifestation of disease or medical condition, such as Alzheimer’s disease (AD), Parkinson’s disease, or another disease characterized by neurodegeneration, reduced mobility, metabolism, and quality of life resulting from muscle wasting in cancer patients, elderly patients, and many others with no history of neuromuscular dysfunction, in addition to muscular dystrophies such as Becker, Congenital, Distal, Duchenne, Emery-Dreifuss, Facioscapulohumeral, Limb-girdle, Myotonic, Oculopharyngeal Muscular Dystrophy. It will be appreciated that there will be many ways known in the art to determine the effective amount for a given application. For example, the pharmacological methods for dosage determination may be used in the therapeutic context. In the context of therapeutic or prophylactic applications, the amount of a composition administered to the subject will depend on the type and severity of the disease and on the characteristics of the individual, such as general health, age, sex, body weight and tolerance to drugs. It will also depend on the degree, severity and type of disease. The skilled artisan will be able to determine appropriate dosages depending on these and other factors. The compositions can also be administered in combination with one or more additional therapeutic compounds. In some embodiments, a therapeutically effective amount is administered in a single dose; in some embodiments, multiple unit doses are required to deliver a therapeutically effective amount. [0162] Treating: As used herein, the term “treating” refers to providing treatment, i.e., providing any type of medical or surgical management of a subject. The treatment can be provided in order to reverse, alleviate, inhibit the progression of, prevent or reduce the likelihood of a disease, disorder, or condition, or in order to reverse, alleviate, inhibit or prevent the progression of, prevent or reduce the likelihood of one or more symptoms or manifestations of a disease, disorder or condition. Beneficial or desired clinical results include, but are not limited to, alleviation of one or more symptom(s), diminishment of extent of the deficit, stabilized (i.e., not worsening) state of a muscular dystrophy, delay or slowing of muscle wasting, and an increased lifespan as compared to that expected in the absence of treatment. Treating can include administering an agent to the subject following the development of one or more symptoms or manifestations indicative of Alzheimer’s disease (AD), muscular dystrophy or other disease characterized by neurodegeneration or neuromuscular dysfunction, e.g., in order to reverse, alleviate, reduce the severity of, and/or inhibit or prevent the progression of the condition and/or to reverse, alleviate, reduce the severity of, and/or inhibit or one or more symptoms or manifestations of the condition. A composition of the disclosure can be administered to a subject who has developed Alzheimer’s disease, muscular dystrophy or other disease characterized by neurodegeneration, neuromuscular dysfunction or is at increased risk of developing such a disorder relative to a member of the general population. A composition of the disclosure can be administered prophylactically, i.e., before development of any symptom or manifestation of the condition. Typically in this case the subject will be at risk of developing the condition. [0163] Variant: As used herein in the context of molecules, e.g., nucleic acids (e.g., ASOs), proteins, or small molecules, the term “variant” refers to a molecule that shows significant structural identity with a reference molecule but differs structurally from the reference molecule, e.g., in the presence or absence or in the level of one or more chemical moieties as compared to the reference entity. In some embodiments, a variant also differs functionally from its reference molecule. In general, whether a particular molecule is properly considered to be a “variant” of a reference molecule is based on its degree of structural identity with the reference molecule. As will be appreciated by those skilled in the art, any biological or chemical reference molecule has certain characteristic structural elements. A variant, by definition, is a distinct molecule that shares one or more such characteristic structural elements but differs in at least one aspect from the reference molecule. To give but a few examples, a polypeptide may have a characteristic sequence element comprised of a plurality of amino acids having designated positions relative to one another in linear or three-dimensional space and/or contributing to a particular structural motif and/or biological function; a nucleic acid may have a characteristic sequence element comprised of a plurality of nucleotide residues having designated positions relative to on another in linear or three-dimensional space. In some embodiments, a variant polypeptide or nucleic acid may differ from a reference polypeptide or nucleic acid as a result of one or more differences in amino acid or nucleotide sequence and/or one or more differences in chemical moieties (e.g., carbohydrates, lipids, phosphate groups) that are covalently components of the polypeptide or nucleic acid (e.g., that are attached to the polypeptide or nucleic acid backbone). In some embodiments, a variant polypeptide or nucleic acid shows an overall sequence identity with a reference polypeptide or nucleic acid that is at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, or 99%. In some embodiments, a variant polypeptide or nucleic acid does not share at least one characteristic sequence element with a reference polypeptide or nucleic acid. In some embodiments, a reference polypeptide or nucleic acid has one or more biological activities. In some embodiments, a variant polypeptide or nucleic acid shares one or more of the biological activities of the reference polypeptide or nucleic acid. In some embodiments, a variant polypeptide or nucleic acid lacks one or more of the biological activities of the reference polypeptide or nucleic acid. In some embodiments, a variant polypeptide or nucleic acid shows a reduced level of one or more biological activities as compared to the reference polypeptide or nucleic acid. In some embodiments, a polypeptide or nucleic acid of interest is considered to be a “variant” of a reference polypeptide or nucleic acid if it has an amino acid or nucleotide sequence that is identical to that of the reference but for a small number of sequence alterations at particular positions. Typically, fewer than about 20%, about 15%, about 10%, about 9%, about 8%, about 7%, about 6%, about 5%, about 4%, about 3%, or about 2% of the residues in a variant are substituted, inserted, or deleted, as compared to the reference. In some embodiments, a variant polypeptide or nucleic acid comprises about 10, about 9, about 8, about 7, about 6, about 5, about 4, about 3, about 2, or about 1 substituted residues as compared to a reference. Often, a variant polypeptide or nucleic acid comprises a very small number (e.g., fewer than about 5, about 4, about 3, about 2, or about 1) number of substituted, inserted, or deleted, functional residues (i.e., residues that participate in a particular biological activity) relative to the reference. In some embodiments, a variant polypeptide or nucleic acid comprises not more than about 5, about 4, about 3, about 2, or about 1 addition or deletion, and, in some embodiments, comprises no additions or deletions, as compared to the reference. In some embodiments, a variant polypeptide or nucleic acid comprises fewer than about 25, about 20, about 19, about 18, about 17, about 16, about 15, about 14, about 13, about 10, about 9, about 8, about 7, about 6, and commonly fewer than about 5, about 4, about 3, or about 2 additions or deletions as compared to the reference. In some embodiments, a reference polypeptide or nucleic acid is one found in nature. In some embodiments, a reference polypeptide or nucleic acid is a human polypeptide or nucleic acid. [0164] Vector: As used herein, the term “vector” refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a "plasmid", which refers to a circular double stranded DNA loop into which additional DNA segments may be ligated. Another type of vector is a viral vector, wherein additional DNA segments may be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) can be integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as "expression vectors”. Standard techniques may be used for recombinant DNA, oligonucleotide synthesis, and tissue culture and transformation (e.g., electroporation, lipofection). Enzymatic reactions and purification techniques may be performed according to manufacturer's specifications or as commonly accomplished in the art or as described herein. The foregoing techniques and procedures may be generally performed according to conventional methods well known in the art and as described in various general and more specific references that are cited and discussed throughout the present specification. See e.g., Sambrook et al., Molecular Cloning: A Laboratory Manual (2d ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (1989)), which is incorporated herein by reference for any purpose. DETAILED DESCRIPTION OF CERTAIN EMBODIMENTS Neurogenesis [0165] Neurogenesis occurs in distinct regions of the adult mammalian brain. Neural stem cells (NSCs) are the endogenous source of new neurons and are active throughout life in virtually all mammals, including humans (Eriksson et al., 1998; Ernst et al., 2014; Moreno- Jiménez et al., 2019; Spalding et al., 2013). Extensive work in rodent models shows that neurogenesis supports learning and memory, sensory functions, and mood regulation (Enwere et al., 2004; Gage, 2019; Imayoshi et al., 2008; Zhang et al., 2008b). NSCs reside in two neurogenic niches: the subgranular zone (SGZ) in the dentate gyrus of the hippocampus and the subventricular zone (SVZ) lining the lateral ventricles. NSCs in the SVZ generate astrocytes and oligodendrocytes that support the existing circuitry as well as neurons in the olfactory bulb that are critical for olfactory discrimination. NSCs in the dentate gyrus give rise to granule neurons important for learning and memory. The majority of NSCs in the human brain are located in the hippocampus. Most hippocampal NSCs reside in a state of dormancy, termed quiescence. For neurogenesis to occur, quiescent NSCs must become activated in response to extrinsic or intrinsic cues. Newly born neurons functionally integrate into the local circuitry within the hippocampus and contribute to cognitive functions. The capacity of quiescent NSCs to activate declines during healthy and pathological aging and this loss precedes the decline in cognition (Enwere et al.2004; Giachino et al.2014; Capilla- Gonzalez et al.2014). [0166] Recent work indicates that endogenous or exogenous NSCs may be a valuable source of new neurons for the millions of individuals suffering from cognitive decline or brain injury. Activation of endogenous NSCs through exercise, re-feeding, or young blood improves age-related cognitive impairments in mice (Brandhorst et al., 2015; van Praag et al., 2005; Villeda et al., 2011, 2014). Accumulation of negative signals that degrade the neurogenic niche may contribute to reduction in newborn neurons in aging and AD. However, it has been difficult to harness the neurogenic potential of NSCs due to the lack of a specific therapeutic target that has the ability to overcome inhibitory signals. The present disclosure appreciates that recent mechanistic studies suggest that BMP signaling may represent a promising pathway to target in the context of AD and other diseases characterized by neurodegeneration. BMPs negatively regulate activation of NSCs (Mira et al., 2010) and are upregulated in AD and APP transgenic mice (Crews et al., 2010). The present disclosure provides technologies to specifically modulate BMP signaling in the neurogenic niche. Adult Hippocampal Neurogenesis [0167] Adult Hippocampal Neurogenesis (AHN) is critical for normal learning and memory. AHN is abundant in healthy aged humans but is reduced from the earliest stages of Alzheimer’s Disease (AD). AHN occurs throughout life in humans and is dramatically reduced in AD (Moreno-Jimenez et al., 2019; Steiner et al., 2019). Work in animal models has underscored the role of AHN in improving cognition in the face of AD pathology. Thus, restoring AHN may be an attractive target for an AD therapy. Interventions that promote adult hippocampal neurogenesis could enhance cognitive function and combat neurodegeneration. [0168] AHN is critical for learning and memory. Newborn dentate granule cells are hyperexcitable and exhibit robust synaptic plasticity. Thus, dysregulation of the quiescent state and/or a failure to integrate into the mature circuitry are thought to contribute to the age- associated decline in neurogenesis and cognitive performance in aging and dementia. [0169] AHN in Humans. Although AHN has been established in rodents and other species for decades, the existence of this process in human has been controversial until quite recently. Reports using BrdU incorporation (Eriksson et al., 1998), ¹⁴ C dating (Ernst et al., 2014; Spalding et al., 2013) and markers of immature neuron (Boldrini et al., 2018; Moreno- Jiménez et al., 2019; Tobin et al., 2019) have provided independent lines of support from multiple labs supporting human AHN. Mathematical modeling of radiocarbon birth dating data yielded estimates that in humans 35% of hippocampal neurons are replaced by newborn neurons during adulthood at a rate of 1.75% per year (Spalding et al., 2013). On the other hand, another recent report using markers for immature neurons failed to detect significant levels of AHN in adult humans (Sorrells et al., 2018). In depth comparison of these reports have revealed several methodological and sample differences that seem likely to explain the failure to detect adult neurogenesis in the Sorrells et al., paper (Kempermann et al., 2018; Lucassen et al., 2019). [0170] AHN and Alzheimer’s Disease. Alzheimer's Disease is a devastating disorder. It is progressive, fatal and has an enormous societal and economic cost.5.8 million Americans are living with AD. By 2050 this number is projected to rise to 14M. In 2019, AD and other dementias cost the nation $290 billion. By 2050, these costs could rise as high as $1.1 trillion. There are no effective treatments. There have been several recent high profile drug trials. Almost all of these trails have been based upon the 'amyloid hypothesis'. There is an enormous unmet need for innovative and effective therapies for AD. Alzheimer's Disease devastates the hippocampus, a brain region necessary for encoding memories. The hippocampus is one of the two sites of adult neurogenesis in the brain. A large number of animal studies have shown that these adult-born neurons are necessary for learning and memory. A recent crucial study provided convincing evidence for robust neurogenesis in the adult human brain. Importantly, the level of adult neurogenesis in AD brain is greatly diminished compared to age-matched controls. (See E. P. Moreno-Jimenez et al. Nature Med. https://doi. org/10.I038/s41591-019-0375-9; 2019; See also related Editorial in Nature 567:433; 28 March 2019). Thus, promoting adult neurogenesis is emerging as a highly attractive target in treating AD. [0171] The hippocampus is one of the earliest and most affected brain regions in AD and its atrophy is a hallmark of disease progression (Allison et al., 2019). Moreover, work in both rodents and humans has demonstrated that hippocampal-dependent learning is impaired in the Alzheimer’s setting (Crews et al., 2010). Notably, AHN levels in AD patients are only 30% of those observed in age-matched controls (Moreno-Jiménez et al., 2019). Critically, a recent mouse study using genetically diverse AD mouse models showed that the total number of hippocampal neurons (NeuN + cells) correlates with cognition (Neuner Neuron 2019). Finally, a recent study has shown that exercise-mediated rescue of pathology in AD mice requires AHN, and that AHN ablation alone exacerbates cognitive defects in these mice (Choi et al., 2018). Thus, strategies to compensate for the degeneration of hippocampal neurons through enhancing endogenous neurogenesis have the potential to open a new pathway for treating Alzheimer’s disease. [0172] Other diseases associated with impaired AHN include e.g., diseases and disorders associated with progressive memory loss, such as Frontotemporal Dementia (Terreros-Roncal et al., 2019), stroke (Lindvall et al., 2015). Impaired AHN is also associated with psychiatric disorders such as major depressive disorder (MDD), bipolar disorder, schizophrenia, post-traumatic stress disorder (PTSD), substance-related and addictive disorders (Yun et al., 2016), and other diseases such as Temporal-Lobe Epilepsy (Cook et al., 1992) , Hippocampal Sclerosis (Tai et al.2018), Niemann Pick Type C (Hong et al., 2015), and Diabetes-mediated hippocampal neuronal loss (Ho et al, 2013; Gold et al., 2007). Subventricular Zone Neurogenesis [0173] In addition to the hippocampus (i.e., the subgranular zone (SGZ) in the dentate gyrus of the hippocampus), NSCs reside in the subventricular zone (SVZ) lining the lateral ventricles. NSCs in the SVZ generate astrocytes and oligodendrocytes that support the existing circuitry as well as neurons in the olfactory bulb that are critical for olfactory discrimination. Recent evidence suggests that SVZ NSCs can give rise to terminally differentiated neurons in the striatum in response to ischemic stroke or neurodegenerative diseases (Arvidsson et al.2002; Parent et al.2002; Thored et al.2006; Ernst et al.2014). [0174] The present disclosure recognizes that strategies to compensate for the degeneration of neurons in the SVZ through enhancing endogenous neurogenesis have the potential to open a new pathway for treating diseases specifically associated with striatal neurogenesis such as Parkinson’s disease (which could benefit both from increasing AHN and striatal neurogenesis in the SVZ; Pitcher et al.2012; Sterling et al.2013) and Huntington’s disease (Sassone et al., 2018). Other diseases including addiction (e.g., chronic cocaine use and lifelong cigarette smoking) are also associated with reduced striatal volume (Barrós-Loscertales et al.2011; Das et al., 2012) and have the potential to be treated through enhancing endogenous neurogenesis in the SVZ. MuSK and Neurogenesis [0175] MuSK is a receptor tyrosine kinase comprised extracellularly of three Ig and one CRD/Fz domain and an intracellular tyrosine domain (TK; Fig.1). The best understood function of MuSK is at the neuromuscular junction (NMJ) where agrin-LRP4 binding to the Ig1 domain triggers MuSK TK activity and synapse differentiation (Kim et al., 2008; Zhang et al., 2008a). [0176] The MuSK-BMP Pathway. The brain harbors neural stem cells (NSCs) that generate neurons and glial cells throughout life (Moreno-Jiménez et al., 2019; Steiner et al., 2019). BMPs regulate at least two important NSC decision points: 1) quiescence, where proliferating stem cells exit the cell cycle and return to replenish a reserve pool that can supply fresh stem cells; and; 2) differentiation into mature progeny (Mira et al., 2010). The present disclosure contemplates that manipulating the BMP pathway in NSCs is an attractive target for regulating neurogenesis in the adult brain. [0177] It was recently discovered that MuSK is also a BMP co-receptor that binds BMP and its receptors ALK3 and 6, upregulates BMP signaling and shapes the composition of the transcriptional response in myogenic cells (Yilmaz et al., 2016). This BMP signaling pathway neither regulates nor requires MuSK TK activity nor is it activated by agrin-LRP4. Importantly, the MuSK Ig3 domain is necessary for high affinity BMP binding but is dispensable for agrin-LRP4 TK activation. Moreover, the Ig3 domain is endogenously alternatively spliced, including in the brain (Garcia-Osta et al., 2006; Hesser et al., 1999). Since BMP signaling induces NSC quiescence and can inhibit integration of newborn neurons we have found that restraining BMP drive by reducing MuSK-BMP signaling could increase neurogenesis (Fig.1). [0178] Yilmaz et al.2016 discloses that the 'Ig3' domain of MuSK is required for high affinity binding of BMPs. The major species of MuSK expressed endogenously is full length. This Ig3 domain can be alternatively spliced endogenously, creating an isoform termed “∆g3MuSK”. This splicing entails the coordinated removal of exons 6 and 7 from the MuSK pre-mRNA. [0179] Exemplary amino acid sequences of human and mouse MuSK Ig3 domains (i.e., of MuSK Ig3 domain polypeptides) are as set out below: MuSK HUMAN_Ig3_Domain: ARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQ LFITKPGLYTCIATNKHGEKFSTAKAAATIS (SEQ ID NO: 116) MuSK MOUSE Ig3 Domain ARILRAPESHNVTFGSFVTLRCTAIGIPVPTISWIENGNAVSSGSIQESVKDRVIDSRLQ LFITKPGLYTCIATNKHGEKFSTAKAAATVS (SEQ ID NO: 117) [0180] Among other things, the present disclosure provides compositions such as MuSK-targeting oligonucleotides that regulate MuSK alternative splicing as a strategy for increasing AHN in AD. MuSK and Muscle Regeneration and/or Growth [0181] Satellite cells account for about 5% of muscle nuclei and are distributed along mature, multinucleated myofibers, usually in a state of quiescence. When muscle is injured, satellite cells usually proliferate before either returning to quiescence or differentiating. Upon differentiation, satellite cells become committed myoblasts that fuse into myotubes, eventually forming mature myofibers in a process termed myogenesis. Bone morphogenetic protein (BMP) signaling regulates satellite cell dynamics and muscle regeneration both in vivo and in vitro by modulating transcriptional outputs. BMP signaling is not detectable in quiescent satellite cells, it is upregulated in proliferating satellite cells, and it is downregulated during differentiation. However, mediators regulating the balance between satellite cell proliferation and differentiation are unknown. [0182] Muscle-Specific Kinase (MuSK), also known as Muscle-Associated Receptor Tyrosine Kinase, is a transmembrane protein that was first recognized for its essential role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK has three extracellular Immunoglobulin(Ig)-like domains and a cysteine-rich frizzled (CRD /Fz) domain, as well as an intracellular tyrosine kinase (TK) domain. The Ig1, TK and potentially the CRD/Fz domains are required for NMJ formation and maintenance. The Ig1 and TK domains are essential for agrin-LRP4 signaling directing synaptic differentiation. For this reason, global deletion MuSK mice are neo-natal lethal. Two isoforms of MuSK that exist in vivo are: full- length (FL) MuSK and a naturally-occurring splice variant that lacks the Ig3 domain (ΔIg3- MuSK). FL MuSK mRNA levels are 10X higher than mRNA of ΔIg3-MuSK but the two are expressed coordinately. [0183] Among other things, the present disclosure provides compositions such as MuSK-targeting oligonucleotides that regulate MuSK alternative splicing as a strategy for increasing muscle regeneration. [0184] MuSK is activated by a nerve-derived proteoglycan called agrin. Agrin has been characterized for its role in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis. In humans, this protein is encoded by the AGRN gene. The agrin protein has nine domains homologous to protease inhibitors. [0185] MuSK is expressed in muscle and is upregulated during muscle regeneration. Data suggest that MuSK is implicated in BMP signaling in myogenesis. MuSK can act as a BMP co-receptor that binds BMP2, BMP4, and BMP7 as well as the Type I BMP receptors ALK3 and ALK6. See, for example, Yilmaz et al., Sci. Signal.9:ra87, doi: 10.1126/scisignal.aaf0890, 2016, incorporated herein by reference. The Ig3 domain of MuSK is required for high-affinity binding to BMP. MuSK upregulates BMP signaling as measured by BMP4-dependent phosphorylation of SMAD1/5/8. Importantly, MuSK-BMP signaling shapes the magnitude and composition of BMP-induced transcriptome in myoblasts and myotubes and this role is independent of any MuSK tyrosine kinase activity. MuSK is a BMP co-receptor that potentiates BMP signaling and regulates myogenic factors, such as myogenic factor 5 (Myf5), in immortalized myogenic cells. [0186] Activated satellite cells express MuSK protein and disruption of MuSK-BMP signaling alters satellite cell proliferation in regenerating muscle in vivo. Additionally, previous studies have suggested the role of the MuSK-BMP pathway in satellite cells and muscle regeneration and that targeting MuSK-BMP pathway enhances muscle growth (see e.g., PCT Publication No. WO 2021/076883, which is incorporated by reference herein). MuSK-Targeting Oligonucleotides [0187] As described herein, a strategy for regulating the MuSK-BMP pathway includes MuSK-targeting oligonucleotides (e.g., MuSK Ig3 targeting oligonucleotides). Specifically, the disclosure provides, among other things, oligonucleotides and compositions thereof that target regions spanning exon 6 and/or exon 7 of MuSK to induce exon-skipping of exon 6 and/or exon 7. Such alternative splicing activity leads to an increased expression of ΔIg3- MuSK. [0188] The present disclosure also describes regions within the MuSK transcript at or near exon 6 and/or exon 7 that are particularly useful as target sequences for oligonucleotides in inducing exon skipping of exon 6 and/or exon 7, thereby generating and ΔIg3- MuSK transcripts. [0189] In some embodiments, the present disclosure also provides specific oligonucleotides and combinations thereof that induce alternative splicing activity of MuSK and generate ΔIg3- MuSK transcripts. [0190] In addition, the present disclosure provides compositions comprising one or more MuSK-targeting oligonucleotides that induce exon skipping of MuSK exons 6 and/or 7, and can be administered to a subject in a therapeutically effective amount to increase neurogenesis and/or muscle regeneration in the subject. [0191] The disclosure includes compositions and methods related to one or more nucleotide sequences that are, comprise, or encode an oligonucleotide that binds to and inhibits expression of messenger RNA (mRNA) produced by a target gene (e.g., MuSK). Oligonucleotides can be single stranded (e.g., an antisense oligonucleotide) or double stranded nucleic acid. In some embodiments, an oligonucleotide comprises a double stranded RNA duplex such as microRNA (miRNA) or small interfering RNA (siRNA). In some embodiments, an oligonucleotide is an siRNA or miRNA, or a vector comprising a nucleotide sequence encoding an siRNA or miRNA. In some embodiments, an oligonucleotide is an antisense oligonucleotide (ASO), or a vector comprising a nucleotide sequence encoding an ASO. [0192] In some embodiments, an oligonucleotide is capable of inhibiting expression of the full-length MuSK sequence comprises three extracellular Immunoglobulin (Ig)-like domains (Ig1, Ig2, and Ig3), a cysteine-rich frizzled (CRD /Fz) domain, as well as an intracellular tyrosine kinase (TK) domain. [0193] As described herein, the oligonucleotides may target the MuSK sequence of human MuSK or one or more non-human species, e.g., a non-human primate MuSK, e.g., Macaca fascicularis MuSK (Gene ID 102127677), or e.g., chlorocebus sabaeus (Gene ID: 103219025), or murine MuSK (Gene ID: 18198). In some embodiments, a MuSK-targeting oligonucleotide comprises an antisense strand that is complementary to a target portion that is identical in the human and/or murine MuSK transcripts. In some embodiments, an oligonucleotide comprises a sequence that is complementary to a target portion of a human MuSK transcript that differs by 1, 2, or 3 nucleotides from a sequence in a murine or human MuSK transcript. It will be appreciated that an oligonucleotide that alters splicing of human MuSK may also alter splicing (i.e., induce exon skipping) of non-primate MuSK, e.g., rat or mouse MuSK, particularly if conserved regions of MuSK transcript are targeted. [0194] The amino acid and nucleotide sequences of human MuSK are known in the art and can be found in publicly available databases, for example, the National Center for Biotechnology Information (NCBI) Reference Sequence (RefSeq) database, where the genomic nucleotide sequence is listed under RefSeq accession numbers NG_016016.2 (SEQ ID NO: 77) and forms of the mRNA/protein sequences are listed under NM_005592.4/NP_005583.1 (muscle, skeletal receptor tyrosine-protein kinase isoform 1), NM_001166280.2/ NP_001159752.1 (muscle, skeletal receptor tyrosine-protein kinase isoform 2), NM_001166281.2/NP_001159753.1 (muscle, skeletal receptor tyrosine-protein kinase isoform 3) and NM_001369398.1/NP_001356327.1 (muscle, skeletal receptor tyrosine-protein kinase isoform 4). See www.ncbi.nlm.nih.gov/gene?Db=gene& Cmd=Details Search&Term=4593, which is incorporated herein by reference. [0195] In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to a target portion of a MuSK transcript, e.g., MuSK mRNA (e.g., complementary to a nucleotide sequence that is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to a target portion of SEQ ID NO: 77, e.g., Bld25/hu7-10 (SEQ ID NO: 63), Bld26/hu73 (SEQ ID NO: 64), etc.). In some embodiments, the target portion comprises a region that corresponds to positions 83776-83800 and/or 83854-83878 of SEQ ID No: 77 or a corresponding region of a different version of the genomic sequence MuSK. The target portion may be 15 – 30 nucleotides long, e.g., 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 nucleotides long, although shorter and longer target portions are also contemplated. [0196] In some embodiments, a target portion of a MuSK transcript, e.g., MuSK mRNA, comprises a sequence of ACTCTGTCAGGTTTCTTCTGGGTCCATTCAAGAGAGTGTGAAAGACCGAGTGATT GACTCAAGAC (region 1, SEQ ID: 126), or a region within or a portion thereof. In some embodiments, a target portion comprises a sequence that is at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50% identical to region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 10 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 15 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 18 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 19 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 20 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 21 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 22 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 23 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 24 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 25 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 35 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to at least 15 consecutive bases and no more than 30 consecutive bases of region 1, SEQ ID: 126. [0197] In some embodiments, a target portion comprises a sequence that is identical to 10 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 11 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 12 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 13 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 14 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 15 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 16 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 17 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 18 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 19 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 20 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 21 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 22 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 23 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 24 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 25 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 26 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 27 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 28 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 29 consecutive bases of region 1, SEQ ID: 126. In some embodiments, a target portion comprises a sequence that is identical to 30 consecutive bases of region 1, SEQ ID: 126. [0198] In some embodiments, a target portion of a MuSK transcript, e.g., MuSK mRNA, comprises a sequence of GGGGAGAAGTTCAGTACTGCCAAGGCTGCAGCCACCATCAGCATAGCAGGTAGG ATGCCCCTTCACATTTG (region 2, SEQ ID 211), or a region within or a portion thereof. In some embodiments, a target portion comprises a sequence that is at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50% identical to region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 10 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 15 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 18 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 19 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 20 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 21 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 22 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 23 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 24 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 25 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 30 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to at least 35 consecutive bases of region 2, SEQ ID: 211. [0199] In some embodiments, a target portion comprises a sequence that is identical to 10 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 11 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 12 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 13 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 14 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 15 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 16 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 17 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 18 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 19 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 20 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 21 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 22 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to23 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 24 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 25 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 26 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 27 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 28 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 29 consecutive bases of region 2, SEQ ID: 211. In some embodiments, a target portion comprises a sequence that is identical to 30 consecutive bases of region 2, SEQ ID: 211. [0200] In some embodiments, the target portion comprises a sequence that is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of the sequences listed below in Table 1. Table 1:

[0201] Administration of MuSK-targeting oligonucleotide(s) as described herein can reduce the level of full-length MuSK transcript or full-length MuSK protein in a subject or in a biological sample (e.g., a blood, serum or plasma sample, or a sample comprising hepatocytes) compared to a level before the administration of the composition. In some embodiments, the level of full-length MuSK transcript or full-length MuSK protein is reduced by at least 10%, at least 15%, at least 20%, at least 25%, at least 30%, at least 35%, at least 40%, at least 45%, at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, or at least 90%, relative to a level before the administration. [0202] In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to a target portion of a MuSK transcript, e.g., MuSK mRNA. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to a nucleotide sequence that is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to a target portion of a MuSK transcript, e.g., MuSK mRNA. [0203] In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of ACTCTGTCAGGTTTCTTCTGGGTCCATTCAAGAGAGTGTGAAAGACCGAGTGATT GACTCAAGAC (region 1, SEQ ID: 126) that includes at least 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 95% identical to a portion of SEQ ID: 126 that includes at least 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 10 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 15 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 18 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 19 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 20 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 21 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 22 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 23 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 24 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 25 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 26 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 27 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 28 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 29 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes at least 30 consecutive bases of region 1, SEQ ID: 126. [0204] In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of ACTCTGTCAGGTTTCTTCTGGGTCCATTCAAGAGAGTGTGAAAGACCGAGTGATT GACTCAAGAC (region 1, SEQ ID: 126) that includes 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 95% identical to a portion of SEQ ID: 126 that includes 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 10 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 15 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 18 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 19 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 20 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 21 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 22 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 23 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 24 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 25 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 26 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 27 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 28 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 29 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 126 that includes 30 consecutive bases of region 1, SEQ ID: 126. [0205] In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to a sequence of ACTCTGTCAGGTTTCTTCTGGGTCCATTCAAGAGAGTGTGAAAGACCGAGTGATT GACTCAAGAC (region 1, SEQ ID: 126). In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to a sequence of that is at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50% identical to region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 10 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 15 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 18 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 19 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 20 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 21 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 22 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 23 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 24 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 25 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 26 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 27 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 28 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 29 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 30 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 35 consecutive bases of region 1, SEQ ID: 126. [0206] In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 10 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 11 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 12 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 13 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 14 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 15 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 16 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 17 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 18 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 19 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 20 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 21 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 22 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 23 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 24 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 25 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 26 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 27 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 28 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 29 consecutive bases of region 1, SEQ ID: 126. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 30 consecutive bases of region 1, SEQ ID: 126. [0207] In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion sequence GGGGAGAAGTTCAGTACTGCCAAGGCTGCAGCCACCATCAGCATAGCAGGTAGG ATGCCCCTTCACATTTG (region 2, SEQ ID 211) that includes at least 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a sequence that is at least 95% identical to a portion of SEQ ID: 211 that includes at least 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a sequence that is at least 90% identical to a portion of SEQ ID: 211 that includes 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a sequence that is at least 95% identical to a portion of SEQ ID: 211 that includes 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 consecutive bases of region 2, SEQ ID: 211. [0208] In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to a portion of sequence GGGGAGAAGTTCAGTACTGCCAAGGCTGCAGCCACCATCAGCATAGCAGGTAGG ATGCCCCTTCACATTTG (region 2, SEQ ID 211). In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 10 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 15 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 18 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 19 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 20 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 21 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 22 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 23 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 24 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 25 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 30 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to at least 35 consecutive bases of region 2, SEQ ID: 211. [0209] In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 10 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 11 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 12 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 13 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 14 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 15 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 16 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 17 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 18 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 19 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 20 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 21 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 22 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 23 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 24 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 25 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 26 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 27 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 28 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 29 consecutive bases of region 2, SEQ ID: 211. In some embodiments, an oligonucleotide comprises a nucleic acid strand that is complementary to 30 consecutive bases of region 2, SEQ ID: 211. [0210] In some embodiments, MuSK-targeting oligonucleotides of the disclosure are antisense oligonucleotides comprising a nucleotide sequence that is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOs: 1-38, 127-142, 159-167, 177-193 in the following Table 2: Table 2:

[0211] In some embodiments, an oligonucleotide has a sequence that differs from that explicitly set forth in Table 2, for example by substitution of one or more residues, or types of residues, with an alternative residue or residue type– e.g., an analog or otherwise corresponding residue type. For example, in some embodiments, one or more “T” residues (or all “T” residues) of a sequence presented in Table 2 is a “U” residue or analog thereof. [0212] In some embodiments, an oligonucleotide comprises mismatch(es) with the target. The base pair may be ranked on the basis of their propensity to promote dissociation or melting (e.g., on the free energy of association or dissociation of a particular pairing, the simplest approach is to examine the pairs on an individual pair basis, though next neighbour or similar analysis can also be used). In terms of promoting dissociation: A:U is preferred over G:C; G:U is preferred over G:C; and I:C is preferred over G:C (I=inosine). [0213] In some embodiments, an oligonucleotide can include one or more (e.g., 2, 3, 4, or 5) nucleotides on the 3’ and/or 5’ end that is not complementary to the target sequence. Chemical Structures of MuSK-Targeting Oligonucleotides [0214] Synthetic oligonucleotides provide useful molecular tools in a wide variety of applications. For example, oligonucleotides are useful in therapeutic, diagnostic, research, and new nanomaterials applications. The use of naturally occurring nucleic acids (e.g., unmodified DNA or RNA) is limited, for example, by their susceptibility to endo- and exo- nucleases. As such, various synthetic counterparts have been developed to circumvent these shortcomings. These include synthetic oligonucleotides that contain chemical modification, e.g., base modifications, sugar modifications, backbone modifications, etc., which, among other things, render these molecules less susceptible to degradation and improve other properties of oligonucleotides. [0215] Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages, and patterns thereof), and/or stereochemistry (e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages), and/or patterns thereof), can have significant impact on properties, e.g., stability, splicing-altering capabilities, etc. In some embodiments, oligonucleotide properties can be adjusted by optimizing chemical modifications (modifications of base, sugar, and/or internucleotidic linkage) and/or stereochemistry (pattern of backbone chiral centers). [0216] In some embodiments, the present disclosure demonstrates that oligonucleotide compositions comprising oligonucleotides with controlled structural elements, e.g., controlled chemical modification, provide unexpected properties, including but not limited to those described herein. In some embodiments, provided compositions comprising oligonucleotides having chemical modifications (e.g., base modifications, sugar modification, internucleotidic linkage modifications, etc.) have improved properties, such as improved splicing-altering capabilities, or improved protein binding profile, and/or improved delivery, etc. Particularly, in some embodiments, the present disclosure provides compositions and methods for altering splicing of transcripts (e.g., MuSK transcripts). In some embodiments, the present disclosure provides compositions and methods for improving splicing of transcripts. In some embodiments, altered transcript splicing by provided compositions and methods include production of products having desired and/or improved biological functions, and/or knockdown of undesired product by, e.g., modifying splicing products so that undesired biological functions can be suppressed or removed. [0217] In some embodiments, a splicing product is mRNA. In some embodiments, alteration comprises skipping one or more exons. In some embodiments, splicing of a transcript is improved in that exon skipping increases levels of mRNA and proteins that have improved beneficial activities compared with absence of exon skipping. [0218] In some embodiments, splicing of a transcript is improved in that exon skipping lowers levels of mRNA and proteins that have undesired activities compared with absence of exon skipping. In some embodiments, a target is knocked down through exon skipping which, by skipping one or more exons, causes premature stop codon and/or frameshift mutations. [0219] In some embodiments, an oligonucleotide of the disclosure includes one or more natural nucleobase and/or one or more modified nucleobases derived from a natural nucleobase. Examples include, but are not limited to, uracil, thymine, adenine, cytosine, and guanine having their respective amino groups protected by acyl protecting groups, 2- fluorouracil, 2-fluorocytosine, 5-bromouracil, 5-iodouracil, 2,6-diaminopurine, azacytosine, pyrimidine analogs such as pseudoisocytosine and pseudouracil and other modified nucleobases such as 8-substituted purines, xanthine, or hypoxanthine (the latter two being the natural degradation products). [0220] Modified nucleobases also include expanded-size nucleobases in which one or more aryl rings, such as phenyl rings, have been added. [0221] In some embodiments, modified nucleobases are of any one of the following structures, optionally substituted:

[0222] In some embodiments, a modified nucleobase is unsubstituted. In some embodiments, a modified nucleobase is substituted. In some embodiments, a modified nucleobase is substituted such that it contains, e.g., heteroatoms, alkyl groups, or linking moieties connected to fluorescent moieties, biotin or avidin moieties, or other protein or peptides. In some embodiments, a modified nucleobase is a “universal base” that is not a nucleobase in the most classical sense, but that functions similarly to a nucleobase. One representative example of such a universal base is 3-nitropyrrole. [0223] In some embodiments, an oligonucleotide described herein includes nucleosides that incorporate modified nucleobases and/or nucleobases covalently bound to modified sugars. Some examples of nucleosides that incorporate modified nucleobases include 4-acetylcytidine; 5-(carboxyhydroxylmethyl)uridine; 2′-O-methylcytidine; 5- carboxymethylaminomethyl-2-thiouridine; 5-carboxymethylaminomethyluridine; dihydrouridine; 2′-O-methylpseudouridine; beta,D-galactosylqueosine; 2′-O- methylguanosine; N ⁶ -isopentenyladenosine; 1-methyladenosine; 1-methylpseudouridine; 1- methylguanosine; l-methylinosine; 2,2-dimethylguanosine; 2-methyladenosine; 2- methylguanosine; N ⁷ -methylguanosine; 3-methyl-cytidine; 5-methylcytidine; 5- hydroxymethylcytidine; 5-methylcytosine, 5-formylcytosine; 5-carboxylcytosine; N ⁶ - methyladenosine; 7-methylguanosine; 5-methylaminoethyluridine; 5-methoxyaminomethyl- 2-thiouridine; beta,D-mannosylqueosine; 5-methoxycarbonylmethyluridine; 5- methoxyuridine; 2-methylthio-N ⁶ -isopentenyladenosine; N-((9-beta,D-ribofuranosyl-2- methylthiopurine-6-yl)carbamoyl)threonine; N-((9-beta,D-ribofuranosylpurine-6-yl)-N- methylcarbamoyl)threonine; uridine-5-oxyacetic acid methylester; uridine-5-oxyacetic acid (v); pseudouridine; queosine; 2-thiocytidine; 5-methyl-2-thiouridine; 2-thiouridine; 4- thiouridine; 5-methyluridine; 2′-O-methyl-5-methyluridine; and 2′-O-methyluridine. [0224] In some embodiments, nucleosides include 6′-modified bicyclic nucleoside analogs that have either (R) or (S)-chirality at the 6′-position and include the analogs described in US Patent No.7,399,845. In other embodiments, nucleosides include 5′- modified bicyclic nucleoside analogs that have either (R) or (S)-chirality at the 5′-position and include the analogs described in U.S. Publ. No.20070287831. In some embodiments, a nucleobase or modified nucleobase is 5-bromouracil, 5-iodouracil, or 2,6-diaminopurine. In some embodiments, a nucleobase or modified nucleobase is modified by substitution with a fluorescent moiety. [0225] In some embodiments, an oligonucleotide described herein includes one or more modified nucleotides wherein a phosphate group or linkage phosphorus in the nucleotides are linked to various positions of a sugar or modified sugar. As non-limiting examples, the phosphate group or linkage phosphorus can be linked to the 2′, 3′, 4′ or 5′ hydroxyl moiety of a sugar or modified sugar. Nucleotides that incorporate modified nucleobases as described herein are also contemplated in this context. [0226] Other modified sugars can also be incorporated within an oligonucleotide molecule. In some embodiments, a modified sugar contains one or more substituents at the 2′ position including one of the following: –F; –CF ₃ , –CN, –N ₃ , –NO, –NO ₂ , –OR’, –SR’, or – N(R’) ₂ , wherein each R’ is independently as defined above and described herein; –O–(C ₁ –C ₁₀ alkyl), –S–(C ₁ –C ₁₀ alkyl), –NH–(C ₁ –C ₁₀ alkyl), or –N(C ₁ –C ₁₀ alkyl) ₂ ; –O–(C ₂ –C ₁₀ alkenyl), –S–(C ₂ –C ₁₀ alkenyl), –NH–(C ₂ –C ₁₀ alkenyl), or –N(C ₂ –C ₁₀ alkenyl) ₂ ; –O–(C ₂ –C ₁₀ alkynyl), –S–(C ₂ –C ₁₀ alkynyl), –NH–(C ₂ –C ₁₀ alkynyl), or –N(C ₂ –C ₁₀ alkynyl) ₂ ; or –O––(C ₁ –C ₁₀ alkylene)–O––(C ₁ –C ₁₀ alkyl), –O–(C ₁ –C ₁₀ alkylene)–NH–(C ₁ –C ₁₀ alkyl) or –O–(C ₁ –C ₁₀ alkylene)–NH(C ₁ –C ₁₀ alkyl) ₂ , –NH–(C ₁ –C ₁₀ alkylene)–O–(C ₁ –C ₁₀ alkyl), or –N(C ₁ –C ₁₀ alkyl)–(C ₁ –C ₁₀ alkylene)–O–(C ₁ –C ₁₀ alkyl), or salt thereof, wherein the alkyl, alkylene, alkenyl and alkynyl may be substituted or unsubstituted. Examples of substituents include, and are not limited to, –O(CH ₂ ) _n OCH ₃ , and –O(CH ₂ ) _n NH ₂ or salt thereof, wherein n is from 1 to about 10, –OCH ₂ CH ₂ OMe (MOE) or salt thereof, –OCH ₂ CH ₂ N(CH ₃ ) ₂ (DMAOE) or salt thereof, –OCH ₂ CH ₂ OCH ₂ CH ₂ N(CH ₃ ) ₂ (DMAEOE) or salt thereof. [0227] In some embodiments, the 2’-OH of a ribose is replaced with a substituent including one of the following: –H, –F; –CF ₃ , –CN, –N ₃ , –NO, –NO ₂ , –OR’, –SR’, or – N(R’) ₂ , wherein each R’ is independently as defined above and described herein; –O–(C ₁ –C ₁₀ alkyl), –S–(C ₁ –C ₁₀ alkyl), –NH–(C ₁ –C ₁₀ alkyl), or –N(C ₁ –C ₁₀ alkyl) ₂ ; –O–(C ₂ –C ₁₀ alkenyl), –S–(C ₂ –C ₁₀ alkenyl), –NH–(C ₂ –C ₁₀ alkenyl), or –N(C ₂ –C ₁₀ alkenyl) ₂ ; –O–(C ₂ –C ₁₀ alkynyl), –S–(C ₂ –C ₁₀ alkynyl), –NH–(C ₂ –C ₁₀ alkynyl), or –N(C ₂ –C ₁₀ alkynyl) ₂ ; or –O––(C ₁ –C ₁₀ alkylene)–O––(C ₁ –C ₁₀ alkyl), –O–(C ₁ –C ₁₀ alkylene)–NH–(C ₁ –C ₁₀ alkyl) or –O–(C ₁ –C ₁₀ alkylene)–NH(C ₁ –C ₁₀ alkyl) ₂ , –NH–(C ₁ –C ₁₀ alkylene)–O–(C ₁ –C ₁₀ alkyl), or –N(C ₁ –C ₁₀ alkyl)–(C ₁ –C ₁₀ alkylene)–O–(C ₁ –C ₁₀ alkyl), wherein the alkyl, alkylene, alkenyl and alkynyl may be substituted or unsubstituted. In some embodiments, the 2’–OH is replaced with –H (deoxyribose). In some embodiments, the 2’–OH is replaced with –F. In some embodiments, the 2’–OH is replaced with –OR’. In some embodiments, the 2’–OH is replaced with –OMe. In some embodiments, the 2’–OH is replaced with –OCH ₂ CH ₂ OMe (MOE). [0228] Modified sugars also include locked nucleic acids (LNAs). In some embodiments, the locked nucleic acid has the structure indicated below. A locked nucleic acid of the structure below is indicated, wherein Ba represents a nucleobase or modified nucleobase as described herein, and wherein R ^2s is –OCH ₂ C4’– . [0229] In some embodiments, each sugar of the oligonucleotide is or comprises a modified sugar moiety. In some embodiments, each sugar of the oligonucleotide is or comprises a 2’-MOE modified sugar. In some embodiments, each sugar of the oligonucleotide is or comprises a 2’-OMe modified sugar. In some embodiments, each sugar of the oligonucleotide is or comprises a 2’-OH modified sugar. In some embodiments, each sugar of the oligonucleotide is or comprises a 2’-H modified sugar. [0230] In some embodiments, the present disclosure provides an oligonucleotide comprising 2’-MOE modified sugar, 2’-OMe modified sugar, 2’-OH modified sugar, 2’-H modified sugar, or combinations thereof. In some embodiments, a provided oligonucleotide comprises at least one 2’-MOE sugar and at least one 2’-OH sugar (RNA sugar). In some embodiments, a provided oligonucleotide comprises at least one 2’-MOE sugar and at least one 2’-H sugar (DNA sugar). [0231] In some embodiments, the present invention provides an oligonucleotide comprising one or more modified internucleotidic linkages independently having the structure of formula I: wherein: P* is an asymmetric phosphorus atom and is either Rp or Sp configuration; W is O, S or Se; each of X, Y and Z is independently –O–, –S–, –N(–L–R ¹ )–, or L; L is a covalent bond or an optionally substituted, linear or branched C ₁ –C ₁₀ alkylene, wherein one or more methylene units of L are optionally and independently replaced by an optionally substituted C ₁ –C ₆ alkylene, C ₁ –C ₆ alkenylene, –C(R′) ₂ –, –Cy–, –O–, –S–, –S–S–, –N(R′)–, –C(O)–, –C(S)–, –C(NR′)–, –C(O)N(R′)–, –N(R′)C(O)N(R′)-, – N(R′)C(O)–, –N(R′)C(O)O–, –OC(O)N(R′)-, –S(O)–, –S(O) ₂ –, –S(O) ₂ N(R′)–, – N(R′)S(O) ₂ –, –SC(O)–, –C(O)S–, –OC(O)–, or –C(O)O–; R ¹ is halogen, R, or an optionally substituted C ₁ –C ₅₀ aliphatic wherein one or more methylene units are optionally and independently replaced by an optionally substituted C ₁ –C ₆ alkylene, C ₁ –C ₆ alkenylene, ^{C C} , –C(R′) ₂ –, –Cy–, –O–, –S–, –S–S–, –N(R′)–, –C(O)– , –C(S)–, –C(NR′)–, –C(O)N(R′)–, –N(R′)C(O)N(R′)-, –N(R′)C(O)–, –N(R′)C(O)O–, – OC(O)N(R′)-, –S(O)–, –S(O) ₂ –, –S(O) ₂ N(R′)–, –N(R′)S(O) ₂ –, –SC(O)–, –C(O)S–, – OC(O)–, or –C(O)O–; each R′ is independently –R, -C(O)R, -CO ₂ R, or –SO ₂ R, or: two R′ on the same nitrogen are taken together with their intervening atoms to form an optionally substituted heterocyclic or heteroaryl ring, or two R′ on the same carbon are taken together with their intervening atoms to form an optionally substituted aryl, carbocyclic, heterocyclic, or heteroaryl ring; –Cy– is an optionally substituted bivalent ring selected from phenylene, carbocyclylene, arylene, heteroarylene, or heterocyclylene; each R is independently hydrogen, or an optionally substituted group selected from C ₁ –C ₆ aliphatic, phenyl, carbocyclyl, aryl, heteroaryl, or heterocyclyl; and each independently represents a connection to a nucleoside. [0232] In some embodiments, the internucleotidic linkage having the structure of formula I is , [0233] In some embodiments, an oligonucleotide comprises both non-natural internucleotidic linkage as described herein and natural phosphate linkage. In some embodiments, each internucleotidic linkages of the oligonucleotide is a non-natural internucleotidic linkage. In some embodiments, each internucleotidic linkages of the oligonucleotide is a chiral internucleotidic linkage. In some embodiments, each internucleotidic linkages of the oligonucleotide is a phosphorothioate linkage [0234] In some embodiments, each internucleotidic linkages of an oligonucleotide is a natural phosphate linkage. In some embodiments, an oligonucleotide comprises at least one natural phosphate linkage and at least one phosphodithioate linkage. In some embodiments, at least 50% internucleotidic linkages of an oligonucleotide are phosphodithioate linkages. In some embodiments, at least 60% internucleotidic linkages of an oligonucleotide are phosphodithioate linkages. In some embodiments, at least 70% internucleotidic linkages of an oligonucleotide are phosphodithioate linkages. In some embodiments, at least 80% internucleotidic linkages of an oligonucleotide are phosphodithioate linkages. In some embodiments, at least 90% internucleotidic linkages of an oligonucleotide are phosphodithioate linkages. In some embodiments, at least 94% internucleotidic linkages of an oligonucleotide are phosphodithioate linkages. In some embodiments, at least 95% internucleotidic linkages of an oligonucleotide are phosphodithioate linkages. [0235] In some embodiments, at least 50% internucleotidic linkages of an oligonucleotide are natural phosphate linkages. In some embodiments, at least 60% internucleotidic linkages of an oligonucleotide are natural phosphate linkages. In some embodiments, at least 70% internucleotidic linkages of an oligonucleotide are natural phosphate linkages. In some embodiments, at least 80% internucleotidic linkages of an oligonucleotide are natural phosphate linkages. In some embodiments, at least 90% internucleotidic linkages of an oligonucleotide are natural phosphate linkages. In some embodiments, at least 94% internucleotidic linkages of an oligonucleotide are natural phosphate linkages. In some embodiments, at least 95% internucleotidic linkages of an oligonucleotide are natural phosphate linkages. [0236] Among other things, the present disclosure provides oligonucleotides of various designs, which may comprises various nucleobases and patterns thereof, sugars and patterns thereof, internucleotidic linkages and patterns thereof, and/or additional chemical moieties and patterns thereof as described in the present disclosure. In some embodiments, provided oligonucleotides can downregulate the MuSK Ig3 domain protein expression, the MuSK Ig3 domain gene expression, and/or the MuSK Ig3 activation of BMP signaling level, thereby increasing adult hippocampal neurogenesis (AHN) and improving cognition in AD. In some embodiments, provided oligonucleotides can downregulate the MuSK Ig3 domain protein expression, the MuSK Ig3 domain gene expression, and/or the MuSK Ig3 activation of BMP signaling level, thereby increasing muscle regeneration. In some embodiments, provided oligonucleotides can direct a decrease in the expression, level and/or activity of MuSK Ig3 domain and/or one or more of its products in a cell of a subject or patient. In some embodiments, provided oligonucleotides can direct a decrease in the expression, level and/or activity of MuSK Ig3 domain and/or one or more of its products in a cell of a subject or patient, while the expression, level, and/or activity of all forms of MuSK remains substantially the same. In some embodiments, a cell normally expresses or produces protein encoded by MuSK Ig3 domain. In some embodiments, provided MuSK-targeting oligonucleotides can direct a decrease in the expression, level and/or activity of MuSK Ig3 domain gene or a gene product and have a base sequence which consists of, comprises, or comprises a portion (e.g., a span of 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 or more contiguous bases) of the base sequence of a oligonucleotide disclosed herein, wherein each T can be independently substituted with U and vice versa, and the oligonucleotide comprises at least one non-naturally-occurring modification of a base, sugar and/or internucleotidic linkage. [0237] As described herein, the naturally highly abundant full length MuSK harbors the BMP-binding Ig3 domain and potentiates BMP signaling and thus restrains neurogenesis. In contrast, ΔIg3-MuSK has lower BMP signaling and promotes AHN and improves cognition. In some embodiments, the present disclosure provides exon-skipping MuSK- targeting oligonucleotides that switch MuSK from the AHN restraining full length MuSK to AHN permissive ΔIg3-MuSK splice form. [0238] As described herein, the highly abundant full length MuSK harbors the BMP- binding Ig3 domain and potentiates BMP signaling and affects muscle regeneration. In contrast, ΔIg3-MuSK has lower BMP signaling and promotes muscle regeneration and/or prevents muscle fibrosis. In some embodiments, the present disclosure provides exon- skipping MuSK-targeting oligonucleotides that switch MuSK from the full length MuSK to the muscle-promoting ΔIg3-MuSK splice form. [0239] In some embodiments, one or more skipped exons are selected from exon 6 and/or 7 of the MuSK gene. In some embodiments, exon 6 of MuSK is skipped. In some embodiments, exon 7 of MuSK is skipped. In some embodiments, both exons 6 and 7 of MuSK are skipped. [0240] In some embodiments, a MuSK-targeting oligonucleotide described herein can provide exon-skipping of exon 6 and/or 7, but does not provide exon-skipping of exon 3 and/or 4. [0241] In some embodiments, a MuSK-targeting oligonucleotide described herein can provide exon-skipping of exon 6 and/or 7 at a greater level than it provides exon-skipping of exon 3 and/or 4. [0242] In some embodiments, a MuSK-targeting oligonucleotide described herein provides exon-skipping such that the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 60% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 40%. [0243] In some embodiments, a MuSK-targeting oligonucleotide alters the splicing of MuSK transcripts such that the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 60% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 40%. [0244] In some embodiments, a MuSK-targeting oligonucleotide alters the splicing of MuSK transcripts such that the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 70% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 40%. [0245] In some embodiments, a MuSK-targeting oligonucleotide alters the splicing of MuSK transcripts such that the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 80% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 40%. [0246] In some embodiments, a MuSK-targeting oligonucleotide alters the splicing of MuSK transcripts such that the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 90% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 40%. [0247] In some embodiments, a MuSK-targeting oligonucleotide alters the splicing of MuSK transcripts such that the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 60% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 30%. [0248] In some embodiments, a MuSK-targeting oligonucleotide alters the splicing of MuSK transcripts such that the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 60% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 20%. [0249] In some embodiments, a MuSK-targeting oligonucleotide alters the splicing of MuSK transcripts such that the level of MuSK transcripts including exons 6 and 7 or the level of MuSK protein forms including sequences encoded by exons 6 and 7, or both, decreases by greater than 60% and the level of MuSK transcripts including exons 3 and 4 or the level of MuSK protein forms including sequences encoded by exons 3 and 4, or both, decreases by less than 10%. [0250] In various embodiments, an active compound is an oligonucleotide that directs skipping of one or more exons in a MuSK gene. In various embodiments, an active compound is an oligonucleotide that directs skipping of multiple exons in a MuSK gene. In some embodiments, an active compound is an oligonucleotide that directs skipping of exon 6, exon 7, or both in a MuSK gene. In some embodiments, an active compound is an oligonucleotide that directs skipping of exon 6 in a MuSK gene. In some embodiments, an active compound is an oligonucleotide that directs skipping of exon 7 in a MuSK gene. In some embodiments, an active compound is an oligonucleotide that directs skipping of exons 6 and 7 in a MuSK gene. In some embodiments, a plurality of oligonucleotides may be used together. In some such embodiments, two or more different exon skipping oligonucleotides (e.g., at least one that directs skipping of exon 6 and one that directs skipping of exon 7) may be used in combination. Alternatively or additionally, in some embodiments, at least one exon skipping oligonucleotide may be used in combination with at least one degrading oligonucleotide (e.g., that targets a transcript for RNase H degradation) which, for example, may target MuSK transcript(s) that include a functional Ig3 domain, or portion thereof. [0251] In some embodiments, oligonucleotides are provided and/or utilized in salt forms. In some embodiments, oligonucleotides are provided as salts comprising negatively- charged internucleotidic linkages (e.g., phosphorothioate internucleotidic linkages, natural phosphate linkages, etc.) existing as their salt forms. In some embodiments, oligonucleotides are provided as pharmaceutically acceptable salts. In some embodiments, oligonucleotides are provided as metal salts. In some embodiments, oligonucleotides are provided as sodium salts. In some embodiments, oligonucleotides are provided as metal salts, e.g., sodium salts, wherein each negatively-charged internucleotidic linkage is independently in a salt form (e.g., for sodium salts, −O−P(O)(SNa)−O− for a phosphorothioate internucleotidic linkage, −O−P(O)(ONa)−O− for a natural phosphate linkage, etc.). [0252] In some embodiments, individual oligonucleotides within a composition may be considered to be of the same constitution and/or structure even though, within such composition (e.g., a liquid composition), particular such oligonucleotides might be in different salt form(s) (and may be dissolved and the oligonucleotide chain may exist as an anion form when, e.g., in a liquid composition) at a particular moment in time. For example, those skilled in the art will appreciate that, at a given pH, individual internucleotidic linkages along an oligonucleotide chain may be in an acid (H) form, or in one of a plurality of possible salt forms (e.g., a sodium salt, or a salt of a different cation, depending on which ions might be present in the preparation or composition), and will understand that, so long as their acid forms (e.g., replacing all cations, if any, with H+) are of the same constitution and/or structure, such individual oligonucleotides may properly be considered to be of the same constitution and/or structure. [0253] In some embodiments, an oligonucleotide composition comprises two or more oligonucleotides. In some embodiments, an oligonucleotide composition comprises two or more pluralities of oligonucleotides, wherein each plurality is independently a plurality of oligonucleotides as described herein. For example, in some embodiments, each plurality independently shares a same base sequence and the same internucleotidic linkages. In some embodiments, at least two pluralities or each plurality independently targets the same exon(s) of the same transcript (e.g., exons 6 and/or 7 of MuSK). In some embodiments, at least two pluralities or each plurality independently targets different exons of the same transcript (e.g., exons 3, 4, 6, and/or 7 of MuSK). In some embodiments, at least two pluralities or each plurality independently targets a different transcript of the same or different nucleic acids. In some embodiments, at least two pluralities or each plurality independently targets transcripts of a different gene. In some embodiments, at least two pluralities or each plurality independently targets different regions on the MuSK transcript. Among other things, such compositions may be utilized to target two or more targets, in some embodiments, simultaneously and in the same system. Characterization of MuSK-targeting Oligonucleotides [0254] MuSK-targeting oligonucleotides provided herein may be identified, assessed and/or characterized for one or more their physical/chemical properties and/or biological activities. Those skilled in the art will be aware of a variety of approaches, including particular assays, that may be utilized for such identification, assessment, and/or characterization. [0255] In some embodiments, a MuSK-targeting oligonucleotide as described herein is characterized in that, for example, the MuSK-targeting oligonucleotide, when contacted with a cell expressing MuSK, will increase the level or activity of MuSK ΔIg3 mRNA and/or protein, e.g., relative to another MuSK form or other appropriate reference. In some embodiments, achieving such increase may be considered to represent “agonizing” MuSK ΔIg3. [0256] In some embodiments, a MuSK-targeting oligonucleotide is characterized by its ability to alter splicing activity of MuSK pre-mRNA in a cell. For example, a cell may be transfected with a MuSK-targeting oligonucleotide, and after a period of incubation, expression of an alternative form of processed form of a MuSK RNA transcript (e.g., where exons 6 and 7 have been skipped), can be measured by RT-PCR. For example, the efficiency of MuSK exon skipping in cultured cells greater than 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, or 95%. [0257] In some aspects, a MuSK-targeting oligonucleotide increases of MuSK ΔIg3 mRNA. In some aspects, a MuSK-targeting oligonucleotide alters splicing of MuSK pre- mRNA. In some aspects, a MuSK-targeting oligonucleotide promotes the skipping of exon 6 and/or exon 7. [0258] Modulation of expression of MuSK ΔIg3 can be measured in a bodily fluid of a subject treated with MuSK MR-targeting oligonucleotide, which may or may not contain cells; tissue; or organ of the animal. Methods of obtaining samples for analysis, such as body fluids (e.g., sputum, serum, CSF), tissues (e.g., biopsy), or organs, and methods of preparation of the samples to allow for analysis are well known to those skilled in the art. The effects of treatment on a subject can be assessed by measuring biomarkers associated with the target gene expression in one or more biological fluids, tissues or organs, collected from an animal contacted with one or more compositions described in this application. [0259] In some embodiments, an increase in MuSK ΔIg3 mRNA means that the intracellular level of MuSK ΔIg3 mRNA is higher than a reference level, such as the level of MuSK ΔIg3 mRNA in a control (for example in a subject that is not being administered an MuSK-targeting oligonucleotide). An increase in intracellular MuSK ΔIg3 mRNA can be measured as an increase in the level of MuSK ΔIg3 protein and/or mRNA produced. In some embodiments, an increase in MuSK ΔIg3 mRNA can be determined by e.g., methods as described below in the examples, and/or by assay techniques such as RNA solution hybridization, nuclease protection, Northern hybridization, reverse transcription, gene expression monitoring with a microarray, antibody binding, enzyme linked immunosorbent assay (ELISA), nucleic acid sequencing, Western blotting, radioimmunoassay (RIA), other immunoassays, fluorescence activated cell analysis (FACS), or any other technique or combination of techniques that can detect the presence of MuSK ΔIg3 mRNA or protein (e.g., in a subject or a sample obtained from a subject). [0260] In some embodiments, by comparing the level of MuSK ΔIg3 mRNA in a sample obtained from a subject receiving a MuSK-targeting oligonucleotide treatment to a level of MuSK ΔIg3 mRNA in a subject not treated with a MuSK-targeting oligonucleotide, the extent to which the MuSK-targeting oligonucleotide treatment increased MuSK ΔIg3 mRNA can be determined. In some embodiments, the reference level of MuSK ΔIg3 mRNA is obtained from the same subject prior to receiving MuSK-targeting oligonucleotide treatment. In some embodiments, the reference level of MuSK ΔIg3 mRNA is a range determined by a population of subjects not receiving MuSK-targeting oligonucleotide treatment. In some embodiments, the level of full-length MuSK mRNA is compared to the level of MuSK ΔIg3 mRNA. In some embodiments, the ratio of the MuSK ΔIg3 mRNA to a full length MuSK mRNA (e.g., MuSK mRNA without exons 6 and 7) in a subject receiving a MuSK-targeting oligonucleotide treatment, for example, greater than 1 fold, 1.5-5 fold, 5-10 fold, 10-50 fold, 50-100 fold, about 1.1-, 1.2-, 1.5-, 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9-, 10-, 15-, 20-, 30-, 40-, 50-, 60-, 70-, 80- , 90-, l00-fold or more higher than a reference ratio. [0261] In some embodiments, an increased level of MuSK ΔIg3 mRNA is, for example, greater than 1 fold, 1.5-5 fold, 5-10 fold, 10-50 fold, 50-100 fold, about 1.1-, 1.2-, 1.5-, 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9-, 10-, 15-, 20-, 30-, 40-, 50-, 60-, 70-, 80-, 90-, 100-fold or more higher than a reference value. [0262] In some embodiments, the increase of MuSK ΔIg3 mRNA in a subject can be indicated by the increase of MuSK ΔIg3 protein as compared to a reference level. In some embodiments, the reference level of MuSK ΔIg3 protein is the MuSK ΔIg3 protein level obtained from a subject having or at risk of having e.g., AD or a disease characterized by neurodegeneration. In some embodiments, the reference level of MuSK ΔIg3 protein is the MuSK ΔIg3 protein level obtained from a subject having or at risk of having e.g., neuromuscular dysfunction, a neurodegenerative disorder, a cardiac disorder (e.g., myocardial infarction, cardiomyopathy), or genetic diseases characterized by muscle wasting prior to treatment. Methods whereby bodily fluids, organs or tissues are contacted with an effective amount of one or more compositions described herein are also contemplated. Bodily fluids, organs or tissues can be contacted with one or more compositions comprising MuSK-targeting oligonucleotides, resulting in expression of MuSK ΔIg3 and modulation of MuSK expression in the cells of bodily fluids, organs or tissues. An effective amount of can be determined by monitoring the effect on functional MuSK ΔIg3 protein expression of MuSK-targeting oligonucleotides that are administered to a subject or contacted to a cell. [0263] In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same, when administered to a population of cells, (e.g., comprising NSCs and/or neural progenitor cells (MPCs)), increases the number of cells that are in an activated state (e.g., active proliferation). Cells within a population can be assessed for whether they are in an activated state by known methods in the art, including e.g., an EdU assay, where EdU+ cycling cells are compared with total cell counts. In some embodiments, a MuSK- targeting oligonucleotide or composition comprising the same, when administered to a population of cells comprising NSCs, decreases the number of quiescent NSCs in the population and/or increases the number of activated NSCs. [0264] In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same, when administered to a population of cells, (e.g., comprising satellite cells (SCs), myoblasts, myogenic progenitor cells (MPCs)), increases the number of cells that are in an activated state (e.g., active proliferation). Cells within a population can be assessed for whether they are in an activated state by known methods in the art, including e.g., an EdU assay, where EdU+ cycling cells are compared with total cell counts. In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same, when administered to a population of cells comprising satellite cells, decreases the number of quiescent satellite cells in the population and/or increases the number of activated satellite cells. [0265] In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same, when administered to a population of cells comprising NSCs and/or NPCs, increases the number of cells expressing genes associated with early neurons (e.g., Dex) and/or decreases the number of cells expressing genes associated with mature neurons (e.g., Map2), astrocytes (e.g., GFAP and S100b), and/or oligodendrocytes (e.g., CNPase and O4). In some embodiments, a MuSK-targeting oligonucleotide, when administered to a population of cells comprising NSCs and/or NPCs, increases the level of expression of genes associated with early neurons (e.g., Dex) and/or decreases the level of expression of genes associated with mature neurons (e.g., Map2), astrocytes (e.g., GFAP and S100b), and/or oligodendrocytes (e.g., CNPase and O4) in the population of cells. [0266] In some embodiments, a population of cells comprises NSCs that have been induced to be NSCs (e.g., from stem cells such as embryonic stems cells or pluripotent stem cells). [0267] In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same, when administered to a population of cells comprising SCs, MPCs, and/or myoblasts, increases the number of cells expressing genes or myogenic factors (e.g., Pax7, MyoD, myogenin, and MERGE) and/or decreases the number of cells expressing genes associated with the MuSK-BMP signaling pathway (e.g., RGS4, Msx2, Myf5, Ptx3, Id1). In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same, when administered to a population of cells comprising satellite cells and/or myoblasts, increases the level of expression of genes associated with myogenic factors (e.g., Pax7, MyoD, myogenin, and MERGE) and/or decreases the level of expression of genes associated the MuSK-BMP signaling pathway (e.g., RGS4, Msx2, Myf5, Ptx3, Id1) in the population of cells. [0268] In some embodiments, a population of cells comprises satellite cells and/or myoblasts that have been induced to be satellite cells and/or myoblasts (e.g., from stem cells such as embryonic stems cells or pluripotent stem cells). [0269] In some embodiments, a population of cells is obtained from a healthy subject. In some embodiments, a population of cells is obtained from a subject having or at risk of having e.g., AD or a disease characterized by neurodegeneration or a subject suffering from a disease or disorder such as a neuromuscular dysfunction, a neurodegenerative disorder, a cardiac disorder (e.g., myocardial infarction, cardiomyopathy), or genetic diseases characterized by muscle wasting. [0270] In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same, when contacted with a population of cells from a subject, increases neurogenesis in a subject. In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same is contacted with the population of cells in vivo, for example, by injection into a subject. In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same is contacted with the population of cells ex vivo by obtaining a population of cells from a subject, and neurogenesis is increased when the treated cells are re-introduced into the subject. [0271] In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same, when contacted with a population of cells from a subject, increases muscle regeneration and/or growth in a subject. In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same is contacted with the population of cells in vivo, for example, by injection into a subject. In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same is contacted with the population of cells ex vivo by obtaining a population of cells from a subject, and muscle regeneration is increased when the treated cells are re-introduced into the subject. [0272] In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same, when administered to a subject, will increase neurogenesis and/or growth, and/or improve cognition. Examples of methods to assess these biological effects are detailed, e.g., in the below examples. [0273] In some embodiments, a MuSK-targeting oligonucleotide or composition comprising the same, when administered to a subject, will increase muscle regeneration and/or growth, and/or neuromuscular function, and/or myogenesis. Examples of methods to assess these biological effects are detailed, e.g., in the below examples. Production of MuSK-Targeting Oliogonucleotides [0274] A MuSK-targeting oligonucleotide described herein can be synthesized by standard methods known in the art, e.g., by use of an automated synthesizer. Following chemical synthesis (e.g., solid-phase synthesis using phosphoramidite method), oligonucleotide molecules can be deprotected, annealed to ds molecules, and purified (e.g., by gel electrophoresis or HPLC). Protocols for preparation of MuSK-targeting oligonucleotide oligonucleotides are known in the art. [0275] In some embodiments, the present disclosure provides technologies for preparing chirally controlled oligonucleotides and compositions thereof. In some embodiments, the present disclosure provides technologies for preparing stereopure oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions thereof are of high purity. In some embodiments, oligonucleotides of the present disclosure are at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% stereochemically pure at linkage phosphorus of chiral internucleotidic linkages. In some embodiments, oligonucleotides of the present disclosure are prepared stereoselectively and are substantially free of stereoisomers. In some embodiments, in provided compositions comprising a plurality of oligonucleotides which share the same base sequence of the same pattern of chiral linkage phosphorus stereochemistry (e.g., comprising one or more of Rp and/or Sp, wherein each chiral linkage phosphorus is independently Rp or Sp), at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% of all oligonucleotides in the composition that share the same base sequence as oligonucleotides of the plurality share the same pattern of chiral linkage phosphorus stereochemistry or are oligonucleotides of the plurality. In some embodiments, in provided compositions comprising a plurality of oligonucleotides which share the same base sequence of the same pattern of chiral linkage phosphorus stereochemistry, at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% of all oligonucleotides in the composition that share the same constitution as oligonucleotides of the plurality share the same pattern of chiral linkage phosphorus stereochemistry or are oligonucleotides of the plurality. [0276] MuSK-targeting oligonucleotides can also be formed within a cell by transcription of RNA from an expression construct introduced into the cell (see, e.g., Yu et al., Proc. Natl. Acad. Sci. USA 2002; 99:6047-6052). An expression construct for in vivo production of oligonucleotide molecules can include one or more antisense encoding sequences operably linked to elements necessary for the proper transcription of the antisense encoding sequence(s), including, e.g., promoter elements and transcription termination signals. Preferred promoters for use in such expression constructs include the polymerase-III HI-RNA promoter (see, e.g., Brummelkamp et al., Science 2002; 296:550-553) and the U6 polymerase-III promoter (see, e.g., Sui et al., Proc. Natl. Acad. Sci. USA 2002; Paul et al., Nature Biotechnol.2002; 20:505-508; and Yu et al., Proc. Natl. Acad. Sci. USA 2002; 99:6047-6052). A MuSK-targeting oligonucleotide expression construct can further comprise one or more vector sequences that facilitate the cloning of the expression construct. Standard vectors that can be used include, e.g., pSilencer 2.0-U6 vector (Ambion Inc., Austin, Tex.). Pharmaceutical Compositions [0277] The present disclosure provides pharmaceutical compositions that comprise and/or deliver MuSK-targeting oligonucleotides as described herein. The present disclosure also provides pharmaceutical compositions that are or comprise cell populations that have been exposed to MuSK-targeting oligonucleotides as described herein. [0278] For example, in some embodiments, a provided pharmaceutical composition may comprise and/or deliver MuSK-targeting oligonucleotides that, when administered, achieves an increase in level and/or activity of a MuSK polypeptide (e.g., a MuSK ΔIg3 polypeptide, or another MuSK variant polypeptide with disrupted Ig3) that lacks an Ig3 domain functional for interaction with BMP. Alternatively or additionally, in some embodiments, a provided pharmaceutical composition may comprise and/or deliver a population of cells that has been exposed to a MuSK-targeting oligonucleotide, so that neuronal cell number and/or activity is increased in the population. [0279] In many embodiments, a pharmaceutical composition will be or comprise an active agent (e.g., a MuSK-targeting oligonucleotide as described herein or a precursor thereof) in combination with one or more pharmaceutically acceptable excipients. Those skilled in the art will appreciate that components of a particular pharmaceutical composition may be influenced by route of administration of the pharmaceutical composition. [0280] The compositions of the disclosure can be formulated for a variety of modes of administration, including systemic and topical or localized administration. Techniques and formulations generally may be found in Remington, The Science and Practice of Pharmacy, (20th ed.2000). [0281] Compositions of the present invention can be prepared and administered in a wide variety of oral, parenteral, and topical dosage forms. Thus, the compositions of the present invention can be administered by injection (e.g. intravenously, intramuscularly, intracutaneously, subcutaneously, intraduodenally, or intraperitoneally). Also, the compositions described herein can be administered by inhalation, for example, intranasally. Additionally, the composition of the present invention can be administered transdermally. It is also envisioned that multiple routes of administration (e.g., intramuscular, oral, transdermal) can be used to administer the compositions of the invention. [0282] In some embodiments, a pharmaceutical composition as described herein may be formulated for delivery by a route selected from intravenous injection, intrathecal administration, oral administration, buccal administration, inhalation, nasal administration, topical administration, ophthalmic administration or otic administration. In some embodiments, a pharmaceutical composition may be formulated for delivery by intrathecal administration. In some embodiments, a pharmaceutical composition may be formulated for delivery by intravenous administration. In some embodiments, a pharmaceutical composition may be formulated for delivery by oral administration. [0283] In certain embodiments, oligonucleotides and compositions are delivered to the CNS. In certain embodiments, oligonucleotides and compositions are delivered to the cerebrospinal fluid. In certain embodiments, oligonucleotides and compositions are administered to the brain parenchyma. In certain embodiments, oligonucleotides and compositions are delivered to an animal/subject by intrathecal administration, or intracerebroventricular administration. Broad distribution of oligonucleotides and compositions, described herein, within the central nervous system may be achieved with intraparenchymal administration, intrathecal administration, or intracerebroventricular administration. [0284] In certain embodiments, parenteral administration is by injection, by, e.g., a syringe, a pump, etc. In certain embodiments, the injection is a bolus injection. In certain embodiments, the injection is administered directly to a tissue, such as striatum, caudate, cortex, hippocampus and cerebellum. [0285] In certain embodiments, methods of specifically localizing a pharmaceutical agent, such as by bolus injection, decreases median effective concentration (EC50) by a factor of 20, 25, 30, 35, 40, 45 or 50. In certain embodiments, the pharmaceutical agent in an antisense compound as further described herein. In certain embodiments, the targeted tissue is brain tissue. In certain embodiments the targeted tissue is hippocampus tissue. In certain embodiments, decreasing EC50 is desirable because it reduces the dose required to achieve a pharmacological result in a patient in need thereof. [0286] In certain embodiments, an antisense oligonucleotide is delivered by injection or infusion once every month, every two months, every 90 days, every 3 months, every 6 months, twice a year or once a year. [0287] In addition to the active ingredients, these pharmaceutical compositions may contain suitable pharmaceutically acceptable carriers comprising excipients and auxiliaries, which facilitate processing of an active compound into preparations which can be used pharmaceutically. The preparations formulated for oral administration may be in the form of tablets, dragees, capsules, or solutions. [0288] Pharmaceutical preparations for oral use can be obtained by combining an active compound with solid excipients, optionally grinding a resulting mixture, and processing the mixture of granules, after adding suitable auxiliaries, if desired, to obtain tablets or dragee cores. Suitable excipients are, in particular, fillers such as sugars, including lactose, sucrose, mannitol, or sorbitol; cellulose preparations, for example, maize starch, wheat starch, rice starch, potato starch, gelatin, gum tragacanth, methyl cellulose, hydroxypropylmethyl-cellulose, sodium carboxymethyl-cellulose (CMC), and/or polyvinylpyrrolidone (PVP: povidone). If desired, disintegrating agents may be added, such as the cross-linked polyvinylpyrrolidone, agar, or alginic acid or a salt thereof such as sodium alginate. [0289] Dragee cores are provided with suitable coatings. For this purpose, concentrated sugar solutions may be used, which may optionally contain gum arabic, talc, polyvinylpyrrolidone, carbopol gel, polyethylene glycol (PEG), and/or titanium dioxide, lacquer solutions, and suitable organic solvents or solvent mixtures. Dye-stuffs or pigments may be added to the tablets or dragee coatings for identification or to characterize different combinations of active compound doses. [0290] Pharmaceutical preparations that can be used orally include push-fit capsules made of gelatin, as well as soft, sealed capsules made of gelatin, and a plasticizer, such as glycerol or sorbitol. The push-fit capsules can contain the active ingredients in admixture with filler such as lactose, binders such as starches, and/or lubricants such as talc or magnesium stearate and, optionally, stabilizers. In soft capsules, an active compound may be dissolved or suspended in suitable liquids, such as fatty oils, liquid paraffin, or liquid polyethylene glycols (PEGs). In addition, stabilizers may be added. [0291] In some embodiments, the pharmaceutical composition is a tablet, a pill, a capsule, a liquid, an inhalant, a nasal spray solution, a suppository, a suspension, a gel, a colloid, a dispersion, a suspension, a solution, an emulsion, an ointment, a lotion, an eye drop or an ear drop. [0292] Depending on the specific conditions being treated, pharmaceutical composition of the present disclosure may be formulated into liquid or solid dosage forms and administered systemically or locally. The pharmaceutical composition may be delivered, for example, in a timed- or sustained- low release form as is known to those skilled in the art. Techniques for formulation and administration may be found in Remington, The Science and Practice of Pharmacy (20th ed.2000). Suitable routes may include oral, buccal, by inhalation spray, sublingual, rectal, transdermal, vaginal, transmucosal, nasal or intestinal administration; parenteral delivery, including intramuscular, subcutaneous, intramedullary injections, as well as intrathecal, direct intraventricular, intravenous, intra-articullar, intra- sternal, intra-synovial, intra-hepatic, intralesional, intracranial, intraperitoneal, intranasal, or intraocular injections or other modes of delivery. [0293] For injection, the pharmaceutical composition of the disclosure may be formulated and diluted in aqueous solutions, such as in physiologically compatible buffers such as Hank's solution, Ringer's solution, or physiological saline buffer. For such transmucosal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are generally known in the art. [0294] Use of pharmaceutically acceptable inert carriers to formulate the compositions herein disclosed for the practice of the disclosure into dosages suitable for systemic administration is within the scope of the disclosure. With proper choice of carrier and suitable manufacturing practice, the compositions of the present disclosure, in particular, those formulated as solutions, may be administered parenterally, such as by intravenous injection. [0295] In some embodiments, compositions as described herein can be formulated using pharmaceutically acceptable carriers available in the art into dosages suitable for oral administration. Such carriers enable the compounds of the disclosure to be formulated as tablets, pills, capsules, liquids, gels, syrups, slurries, suspensions and the like, for oral ingestion by a subject (e.g., patient) to be treated. [0296] For nasal or inhalation delivery, one or more solubilizing, diluting, or dispersing substances such as, saline, preservatives, such as benzyl alcohol, absorption promoters, and fluorocarbons, may be employed. [0297] In some embodiments, a provided composition may comprise and/or deliver a precursor of an active agent, wherein the precursor becomes or releases active therapeutic agent upon administration. In some embodiments, for example, a precursor may be or comprise a prodrug of a small molecule agonizing agent, or a nucleic acid that encodes a protein agonizing agent, etc. [0298] In some particular embodiments, a provided pharmaceutical composition comprises or delivers a therapeutically effective amount (e.g., an amount that is effective when administered according to an established protocol) of a provided oligonucleotide (which may, as described herein, be provided in a pharmaceutically acceptable salt form, e.g., as a sodium salt, ammonium salt, etc.); in some embodiments, such a provided pharmaceutical composition includes a relevant oligonucleotide and at least one pharmaceutically acceptable inactive ingredient selected from pharmaceutically acceptable diluents, pharmaceutically acceptable excipients, and pharmaceutically acceptable carriers. In some embodiments, a salt form of a provided oligonucleotide comprises two or more cations, for example, in some embodiments, up to the number of negatively charged acidic groups (e.g., phosphate, phosphorothioate, etc.) in an oligonucleotide. [0299] Pharmaceutically acceptable salts are generally well known to those of ordinary skill in the art, and may include, by way of example but not limitation, acetate, benzenesulfonate, besylate, benzoate, bicarbonate, bitartrate, bromide, calcium edetate, carnsylate, carbonate, citrate, edetate, edisylate, estolate, esylate, fumarate, gluceptate, gluconate, glutamate, glycollylarsanilate, hexylresorcinate, hydrabamine, hydrobromide, hydrochloride, hydroxynaphthoate, iodide, isethionate, lactate, lactobionate, malate, maleate, mandelate, mesylate, mucate, napsylate, nitrate, pamoate (embonate), pantothenate, phosphate/diphosphate, polygalacturonate, salicylate, stearate, subacetate, succinate, sulfate, tannate, tartrate, or teoclate. Other pharmaceutically acceptable salts may be found in, for example, Remington, The Science and Practice of Pharmacy (20th ed.2000). Preferred pharmaceutically acceptable salts include, for example, acetate, benzoate, bromide, carbonate, citrate, gluconate, hydrobromide, hydrochloride, maleate, mesylate, napsylate, pamoate (embonate), phosphate, salicylate, succinate, sulfate, or tartrate. [0300] As appreciated by a person having ordinary skill in the art, oligonucleotides may be formulated as a number of salts for, e.g., pharmaceutical uses. In some embodiments, a salt is a metal cation salt and/or ammonium salt. In some embodiments, a salt is a metal cation salt of an oligonucleotide. In some embodiments, a salt is an ammonium salt of an oligonucleotide. Representative alkali or alkaline earth metal salts include sodium, lithium, potassium, calcium, magnesium, and the like. In some embodiments, a salt is a sodium salt of an oligonucleotide. In some embodiments, pharmaceutically acceptable salts include, when appropriate, nontoxic ammonium, quaternary ammonium, and amine cations formed with counterions such as hydroxide, carboxylate, sulfate, phosphate, nitrate, sulfonate, phosphorothioate, etc. that may be within provided oligonucleotides. As appreciated by a person having ordinary skill in the art, a salt of an oligonucleotide may contain more than one cations, e.g., sodium ions, as there may be more than one anions within an oligonucleotide. [0301] In some embodiments, provided oligonucleotides, and compositions thereof, may be effective over a wide dosage range. For example, in the treatment of adult humans, dosages from about 0.01 to about 1000 mg, from about 0.5 to about 100 mg, from about 1 to about 50 mg per day, and from about 5 to about 100 mg per day are examples of dosages that may be used. The exact dosage will depend upon the route of administration, the form in which the compound is administered, the subject to be treated, the body weight of the subject to be treated, and the preference and experience of the attending physician. [0302] In some embodiments, the present disclosure provides technologies (e.g., compositions, methods, etc.) for combination therapy, for example, with other therapeutic agents and/or medical procedures. In some embodiments, provided oligonucleotides and/or compositions may be used together with one or more other therapeutic agents. In some embodiments, provided compositions comprise provided oligonucleotides, and one or more other therapeutic agents. In some embodiments, the one or more other therapeutic agents may have one or more different targets, and/or one or more different mechanisms toward targets, when compared to provided oligonucleotides in the composition. In some embodiments, a therapeutic agent is an oligonucleotide. In some embodiments, a therapeutic agent is a small molecule drug. In some embodiments, a therapeutic agent is a protein. In some embodiments, a therapeutic agent is an antibody. A number of a therapeutic agent may be utilized in accordance with the present disclosure. In some embodiments, provided oligonucleotides or compositions thereof are administered prior to, concurrently with, or subsequent to one or more other therapeutic agents and/or medical procedures. In some embodiments, provided oligonucleotides or compositions thereof are administered concurrently with one or more other therapeutic agents and/or medical procedures. In some embodiments, provided oligonucleotides or compositions thereof are administered prior to one or more other therapeutic agents and/or medical procedures. In some embodiments, provided oligonucleotides or compositions thereof are administered subsequent to one or more other therapeutic agents and/or medical procedures. In some embodiments, provide compositions comprise one or more other therapeutic agents. Production of Pharmaceutical Compositions [0303] For preparing pharmaceutical compositions from the compositions of the present invention, pharmaceutically acceptable carriers can be either solid or liquid. Solid form preparations include powders, tablets, pills, capsules, cachets, suppositories, and dispersible granules. A solid carrier can be one or more substance that may also act as diluents, flavoring agents, binders, preservatives, tablet disintegrating agents, or an encapsulating material. [0304] In powders, the carrier is a finely divided solid in a mixture with the finely divided active component. In tablets, the active component is mixed with the carrier having the necessary binding properties in suitable proportions and compacted in the shape and size desired. [0305] The powders and tablets preferably contain from 5% to 70% of the therapeutic agent. Suitable carriers are magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like. The term “preparation” is intended to include the formulation of the active therapeutic agent with encapsulating material as a carrier providing a capsule in which the active component with or without other carriers, is surrounded by a carrier, which is thus in association with it. Similarly, cachets and lozenges are included. Tablets, powders, capsules, pills, cachets, and lozenges can be used as solid dosage forms suitable for oral administration. [0306] For preparing suppositories, a low melting wax, such as a mixture of fatty acid glycerides or cocoa butter, is first melted and the active component is dispersed homogeneously therein, as by stirring. The molten homogeneous mixture is then poured into convenient sized molds, allowed to cool, and thereby to solidify. [0307] Liquid form preparations include solutions, suspensions, and emulsions, for example, water or water/propylene glycol solutions. For parenteral injection, liquid preparations can be formulated in solution in aqueous polyethylene glycol solution. [0308] When parenteral application is needed or desired, particularly suitable admixtures for compositions of the invention are injectable, sterile solutions, preferably oily or aqueous solutions, as well as suspensions, emulsions, or implants, including suppositories. In particular, carriers for parenteral administration include aqueous solutions of dextrose, saline, pure water, ethanol, glycerol, propylene glycol, peanut oil, sesame oil, polyoxyethylene-block polymers, and the like. Ampoules are convenient unit dosages. The compositions of the invention can also be incorporated into liposomes or administered via transdermal pumps or patches. Pharmaceutical admixtures suitable for use in the present invention include those described, for example, in Pharmaceutical Sciences (17th Ed., Mack Pub. Co., Easton, PA) and WO 96/05309, which is herein incorporated by reference. [0309] Aqueous solutions suitable for oral use can be prepared by dissolving the active component in water and adding suitable colorants, flavors, stabilizers, and thickening agents as desired. Aqueous suspensions suitable for oral use can be made by dispersing the finely divided active component in water with viscous material, such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, and other well-known suspending agents. [0310] Also included are solid form preparations that are intended to be converted, shortly before use, to liquid form preparations for oral administration. Such liquid forms include solutions, suspensions, and emulsions. These preparations may contain, in addition to the active component, colorants, flavors, stabilizers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilizing agents, and the like. [0311] The pharmaceutical preparation is preferably in unit dosage form. In such form the preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packeted tablets, capsules, and powders in vials or ampoules. Also, the unit dosage form can be a capsule, tablet, cachet, or lozenge itself, or it can be the appropriate number of any of these in packaged form. [0312] The quantity of active component in a unit dose preparation may be varied or adjusted according to the particular application and the potency of the active component. The composition can, if desired, also contain other compatible therapeutic agents. Patient populations [0313] In some embodiments, an appropriate patient or population is one suffering from and/or susceptible to a disease, disorder or a condition associated with neurodegeneration (e.g., AD) or that otherwise would benefit from increased neurogenesis. In some embodiments, an appropriate patient or population is one suffering from and/or susceptible to a disease, disorder such as neuromuscular dysfunction, a cardiac disorder (e.g., myocardial infarction, cardiomyopathy), or genetic diseases characterized by muscle wasting or that otherwise would benefit from increased muscle regeneration). [0314] In some embodiments, such neurodegenerative disease, disorder, or condition is one or more of Alzheimer’s Disease (AD), Parkinson’s disease, dementia (e.g., Frontotemporal dementia), stroke, Major Depressive Disorder (MDD), bipolar disorder, Schizophrenia, Post-Traumatic Stress Disorder (PTSD), substance-related and addictive disorders (e.g., chronic cocaine use and lifelong cigarette smoking), Temporal-Lobe Epilepsy, Hippocampal Sclerosis, Niemann Pick Type C, Diabetes-mediated hippocampal neuronal loss, brain injury (e.g., traumatic and/or anoxic brain injury), and Huntington’s disease. [0315] In some embodiments, population may additionally or alternatively be suffering from and/or susceptible to a disease or disorder of the lung. In some embodiments, such a disease or disorder is one or more of idiopathic pulmonary fibrosis (IPF), acute respiratory distress syndrome (ARDS), pneumonia, and lung complications due to viral infections. [0316] In some embodiments, an appropriate patient or population is model organisms. In some embodiments, an appropriate patient or population is humans. In some embodiments, a human has an age in a range of from about 0 months to about 6 months old, from about 6 to about 12 months old, from about 6 to about 18 months old, from about 18 to about 36 months old, from about 1 to about 5 years old, from about 5 to about 10 years old, from about 10 to about 15 years old, from about 15 to about 20 years old, from about 20 to about 25 years old, from about 25 to about 30 years old, from about 30 to about 35 years old, from about 35 to about 40 years old, from about 40 to about 45 years old, from about 45 to about 50 years old, from about 50 to about 55 years old, from about 55 to about 60 years old, from about 60 to about 65 years old, from about 65 to about 70 years old, from about 70 to about 75 years old, from about 75 to about 80 years old, from about 80 to about 85 years old, from about 85 to about 90 years old, from about 90 to about 95 years old or from about 95 to about 100 years old. [0317] In some embodiments, a human is a human infant. In some embodiments, a human is a human toddler. In some embodiments, a human is a human child. In some embodiments, a human is a human adult. In yet other embodiments, a human is an elderly human. [0318] In some embodiments, an appropriate patient or population may be characterized by one or more criterion such as age group, gender, genetic background, preexisting clinical conditions, prior exposure to therapy. [0319] In some embodiments, an appropriate patient or population is one suffering from e.g., neuromuscular dysfunction, a neurodegenerative disorder, a cardiac disorder (e.g., myocardial infarction, cardiomyopathy), or genetic diseases characterized by muscle wasting. In some embodiments, an appropriate patient or population is one suffering that has received surgery or experienced injury, trauma and/or prolonged immobilization (e.g., from bed-rest or casting). In some embodiments, an appropriate patient or population is one suffering from sarcopenia. In some embodiments, an appropriate patient or population is one suffering from or at risk of muscle fibrosis resulting from a disease or condition including, but not limited to, trauma, heritable disease, muscle disorder, and aging. Trauma can result from, for example, radiation treatment, crush injury, laceration, and amputation. In some embodiments, an appropriate patient or population is one suffering from or at risk of heritable disease associated with muscle fibrosis such as Congenital Muscular Dystrophy, Duchenne Muscular Dystrophy, Becker’s Muscular Dystrophy, Amyotrophic Lateral Sclerosis (ALS), age- associated sarcopenia, Distal muscular dystrophy, Emery-Dreifuss muscular dystrophy, Facioscapulohumeral muscular dystrophy, Limb-girdle muscular dystrophy, Myotonic muscular dystrophy, and Oculo-pharyngeal muscular dystrophy. [0320] In some embodiments, an appropriate patient or population maybe defined by those in accordance with the screening tools for diseases or disorders associated with Alzheimer’s disease. In some embodiments, an appropriate patient or population maybe defined by those in accordance with the screening tools for other diseases characterized by neurodegeneration, e.g., Parkinson’s disease, dementia (e.g., Frontotemporal dementia), stroke, Major Depressive Disorder (MDD), bipolar disorder, Schizophrenia, Post-Traumatic Stress Disorder (PTSD), substance-related and addictive disorders (e.g., chronic cocaine use and lifelong cigarette smoking), Temporal-Lobe Epilepsy, Hippocampal Sclerosis, Niemann Pick Type C, Diabetes-mediated hippocampal neuronal loss, brain injury (e.g., traumatic and/or anoxic brain injury), and Huntington’s disease. [0321] In some embodiments, an appropriate patient or population maybe defined by those in accordance with the screening tools for diseases or disorders associated with muscle fibrosis and/or muscle wasting. In some embodiments, an appropriate patient or population maybe defined by those in accordance with the screening tools and methods for diagnosing a disease associated with muscle fibrosis and/or muscle wasting. [0322] In some embodiments, an appropriate patient or population may be defined according to the results obtained in structural imaging (e.g., magnetic resonance imaging (MRI), computed tomography (CT), ultrasound etc.). In some embodiments, an appropriate patient or population may be defined according to the results of cognitive tests. In some embodiments, an appropriate patient or population may be defined according to the results of neurological tests. In some embodiments, the cognitive tests involve one or more tests of Motor Screening Task (MOT), Reaction Time (RTI), Paired Associates Learning (PAL), Spatial Working Memory (SWM), Pattern Recognition Memory (PRM), Delayed Matching to Sample (DMS), Rapid Visual Information Processing (RVP). Rapid Visual Information Processing (RVP), Delayed Matching to Sample (DMS), Match to Sample Visual Search (MTS). In some embodiments, an appropriate patient or population may be defined according to the results of assessments such as measuring muscle enzymes, EMG, muscle biopsy, genetic testing, heart testing (e.g., ECG), assessments of strength and respiratory function. Administration [0323] Those skilled in the art will appreciate that, in some embodiments, dosage administered to a subject, particularly a human, may vary, for example depending on the particular therapeutic and/or formulation employed, the method of administration, the dosing regimen, one or more characteristics of the particular subject being treated, etc.. In some embodiments, a clinician skilled in the art will determine the therapeutically effective amount of a therapeutic to be administered to a human or other subject in order to treat or prevent a particular medical condition. The precise amount of the therapeutic required to be therapeutically effective will depend upon numerous factors, e.g., such as the specific activity of the therapeutic, and the route of administration, in addition to many subject-specific considerations, which are within those of skill in the art. [0324] In some embodiments, administration may be ocular, oral, buccal, dermal (which may be or comprise, for example, one or more of topical to the dermis, intradermal, interdermal, transdermal, etc), enteral, intra-arterial, intradermal, intragastric, intramedullary, intramuscular, intranasal, intraperitoneal, intrathecal, intravenous, intraventricular, within a specific organ (e.g., intrahepatic), mucosal, nasal, oral, rectal, subcutaneous, sublingual, topical, tracheal (e.g., by intratracheal instillation), vaginal, vitreal, etc. [0325] Those skilled in the art, reading the present disclosure will appreciate that, in some embodiments, it may be desirable to achieve delivery of a MuSK-targeting oligonucleotide composition to muscle. Alternatively or additionally, in some embodiments, it may be desirable to achieve delivery of a MuSK-targeting oligonucleotide composition to the CNS (e.g., the brain, such as the hippocampus and/or the subventricular region) and/or to the lung. [0326] In some embodiments, a MuSK-targeting oligonucleotide composition is delivered via systemic delivery and/or local delivery to muscle (e.g., via intramuscular injection). [0327] In some embodiments, a MuSK-targeting oligonucleotide composition is administered using a viral vector to effectively deliver a MuSK-targeting oligonucleotide composition in the form of a nucleic acid payload. In some embodiments, a viral vector targets certain cell types (e.g., myoblasts, myocytes, myotubes, satellite cells and myofibers). AAV1, AAV6, and AAV9 vectors have been used to target different muscle cell types (See, for example, Arnett et al., Mol Ther Methods Clin Dev.1. pii: 14038, 2014 and Riaz et al., Skeletal Muscle 5 (37) 2015). [0328] Those skilled in the art, reading the present disclosure will appreciate that, in some embodiments, it may be desirable to achieve delivery of a MuSK-targeting oligonucleotide composition to the CNS, and, in some embodiments to the brain. [0329] In some embodiments systemic administration achieves delivery to CNS (e.g., brain e.g., hippocampus and/or subventricular zone). In some embodiments, an agent (e.g., an agonizing agent or MuSK-targeting oligonucleotide) is delivered to the central nervous system (CNS), via intracerebroventricular administration. [0330] Additionally, certain viral vectors are known to selectively target neurons, and to effectively deliver genetic payloads to the brain. For example, AAV2/1 vectors have been established to effectively deliver nucleic acid payloads (e.g., gene therapy, encoded RNAs, etc) to neuronal cells in the hippocampus. See, for example, Hammond et al PLoS One 12:e0188830, 2017; Guggenhuber et al PLoS One 5:e15707, 2010; Lawlor et al Mol. Neurodeg.2:11, 2007). Analogously, certain AAV vectors (e.g., AAV2/1 and/or AAV4 vectors) have been established to target and effectively deliver nucleic acid payloads to certain cells in the subventricular zone cells. See, for example, Liu et al Gene Thep 12:1503, 2005; Bockstael et al Hum Gene Therap 23:doi.org/10.1089/hum.2011.216, 2012). [0331] For subjects suffering from or susceptible to a disease, disorder or condition associated with neurodegeneration, administration that achieves delivery to the CNS, e.g., to the brain (e.g., to the hippocampus and/or the subventricular region) may be desirable. [0332] In some embodiments, effective delivery may be achieved by systemic administration of a composition as described herein. Alternatively or additionally, in some embodiments, effective delivery may be achieved by local administration to the CNS and/or to the brain, for example by intrathecal and/or intracavitary (e.g., intracerebroventricular) delivery. [0333] Technologies for local administration to the CNS and/or to the brain have been developed and demonstrated to be effective, for example, for various protein therapeutics (see, for example Calias et al., Pharmacol. & Therap.144:122, 2014), for small molecules (see, for example, Dodou Pharm. J.289:501, 2012), for cell compositions (see, for example, Eftekharzadeh et al., Iran J Basic Med Sci 18:520, 2015); and nucleic acid therapeutics (see, for example, Otsuka et al, J. Neurotrauma 28:1063, 2011; see also prescribing information for onasemnogene abeparvovec-xioi [sold under the brand name Zolgensma ^TM ] and that for nusinersen [sold under the brand name Spinraza ^TM ]). [0334] Those skilled in the art will be aware that intrathecal delivery may be particularly effective to achieve delivery to the hippocampus, including for cellular, protein, and nucleic acid therapeutics. [0335] Systemic administration technologies (including, e.g., oral, parenteral, mucosal, etc) are well established for a wide variety of agents. Systemic administration that achieves CNS and/or brain delivery, in some embodiments, may depend on ability to cross the blood brain barrier (BBB). [0336] Certain active agents and/or delivery systems are known to cross the BBB. Recent technologies have been shown to achieve CNS and/or brain delivery even of agents, such as oligonucleotides, that had historically been considered to be particularly challenging in that regard. To give but one example, Min et al. Angew Chem Int Ed Engl doi: 10.1002/anie.201914751, 2020, incorporated herein by reference, describes glucose-coated polymeric nanocarriers that transport oligonucleotides across the BBB. [0337] It has also been reported that incorporation of certain particular chemistries into oligonucleotide therapeutics can facilitate their travel across the BBB. For example, Khorkova et al (Nature Biotech 35:249, 2017, incorporated herein by reference) have described that: “2′-modified phosphorothioate oligonucleotides ... may be particularly adaptable for CNS disorders, given their long half-life, with effects in the brain lasting up to 6 months following a single injection. In another type of sugar moiety modification, locked nucleic acids (LNAs), a bridge is introduced that connects the 2′ oxygen and 4′ carbon. This modification substantially elevates the melting temperature of the LNA–DNA and LNA–RNA hybrids, thus allowing the creation of shorter ODN-based compounds with increased bioavailability and reduced manufacturing costs. A recently proposed tricyclo-DNA, a conformationally constrained oligonucleotide analog, has three additional C-atoms between C(5′) and C(3′) of the sugar (Fig.2). This modification increases stability, hydrophobicity and RNA affinity, and improves tissue uptake and BBB permeability”. (citations omitted). [0338] For subjects suffering from or susceptible to a disease or disorder such as idiopathic pulmonary fibrosis (IPF), acute respiratory distress syndrome (ARDS), pneumonia, and lung complications due to viral infections, administration that achieves delivery to the lungs may be desirable. [0339] In some embodiments, oligonucleotides (e.g., antisense oligonucleotides) are developed to enhance their delivery to target site(s). As described in the art, oligonucleotide is covalently or non-covalently bound to additional chemical moieties (e.g., a carrier or ligand) to enhance the delivery. See Thomas C. Roberts et al. Nature Reviews Drug Discovery volume 19, pages 673–694 (2020), the entirety of which is incorporated herein by reference). [0340] As appreciated by those skilled in the art, various technologies of bioconjugation can be utilized to enhance the delivery oligonucleotides to target site(s). For example, oligonucleotides can be covalently conjugated to lipids (e.g., cholesterol that facilitates interactions with lipoprotein particles in the circulation), peptides (for cell targeting and/or cell penetration), aptamers, antibodies and sugars (e.g., N-acetyl galactosamine to enhance safer delivery to the target site (See Verma, Ann Indian Acad Neurol.201821(1): 3– 8. doi: 10.4103/aian.AIAN_298_17), N-acetylgalactosamine (GalNAc)). [0341] As appreciated by those skilled in the art, lipid conjugates include, e.g., oligonucleotides bound to Cholesterol, α-tocopherol (vitamin E), long-chain (>C18) fatty acids, lipoprotein particles (for example, HDL and LDL), etc. [0342] As appreciated by those skilled in the art, conjugation of N- acetylgalactosamine (GalNAc) can enhance the uptake of oligonucleotides into target sites (e.g., hepatocytes). [0343] As appreciated by those skilled in the art, antibody and aptamer conjugates can be used to enhance oligonucleotide delivery. Various receptors have been successfully targeted for oligonucleotide delivery, including, e.g., the HIV gp160 protein, HER2, CD7 (T cell marker), CD71 (transferrin receptor, highly expressed in cardiac and skeletal muscle) and TMEFF2. Similarly, oligonucleotides have also been conjugated with antibodies against CD44 (a neural stem cell marker), EPHA2 and EGFR193. Additionally, aptamers can be conjugated to oligonucleotide to enhance its delivery. [0344] As appreciated by those skilled in the art, various nanocarriers can be used to enhance oligonucleotide delivery. For example, oligonucleotide can form non-covalent complex with cationic polymers (for example, polyethylenimine), dendrimers, CPPs (for example, MPG-8, PepFect6, RVG-9R228, and Xentry-KALA229) and inorganic methods (for example, calcium phosphate nanoparticles). [0345] As appreciated by those skilled in the art, various lipoplexes and liposomes (e.g., lipid nano-particles (LNPs)) can be used to enhance oligonucleotide delivery. [0346] In some embodiments, a MuSK-targeting oligonucleotide is modified to form a bioconjugate (e.g., conjugated with sugar, peptide, antibody, aptamer, lipid, etc.) to enhance its delivery to target site(s). In some embodiments, a MuSK-targeting oligonucleotide is formulated as lipoplexes and liposomes (e.g., lipid nano-particles (LNPs)) to enhance its delivery to target site(s). [0347] Certain technologies have been developed to improve the efficiency of cellular delivery of ASOs to target site, e.g., muscle. For example, aminoglycosides (AGs) are shown to improve the delivery of antisense phosphorodiamidate morpholino oligomer (PMO) both in vitro and in vivo (See Wang, et al., Mol Ther Nucleic Acids, 2019; 16: 663–674, doi: 10.1016/j. omtn.2019.04.023). Short cell-penetrating peptides (CPPs) that can be either directly attached to oligonucleotides through covalent linkages or through the formation of noncovalent nanoparticle complexes can facilitate cellular uptake (See McClorey et al.; Biomedicines 2018, 6(2), 51). ASO fatty acid conjugates are also reported to enhance the functional uptake of antisense oligonucleotide (ASO) in the muscle (See Prakash et al.; Nucleic Acids Research, 47, 2019, 6029–6044). [0348] Those skilled in the art will be familiar with eteplirsen (ExonDys 51), an approved treatment for Duchenne muscular dystrophy (DMD), which is a third-generation phosphorodiamidate morpholino ASO. [0349] Eteplirsen, sold under the brand name Exondys 51 ^TM , (Sarepta Therapeutics’) causes exon 51 to be spliced out in pre-mRNA, restoring the reading frame in the 13% of patients with amenable frame-shifting mutations (See Crudele et al. Human Molecular Genetics, Volume 28, Issue R1, pp. R102–R107, 2019). [0350] Eteplirsen is administered via intravenous infusion over 35 to 60 minutes. In particular, its recommended dosage is 30mg/kg body weight weekly. In a single-dose vial, the pharmaceutical composition is formulated as a 100mg/2mL or 500mg/mL (50mg/mL) solution. [0351] Those skilled in the art will further be familiar with other delivery systems used with oligonucleotide therapeutics. For example, the first approved RNAi oligonucleotide therapeutic, Patisiran (Onpattro), which is developed by Alnylam Pharma for treatment for TTR (hereditary transthyretin amyloidosis, polyneuropathy), utilizes a nanoparticle delivery system (i.e., lipid nano-particles, LNP formulation); it also includes co- treatment with steroids and antihistamines. [0352] Patisiran is administered via intravenous infusion. In particular, for patients weighing less than 100 kg, its recommended dosage is 0.3 mg/kg once every 3 weeks. For patients weighing 100 kg or more, the recommended dosage is 30 mg once every 3 weeks. [0353] Other approved oligonucleotide therapeutics are typically administered via intravenous infusion to various organs, e.g., eyes, liver, skeletal muscle, spinal cord, etc.. [0354] In some embodiments, an oligonucleotide therapeutic as described herein may be administered intravenously. In some such embodiments, such oligonucleotide therapeutic may be administered according to a regimen reasonably comparable to that used for eteplirsen [sold under the brand name Exondys 51 ^TM ]. In some such embodiments, such oligonucleotide therapeutic may be administered according to a regimen reasonably comparable to that used for Patisiran [sold under the brand name Onpattro]. [0355] In some embodiments a lower dose of an MuSK-targeting oligonucleotide oligonucleotide as described herein is 12 mg. In some embodiments, a total of 5 mg to 60 mg per dose of MuSK-targeting oligonucleotide is administered to a subject. In some embodiments, a total of 12 mg to 48 mg per dose of MuSK-targeting oligonucleotide is administered to a subject. In some aspects, a total of 12 mg to 36 mg per dose of MuSK- targeting oligonucleotide is administered to a subject. In some aspects, a total of 12 mg per dose of MuSK-targeting oligonucleotide is administered to a subject. [0356] Those skilled in the art will be familiar with nusinersen [sold under the brand name Spinraza ^TM ], an antisense oligonucleotide therapeutic that targets the survival motor neuron-2 (SMN2)-directed gene transcript and is indicated for the treatment of spinal muscular atrophy (SMA) in pediatric and adult patients. Spinraza is administered intrathecally. In particular, its recommended dosage is 12 mg/5 mL (2.4 mg/mL) in a single- dose vial per administration, according to a regiment that involves four loading doses; the first three of which are administered at 14-day intervals, and the fourth of which is administered 30 days after the 3rd dose; a maintenance dose is administered once every 4 months thereafter. It is recommended that platelet count, coagulation laboratory testing, and quantitative spot urine protein testing is done at baseline, and prior to each dose. [0357] In some embodiments, an oligonucleotide therapeutic as described herein may be administered intrathecally. In some such embodiments, such oligonucleotide therapeutic may be administered according to a regimen reasonably comparable to that used for nusinersen [sold under the brand name Spinraza ^TM ]. [0358] In some embodiments, an oligonucleotide therapeutic as described herein may be administered intrathecally. In some such embodiments, such oligonucleotide therapeutic may be administered according to a regimen reasonably comparable to that used for nusinersen [sold under the brand name Spinraza ^TM ]. [0359] An oligonucleotide therapeutic as described herein may be administered according to any of the dosing regimens described herein. Cell Therapy [0360] In light of the ability of MuSK-targeting oligonucleotide compositions, as described herein, to promote neurogenesis (e.g., in cell populations that are or comprise neural progenitor cells), those skilled in the art reading the present disclosure will appreciate that, among other things, the present disclosure provides technologies for enhancing level of neural cells present in a cell population. That is, contacting an original cell population with a MuSK-targeting oligonucleotide composition as described herein can generate a resulting population with an increased level and/or percentage of neural cells as compared with that in the original population; administration of such MuSK-targeting oligonucleotide composition as described herein can achieve such increase. [0361] Additionally, MuSK-targeting oligonucleotide compositions, as described herein, promote muscle regeneration (e.g., in cell populations that are or comprise SCs, MPCs, and/or myoblasts), and those skilled in the art reading the present disclosure will appreciate that, among other things, the present disclosure provides technologies for enhancing level of SCs, MPCs, and/or myoblasts present in a cell population. That is, contacting an original cell population with a MuSK-targeting oligonucleotide composition as described herein can generate a resulting population with an increased level and/or percentage of SCs, MPCs, and/or myoblasts as compared with that in the original population; administration of such MuSK-targeting oligonucleotide composition as described herein can achieve such increase. [0362] In some embodiments, an original cell population may be or comprise NSCs and/or NPCs. In some embodiments, an original cell population may be or comprise SCs, MPCs, and/or myoblasts. In some embodiments, an original cell population is or comprises embryonic stems cells and/or pluripotent stem cells. In some embodiments, embryonic stems cells and/or pluripotent stem cells are or have been differentiated into neural or neural precursor cells, for example using techniques known in the art (see e.g., U.S. Pat.9,631,175). In some embodiments, embryonic stems cells and/or pluripotent stem cells are or have been differentiated into myogenic progenitor cells, for example using techniques known in the art (See e.g., Miyagoe-Suzuki et al.., Stem Cells Int.78246142017). [0363] In some embodiments, as discussed above, administration to a cell population delivers the MuSK-targeting oligonucleotide composition such that it is exposed to (i.e., contacts) a relevant original cell population in vivo (e.g., in a human, and in particular in an adult human, for example into in the brain – e.g., the hippocampus and/or subventricular region of the brain, of such human). [0364] In some embodiments, as discussed above, administration delivers the MuSK- targeting oligonucleotide composition such that it is exposed to (i.e., contacts) a relevant original cell population in vivo (e.g., in a human, and in particular in an adult human, for example into muscle tissue, of such human). [0365] In some embodiments, administration in accordance with the present disclosure contacts a MuSK-targeting oligonucleotide composition with a population of cells (e.g., an original population of cells), that for example, may be or comprise neural progenitor cells, SCs, MPCs, and/or myoblasts, ex vivo. For example, in some embodiments, a MuSK- targeting oligonucleotide composition is administered ex vivo (e.g., in vitro) to a population of cells from a subject. In some embodiments, a population of cells obtained from a subject. [0366] Oligonucleotides that direct exon skipping of MuSK transcript(s) to favor forms that lack functional Ig3, and/or that direct degradation (and/or block translation) of forms that include functional Ig3, may be utilized. [0367] In some embodiments, a population of cells is contacted with a MuSK- targeting oligonucleotide composition and simultaneously or subsequently stimulated and/or expanded. Alternatively or additionally, a population of cells is enriched and/or selected for cells exhibiting characteristics of activated NSCs (e.g., expression of Dex) or satellite cells or for expression of myogenic factors (e.g., Pax7, MyoD, myogenin, and MERGE) or for decreased/lack of expression of genes associated with the MuSK-BMP signaling pathway (e.g., RGS4, Msx2, Myf5, Ptx3, Id1). [0368] In some embodiments, a resulting population of cells, achieved by contacting an original population of cells with a MuSK-targeting oligonucleotide composition ex vivo is then administered to a subject. In some embodiments, a resulting population of cells is administered to a subject suffering from or susceptible to a disease or disorder such as a neuromuscular dysfunction, a neurodegenerative disorder (e.g., AD), a cardiac disorder (e.g., myocardial infarction, cardiomyopathy), or genetic diseases characterized by muscle wasting. In some embodiments, a resulting population of cells is administered to the subject from whom the original population of cells was obtained. In some embodiments, a resulting population of cells is administered to a different subject than the one from which the original population of cells was obtained; in some such embodiments, the original population was obtained from a healthy subject and the resulting population is administered to a subject suffering from or susceptible to a disease or disorder such as a neurodegenerative disorder (e.g., AD), a neuromuscular dysfunction, a cardiac disorder (e.g., myocardial infarction, cardiomyopathy), or genetic diseases characterized by muscle wasting. [0369] In some embodiments, administering a population of cells, contacted with a MuSK-targeting oligonucleotide composition effectively treats a disease or disorder such as a neuromuscular dysfunction, a neurodegenerative disorder (e.g., AD), a cardiac disorder (e.g., myocardial infarction, cardiomyopathy), or genetic diseases characterized by muscle wasting in the subject. [0370] In some embodiments, a population of stimulated and/or expanded NSCs, SCs, MPCs, and/or myoblasts described herein can be formulated into a cellular therapeutic. In some embodiments, a cellular therapeutic includes a pharmaceutically acceptable carrier, diluent, and/or excipient. Pharmaceutically acceptable carriers described herein, for example, vehicles, adjuvants, excipients, and diluents, are well known and readily available to those skilled in the art. Preferably, the pharmaceutically acceptable carrier is chemically inert to the active agent(s), e.g., a cellular therapeutic, and does not elicit any detrimental side effects or toxicity under the conditions of use. [0371] In some embodiments, a cellular therapeutic can be formulated for administration by any suitable route, such as, for example, intravenous, intratumoral, intraarterial, intramuscular, intraperitoneal, intrathecal, epidural, and/or subcutaneous administration routes. Preferably, the cellular therapeutic is formulated for a parenteral route of administration. In some embodiments, a cellular therapeutic is administered to a subject via an infusion. [0372] In some embodiments, a cellular therapeutic suitable for parenteral administration can be an aqueous or non-aqueous, isotonic sterile injection solution, which can contain anti-oxidants, buffers, bacteriostats, and solutes, for example, that render the composition isotonic with the blood of the intended recipient. An aqueous or nonaqueous sterile suspension can contain one or more suspending agents, solubilizers, thickening agents, stabilizers, and preservatives. [0373] In some embodiments, a single therapeutic cell described herein is capable of expanding and providing a therapeutic benefit. In some embodiments, 10 ² or more, e.g., 10 ³ or more, 10 ⁴ or more, 10 ⁵ or more, or 10 ⁸ or more, therapeutic cells are administered as a cellular therapeutic. Alternatively, or additionally 10 ¹² or less, e.g., 10 ¹¹ or less, 10 ⁹ or less, 10 ⁷ or less, or 10 ⁵ or less, therapeutic cells described herein are administered to a subject as a cellular therapeutic. In some embodiments, 10 ² -10 ⁵ , 10 ⁴ -10 ⁷ , 10 ³ -10 ⁹ , or 10 ⁵ -10 ¹⁰ therapeutic cells described herein are administered as a cellular therapeutic. [0374] A dose of a cellular therapeutic described herein can be administered to a subject at one time or in a series of subdoses administered over a suitable period of time, e.g., on a daily, semi-weekly, weekly, bi-weekly, semi-monthly, bi-monthly, semi-annual, or annual basis, as needed. A dosage unit comprising an effective amount of a cellular therapeutic may be administered in a single daily dose, or the total daily dosage may be administered in two, three, four, or more divided doses administered daily, as needed. In some embodiments, a cellular therapeutic is administered in combination with another therapy. Combination Therapy [0375] In some embodiments, a MuSK-targeting oligonucleotide therapy as described herein is administered in combination with another therapy – e.g., so that a subject is simultaneously or sequentially exposed to both therapies. [0376] The dosage of the MuSK-targeting oligonucleotide therapy as described herein and the dosage of another therapy administered in combination, as well as the dosing schedule can depend on various parameters, including, but not limited to, the disease being treated (e.g., a neuromuscular dysfunction, a neurodegenerative disorder, a cardiac disorder, or a genetic disease characterized by muscle wasting), the subject's general health, and the administering physician's discretion. [0377] MuSK-targeting oligonucleotide therapy can be administered prior to (e.g., 5 minutes, 15 minutes, 30 minutes, 45 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 8 weeks, or 12 weeks before), concurrently with, or subsequent to (e.g., 5 minutes, 15 minutes, 30 minutes, 45 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 8 weeks, or 12 weeks after) the administration of the other therapy, to a subject in need thereof. In various embodiments MuSK-targeting oligonucleotide therapy and the other therapy are administered 1 minute apart, 10 minutes apart, 30 minutes apart, less than 1 hour apart, 1 hour apart, 1 hour to 2 hours apart, 2 hours to 3 hours apart, 3 hours to 4 hours apart, 4 hours to 5 hours apart, 5 hours to 6 hours apart, 6 hours to 7 hours apart, 7 hours to 8 hours apart, 8 hours to 9 hours apart, 9 hours to 10 hours apart, 10 hours to 11 hours apart, 11 hours to 12 hours apart, no more than 24 hours apart or no more than 48 hours apart. In one embodiment, MuSK-targeting oligonucleotide therapy and the other therapy are administered within 3 hours. In another embodiment, MuSK-targeting oligonucleotide therapy and the other therapy are administered at 1 minute to 24 hours apart. [0378] A synergistic combination of MuSK-targeting oligonucleotide therapy and the other therapy, might allow the use of lower dosages of one or both of these agents and/or less frequent administration of the therapies to a subject suffering from neuromuscular dysfunction, a neurodegenerative disorder, a cardiac disorder, or genetic diseases characterized by muscle wasting. A synergistic effect might result in the improved efficacy of these agents and/or the reduction of any adverse or unwanted side effects associated with the use of either agent alone. [0379] In some embodiments, MuSK-targeting oligonucleotide therapy is administered in combination with a standard of care treatment for a relevant disease, disorder, or condition (e.g., a neuromuscular dysfunction, a neurodegenerative disorder, a cardiac disorder, or genetic diseases characterized by muscle wasting). [0380] Therapies for DMD include deflazacort (Emflaza; PTC Therapeutics) eteplirsen (Exondys 51; Sarepta Therapeutics), Ataluren (Translarna; PTC Therapeutics), and glucocorticoids such as prednisone. In some embodiments, MuSK-targeting oligonucleotide therapy is administered in combination with one or more therapies for DMD. [0381] Approved therapies for ALS include Radicava, Rilutek, Tiglutik, and Nuedexta. In some embodiments, MuSK-targeting oligonucleotide therapy is administered in combination with one or more therapies for ALS. [0382] Approved therapies for cardiomyopathy include but are not limited to angiotensin II-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs) and spironolactone. In some embodiments, MuSK-targeting oligonucleotide therapy is administered in combination with one or more therapies for cardiomyopathy. [0383] In some embodiments, MuSK-targeting oligonucleotide therapy is administered in combination with one or more therapies that relieves a symptom or characteristic of a relevant disease, disorder or condition, or of a therapy therefor. In some embodiments, MuSK-targeting oligonucleotide therapy is administered in combination with one or more other therapies that relieves a symptom or characteristic so that the side effects associated with said other therapies are relieved. In some embodiments, the side effect associated with therapy is characterized by one or more of nausea, vomiting, loss of appetite, muscle cramps and spasms, increased frequency of bowel movements, headache, confusion and dizziness, constipation, fatigue, excessive saliva and phlegm, pain, depression, sleep problems, and uncontrolled outbursts of laughing or crying. [0384] Any therapy which is known to be useful, or which has been used, will be used or is currently being used for the treatment or prevention of neuromuscular dysfunction, a neurodegenerative disorder, a cardiac disorder, or genetic diseases characterized by muscle wasting, can be used in combination with the MuSK-targeting oligonucleotide therapy in accordance with the invention described herein. EXEMPLIFICATION Example 1: Design and Screening of MuSK-targeting Oligonucleotides [0385] In this Example, human MuSK-targeting oligonucleotides were designed and tested for their ability to induce exon skipping of the MuSK exon 6 and/or exon 7. Methods A. Cell types [0386] The choice of cell type was based on the expression of MuSK and the relevance of the cell type for the study. Two cell types were retained and tested: [0387] 1. HEK293 (ATCC, CRL-1573) is a cell line commonly used in neuroscience studies because of its ability to differentiate to neurogenic lineage (Shaw et al., 2002). [0388] 2. LHCN-M2 (Evercyte, CkHT-040-231-2) is a cell line that was shown to highly express MuSK (19.8NX according to ProteinAtlas). In HEK293, MuSK expression was variable, and sometimes not high enough to be detected with qPCR. In LHCN-M2, MuSK expression was more consistent and detectable. Therefore, LHCN-M2 was chosen. B. Cell Culture [0389] LHCN-M2 were obtained from Evercyte (CkHT-040-231-2) and were cultured according to their protocol. [0390] The cell vessels were pre-coated with 80 µl/cm² of 0.1% porcine gelatin (Sigma-Aldrich, Cat# G1890) in water for at least 4h in 37^C and up to one week. Before plating the cells, excess gelatin was removed. [0391] For detachment, cells were rinsed twice with PBS (Thermofisher, 14190144) and were incubated with Trypsin-EDTA solution (Sigma, T3924-100ML) (room-temperature; 20 µl/cm²) for 2 minutes. [0392] Once the cells are detached, about 160 µl/cm² of growth medium was added to the trypsin. Cells were detached by pipetting and diluted at the appropriate density (between 1/2 to 1/6). Final volume of growth medium was 240 µl/cm². [0393] LHCN-M2 cells were grown in MyoUp medium at 37°C in a humidified atmosphere with 5 % CO2. Cells were passaged twice a week when having reached about 30 - 40 % confluence. [0394] MyoUp medium: DMEM (Thermofisher Cat # 10566016) / M199 (Gibco, Cat# 31150022) (4+1) 15 % Fetal bovine serum (FBS) (Hyclone, SH30071.03) 20 mM Hepes (Sigma Aldrich, Cat# H0887) 3 µg/ml Zinc sulfate (Sigma, Cat# Z0251) 1.4 µg/ml Vitamin B12 (Sigma, Cat# V2876) 0.055 µg/ml Dexamethasone (Sigma Aldrich, Cat# D4902) 2.5 ng/ml HGF (Merck Millipore, Cat# GF116) 10 ng/ml bFGF (Peprotech, Cat# 100-18C) C. ASO Transfection [0395] ASOs were diluted in cell culture grade water to reach a concentration of 100 µM and were preserved at -20^C. [0396] LHCN-M2 cells were plated in gelatin-coated 6 well plates at 35,000 cells/well in 2.25mL. After 2 days, cells reached 60% confluency and were ready to be transfected with the ASOs and lipofectamine RNAiMAX (Invitrogen, 13778150) according to the manufacturer’s protocol: [0397] 24 hours after transfection, cells were rinsed with PBS and the RNA was extracted. D. RNA extraction [0398] To obtain the best RNA extraction ratio, two kits were tested: Zymo Research Quick-RNA™ Miniprep Kit (cat# 50444597) and Qiagen RNeasy Plus Mini Kit (cat# 74136). [0399] Cells were seeded in 6-well plates at a density of 45000 cells/well. The RNA was extracted 2 days after seeding. The RNA concentration was measured using a nanodrop (Thermofisher, NanoDrop ™ 8000 Spectrophotometer) and the results are given in Table 3. Table 3 Table 3: Yield of RNA extraction from LHCN-M2 cells with ZYMO or QIAGEN extraction kits. [0400] With the Zymo kit, a yield of RNA extraction of 3.82 µg/well was obtained, while 2.9 µg/well was obtained with the Qiagen kit. Therefore, the Zymo kit was chosen for the study. [0401] The Zymo Research Quick-RNA™ Miniprep Kit is used for RNA extraction (cat# 50444597). Zymo Kit Protocol: All steps at room temperature and centrifugation at 13,000 x g for 30 seconds, unless specified. 1. Cells are lysed in 400 µL of RNA Lysis buffer using a cell scraper. 2. Lysates are vortexed for 20s to be homogenized and centrifuged for 30s at 13,000 x g to remove the cell debris. 3. The supernatants are transferred into a Spin-Away™ Filter (yellow) in a Collection Tube and centrifuged to remove the majority of genomic DNA. 4. 0.5 volume of ethanol (95-100%) is added to the flow-through and well mixed. The samples are transferred into a Zymo-Spin™ IIICG Column (green) in a Collection Tube and centrifuged. 5. The RNA, attached to the column, is DNase treated. (D1) Wash the column with 400 μl RNA Wash Buffer and centrifuge. Discard the flow-through. (D2) In a nuclease-free tube, 5 μl DNase I (1 U/μl) is added to 75 μl DNA Digestion Buffer and mix. Mixture is directly added into the column matrix. (D3) The column incubates at room temperature (20-30°C) for 15 minutes. 6. 400 μl of RNA Prep Buffer is added to the column and centrifuged. The flow-through is discarded. 7. 700 μl of RNA Wash Buffer is added to the column and centrifuged. The flow- through is discarded. 8. 400 μl of RNA Wash Buffer is added to the column and centrifuged for 1 min to ensure complete removal of the wash buffer. Then, the column is transferred into a 1.5 mL nuclease-free tube. 9. 100 μl of DNase/RNase-Free Water is added directly to the column matrix and centrifuged. 10. Extracted RNA is usually immediately transcripted to cDNA, or stored at -80°C if necessary. cDNA transcription: The reverse transcriptase SuperScript™ IV VILO™ Master Mix from Thermofisher (11756050) is used. 4 uL of the enzyme is added to 16 uL of RNA (corresponding to ~550-650 ng). According to the manufacturer’s protocol, the reverse transcription is obtained by the following steps: - 10 min at 25°C to anneal the primers - 10 min at 50°C to perform the reverse transcription - 5 min at 85°C to inactivate the enzyme The cDNA is then diluted by 2 in DNase RNase free water and conserved at -20°C until the qPCR is done. For MuSK analyses, the cDNA was used at this concentration. For housekeeping gene analyses, the cDNA was further diluted by 5. E. qPCR [0402] Two qPCR technologies were tested, TaqMan and SYBR Green. [0403] Relative MuSK expression was measured by qPCR using Taqman or SYBR green technology in LHCN-M2 cells. Both gave similar results regarding MuSK inhibition by siRNA (Thermofisher, 4392420) (FIG.3). However, the Cq, related to the level of detection, was lower with SYBR green than for Taqman - around 22 and 27 respectively for the controls, indicating better detection with SYBR green technology. Since the level of detection is important to discriminate the level of MuSK inhibition between conditions, SYBR Green technology was chosen for the study. [0404] SYBR Green qPCR Protocol: [0405] To analyze the gene expression, SYBR Green technology was used. Results were normalized to two housekeeping genes (GAPDH and YWHAZ). qPCR was performed in 384-well plates. cDNA was used at 1/2 to analyze MuSK expression and at 1/10 to analyze HKG expressions. Measures were performed in duplicates or triplicates. [0406] The primer sequences are shown below in Table 4: Table 4 [0407] In each well, 9 µL of the premix [3.5 µL RNAse/DNAse free water, 5 µL SYBR Green (Biorad, 1725120), 0.5 µL primer at 10 µM] is deposited and 1 µL of the cDNA at the appropriate dilution was added. After being sealed, the plate was centrifuged, briefly vortexed and centrifuged a second time. The Thermocycler QuantStudio 6 or 7 Pro (Thermofisher) was used to perform the qPCR. The steps are: - 30 s at 95°C - PCR (X40 cycles): - 3 s at 95°C - 30 s at 60°C - Melting curve (step and hold, 4s): - 20 s at 65°C - 15s at 95°C Design and Screen of Human ASOs [0408] A first batch of 38 human antisense oligonucleotides (ASOs) were designed and then subsequently produced by Microsynth (Switzerland). The ASO sequences are shown below in Table 5. Table 5:

[0409] All ASOs Bld1-Bld38 were designed to include 2’-MOE modification on each sugar and where there is a phosphorothioate internucleotidic linkage between each nucleotide. Sequences were designed so that they would avoid activation of RNase H. All ASOs were 25 nucleotides in length. Alignment of ASOs Bld1-Bld38 to the MuSK genomic sequence along regions including exons 6 and 7 is shown in FIG.4. Antisense oligonucleotides targeting Exon6 i. Alignment to the genetic sequence [0410] The ASOs were designed to be complementary to regions of the MuSK Exon6 genetic sequence, presented in FIG.5. ii. Cell observations [0411] Cells were plated at 30,000 cells/well in gelatin pre-coated 6-well plates and were transfected 48h after seeding with ASO at 50 nM and 100 nM. 24 h after transfection, cells were observed (FIG.4) and the RNA was extracted and analyzed. FIG.6 shows microscopic acquisitions of LHCN-M2 cells 24 h after being transfected with the ASO at 100 nM (Scale = 100nm). The data of Bld5, Bld8, Bld10, and Bld18 are not shown. [0412] Some ASOs induced a visible effect to the cells after 24 h: Bld8 (data not shown), Bld5 (data not shown), Bld10 (data not shown), Bld126 and Bld14 appeared to have a negative effect on the cell health. Other ASOs induced small differences. For example, cells transfected with the ASOs Bld11, Bld13, and Bld15 were shorter. Otherwise, cells in the other treatment groups were healthy and similar to the control, including Bld18, the data of which are not shown in FIG.6 and and Bld9. iii. MuSK expression analyses [0413] 24 h after transfection, RNA was extracted and MuSK expression was measured by qPCR. The primers were designed to span either the 3-4 exon/exon junction (named MuSK34) or the 6-7 exon/exon junction (named MuSK67). The MuSK34 primer therefor detects all forms of the MuSK transcript (both the long form (i.e., containing the Ig3 domain and the short form (i.e., MuSKΔIg3)) while the MuSK67 primer detects only the long form of MuSK and not MuSKΔIg3. The primer design rationale is shown in FIG.2. Results were normalized to two housekeeping genes, YWHAZ and GAPDH, whose stabilities were assessed using the software BestKeeper and are shown in FIG.7. [0414] The qPCR results show that the ASOs Bld7, Bld8, Bld9, Bld11, Bld13, Bld16, Bld15, and Bld18 induced a decrease in the expression of MuSK34 (>75%) and of MuSK67 (>90%). The ASOs Bld13, Bld4, Bld5, Bld6, Bld12 and Bld14 and Bld17 induced a decrease of MuSK34 (between 50-75%) and a higher decrease of MuSK67 (70-85%). The ASOs Bld3 and Bld17 induced slighter effects on MuSK34 and MuSK67 expression (20-50%). Finally, the two ASOs Bld1 and Bld18 induced an increase in the expression of MuSK34 and 67. [0415] The goal of the screen of ASOs was to identify an ASO that would induce a moderate/important decrease of MuSK67 with no effect on MuSK34 (i.e., would induce an increase in MuSKΔIg3). The results shown in FIG.7 indicate that the ASOs tested targeting Exon 6 may not be targeting the appropriate region to obtain a good skipping of Exons 6 and 7. [0416] The results were correlated with the ASO alignment (FIG.8) in order to identify key regions on the sequence important for MuSK expression. In FIG.8, Green indicates a slight decrease or an increase in MuSK expression (between 90-300% of the control). Orange indicates a moderate decrease in MuSK expression (MuSK34 between 40 and 70% of the control, MuSK67 < 45% of the control). Red indicates high decrease in MuSK expression (MuSK34 <40 % of the control, MuSK67 < 20% of the control). Red areas indicate key regions for the expression of MuSK where ASOs induced a decrease of MuSK34 by >60% and MuSK67 by >80%. [0417] The relative expression of MuSK 67 for each of the ASOs Bld1-Bld18 at 50nM are shown in Table 6 below: Table 6:

a) * represents a phosphorothioate linkage, and each sugar of the oligonucleotides is a 2’-MOE modified sugar. b) a value of 1.0 represents the level of MuSK67 expression for untreated cells. Antisense oligonucleotides targeting Exon7 i. Alignment to the genetic sequence [0418] The alignment of the ASOs Bld19-Bld38 on the genetic sequence of Exon7 of MuSK is presented in FIG.9. ii. Cell observations [0419] Cells were plated at 30,000 cells/well in gelatin pre-coated 6-well plates and were transfected 48h after seeding with ASO at 50 nM and 100 nM. 24 h after transfection, cells were observed (FIG.10) and the RNA was extracted and analyzed. FIG.10 shows microscopic acquisitions of LHCN-M2 cells 24 h after being transfected with the ASO at 100 nM (Scale = 100nm). [0420] After 24 h of transfection, cells looked healthy in all conditions. Cells transfected with the ASOs Bld19 and Bld30 were shorter than the control, while cells transfected with the ASOs Bld32 and Bld34 were more elongated. Cell transfected with the ASOs Bld23, Bld24, Bld25, Bld26, Bld27, Bld28, Bld35, Bld36, Bld37, Bld38 did not present any significant differences compared to the control (data not shown). iii. MuSK expression analyses [0421] 24 h after transfection, RNA was extracted, and MuSK gene expression was analyzed in qPCR (FIG.11).Methods described for screen of ASOs to Exon6 were used. [0422] Relative expression of each ASO at 50nM is shown in Table 7 below. Table 7:

a) * represents a phosphorothioate linkage, and each sugar of the oligonucleotides is a 2’-MOE modified sugar. b) a value of 1.0 represents the level of MuSK67 expression for untreated cells. [0423] ASOs Bld29 and Bld31 induced a decrease in the expression of MuSK34 (>75%) and of MuSK67 (>90%). ASOs Bld30, Bld32and Bld34 induced a decrease of MuSK34 (between 40-60%) and a higher decrease of MuSK67 (55-85%). ASO Bld19 induced slighter effects on MuSK34 and MuSK67 expression (<20%). ASOs Bld19, Bld20, Bld24, Bld23 and Bld33 induced an increase in expression of MuSK34 and 67. [0424] ASOs Bld25, Bld26, Bld27, Bld28, Bld35 and Bld38 induced a decrease of MuSK67 > 60% at 50nM and a decrease of MuSK34 < 40% for both concentrations. Therefore, these ASOs were considered good candidates to be tested at additional doses. [0425] The alignment of these results to the genetic sequences indicated that one region is key region to regulate the splicing of the exons 6 and 7 without affecting the transcription of the other exons (indicated in purple in FIG.12). [0426] The alignment of these results to the MuSK exon7 genetic sequence indicated that some regions may be key regions to regulate the splicing of the exons 6 and 7 without affecting the transcription of the other exons (indicated in purple in FIG.12). In FIG.12, green indicates a slight decrease or an increase in MuSK expression (between 90-300% of the control). Orange indicates a moderate decrease in MuSK expression (MuSK34 between 40 and 70% of the control, MuSK67 < 45% of the control). Red indicates high decrease in MuSK expression. MuSK34 <40 % of the control, MuSK67 < 20% of the control Purple and grey areas indicate regions that may be targeted to obtain an efficient skipping of exons 6/7 with lower effect on other exons based on the results shown in FIG.11 (i.e., the regions targeted by ASOs hu7-10, hu73, hu717, hu730, hu711 and hu7158). These regions “region 1” and “region 2” are shown in FIG.4. Dose Response of Exemplary ASO candidates [0427] The first ASO screen at 50 and 100 nM indicated that Bld25, Bld26, Bld27, Bld28, Bld35 and Bld38 were potential candidates that could induce efficient skipping of exons 6/7 to generate MuSKΔIg3 transcript expression. These ASOs were tested at different concentrations: 2.5, 5, 25, 125 and 400 nM to examine the dose response. Results are shown in FIG.13 (panels A-F). [0428] Specifically, FIG.13 shows relative MuSK expression in response to various doses of the 6 candidate ASOs (Bld25(A), Bld26 (B), Bld27 (C), Bld28 (D), Bld35 (E), Bld38 (F)). MuSK34 (in blue) and MuSK67 (in red) expression was measured by qPCR and each was normalized to the housekeeping genes and to the values obtained for untreated cells. The estimated IC is indicated on each graph. The 5 tested doses were 2.5, 5, 25, 125, 400 nM. [0429] The results from the dose response study indicated that ASO Bld35 induced both a decrease of MuSK34 and of MuSK67 of 20-40% and 50-70%, respectively. Therefore, the difference between the expression of MuSK34 and MuSK67 is too low to obtain a high ratio of ΔIg3 MuSK without affecting the transcription of the other exons. [0430] For the ASOs that Bld25, Bld26, Bld27, Bld28 and Bld38, MuSK34 expression was between 75 and 85% of the control level while MuSK67 was at 50% of the control level, making them potential candidates. [0431] For ASO Bld38, the inhibition of MuSK67 was limited at 60% of the control level, even at high concentrations (400 nM). [0432] For ASOs Bld27 and Bld28, a concentration higher than 125 nM induced a decrease in MuSK34 expression > 75%. [0433] For ASOs Bld25 and Bld26, MuSK34 expression reached a plateau of 60% of the control level when the ASO concentration was between 25 and 400 nM, while MuSK67 expression decreased to 10% of the control. These results indicate that ASOs Bld25 and Bld26 result in a targeted decrease in expression of MuSK67, with less of an effect on MuSK34 expression, making them the 2 best candidates of this study. The estimated IC50 values were 11.5 nM and 11.4 nM for Bld25 and Bld26, respectively. [0434] A more targeted dose response was performed in this area to refine these results (FIG.14). These additional data indicated that the IC50 is actually between 5 and 7.5 nM for both Bld25 and Bld26. With ASO Bld26, MuSK34 expression dropped at the same ASO concentration as MuSK67 (7.5 nM). With ASO Bld25, at a concentration of 7.5nM, MuSK67 expression decreased by 70% while MuSK34 expression was at 94% of the control. Therefore, Bld25 may be a better candidate than Bld26 to obtain a selective skipping of exons 6 and 7. [0435] An additional test was done by combining both Bld25 and Bld26 at a final concentration of 12.5 nM. Results are shown in FIG.15. Specifically, FIG.19 shows MuSK34 expression in green and MuSK67 expression in red measured by qPCR and normalized to housekeeping genes and to the controls. [0436] The Bld25/Bld26 mix resulted in MuSK34 expression at a level of 72% of the control level, while MuSK67 expression was at a level of 6% of the control level. Of note, MuSK67 expression was at 8% when inhibited by siRNA (Thermofisher, cat# 4392420, Assay Id s224071) against MuSK at 10nM (data not shown). These results suggest that combining several oligos (e.g., Bld25 and Bld26) may be a good strategy to obtain a selective skipping of exons 6 and 7. Confirmation of Exon skipping by Gel Migration [0437] To verify the ASO-induced splicing of the RNA, we amplified the genetic sequence from exon 3 to exon 9 by PCR and the size of the PCR product was measured by migrating it on gel electrophoresis. [0438] Several forms of MuSK RNA exist naturally in human.3 variants were identified in the literature (FIG.26): Variant 1, NM_005592.4 (full length: 972 bp and ΔIg3: 687 bp) Variant 2, NM_001166280.2 (full length: 783 bp and ΔIg3: 453 bp) Variant 3, NM_001166281.2 (full length: 708 bp and ΔIg3: 423 bp) [0439] Full length and ΔIg3 indicate the lengths of the full-length sequence and ΔIg3 (6,7) sequence amplified by PCR from exon 3 to exon 9. Compared to variant 1, the exon 8 is missing in variant 2 and variant 3. In addition, a small exon of 30 bases is present only in variant 2. Therefore, skipping exons 6 and 7 would produce 3 additional MuSK RNA forms. [0440] The sequence of exon3-9 of the cDNA from the dose response presented in FIG.10 was amplified by PCR in the conditions without or with hu7-10 (Bld25) and hu73 (Bld26) at 5 and 25 nM. Results from the gel electrophoresis are shown in FIG.16. In FIG. 16, “Long” (with exon6-7) and “Short” (without exon 6-7, i.e., ΔIg3) designed synthetic sequences were based on variant 1. [0441] As shown in FIG.16, several bands were detected. In the control conditions, major bands were visible at approximately 1kb, 970b (red arrow), and a double band at 700- 750b (green arrows) (see FIG.16, panel B). In conditions where splicing of the exons 6/7 occured (confirmed previously by qPCR), major bands were observed at approximately 690b (yellow arrow) and 450b (blue arrow) (FIG.16, panel B’), and a lighter band at 970b. An additional double band was detected at 600b (orange arrow). [0442] Based on the sequences presented in FIG.16 it appears that: [0443] The red arrow indicated the cDNA of variant 1 full-length (972 bases), while the double bands highlighted by the green arrow correspond to the variant 2 and 3 full-length (738 and 708 bases respectively). This would explain why we observed a small fraction of the red band in the Bld25 at 25 nM condition (see FIG.16 B’) and the fraction of the green band was too light to be detected. [0444] For the ASO hu7-10 (Bld25) at 25 nM, the yellow band corresponded to Δ6,7 variant 1 (687 bases) and the blue band corresponded to Δ5+,6,7 variant 2 and Δ6,7 variant 3 (453 bases). [0445] Next the bands were sequenced to confirm these bands correspond to the indicated variants. Conclusions [0446] This study aimed to find ASOs that would induce the skipping of the exons 6 and 7 in MuSK protein without affecting the other exons.38 ASOs were designed and manufactured to be tested. LHCN-M2 cell line was chosen for its qPCR detectable MuSK expression. [0447] In the first screening, we tested each of the 38 ASOs at concentrations of 50 and 100 nM. From this screen, the 6 best candidates in a key region near/on the exon 7 were selected or further testing. These 6 candidates were further tested at different doses: 2.5, 5, 25, 125 and 400 nM. The results indicated that a dose below 25 nM would be enough to obtain the desired splicing without affecting the transcription of the other exons, and that 2 ASOs, Bld25 and Bld26, were better to obtain the desired splicing, while maintaining stability of the expression of the other exons at higher doses. These 2 candidates were tested at additional doses, 5, 7.5, 12.5 and 25 nM. These results indicated that the IC50 would be between 5 and 7.5 nM for both ASOs. Additionally, Bld25 was considered the best candidate since there is a dose (7.5 nM) where we obtained an efficient skipping of exons 6/7 (by 70%) with little effect on the other exons (expression was 94% of the control level). [0448] Additionally, a combination of these 2 candidates (Bld25 and Bld26) at 12.5 nM was also shown to be efficient in reducing the level of expression of full-length MuSK transcripts by 94% (indicated by MuSK67 in FIG.15), where the total MuSK expression (indicated by MuSK34 in FIG.15) was only reduced by 28%. Migration on gel electrophoresis and further sequence confirmed this was due to exon skipping. Example 2: In vivo evaluation of exon-skipping induced by MuSK-Targeting Oligonucleotides [0449] Preliminary confirmation of activities for oligonucleotides provided herein have been confirmed by testing corresponding murine oligonucleotide sequences in an established mouse model. See, e.g., Renault et al., 2009, the entirety of which is incorporated herein by reference. [0450] In this experiment, the corresponding murine oligonucleotides are further evaluated in vivo in wild-type mice at ages where AHN has declined. Further evaluations such as pharmacodynamic and safety studies are conducted to establish optimal conditions for ASO-mediated MuSK exon skipping in aging wild type mice. Experiment #1: Tolerability, exon skipping and PK [0451] ASOs are delivered by intracerebroventricular (ICV) stereotactic injection in 4 doses ranging from 5 - 100µg, n=6/group. A scrambled ASO (with the same number of bases) will serve as a control. [0452] Mice are monitored for potential immediate safety signals (e.g. seizures, hindlimb weakness, prolonged lethargy) and animals where these issues do not resolve within the first hours after dosing are euthanized. [0453] Mice receiving doses that do not show tolerability signals are monitored daily. [0454] Unfixed brains are harvested at 4 weeks. One-half of the brains are sectioned and analyzed by histology for signs of inflammation or other toxicity by a board-certified veterinary pathologist. [0455] The hippocampus and cortex from the other half are dissected and further divided for RNA isolation and PK analysis. The level of MuSK alternative splicing (i.e., skipping of exons 6-7) are assessed by TaqMan assays and gel-based PCR as described in Examples 1-2. For the latter, gel bands are excised and sequenced to confirm correct skipping. The remaining portion for of cortex are used for HPLC quantification of the ASO (PK). Experiment #2. Neurogenesis (fixed brains) [0456] Neurogenesis Group size: To determine the number of animals required to assess increased neurogenesis, a power analysis using G*Power version 3.1 was performed (Faul et al., 2007). To allow for possible loss of animals during the experiment 6 animals/group are allocated. Analyses is performed using either GraphPad Prism or R. [0457] In this experiment, ASOs are delivered to a second set of animals with at least three non-toxic doses (as determined in Experiment 1). [0458] For these animals EdU is delivered from 3 to 4 weeks post-injection. Animals are perfused, fixed and immunohistochemistry is performed against EdU and DCX to assess the numbers of new neurons (EdU+/DCX+ cells). [0459] Maturation of the newborn cells is assessed by performing a 30-day chase after administration of the EdU and measuring Edu+/NeuN+ cells. Experiment #3. Cognition [0460] Cognition group size: An analysis using G*Power 3.1.9.4. (Faul et al., 2007) was performed to determine the group size of cognition experiment. Based on the prior studies, 18 animals per group is sufficient to observe an effect size (d) of 1 (a=.05; power = .80). [0461] Aged wild-type mice are dosed by ICV at 11 months of age and are assessed for cognition at 12 months of age. A single dose is performed to promote AHN as determined from Experiment #2 (18 animals per group). [0462] The mice are evaluated using tests including Novel Object Location task, a hippocampal-dependent spatial learning task, and a Conditioned Fear and a Y-maze to measure spatial working memory (Gotz and Ittner, 2008), two tasks commonly used to test cognition. [0463] Pairwise comparisons will be analyzed by using the Student’s t test. Experiments with more than two groups will be analyzed using a Bonferroni correction for multiple comparisons. [0464] Female mice. Efficacy of ASO treatment on promoting neurogenesis using the optimal dose determined above in female mice is also assessed. [0465] Discussion. Experiments 1-3 are designed such that they will relate the dose delivered to safety, PK, level of MuSK splicing, degree of AHN promotion and cognitive improvement. [0466] A 4 week period of exposure was utilized since this is the time course over which NSCs are born and mature (Babcock et al., 2021). However, additionally studies with longer exposures, with and without repeat dosing will also be performed. [0467] In addition to the HPLC measurement of ASO in the brain hybridization-based method will also be utilized. Example 3: In vivo evaluation of exon-skipping induced by MuSK-Targeting Oligonucleotides in FAD model [0468] In this experiment, the corresponding murine oligonucleotides from Example 2 are evaluated in Familial Alzheimer’s Disease (FAD) mouse model where plaque burden is well established and tangles are present. This experiments aims to determine whether corresponding murine oligonucleotides and the exon-skipping approach is effective in the hostile, inflammatory milieu along with a high plaque burden and neurofibrillary tangles that characterize the AD brain, and whether corresponding oligonucleotides promote AHN in an FAD mouse model. [0469] FAD Mouse Model.3xTg is used in this experiment, which harbors transgenes for Tau, PSEN1 and APP FAD alleles (Oakley et al., 2006; Kimura and Ohno, 2009; Belfiore et al., 2019). This model has been characterized and develops both amyloid plaques at 6 months and neurofibrillary tangles by 12 months. AHN is decreased as early as 3 months of age and is essentially undetectable by 12 months. We have confirmed a reduction AHN at 6 months in these mice. This decrease in AHN is strongly correlated with the increase in amyloid burden (Rodríguez et al., 2008). Animals are dosed with ASO at 11 months and analyzed at 12 months of age, when AHN and cognitive phenotypes are evident. Female 3xTg mice are used since they show an earlier and more consistent pathological profile (Belfiore et al., 2019). [0470] Experimental Approach. The dosing strategy (level, duration) is based on the results from Example 3. Three groups are dosed: scrambled ASO, and two doses of MuSK exon-skipping ASOs. Group sizes will be n=18 in order to assess both AHN and cognition.6 animals from each group are also treated with EdU once a day for 7 days for neurogenesis analysis. In order to control for potential effects of handling, the remaining animals are injected with saline. Neurogenesis and cognition analyses are performed as described in Example 3. The effects of ASO treatment on AD histopathology is also assessed. Example 4: Formulation and Administration of MuSK-Targeting Oligonucleotides A. Formulation [0471] In this Example, human MuSK-targeting oligonucleotides as described herein are formulated into suitable forms to enhance the delivery to target site(s) and are administered to human subject via various means. [0472] In some embodiments, human MuSK-targeting oligonucleotides are formulated into lipid complex, as a homogeneous solution in a single-dose vial. In some embodiments, single-dose vial is 10 mg/5 mL (2 mg/mL). B. Administration 1. Indication [0473] MuSK-targeting oligonucleotides are indicated for the treatment of the AD in adults. 2. Dosage and Administration 2.1 Dosing Information [0474] MuSK-targeting oligonucleotides are administered by a healthcare professional. [0475] MuSK-targeting oligonucleotides are administered via intravenous (IV) infusion. Dosing is based on actual body weight. For patients weighing less than 100 kg, the recommended dosage is 0.3 mg/kg once every 3 weeks. For patients weighing 100 kg or more, the recommended dosage is 30 mg once every 3 weeks. [0476] Missed Dose: If a dose is missed, administer MuSK-targeting oligonucleotides as soon as possible. If MuSK-targeting oligonucleotides are administered within 3 days of the missed dose, continue dosing according to the patient’s original schedule. If MuSK-targeting oligonucleotides are administered more than 3 days after the missed dose, continue dosing every 3 weeks thereafter. 2.2 Preparation [0477] MuSK-targeting oligonucleotides are filtered and diluted prior to intravenous infusion. The diluted solution for infusion is prepared by a healthcare professional using aseptic technique as follows: 1. Remove MuSK-targeting oligonucleotides vial from the refrigerator and allow to warm to room temperature. Do not shake or vortex. 2. Inspect visually for particulate matter and discoloration. Do not use if discoloration or foreign particles are present. 3. Calculate the required dose of MuSK-targeting oligonucleotides based on the recommended weight-based dosage [see Dosage and Administration (2.1)]. 4. Withdraw the entire contents of one or more vials into a single sterile syringe. 5. Filter MuSK-targeting oligonucleotides through a sterile 0.45 micron polyethersulfone (PES) syringe filter into a sterile container. 6. Withdraw the required volume of filtered MuSK-targeting oligonucleotides from the sterile container using a sterile syringe. 7. Dilute the required volume of filtered MuSK-targeting oligonucleotides into an infusion bag containing 0.9% Sodium Chloride Injection, USP for a total volume of 200 mL. Use infusion bags that are di(2-ethylhexyl)phthalate-free (DEHPfree). 8. Gently invert the bag to mix the solution. Do not shake. Do not mix or dilute with other drugs. 9. Discard any unused portion of MuSK-targeting oligonucleotides. 10. The diluted solution should be administered immediately after preparation. If not used immediately, store in the infusion bag at room temperature (up to 30°C [86°F]) for up to 16 hours (including infusion time). Do not freeze. 2.3 Infusion [0478] MuSK-targeting oligonucleotides are infused as follows: 1. Use a dedicated line with an infusion set containing a 1.2 micron polyethersulfone (PES) in-line infusion filter. Use infusion sets and lines that are DEHP-free. • 2. Infuse the diluted solution of MuSK-targeting oligonucleotides intravenously, via an ambulatory infusion pump, over approximately 80 minutes, at an initial infusion rate of approximately 1 mL/min for the first 15 minutes, then increase to approximately 3 mL/min for the remainder of the infusion. 3. Administer only through a free-flowing venous access line. Monitor the infusion site for possible infiltration during drug administration. Suspected extravasation should be managed according to local standard practice for non-vesicants. • 4. Observe the patient during the infusion. 5. After completion of the infusion, flush the intravenous administration set with 0.9% Sodium Chloride Injection, USP to ensure that all ONPATTRO has been administered. References Shaw, G., Morse, S., Ararat, M., & Graham, F. L. (2002). Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. The FASEB Journal^: Official Publication of the Federation of American Societies for Experimental Biology, 16(8), 869–871 Example 5: Design and Screening of 20-mer MuSK-targeting Oligonucleotides [0479] In this Example, additional human MuSK-targeting oligonucleotides were designed based on the lead candidates from Example 1 targeting exon 7 of MuSK. The screen in Example 1 identified 6 lead ASOs that targeted two regions within the MuSK exon 7. Upon further dose response experiments and analysis of the resulting MuSK transcripts, one of these regions was identified as a key region to modulate the splicing of Ig3 domain. This region, or “region 1” corresponds to the core sequence SEQ ID NO: 126 (ACTCTGTCAGGTTTCTTCTGGGTCCATTCAAGAGAGTGTGAAAGACCGAGTGATTGACT CAA GAC) which is located at positions 83841-83905 of the MuSK transcript (SEQ ID NO: 77) (or corresponding regions within other MuSKvariant sequences). In this Example, additional ASOs are designed to target the region corresponding to SEQ ID NO: 126 (“region 1”) of exon 7 and specifically to include different portions of the sequences of ASOs Bld25 and Bld26. These ASOs were designed to test whether shorter ASOs of 20 nucleotides, rather then 25 nucleotides (as tested in Example 1) would have increased activity. [0480] The additional oligonucleotides were tested for their ability to induce exon skipping of the MuSK exon 6 and/or exon 7. Design of Human ASOs [0481] Human antisense oligonucleotides (ASOs) were designed as described above and as shown in FIG.17, and produced by Microsynth (Switzerland). The ASO sequences are shown below in Table 8. Table 8: [0482] All ASOs in Table 8 were designed to include 2’-MOE modification on each sugar and where there is a phosphorothioate internucleotidic linkage between each nucleotide. All ASOs in Table 8 were 20 nucleotides in length. Screen of Shorter Antisense oligonucleotides targeting Exon7 Region 1 [0483] ASO transfection and cell culture, RNA extraction, cDNA transcription, qPCR were performed according to the methods described in Example 1, unless indicated otherwise. i. Alignment to the genetic sequence [0484] The alignment of the ASOs in Table 8 on the genetic sequence of Exon7 of MuSK is presented in FIG.17. ii. Cell observations [0485] LHCN-M2 cells were plated at 30,000 cells/well in gelatin pre-coated 6-well plates and were transfected 48h after seeding with ASO at 12.5 nM and 100 nM. 24 h after transfection, cells were observed (data not shown) and the RNA was extracted and analyzed. [0486] After 24 h of transfection, cells looked healthy in all conditions except for cells treated with ASOs Bld54, Bld55, and Bld56 at the 100nM dose (data not shown). iii. MuSK expression analyses [0487] 24 h after transfection, RNA was extracted, and MuSK gene expression was analyzed in qPCR. Relative gene expression of total MuSK (MuSK34) and MuSKIg3 domain (MuSK67) is shown in FIG.18. Methods described for screening of ASOs in Example 1 were used. [0488] ASOs with the modifications used in this Example are shown in Table 9 below. Table 9:

a) * represents a phosphorothioate linkage, and each sugar of the oligonucleotides is a 2’-MOE modified sugar. b) a value of 1.0 represents the level of MuSK67 expression for untreated cells. [0489] Results from the screen showed that these shorter ASOs (20-mers) targeting region 1 of Exon 7 resulted in less potent activity than the ASOs Bld25 and Bld26 (25mers) and had either little/no effect on MuSKdelIg3 level or inhibited levels of total MuSK. Example 6: Design and Screening of Additional MuSK-targeting Oligonucleotides targeting Region 1 of Exon 7 [0490] In this Example, additional human MuSK-targeting oligonucleotides were designed based on the lead candidates from Example 1 targeting region 1 of exon 7 of MuSK SEQ ID NO: 126 (CTCTGTCAGGTTTCTTCTGGGTCCATTCAAGAGAGTGTGAAAGACCGAGTGATTGACTC AAG AC), which is located at positions 83841-83905 of the MuSK transcript (SEQ ID NO: 77) (or corresponding regions within other MuSK variant sequences). [0491] Sequences were desined to specifically to include different portions of the sequences of ASOs Bld25 and Bld26. Because shortening the length of the ASOs targeting this region was showed less activity, ASOs designed in this Example were produced to be 25 nucleotides in length. [0492] The additional oligonucleotides were tested for their ability to induce exon skipping of the MuSK exon 6 and/or exon 7. Design of Human ASOs [0493] Human antisense oligonucleotides (ASOs) were designed as described above and are shown in Fig.19. These ASOs were produced by Microsynth (Switzerland). The ASO sequences are shown below in Table 10. Table 10: [0494] All ASOs in Table 10 were designed to include 2’-MOE modification on each sugar and where there is a phosphorothioate internucleotidic linkage between each nucleotide. All ASOs in Table 10 were 25 nucleotides in length. Screen of Antisense oligonucleotides targeting Exon7 Region 1 [0495] ASO transfection and cell culture, RNA extraction, cDNA transcription, qPCR were performed according to the methods described in Example 1, except as where indicated otherwise. i. Alignment to the genetic sequence [0496] The alignment of the ASOs in Table 10 on the genetic sequence of Exon7 of MuSK is presented in FIG.19. ii. Cell observations [0497] LHCN-M2 cells were plated at 35,000 cells/well in gelatin pre-coated 6-well plates and were transfected 48h after seeding with ASO at 5nM, 12.5 nM, 25nM, 50nM, and 125 nM. Each of the ASOs in Table 10 were tested with Bld25, Bld26, Bld27, Bld28, Bld35 and Bld38 (leads identified in Example 1). 24 h after transfection, cells were observed (data not shown) and the RNA was extracted and analyzed. [0498] After 24 h of transfection, cells looked healthy in all conditions except for cells treated with ASOs Bld25-3 and Bld25-4 at the 140nM dose (data not shown). iii. MuSK expression analyses [0499] 24 h after transfection, RNA was extracted, and MuSK gene expression was analyzed in qPCR (FIG.20). Panel A shows relative gene expression of MuSK67 and Panel B shows relative gene expression of total MuSK (MuSK34). The new sequences were compared to Bld25 and Bld26 from Example 1. FIG.21 shows the same data from only the ASOs which showed relative expression of MuSK67 of less than 50% and total MuSK (MuSK34) of greater than 60% compared to the untreated control. [0500] FIG.22 shows a comparison of Bld25-5 to Bld25 after transfection with ASO for 24hours (Panels A and B) and 48 hours (Panels C and D). Methods described for screen of ASOs in Example 1 were used. [0501] ASOs with the modifications used in this Example are shown in Table 11 below. Table 11: a) * represents a phosphorothioate linkage, and each sugar of the oligonucleotides is a 2’-MOE modified sugar. Table 12: Potency Table 13: Selectivity MuSK 34 (IC in nM) [0502] Table 12 shows the concentration at which there is either 50% (IC50) or 75% (IC75) inhibition in total MuSK67 expression. Table 13 shows the IC10 and IC25 values of MuSK34 (nM) of each ASO, and represents concentration in which there is either 10% (IC10) or 25% (IC25) inhibition in total MuSK expression (MuSK34). ASOs performing exon skipping of exon 6 and/or 7, are expected to show lower IC50/IC75 values of MuSK67 and higher IC10/25 values of MuSK34. [0503] Results from this screen showed that ASOs Bld25, Bld25-5, Bld26-2, and Bld26 showed the best potency and selectivity (see Tables 12 and 13). Confirmation of Exon skipping by Gel Migration [0504] To verify the ASO-induced splicing of the RNA, the genetic sequence from exon 3 to exon 9 was amplified by PCR and the size of the PCR product was measured by migrating it on gel electrophoresis. [0505] Several forms of MuSK RNA exist naturally in human.3 variants were identified in the literature (FIG.26): Variant 1, NM_005592.4 (full length: 972 bp and ΔIg3: 687 bp) Variant 2, NM_001166280.2 (full length: 783 bp and ΔIg3: 453 bp) Variant 3, NM_001166281.2 (full length: 708 bp and ΔIg3: 423 bp) [0506] Full length and ΔIg3 indicate the lengths of the full-length sequence and ΔIg3 (6,7) sequence amplified by PCR from exon 3 to exon 9. Compared to variant 1, the exon 8 is missing in variant 2 and variant 3. In addition, a small exon of 30 bases is present only in variant 2. Therefore, skipping exons 6 and 7 would produce 3 additional MuSK RNA forms. [0507] The sequence of exon3-9 of the cDNA from the dose response presented in this Example was amplified by PCR in the conditions without or with Bld25 and Bld25-5 at 50 nM. Results from the gel electrophoresis are shown in FIG.27. In FIG.27, “4/5/6/7/EWS/8/9” indicates full length variant 1, “4/5/5+/6/7/EWS/9” indicates full length variant 2, and “4/5/6/7/EWS/9” indicates full length variant 3. Similarly, “4/5/EWS/8/9” indicates ΔIg3 (6,7) in variant 1, “4/5/9” indicates Δ5+/Ig3 (6,7) of variant 2, and indicates the ΔIg3 (6,7) of variant 3. [0508] As shown in FIG.27, several bands were detected. In the control conditions, major bands were visible where the full length variants would be expected. In conditions where splicing of the exons 6/7 occured (confirmed previously by qPCR), major bands were observed at for the spliced versions of the variants. [0509] Intensity of the bands was also examined. Intensity of bands from Bld25 and Bld25-5 products are also shown above the gel images in FIG.27. These results show that amount of MuSK PCR product with ASO is about 80-90% of the amount of MuSK PCR product in untreated conditions (controls). Therefore, total MuSK is decreased by only a small amount. [0510] Next, the bands of pcr products from cells treated with ASO 25-5 were sequenced to confirm these bands correspond to the indicated variants. FIG.28 shows that the sequence of the band lower band positioned where Δ6,7 variant 1 (687 bases) was indeed the sequence of this splice variant. Example 7: Design and Screening of Shortened MuSK-targeting Oligonucleotides targeting Region 1 of Exon 7 [0511] In this Example, additional human MuSK-targeting oligonucleotides were designed by reducing the size of the lead ASOs identified in Example 1 and Example 6 (Bld25, Bld25-5, Bld26, and Bld26-2). These ASOs target region 1 of exon 7 of MuSK SEQ ID NO: 126 (ACTCTGTCAGGTTTCTTCTGGGTCCATTCAAGAGAGTGTGAAAGACCGAGTGATTGACT CAA GAC) which is located at positions 83841-83905 of the MuSK transcript (SEQ ID NO: 77) (or a corresponding regions within other MuSK variant sequences). [0512] Sequences were designed by shortening the sequences of ASOs Bld25, Bld25- 5, Bld26- and Bld26-2 by different amounts. ASOs designed in this Example were produced to be 21 and 23 nucleotides in length. [0513] These ASOs were then tested for their ability to induce exon skipping of the MuSK exon 6 and/or exon 7. Design of Human ASOs [0514] Human antisense oligonucleotides (ASOs) were designed as described above and as shown in FIG.23. The ASOs were produced by Microsynth (Switzerland). The ASO sequences are shown below in Table 14. Table 14: [0515] All ASOs in Table 14 were designed to include 2’-MOE modification on each sugar and where there is a phosphorothioate internucleotidic linkage between each nucleotide. All ASOs in Table 14 were 21 or 23 nucleotides in length. Screen of 21-mer and 23-mer Antisense oligonucleotides targeting Exon7 Region 1 [0516] ASO transfection and cell culture, RNA extraction, cDNA transcription, qPCR were performed according to the methods described in Example 1, except as where indicated otherwise. i. Alignment to the genetic sequence [0517] The alignment of the ASOs in Table 14 on the genetic sequence of Exon7 of MuSK is presented in FIGs.23. ii. Cell observations [0518] LHCN-M2 cells were plated at 35,000 cells/well in gelatin pre-coated 6-well plates and were transfected 48h after seeding with ASO at 5nM, 12.5 nM, 25nM, 50nM, and 125 nM. Each of the ASOs in Table 14 were tested in addition to Bld25, Bld25-5, Bld26, and Bld26-2 (leads identified in Examples 1 and 6). 24 h after transfection, cells were observed (data not shown) and the RNA was extracted and analyzed. [0519] After 24 h of transfection, cells looked healthy in all conditions (data not shown). iii. MuSK expression analyses [0520] 24 h after transfection, RNA was extracted, and MuSK gene expression was analyzed in qPCR (FIGs.24-25). [0521] ASOs with the modifications used in this Example are shown in Table 15 below. Table 15: a) * represents a phosphorothioate linkage, and each sugar of the oligonucleotides is a 2’-MOE modified sugar. [0522] Results from this screen showed that ASOs Bld25-E and Bld25-5-A showed the best activity (see FIG.24 and FIG.25). Bld25-E showed MuSK67 maximum correction of 80%, with less of an effect on total MuSK (MuSK34), and an IC50 of MuSK67 of about 21nM. Bld25-5-A showed MuSK67 maximum correction of 80%, with less of an effect on total MuSK (MuSK34) and an IC50 of MuSK67 about 35nM. These results indicate that ASOs Bld25-E and Bld25-5-A are additional candidates to effectuate exon6-7 skipping in MuSK and have shorter lengths (21-mer and 23-mer) than the lead ASOs idenfitied from Examples 1 and 6. Example 8: Analysis of MuSK Protein [0523] This Example aims to examine the resulting MuSK protein after treatments with the ASOs described herein. Timing of Effect on MuSK Protein [0524] In order to examine resulting MuSK protein produced from ASO-treated cells, it is important to understand the relative timing of the effect of targeting MuSK with RNA. [0525] Length of time from RNA treatment was examined to determine how long after treatment will there be an effect on MuSK protein (i.e., production of MuSKΔIg3). [0526] In this experiment, LHCN-M2 cells were treated for 48h with 10nM of siRNA (Thermofisher, 4392420, assay ID s224071) against MuSK and were then stained for MuSK protein on days 2, 3, 4, and 5 (with MuSK antibodies isolated from patients with a disease involving the natural production of MuSK antibodies followed by goat anti-human (A-2133)) following siRNA treatment. Results for each timepoint in treated and untreated cells are shown in FIG.29. Results show that in the untreated wells, MuSK protein amount increases while cells start to be confluent. In wells treated with siRNA, MuSK protein amount decreases, especially 5 days after the transfection. Overall, these results show that MuSK protein amount can be modulated, and the best timing to observe an effect is 5 days after modulating the RNA. [0527] FIG.29 shows the cells at Day 5 magnified and stained for MuSK (red) (with MuSK antibodies isolated from patients with a disease involving the natural production of MuSK antibodies followed by goat anti-human (A-2133)) and actin phalloidin (green) (ab ab176743 at 1:1000). These results confirm that (i) the MuSK antibody used to stain for MuSK protein works in immunofluorescence, (ii) MuSK protein level increases over time, probably along with cell differentiation, and (iii) MuSK siRNA (“Si-MuSK”) induces a reduction of MuSK protein, especially after 5 days of exposure. Measuring Removal of Ig3 domain of MuSK [0528] Since ASOs as described herein are targeting the Ig3 domain and inducing exon skipping (6,7) to produce MuSKΔIg3, there needs to be a way to detect MuSKΔIg3 protein. Timing of the effects of the ASOs/RNA on MuSK protein has been established. An assessment (e.g., Western blot analysis) will be performed. Such an assessment includes assessment of MuSKΔIg3 protein produced from cells treated with ASOs described herein. A MuSK antibody that targets the MuSK cytoplasmic domain will be utilized for identification of MuSKΔIg3 protein. Antibodies are produced and tested using the recombinant MuSK cytoplasmic domain. [0529] Since human and murine MuSK protein sequences vary, human MuSK controls should be used for assessment (e.g., by Western Blot). Positive controls (i.e., MuSKΔIg3 protein and human FL MuSK protein) are used to confirm the forms of MuSK that are present. Plasmids coding for the different WT and D3 (Ig3) isoforms of MuSK protein are obtained. Cells are transfected with the plasmids and positive control isoforms are expressed and obtained. [0530] Human MuSK antibodies targeting the cytoplasmic domain of MuSK and human MuSK positive controls (i.e., MuSKΔIg3 protein and human FL MuSK protein) are obtained, and such reagents are used in a assessment (e.g., Western Blot) to characterize the MuSK protein produced from cells treated with ASOs described herein. LISTING OF SEQUENCES Oligonucleotide (SEQ ID NO: 1) GCTAGGGTGGTCTTTTAGAAATGCA Oligonucleotide (SEQ ID NO: 2) GGTCAAGCTAGGGTGGTCTTTTAGA Oligonucleotide (SEQ ID NO: 3) CTGCAGGAAATGGTCAAGCTAGGGT Oligonucleotide (SEQ ID NO: 4) GAAGTGGTGAGTGACGCTCCTGCAG Oligonucleotide (SEQ ID NO: 5) GTTAGGAAGACAGAAGTGGTGAGTG Oligonucleotide (SEQ ID NO: 6) ATCCTGGCAAAAACTGTTAGGAAGA Oligonucleotide (SEQ ID NO: 7) GTGGGATTCAGGAGCCCGCAGGATC Oligonucleotide (SEQ ID NO: 8) GGTGACATTGTGGGATTCAGGAGCC Oligonucleotide (SEQ ID NO: 9) GGAGCCAAAGGTGACATTGTGGGAT Oligonucleotide (SEQ ID NO: 10) GGTCACAAAGGAGCCAAAGGTGACA Oligonucleotide (SEQ ID NO: 11) ACAGTGCAGGGTCACAAAGGAGCCA Oligonucleotide (SEQ ID NO: 12) CTGTTGCTGTACAGTGCAGGGTCAC Oligonucleotide (SEQ ID NO: 13) GGGACAGGAATGCCTGTTGCTGTAC Oligonucleotide (SEQ ID NO: 14) CAGGTGATGGTGGGGACAGGAATGC Oligonucleotide (SEQ ID NO: 15) CCGTTTTCAATCCAGGTGATGGTGG Oligonucleotide (SEQ ID NO: 16) TGACACTCACAGCATTTCCGTTTTC Oligonucleotide (SEQ ID NO: 17) AAGTCCCCACACACATGACACTCAC Oligonucleotide (SEQ ID NO: 18) GGTCTTCCCCAGACAAGTCCCCACA Oligonucleotide (SEQ ID NO: 19) ACTATGTCAGTAGATTTGAAGGGAA Oligonucleotide (SEQ ID NO: 20) TCCCACTATACTATGTCAGTAGATT Oligonucleotide (SEQ ID NO: 21) TCAGTCAAGGATTTCCCACTATACT Oligonucleotide (SEQ ID NO: 22) AAAAGAACTCAGTCAAGGATTTCCC Oligonucleotide (SEQ ID NO: 23) GTAAAGGAAAATAAAAGAACTCAGT Oligonucleotide (SEQ ID NO: 24) AACCTGACAGAGTAAAGGAAAATAA Oligonucleotide (SEQ ID NO: 25) GGACCCAGAAGAAACCTGACAGAGT Oligonucleotide (SEQ ID NO: 26) CACTCTCTTGAATGGACCCAGAAGA Oligonucleotide (SEQ ID NO: 27) CACTCGGTCTTTCACACTCTCTTGA Oligonucleotide (SEQ ID NO: 28) GTCTTGAGTCAATCACTCGGTCTTT Oligonucleotide (SEQ ID NO: 29) GATAAACAGCTGCAGTCTTGAGTCA Oligonucleotide (SEQ ID NO: 30) AGTCCTGGCTTGGTGATAAACAGCT Oligonucleotide (SEQ ID NO: 31) ATGTGTAGAGTCCTGGCTTGGTGAT Oligonucleotide (SEQ ID NO: 32) GTAGCTATGCATGTGTAGAGTCCTG Oligonucleotide (SEQ ID NO: 33) TGCTTATTGGTAGCTATGCATGTGT Oligonucleotide (SEQ ID NO: 34) ACTTCTCCCCATGCTTATTGGTAGC Oligonucleotide (SEQ ID NO: 35) CCTTGGCAGTACTGAACTTCTCCCC Oligonucleotide (SEQ ID NO: 36) CCTGCTATGCTGATGGTGGCTGCAG Oligonucleotide (SEQ ID NO: 37) GGGCATCCTACCTGCTATGCTGATG Oligonucleotide (SEQ ID NO: 38) GCAAATGTGAAGGGGCATCCTACCT hu6-75; SEQ ID NO: 39 TGCATTTCTAAAAGACCACCCTAGC hu6-69; SEQ ID NO: 40 TCTAAAAGACCACCCTAGCTTGACC hu6-58; SEQ ID NO: 41 ACCCTAGCTTGACCATTTCCTGCAG hu6-39; SEQ ID NO: 42 CTGCAGGAGCGTCACTCACCACTTC hu6-27; SEQ ID NO: 43 CACTCACCACTTCTGTCTTCCTAAC hu6-12; SEQ ID NO: 44 TCTTCCTAACAGTTTTTGCCAGGAT hu610; SEQ ID NO: 45 GATCCTGCGGGCTCCTGAATCCCAC hu619; SEQ ID NO: 46 GGCTCCTGAATCCCACAATGTCACC hu628; SEQ ID NO: 47 ATCCCACAATGTCACCTTTGGCTCC hu637; SEQ ID NO: 48 TGTCACCTTTGGCTCCTTTGTGACC hu646; SEQ ID NO: 49 TGGCTCCTTTGTGACCCTGCACTGT hu656; SEQ ID NO: 50 GTGACCCTGCACTGTACAGCAACAG hu669; SEQ ID NO: 51 GTACAGCAACAGGCATTCCTGTCCC hu681; SEQ ID NO: 52 GCATTCCTGTCCCCACCATCACCTG hu693; SEQ ID NO: 53 CCACCATCACCTGGATTGAAAACGG hu6110; SEQ ID NO: 54 GAAAACGGAAATGCTGTGAGTGTCA hu6125; SEQ ID NO: 55 GTGAGTGTCATGTGTGTGGGGACTT hu6139; SEQ ID NO: 56 TGTGGGGACTTGTCTGGGGAAGACC hu7-75; SEQ ID NO: 57 TTCCCTTCAAATCTACTGACATAGT hu7-66; SEQ ID NO: 58 AATCTACTGACATAGTATAGTGGGA hu7-53; SEQ ID NO: 59 AGTATAGTGGGAAATCCTTGACTGA hu7-45; SEQ ID NO: 60 GGGAAATCCTTGACTGAGTTCTTTT hu7-33; SEQ ID NO: 61 ACTGAGTTCTTTTATTTTCCTTTAC hu7-22; SEQ ID NO: 62 TTATTTTCCTTTACTCTGTCAGGTT hu7-10; SEQ ID NO: 63 ACTCTGTCAGGTTTCTTCTGGGTCC hu73; SEQ ID NO: 64 TCTTCTGGGTCCATTCAAGAGAGTG hu717; SEQ ID NO: 65 TCAAGAGAGTGTGAAAGACCGAGTG hu730; SEQ ID NO: 66 AAAGACCGAGTGATTGACTCAAGAC hu744; SEQ ID NO: 67 TGACTCAAGACTGCAGCTGTTTATC hu758; SEQ ID NO: 68 AGCTGTTTATCACCAAGCCAGGACT hu766; SEQ ID NO: 69 ATCACCAAGCCAGGACTCTACACAT hu776; SEQ ID NO: 70 CAGGACTCTACACATGCATAGCTAC hu785; SEQ ID NO: 71 ACACATGCATAGCTACCAATAAGCA hu796; SEQ ID NO: 72 GCTACCAATAAGCATGGGGAGAAGT hu7111; SEQ ID NO: 73 GGGGAGAAGTTCAGTACTGCCAAGG hu7136; SEQ ID NO: 74 CTGCAGCCACCATCAGCATAGCAGG hu7146; SEQ ID NO: 75 CATCAGCATAGCAGGTAGGATGCCC hu7158; SEQ ID NO: 76 AGGTAGGATGCCCCTTCACATTTGC MuSK Genomic Sequence (SEQ ID NO: 77) 1 tatacagtca tttatcactt aacatcaggg atatgttctg agaaatgcat ccatagttca 61 ttttgttatt gtgtgaacat catagagtat acttacagaa accttgatgg tatagcccac 121 tgcacaccta ggctgtatgg atagcctatt gcccgtaggc tacaaacctg tcagcatgtt 181 actacactga atactgtagg caattgtagc acaatggtac gtatttgtgt atctaaacat 241 agaaaacata cagtaaaaat acagtataaa agataaaaat ggtacacctg cattgggcac 301 ttaccatgaa cgaagatttc agcactgaag tttgctctgg gtaagtcagt gagtgagtga 361 tgtgtgaatg tgaaggccta ggacattact gtacactgct gtaaacttta taaatactgt 421 acacttagac tacgctaaat ttatttttaa aatatttttc tttctttaat aataaattaa 481 ccttagctta ccacaactat tttattttat aaacttttaa aatttgtaat ctttttgact 541 cttttgtaat aatactctgt ttgaaacaca aatatattgt acagttatac aaaaatagtt 601 tttcttcata tccttaagct cttttctatc ttaaaatttt atttttattt tttactttct 661 aaactttttt tgttaaacac taagacaaaa acacacaata gccttggcct acacagggtc 721 aggatcaaaa catcactgcc tttcaacagc ttgtcctact ggaaggtcct caggggcaat 781 aacacacatg gagctgccat ctcctatggt aacaatgtat tcttctagaa tacctgcctg 841 aggctgtttt acaatcaatt ttttatttat ttttattttt tatgttttta aataagtaca 901 gggtatacac agtaaaataa taataaaaat atagtacatt aaaaaaacca gcaacatggt 961 catttattat cattatcaac tattatgtac tctacataat tgtatgtgct tttttattca 1021 aaaagaaaat cattaagaac acagcaatat taatatttat tctttttttt agaagaacct 1081 gatttattta tttaattttt ttattatact ttaagttctg ggatacatgt gcaaaacgtg 1141 taggtttgtt acacaggtat acatgtgcca tggtggtttg ctgtatccat caacccatca 1201 tctacattag gcatttctcc taatgctatc cctcccctag ccccccaccc cttgacaggc 1261 cccagtatgt gattctcccc tccctgtgtc catgtgttct cattgttagc tcccacttat 1321 gagtgagaac atgtggtgtt tggttttctg ttcctgtatt agtttgctga gaatgatggt 1381 ttccagcttc atccatgtcc ctgcaaagga tataaactca ttgtttttta tggctgcata 1441 gtattccgta gtgtatatgt gccacatttt ctttatctag tctatcattg attggcattt 1501 gggttggttc caagtctttg ccattgtgaa tagtgctgaa ataaacatat atgtgcatgt 1561 gtctttatag tagaatgatt tatagtcctt tgggtatata cccagtaatg agattgctgg 1621 gtcaaatggt atttctggtt ctaatccttg aagaattgcc acactgtctc ccacaatggt 1681 tgaactaatt tacactccca caaacagtgt aaaagcattc ctatttttcc acattctctc 1741 cagcatcggt tgcttcctga ctttttaatg attgccactc taacaggcat gagatggtat 1801 ctcattgtgg ttttgatttg catttctcta atgaccaata atgatgagct ttatttcata 1861 tgtttgttgg ctgcataaat gtcttatttt gagaagtgtc tgttcatatc cttcgcccac 1921 tttttgatgg ggttgtttgt ttttttcttg taaatttgtt taagttcttt gtagattctg 1981 gatattagcc ctttgtcaga tggatagatt gcaaaaattt tctcccactc tgtaggttgc 2041 ctgctcactc taatgatagt tccttttgct gagcagatgg tctttagttt aattaggtcc 2101 catttgtcaa ttttgacttt tgttgccatt gcttttgggg ttttagtcat gaagtctttg 2161 cccatgccta tgtcctgaat ggtattgcct aggttttctt ctagggtttt tatggtttta 2221 ggttttacat ttaagtattt aatccatctt gagttaattt ttgtatgaga tataaggaag 2281 gggtccagtt ccagttttcc gcatatggct agccagtttt cccaacacca tttattaaat 2341 agggaatcct ttccctactg cttgtttttg tcaggtttgt caaagatcag atggttgtag 2401 atgtgtggca ttatttctta ggcctctgtt ctgttccatt ggtctatata tctgttttgg 2461 taccagtacc atgctgtttt ggcaaaccag gaagaagctg aatccctgaa tataccaata 2521 agaagttctg aaattgaggc agtaattaat agcctaccga gcaaaaaaaa aaaaaaaaaa 2581 aaaaaaatcc aggaccagac ggattcacag ccgaattcta ccagaggtac aaagaggagc 2641 tggtaccatt ccttctgaaa ctattccaat caatagaaaa agagggaatc ctctctaact 2701 aattttatga gtccagcatc atcctgatac caaaacctgg cagaggcaca accaaaaaca 2761 gaaaatttca ggccaatatc cctgatgaat attgatgtga aaattctcaa taaaatactg 2821 gcaaactgaa tccaacagca catcaaaaag cttacccacc acgatcaagt tggcttcatc 2881 cctgggatgc aaggctggtt aaacatatgc aaatcaataa atgtaatcca tcacataaac 2941 agaaccagtg acaaaaacca catgattatc tcaatagatg cagaaaaggc tttcaataaa 3001 atttaacacc cctttatgct aaaaactctc aataaactag gtattgatgg aacccatcga 3061 aaaaaaatga gctatttatg acaaacccac agccaatgtc acactgaatg agaaaaagct 3121 ggaagtattc cctttgaaaa ctggcacgag acaaggatgc cctctctcac cactcgtatt 3181 caacctacta ttggaagttc tggccagggc aatcaggcaa gagaaagaaa taaagcgtat 3241 tcaaatagga agagagaaag tcaaattgtc tctgtttgca gatgacatga ttgtatattt 3301 agaaaacccc atcatctcag ccccaaatct ccttaagctg ataagcaact tcagcaaagt 3361 cccaggatac aaaatcaatg tgcaaagatc acaagattcc tatataccaa taacagacaa 3421 acagagagcc aaatcatgag tgaactccca ttcacaattg ctacaaagag aataaaatac 3481 ctaggaatcc aacttacaag ggatatgaag gacctcttca aggagaacta caaaccactg 3541 ctcaagggaa taaaagagga cacaaataaa tggaaaaaca ttccatgctc atgataggaa 3601 gaatcaatat tgtgaaaatg gctgtactgc ccaaggtaat ttatagattc aatgctatcc 3661 ccatcaagct accattgact ttcttcacag aattagaaaa aactacttta aatttcatat 3721 ggaaccaaaa aagagcccat atagccaagg caatcctaag caaaaagaac aaagctggcg 3781 gcatcacact acctgactct aaagttctat aaatgaactc acgaggccaa agaatgaaga 3841 agacaccaac acaaagggga aaaaatcaaa acaatatggt cattgcaatg gtagagatat 3901 gcacagtata ttatggaaac ccagagaaga caaacgtaac acagctttgg gaagatatgg 3961 aatttttctc ccaggaggag aggatgatca agctgagaga tgtgtgaact gagtggaaag 4021 gaggggagta gtattccaag agaagcaaac agtatgagca attcatggag gtaggaaagc 4081 tgtatacagg gaaccatcag caggttgttg aataaaggaa gctgaatgag gctgggcaca 4141 gtagctcacg cctgcattcc cagcactttg agaggccgag gtggaatcat catttgaggc 4201 cagcagtttg agaccagcct gggtaacata gcctgaccac atctctccaa aaaataaaaa 4261 taaattagcc tgctgtagtg gcagtgcctg tagtcctagc tactctgaaa ggatcacttg 4321 agtccaggag gctgaggttg cagtgagcta tgattacccc attgcactcc agcctgggca 4381 acagagcaag accctgactc tgaaaaaaaa aaaaaacaaa aaacaaaaac aggatcgtaa 4441 aagacaatac taacatacaa caaagcatgc agattccagt aaagcctgtc atattaggca 4501 gattaggcag gtttaaatat atttttatgt gatgatgagc ccctaaaggc ttttgagcag 4561 gagggactat ctgaaaaaag atatagaatg gttaagaccc aagacagaga gaaggtacaa 4621 ggactatttg gttgataaaa tctgtaggaa ttggaatggg ctgaatgtgg gagtgggggt 4681 ggggtgagag atggggagga ctgaagactg aatagaccca gatttctggt ttgagtccgg 4741 gagaggtggg gtgctgaatt cgaaggtcag gacacctata cctctgggaa tacagcgatg 4801 gttgcaaaag gcatctggta ttgtccttct gccactgtct taaaagggat tctaaaggga 4861 ttttcttgcc cttgttcctc cagccctaca cttgcattac tggcctacgt ggatgctcac 4921 cagctggctg tgtccatcat tgcagccaag tctgagaatt cctgattata cttagagcct 4981 gtggagctgc tgacacaaac agtcattagc agacaaccct tttgcaacaa agtatgcttt 5041 aaaatgtaaa ctgtggagcc attttccttg cgttgtccag aaggaacttc gtcctgcgtg 5101 agcctggatt aatcatgaga gagctcgtca acattccact ggtacatatt cttactctgg 5161 ttgccttcag cggaactgag aaacttccaa aaggttggtt tgagcaatcg tgtcttcttg 5221 ttgtcttgtc atggttgtaa agtgtgtgta tatgagatat gaccaagact gatttatagt 5281 atggtgggct tgggttttac ttgaagaagt aagggtgaaa tgtatgatga gggaggaaat 5341 tatatacata agcaattggt tgatggtctc tctaccaata ttttactccg aagttctgca 5401 ataaaaggct tagccacata gtgcatgcag agctctgact tctagggcaa aacataagca 5461 tgtacactgc aagttatcaa ggtctatttt gtttatgcga atgtcaaatt tcagggtggt 5521 ctaagtggat gatgacaacc ttttcgcatc aggtttgcca ggaatagaat caaccccatt 5581 ctcagacatc cagagcattt gcttctgaat aaaaatcact tttattttca gttttagctt 5641 tgccaaactc ttaataaata ttttagttgc taaaaattgg aaatacagaa agacgtacac 5701 aatttgcctg tgtaacaaac ccggaagaca atggatttta aataactttg aggctggagt 5761 catgatttgg cttggcaaga gactgcaaaa gtttttttca gagcctttgg aatgtaccgg 5821 aaataacacc acctcagggg aaaggaaagc aacttaagaa actgacaaac acctgttgca 5881 gtagcaagaa tgtccagtga tatagtttct ggccagtgta ttatgaaact gggactagcg 5941 tatttgaaat cagaaagact ggaaagtctg tgatttgcaa agtgactaag ggtatcactg 6001 aaatcttttt ttaaaaagac atgagaaagc agatcgagtg gtatcaatac aagagttttc 6061 aaatttaatg ttataccata gagtaaaaag agatttttgc ttcaggacat gttcaaatta 6121 atcattttcc ctttatatta atcaaagcac tgaaacagtt tgtattgtgt agataaatga 6181 aggtggtatc tgtatataga tgcaaaatgt atctttagat tttctggttc actaaaaatt 6241 ctggagccat aaggtcaaag ttcacatgca aataagatgc gggtttcttc acaaacaatc 6301 tgatttcaca gatttttttg tttcattttg ttgcttctct ttttccattt tacttgagta 6361 taatggtatc ttcaaatgta tttaaacatt taatttctaa tgaatacttt aaggcatcta 6421 cagataaaag agactctaga tcttttcaaa cagctaataa tagtcagaaa gacttaacat 6481 tggcttcaga ttattttaat acttcctgat caaacaacgg atgtccggta aggccccacc 6541 tggatgtttg aacgtatggg ttgtcttaag tattatttgt atatttctaa accacgcagt 6601 tacataaaaa tgatagggtt aaatactaaa atacagtctt ataaagagca ggacaattga 6661 ttttgatgat tcaaataagg atttgttgta cacacacaca aaacccccaa aatctctcta 6721 tctgaataag tcttaattta tattctagaa agaattgatt ttcatttcca aactttacaa 6781 ataaagccct taattcaaat gcacactatc tctattttga aaatattgaa atatagtggc 6841 atagagataa caaagccaaa caccctgact tttaaataaa ctaaccagat cattcaccca 6901 atttcatttc ttataattta tttactacta gaattaggtt ttaaaatcaa aaaatttaag 6961 caattttttc tcagtctatt gtactgtaaa atctaaatta gtatgagttt aacatcactc 7021 ttagccaaaa taccatgtct aggagaacaa acatttattt actacataca gcagttctga 7081 gaataactaa tatcatgaaa gcataatcct taaaatttta aatgttgaag ggtgaggaat 7141 acattggtag aaaagaacca caataaaatt ttattatttt cattattatt attattattt 7201 gagacagagt ctcgttctgt tgccaggctg cagtgcagtg gtgtgatctc agctcactgc 7261 aacctcctcc tcccaggttc aagctatact cctgcctcag actcgcaaat acctgggact 7321 acaggtgcaa gccaccacac tcggctaatt tttatatttt tagtagagac agggtttcac 7381 catgttggcc aagatggtct ccatctcttg acctcgtgat ctgcctgcct cggcctccca 7441 aagtgctggg attacaggca tgagccactg cgccagccat tatactactg aaactaataa 7501 aaatggccca cccaaactat ttctactatt tctagaaaac tactgttttc cctattcttg 7561 gcagacggta ataacaaaaa gagtttttta gataatatac ttcttcctaa gtcctttatc 7621 atgaatgcat aaaggaaatt gtacaatatg tattagctaa taaattgaca tatttaaaat 7681 aacacaaaag tattcagtgg attattttct gactttctgc acatcatttt ttgataaaaa 7741 ttaatatcca actttgtaga attaattgtt catagttttc attttagttt aattaaggct 7801 actaatgccc aatgataagg ggaagaatca ttgtctttct gaatcatttc aactagtgat 7861 attttcaatg atgaattcag tgccataacc caagtagtag aatttcacaa actgtcattt 7921 atgaaagtag ccaatgttcc actggataat tggcttaact acatacatca ataacattta 7981 atgctttatt agggagtatt aaatgtatgg tgcaatgtta gattctgcag gagcataaga 8041 gttcatgtaa gcagctctgg atttgcttaa tatgcacaaa gaactatcaa aagtctcact 8101 ttcaaaacac ccgacttact acaatacgtt gaagtgtttg agcgtacgtg attttatctt 8161 tagatagatt tgaataacct cctcttttaa attgtatgta tataaggata ggattcacag 8221 atttgacata tgactaagtc atgactgaca cagctgtcat tgaaatccag gacacacagt 8281 cctggatgaa tattttatat tgacatgcat tgaaagagtt actcattgca tgtttgagta 8341 aacagagttg cttcaaatat tattgacctt aaagaaaaga aggaaggagc agaaatttca 8401 agatctcttt aaactctacc ttatttccaa aggtaaatga agtaggcagc ttctcagtga 8461 aataaaacct gatgtcgttg aaggagagta acaagtgagg ggtggaaaga gggcctgaaa 8521 ggagtggctc tattcaggaa gatgagagga tcacatgggc catgctgaag acccagctgg 8581 ggctaggaac tgcagctttc tttatagtgc ccctgacctg aacatttact gcactatacc 8641 cagcagtgct atgtgaacat agggtaggga ggacagatgg ctggattaat tcaggattgg 8701 cactttccag ggtcagtaca gctaaagaac tagagagtaa aggagttgga gttatatggc 8761 agcgtaccat gagatacaga ttggatcagg aagaaagtaa aacaaggata tttaatgctt 8821 ggaagagaag gttaaaaagt ttaaaccaac cccaaagtgt tttgttgtac taaaaaaaaa 8881 atactgcatt cataatgtta gagaaacatg aatattttcc aagtcagagc cctaatttta 8941 ctaaaataga aaggagcaaa tacaccttgt ttctttatgt acccaatcat tgggtcatgt 9001 caatccaaaa ataatcaatc aaaagttggt aagtcaatag tcatatgcga gagcccataa 9061 aatacaaagg aaaggtaatg tcatgtcctt ctcatcaagc agttgatatc caagtcaagc 9121 ttttcttcgg gtccagaaaa ggattgtgtt cattttcatg tatttgttat tcatgtagtc 9181 cttggattga gagaagaaat agtgccctag tttaaacgag ctctggctga gatgaaagct 9241 ggatagtaga atgaaagtaa acaagagaca gtgtgctgag tcaacaaata tcattaaata 9301 caactgatcc atgtgattgt gtcagtgaaa accggaaagc agatttggat aactggaaat 9361 atggacaatg tggacttggc attctgtgtg tagaaactga tattgatgta catcttctct 9421 tatccatctg tgcataatca gtatgatctt gaagatgcag tatgtcttag agaaaggaag 9481 tataaaccaa ctttaaccct gaagttcagc tagttcagct ctatcacttc ctatttttgt 9541 gatatgtaga caagttgtgc aaccattttt agtccccatt tctggtctgc aagtggaaat 9601 attaatagta tctacctttt ttgtgttaaa taaaaagata atgaataaaa agtataatgc 9661 atggcacata ccagattctt aatcactttt agatgctaat attagtaaaa acagtcaaac 9721 ttcacacaag actgttatgt cactgaatct tatgggaagg tgttaactta ataaagttct 9781 tagtaacacc ttccatattt ctccatgtct attttccaag acattctaag actcacttct 9841 ttgatcttaa ctgatctcaa cagttcatgt gacatctcca gtgtgtcacc tcattggaaa 9901 gataacatta atagtaagtc tattacctct gccacttctg catctgtgta ttgagtgaaa 9961 ataacactag tgcataaagt ttctctctta taaaagtagc acatggtatt taagattgat 10021 tttgaaaatg caaaatacat aaagtttaag acagaagaag tcatccatac ttccaggact 10081 attaacacat tggcatattt tcttccattt ttttctacat atttttaaag tccttattaa 10141 cattgtgctg cctgctattt ttacttagca ctaaagcatg agcatattct atattattag 10201 taatcttcca aacgtcatgt gtggtgacta aataatattc tgtttagata acagtgtgct 10261 agtatatgtt taatattcac ctcactgaga aaaaaaaaga cgtggatttg ttgctcttgt 10321 ttatttctgc agtaaaatac tctatagtaa aaaactctat tgtgtctgtg gccagtctca 10381 agctactatc aaataatgag cactgagttg ggaaatagca tgtgtagtag catccttcat 10441 atattatttc taccacacag acacattaca gataacctca agaacttata taataataaa 10501 atgtagttaa atcattggga atttcaagta ttaatacttt gtttttaata tatttgatta 10561 taaatgtata caacttagtt tttaataatg attgtatata acaatcacct ctcaaaattc 10621 ctaaaaaatt accaagtggc tcttgcaaac ctgcggaaga caaaacttgt gtgcctcaat 10681 cttctcccac ttgactacga ttaatagaat ttagtacaat tgatctgttt tctgcagtaa 10741 aagtcaccta tatgcctttc tatatgtgag attatttcct taggatagat tcccagagat 10801 gatgatgatg atgatgatga tattattatt attttagaga tagagtcttg ctctgtcaca 10861 caggctggag tacagaggtg caatcacagc tcactgaaac tttgaactcc taggctcagt 10921 tgatcctccc acctcagctt cttcccaagt agctgggatt acaaagtgtg tgccaccatg 10981 ccggctaatt tttaaatttt ttgtagagat gtggtttctc tgtgctgccc agcctggtct 11041 caaactccta ggctcaagtg atcctcccac ctcggcctca aaagtgctgg gattacagac 11101 atgagccacc aaccacaccc agcctgagat aaaatattaa cggtataata catttgaatg 11161 taataaagac aaggaaaaca atcaaacagc ctgggtttct ttttctaaat tatagaatca 11221 agtaacattt gcacagtgct ccatgtggac caaggacaat tttaaatggt ttccatttat 11281 ttattccttg tgacaagtta tgtggaggct atacattatc tccgtctata gctgagacac 11341 tgaggttaag tgtggttaag tgacttgcag agtcggtaag tgatggagct gggatgtgaa 11401 ttcaagtcct gtgccacatt gcctcttttt tttttttttt tttttttttg agacagagtc 11461 ttgcactgtc gcccaggctg gagtgcagtg tcgcgatctc agctcattac aagctccgcc 11521 tccctggttc acgccattct cctgcctcag cctcccgagt tgctgggact acaggcaccc 11581 gccaccacgc ccggctaatt ttttgtattt ttagtagaga tggggtttca ccctgttagc 11641 caggatggtc tcgatctcct gacctcgtga tccgcccgcc tcggcctctc aaagtgctag 11701 gattacaggc gtgagccacc gtgcctggcc gctacattgc ctcttaatgt gtagttgctc 11761 aatagtcttc cctttttttt tttttttttt tttttttggg actgagtctc actctgttgc 11821 ccaggctgga gtgcagcggt gcggtctcgg ctcactgcaa tctccacctc ctgggttcaa 11881 gtgattctcc tgcctcagcc tcccgagtag ctgggattac aggcctgcac caccacaccc 11941 agctaatttt tgtattttta gtagagatgg gatttcacca tgttggccag gaatctcttg 12001 aactcgtggt cctccccgcc tcggcctccc aaagtgctcg gattacaggc gtgagccacc 12061 gcacctggcc tagtctttct ttttaaacag taaaagcatt caacatcatc aattaacctt 12121 tgggctcatt gttaaccaca ctccacaagc ttaataaaat attgtttttg ttctttatct 12181 ctcaatatct agatgattat actattaatt gcttatttca ttcattcgtt gtttagaaaa 12241 taacttttta ttgagattga ctttctcaaa ctttatgaat tataagtttg cctccattgc 12301 attttgaaaa ttaacacttc tttggcattc tatctgctac aatttttttc tattatgaaa 12361 gcaatatgta ttcatttttt taaaaaatcc tgtaagatac agaaaaacaa aaatataaaa 12421 ttacacataa tgctcatagc aagggataag tgctcttagc attttgctat tcattctttc 12481 agtctctttc tctcatatat gtgtgtgtgt atatgtaagt gtatatatgt tgtatatata 12541 cacatacaca cacatatatt atatattata tattatatat gtgtgtgtat gtgtatgtaa 12601 ttttattttg taaattttaa gttccggggt acaagtgcag gatgtgcagt tttgttacat 12661 aggtaaacgt gtgccatggt ggtttgctgc acctgtcacc catcacctaa ataactgggc 12721 tcagcatgta ttagctattt ttcataatgc tctccctccc ccaatcccac ctgctgacag 12781 gccccagtgt gtgttgttcc cttccctgtg tccatgtgtt ctcattgttc agttcccact 12841 tataagtgaa aacgtggtgt ttgcttttct gttcctgcat tagtttgctg aagagaatgg 12901 cttccagctc tatccatgtc cctgcaaagg acataatctc attccttttt atggctgcat 12961 agtattccat ggtgtatatg tatcacattt tctttatcca gtctatcatt gatggtcact 13021 tgggttgctt ccatgtcttt gctattgtga atagtgctgc agtgaacata ggtgtgcatg 13081 tatctttaca aatttcagag gctgttattt cattgaggaa agagaagcat ttaaataaga 13141 agctctctct tcagctgcct accagcaaag gggaaaaacc tacctctctg catccatctt 13201 gtcctccttc tccctcactg tgctttaaga ggactttctc ttcctatccg tggttaaccc 13261 gtctttcttc ctctgagccc cacataaatc tgctttctca gggacctatt tccctcaatt 13321 atctcctgtc tttctccaat gtcctacatt tttgcttcta ctaggtgctt ccagtcagca 13381 tttaaaccca ctcttgtcac catactcacc tccagcacca tgcagcccct ttcttccctt 13441 ttattgttaa actctgctgc aaaaagatgt cttccctctc ctcttagttt ccacttcctt 13501 atcacaacct aacccccacc actgcaatct ggcttccgcc aaatctgcaa gcaccaaaat 13561 caacatgacc tcctcatcag gaaactcagt gggcactttt aggtccttat ttaacttaac 13621 gtctcggcag catttgattc tccctctttt gtgaaacgtg tgctactctt gggctctgcc 13681 aatagcctcc actggctttg cttacaactc tgatttcttc ctctcagtct cttttctaaa 13741 ctcttcattc tcccacccat cttttataaa tgtttgtgtt ttcttctaat tggcttaggg 13801 caccagcctc cctccgtctt caggctttca cgggtaccgt ttcctctgcc tggaacactc 13861 ttctctctcc actgcaccaa gccaaatttg aatcatcctg tgaatgtgtg tgaatgtatt 13921 gtgtagtttt tttttattcc tagttttatc aagttcagtg gttgagaaac attatttatc 13981 atgttaaaga aatactatta tattccgact ctactaatgg ttttcaagta gggaatggat 14041 agttaactct gttactgcct ttttgactgt gataggtatc ttttaaacta tgactatagt 14101 aaatcctgtt taaaggactt ttctattaaa ttatccttat atttttgcaa ggattttttt 14161 tctgcctaaa tgcatagtaa taattttgaa atttatgatt taatttaatt tgctttttaa 14221 aattttactt tagggcttta catcctgctt gacttacatt agcattgttt tattccaaag 14281 attgatttga gaagctttct atactttata ttccctatag cttttgtttg tttgtttttg 14341 agacaaggtc tttctctgtc acccaggctg gagtgcagtg gtgcaatcac agctcactgc 14401 agccttgacc tcctgggctc aagtgatcct cctgcctcag gctcccaagt agctgggact 14461 acagatgtgt gccacctgta cccggctaat ttttttattt ttgtattttt tgtagagatg 14521 cagtcttgcc atgttgccca ggctggtctc aaaacacctg gatccttcag tggatccttc 14581 tgggctcaat ggatcatcct gcctcagcct cccaaagtgt tgagattaca ggtatgagcc 14641 actgcacctg gctccttgta gcttttatgt aactggagac ttaattcttt cttaagagtt 14701 ttttaaaact tatctgaaaa actttggggc attatatttt tttcagaagt gttctttgct 14761 aatctaatct ttttcttctg tgagtattgt tgatgatttt accccaccct ttactacatg 14821 tgaacaattt tgtttttaaa attcttaatt ctttagattt tcatctttaa atattcatta 14881 ctgtttagct ctgttgaatt gtggtccaag aatgtgacat ataatctgtt tttaaaattt 14941 atttaagctt taattttcat gggcatttga aaatatgtgt catctatcag ggcttacagt 15001 tgatgtgcat atctgtttaa ttaattttac taattctgct attctgtttt actacatata 15061 taattatatt tttgtctttt gatctataaa caggattggg attttttgtt tttttgctat 15121 ctttttattg tctatttctt acagatttta ttatggttag aaaatataga ctatataaaa 15181 tcaattcttt gagctgggtt aaaatctcct atgtagcttg gtatattttc tttatgtttg 15241 aatgtttcat ctatgcatca tttacaaaat gtattctgta attgtttcat tgttttataa 15301 atgtacatta tatctagtgt taattttgat gtttatatct tctatatctt tactgtagtt 15361 ctgtttgata tattagtgtc tgaaggagat ctcttaaagg gttacactat gttaaaacat 15421 ttctccatgt actcttgtga taattttact tttgggtttg agtccatatt tttaaataat 15481 taagtttcat gattgtcata tctttttagg gcttgttcct tttatcatta agcaatgttt 15541 ctttttttct tataaatgca tatgccccta tattacattt ttcttatatt actattgcta 15601 tgtcactttc tttgggatat cgtttgcttt atacatattt tccctcccct ttatttttaa 15661 catttctgtt ttattttatt taagtgtgtc ttttgtgttt gatagcatct gtcatttcat 15721 aggtcagctt ataccattgg cacttactgt gatttctggt atatttggac ttgtttcttc 15781 catattattt tatgtcttct gttaaccatg ctttttcttg gcttatttat tcctcctctt 15841 cttcctgttt gtttttgctt ttgtttttga ttgataaagc ctttctggta cctctttttt 15901 tctctgttgt tttggaattt ttgaatttta tttatttttt agtagtaacc attaataagg 15961 ttttaacata atcatttaac catagatgct tctttctgtt tgaagttatt caatatttct 16021 gtcctcttgt ttatggcaaa gagcttagca ttttttaatt acttagcatt ttaaacttct 16081 ttcctgaact ttgatcttat agttgtttgt ctagaattta attccactct ttttaaacac 16141 aaaaatttgt gattttttaa tattccatag tgtgttaaaa ttgcaatggt atttcaccac 16201 catttatgct attgtttttt ataactcacc cctttctttc tggtataaat tattccttag 16261 tgagtttatt tactctagta actatttcag agaaagtctg tgagtggtaa acactctcaa 16321 tatttgttta taagtgttct gagtttaaaa ttattaccta agctagctgt gtaattctaa 16381 gctaacagtt atttttacgc agtcatgtaa aggtattagc ctattgcctt ttggtatcaa 16441 ttgttgttgc tgaataatct caggttaccc aaaattggca ttcctattaa ggaattaaac 16501 tttttctttc tggtagagtt taagatttta tttatcttta atttttacag ttttaattca 16561 atgtgtccaa gtatgaattt ctttcttttt ttcttttttt ttttttcttc tgagacagag 16621 tctccctcta tcactcaggc tggagtgcag tggtgcgatc tcagctcact gcagcctcca 16681 cctcctgggt tcaagcgatt atagtacttc agcctcccac atagctggga ctacaggtgt 16741 gcaccaccat gtccagctaa attttttgta tttttagtag agacagggtt tcaccatgtt 16801 agccaggctg gtcttgaact cctgagctca agtgatctgc cctcctcggc ctcccaaagt 16861 gctgggatga caggtgtgag ccaccatgcc cagctgtatt tcttttttaa atctgtcttg 16921 tcatttggtg ggtactttcg accttaatat tccagggttt gtttttcagt tttgaaaaat 16981 tatcagccat ttatctcttt atatattgct tctaggctgc tcccctcttt tatttttctc 17041 aaactcctat cagaggtgta ttagtgcctg tcactgtata ctttatatct cctaactatt 17101 ctttaatagt gtccatgtct gtatttcttt gtattatgtt ctgtatatta taatgatcct 17161 tatgatatat atatcatata tatgatatat ataatgatcc ttataatata ttatattata 17221 tataatatat attatatatt atatattata taatatatat tatatattat atatataata 17281 ttatatatat tatataatat atattatata atatatatta tatataatat atattatata 17341 tattataagg atcgttataa tatatattat aaaaattatt ataatatata ttataacaat 17401 ccttataata tatattataa tgattattct gttgaaaagc tgggaagaaa gtggccctga 17461 tgactgtgta taagatgtca ttttacataa aaattctgct ttcttatttc aactactatg 17521 tttcaacttt tttatttact ccttttgtga aggccttata aatacagttt tgttcattta 17581 aacagtacat cagtcactgt gctcaccctg ggaattaaat gatgtctaaa acatgatccc 17641 tgacctaaag ctcaaggttt taataattga gtgtgggtca aagacgtaaa cagatcattt 17701 taatagtatc tgtgtgacaa gtggcattat aagaatgaca tttcaggata acataaggtt 17761 aaggaaagag gcatttgggt ctgcctagca tgtcagggga agtggaagga gatggatgct 17821 taaactgaat cgtaaaagac aaaataacat tagcaaggga gatatggggc aagtaaaacg 17881 ctcccactca ccattttttt tcactctcag cagatgagct tgcctttgac tttaccaaaa 17941 aataataata ataataaggt ttattcagaa agtggatgta tcttttatgg ccaaacaacg 18001 tgccagtctg ttctagatgc tctataagtc tgtcactgac tatttcactt ctaaatgtca 18061 atcatactac ttatttggct ttgatgtata ccttgccctt taactgaagg gaccatataa 18121 tttactgtat aaatgcaggt agccctcatt tcacagagga gtgagaaaaa agaaaggacg 18181 atgtctatag cctttcctcc tgttgtctta aaaaaaataa aatagaacaa aacagctttg 18241 agatctaatt cacataccgt gcgctttacc cattaaagtg tacaattcac aaagtggtgt 18301 ctcttcattt tctagttgta tgcccaagtg aattctctat gaatctgatg aagcttaagc 18361 ttcagattct ctcatttgca ggagcccttt ctaagaccct cagtgggctt tagcaatgtg 18421 cttttatgag tgtctatttt tataaaatta ggggaaaatt gttcttaaaa aacaattttt 18481 taaattatta tccttttcca ccctgacttc ccttcagact cacttccctt tatgctgatg 18541 atattggggt ggacacagaa attttgtatt cataatttta tattttttct ttaaaaagta 18601 caaattgcac aaacttgggc cccataaaac ttggatctgc ctctcctcgt atatcataaa 18661 ctctaagccc tgctctcctg agagacttct cttttgattt tcaaatgcct agtttggaag 18721 tagaaacaac attctttaca taagctcttc ctttcttttg gcaaatttct actctgggga 18781 aacagaattc tcattcaggt atgtaatggc ttctgactgc ttaaggaagg gttagtaaac 18841 aaaattctag aatgttctct tttgatttct cctttccttt cagctcctgt catcaccact 18901 cctcttgaaa cagtggatgc cttagttgaa gaagtggcta ctttcatgtg tgcagtggaa 18961 tcctaccccc agcctgagat ttcctggact agaaataaaa ttctcattaa gtaagtattc 19021 cacattttaa tttttttaaa tttttgtggg tatatagtag gtgtatatat atgtatatat 19081 ttatgaagta gatgagatgt tttgatacag gcatgcaatg taaaataagt acctcatgga 19141 gaatggggta tccatcccct caagcattaa tcatttgaat tacaaacaat ccaattacac 19201 actttaagtt attttaaaat gtacaactaa gttattgttg actatagtca ctctgttgtc 19261 ttatcaaata gtaggacttt ttcattcttt ctattttttt tgcacccact aaacatcccc 19321 tactcccccc gatccctgta ctaccctttc cagcctctgg taaccatcct tttacgctcc 19381 atgtccatga gttcaattgt tttgatgttt agatcccaca aataagtgag aacatgcaat 19441 gtttgtcttt ctgtgcctgg ctaatttcat ttaacataat gatctccagt tccatccatg 19501 tctttgcaaa tgactggatc tcattctttt tatggctgaa tagtactcca ttgtgtatat 19561 gtaccacatt ttctttatcc attcatctgt taatgaacac ataggttgct ttcaaatctt 19621 agttactgaa aacagtgctg caacaaacat aggagtatag atatctcttt gatatactga 19681 tttcctttca tttgcttata tatgcagcag tggggttgct ggatcatatg gtagctcaat 19741 ttttagtttt ttgaggaaac ttcaaactat tctccatagt ggttgtacca atttacattc 19801 ccacatcaac agtgtacaag gattccctta tctacacatc cttgcgagca tttgttattg 19861 cctgtctttt ggctctaagc cattttcact gaggtgagat gatatcttat tgtagttttt 19921 atttgcattt ctctgatgat cagtgatgtt gagcactttt tcatatgcct gtttgccatc 19981 tgcatgtctt ctttcgagaa attgttcaaa cttttttgcc tatttttgat tggattaata 20041 tattttttac tatagagttg tttgagctcc atatatattc tggttattaa tcctttgtca 20101 gatgggtagt ttgcaaatat ttcctcccat tctatttgtt gtctcttcac tttgtttatt 20161 gtatcctttg ctgtgcagaa ggccttttaa cttgatgtga tcccatttgt ccatttttgt 20221 tttggttgcc tatgcctgtg ggtatctctc aagaaatttt tccccagacc aatgtcctgg 20281 agagtttccc caatgttttc ttggagtagt ttcatagatt gaagtcttag atttaaatct 20341 ttaatccatt ttgatttgat ttttgtatat ggagagagat aggggtctag ttttattctt 20401 ctgtacatgg atatccagtt ttccacacat catttactga agagactgtc tttttcccag 20461 tgtatgttct tggtacctct gtcaaaaatg aaatgagttc actgcaggtg catgaattta 20521 tttctgggtt ctctgttttt tcccattggt ctatgtgtct cttttgatga aagtactgtg 20581 ctgttttggt tactctagct ctgtagtatg atttgaagta aggcaatgtg attcctccag 20641 tttttttctt ttttcttttg gctattctgg gcctttcgtg gtttcacata aattttagga 20701 tttttttttt ctatttctgt gaagaatgtc atcggtattt tgataggaat tgcatggaat 20761 ctatagactg cttttggtag tatgaacatt ttaataatat tgattcttcc aatccattaa 20821 tatggaatat ttttccattt ttttggtgtc ctcatgaatt tctttcattg atgtcttaca 20881 gttttcatta tagagatctt tcacttcttt gattaattcc tagctattta attttatgtg 20941 tggctattgt aaataggatt atttttaaat ttatttttca tattgttcat tgttggtata 21001 tacaaatgtt actgattttt gtacattgat tttgtatcct gcaacttcat tgaatttatc 21061 agttctaata gttttctgtg gagtatttaa gtttttccaa atataagagc atatcatttg 21121 taaacaaaga taattcttcc cttccaattt ggatggccct taatatcttt ctcttgtctg 21181 attgctctag gtaggacttc caggactgtg ttgaattaac agtggtgaca gtgagcatcc 21241 ttgttgcatt ccagactaga ggaaaggctt tcagtttttc cccattcagt atgatactac 21301 tagctgtggg tctgtcatat atggctttta ttattttgag gcattttcca tctatttttt 21361 gagggttttt atcacaaagg gatgctgaat ttttatcaaa tgctttttca gcatatattg 21421 aaataatcgt atgtttctta cccttcatct gttgatatga tgtatcacat tgattgattt 21481 gcatatgttg aactatcctt gtatcccagg gataagtttc acttggtgat gatatatgat 21541 ctttctaatg tattgttgaa tttggtttgc tagtattttg tgcagtctgg ataggccaat 21601 aatcccaaat catcaagtcc tggttccttt tttgcttagc agtttttccc acttatcttt 21661 tcctcttgaa ttttactata accagaaaaa agaaatgagg ccgcagcttc gacacatttc 21721 ttagaaattt cctcagctaa atatctgagt tcatcattca caagctttgt tttccacata 21781 actgcaggac accattcagc taagttctct gtcctgcata acaaggatcc ccctttcttc 21841 ttttcccagt agcatgctcc tcatttccac tcaagtcctc accagtagtg ctttgaacat 21901 acatatttct acgaatagtc tgttcatgat aatttaggta ttctttaaga tgatgtagat 21961 tttctctacc atggaactct cttccttcca attcctcagg agcagaatca ttaacacacg 22021 tatttctatt aacagtctct ttgaggaaat acaggctttt tctagcatgc ttttcaaatt 22081 tttttcggtt ctaactattc atcaattgca aagccacatc cacatgttta ggtatttgtt 22141 gcagcagcac cacacttcca ggtaccaaaa cctgtattta tttattatcc ttgctgtaac 22201 aaattaccac aaacttagtg gcctaaaaca acataaacgt actatgttac agttctggag 22261 ttcacacgta tgaaataaat ctctctgggc taaaatcaaa gtgttggcag ggctgagttc 22321 cttctggagg ctctagggaa gaatctgatt tcttgccttt cctagcttct agaggccacc 22381 tgcgttcctt ggccccctac tccacttata agtctagcaa tggcactact ctgacctctg 22441 cctccattgt catacctccc tttatcaatc tgcctctctc ttccatcttt taaggatact 22501 tattatcaca cagggaccat tcgaatagtc cagaacactc cattttaaga ttcttaacat 22561 ctgcaaaata aggtaacata ttgacagatt ttggtgatta aaacaagaac ctctgtggga 22621 gtgttattct gcttaccaca cgcatttggc ataaaaaaac tcttatttgg ttaaaagaaa 22681 ctctctttta tattgctgct tctcttccta tttctttcta ctgccctaat tcccttctca 22741 acaaatggtt tgcatataat taaataggta atatatgtaa agcatatatt tttatagttg 22801 gaaattgttt tcctccctta tgtatcccaa gtaactagaa gtgtgcctgg cacttgttag 22861 caatcagtaa gtaattgttt aatgaaagaa taaatattca actaatcatt agttacttct 22921 ataagtaatt aaccctttct gttcatcgta tttatacata tgcatgttct ttatctatta 22981 atagctgcta cttcccagaa cttattggga gaagacacct atgtcttggt tttatatgct 23041 tttctgaata aagtaaactt tacattttgt cttatcagtg ggcatcaccc tttgaaagca 23101 tttttgaagg actatggtac tttgactatt ggagcctaag aaagatgaga atataatgtt 23161 agctttatat tatcaagtaa ggttattcta ttattcagaa gtcactcaag tttcctctca 23221 cctttattct acttcctcat taacaagtca tcggtttgat acattaatca tggcaaaaaa 23281 atcacagagg aagcactaat ctgtcatttt tttctgtgac ctgcagactc tttgacaccc 23341 ggtacagcat ccgggagaat gggcagctcc tcaccatcct gagtgtggaa gacagtgatg 23401 atggcattta ctgctgcacg gccaacaatg gtgtgggagg agctgtggag agttgtggag 23461 ccctgcaagt gaagatgagt gagtgggaaa cagattcgtc tattgatttg aaagttgact 23521 tggtacactt agttttgtat ttatttttta catttttttt ttgagacaga gtctcactct 23581 gttgctcagg ctggagtgca gtggcatgat ctcggttcac tgcaacctcc acctcctggg 23641 ttcaagtgat tctcctgcct caggctcctg agtagctggg actacaggtg cgtgccacca 23701 agctcagcta atttttctat tttcagaata tacagggttt cactatgttg gacaggctgg 23761 tctcgaactc ctgacctctg gtgatccgcc caccttggca tcctgaagtg ctggaattac 23821 aggcgtgagc cactgtgccc ccgctgactt ggtacacttt aaaacagtca gtaaatagag 23881 attttctcag gcctggtgat tcagcactga gacaagttca agttcaagca caaccctgag 23941 gccaattaat cccacacctc ttatgcctgc tatcaaccac taccctaagg caagcctctc 24001 aattctctat cctctcccat tttcttacct tcactcatct cctgacttct tccaccctga 24061 attctttcac caggaaaact tcctctgaaa catttaccct acacctgtga aacacaacca 24121 aacacacttt ttatttctaa cctctttgca gacacttttg ccttatttca aatttgatat 24181 tcttctgagt gattttctgc ttcagtggaa gctgttctat tttctccact tcatgtctac 24241 aagactgcca aacactagta ggtaatctcc cagccctcag tgttgctttt aaaccattct 24301 attttgtatt cctatacaaa atctttcctc tgatgagggc ttatgccatt ctgacctatc 24361 ttttctctaa ctgtattcat catgtcatct gctcttctag gcacttcccc atatttatta 24421 aaaactttga ttccaggctt actatctttc tatccatctc tactcctgca attaccctaa 24481 gaaattttaa cagccatgaa atagaaccac tagccactta attctcataa ttccttgacc 24541 tgcagaaatc cagtgatgtt tgtctttttt tttcaatttt aaggctcata cttttaatct 24601 ctatgtacac acgtatgtag tcgttaaggt aagtctgcca ctgtgaggaa aggtagtttc 24661 attttatttt tttaactttc attttgagtt caggggtaca tctgcagaat gtgcagttgt 24721 tttacatagg taaacatgtg ccatggtggt atactgcaca gatcatccca tcacctaggt 24781 attaagccta gcatccattc tattcttctt gatgttctcc ctccccacac caacaccccc 24841 gacaggcccc gtgtgtgctg tttcccccca tgtgttcatg tgttcccatc gttagctccc 24901 acttctaagt gagaacatgc agtgtttggt tatctgttcc tgcattagtt tactgaggat 24961 aatggcttcc aactccatcc atgtccctgc aaaggacatg atttcattcc attttatggc 25021 tctgtagtat tccatggtgt ttaggtacca cattttcttt atccagtcca tcattaatgg 25081 gcatttaggt tgtttgtgtt aactgtttta ttgttttttt gttatatata tttatatata 25141 aatatatgta aacatatatt taaatataaa tacatacata tatttaaata tatacaaata 25201 tatacttaaa tatataaaaa catatttaaa tataaatacg tataactata tatttaaata 25261 tataaatata tagctatagt tatatatagt tatatattta catttaaata tatagtttta 25321 taatttattt atataaacta cataaataaa ctatatattt atataaaata taaataaact 25381 atatatttat ataaatatat catatatata ttcatatttt atataatata taatatataa 25441 atatataaat atataaacta tatatttata tattgtatag ttatatttat atataaatat 25501 atagctatat atttatattt aaatatatat taaatatata tttaaatata aatatataaa 25561 tatatataaa tacatattta tatatatgta aaaaatataa aaatatgtga aaaatacata 25621 tttatatata atatatgtaa aaaatattaa aatatgtaaa aaatacatat ttatatatat 25681 gtaaaaaata taaaaatatg taaaaaatac atatttatat ataaatatat acaactatat 25741 ataaatatat agttatatat atttatatat tatatatatt tatatatttt ttactacata 25801 atatataaca tattatatat tttagtatat atattatata ttagtatata ttagtaatat 25861 accatataat atacatagta tattatatat aactatatat agttatatat aaatatataa 25921 ctatatatgt tatatatagt ttatatataa tattatatat tatatataaa ctatatatat 25981 cacatatagt ttatatattt tttaatatat aatatataac tatatattta aatatataaa 26041 tatgtaacta tatatttata tataactata tatttaaata taaatatata tttaaatata 26101 aattatataa atatacataa aaatacatat ttaaatataa tatataaata tatatttaaa 26161 tataaatata tatttatata ttatattata aatattataa ttatatatta tatattataa 26221 atatataata tatattatat attaatataa gtataaatat ataaatatat attatgtaag 26281 tataaatata taaatatata ttatataagt ataaatatag aaatatatat tatataagta 26341 taaatataga aatatatatt taagtataaa tatataaata tataaatata tatttaagta 26401 tatataaata tatataaata tatatttaag tataaatata tatttaagta tatataaata 26461 tatataaata tatatttaag tacaaatata taaatatata taaatatata tttaagtata 26521 aatatagaaa tatatattta aatataagta tatatatatt taaatataag tatatacata 26581 aatatatata tttaaatata agtatataca taaatatata tatttaaata taaatatata 26641 tttcaatata agtatatata aatatatatt taaatataag tatatatata aatatatatt 26701 taaatataag tatatatata aatatatatt taaatataag tatatatata aatatatatt 26761 taaatataag tatatatata aatatatata tttaaatata agtatatata taaatatata 26821 tatttaaata taagtatata tataaatata tatatttaaa tataagtata tatataaata 26881 tatatattta aatataagta tatatataaa tatatatatt taaatataag tatatatata 26941 aatatatata tttaaatata agtatatata taaatatata tatttaaata taagtatata 27001 tataaatata tatatttaaa tataagtata tatataaata tatataaata taagtatata 27061 tataaatata tatatttaaa taaatatata tatatttttt gagacggagt ctcgctcagg 27121 ctggagtgca gtggcatgat catggctcac tgcaacctct gcctcctgag ttcaagcaat 27181 tctcctgcct cagcctccca agtagctgag attacaggca tgtgccaccg gaccctgcta 27241 atttttgtat ttttggtaga gtcagagttt cgccaagttg gccaggccag tctcaaactc 27301 ctaaccttga gtaatctgcc cactttggcc tcccaaagtt ctgggattac aggcatgagc 27361 ctgtttgtgt taactcttta tcagcgtagc caatcgatga ctcactcttg gccttgtcac 27421 ccactggaag tagtctgcat ttaaaatctt cagcttcagt atgtcactct catcatggac 27481 attttttggt acagccttgt cagatgagca aaacagtttc ccatactcat gatttgcctc 27541 caagtagagt ttgtgggcac aaacttccat tgtctccttc tcagctaaca acagtgtctc 27601 agtctctctc attctcctac tcttgctata caacctcaac atcaccagca tcatcatgtt 27661 ctcttacctt gattcgtctc tgttctcctt tccattgatt ccccaatggg gcttttattt 27721 ccttccatac ttagttcttt cttctacctg gtgatgtatc atcaaacact gccttaccag 27781 catctttaaa tctcatggcc tcctgtcctg taagcatctg ctacttgcaa actgtcaatc 27841 ttacaatgat gtaaccttca tcttctcttc tctgacatgc ttataaccat acatacgggc 27901 accacacaaa ttagaggaat ttaggtctac ttgggacatt tatttttagt ttttgtgttg 27961 ttgtctttcc tcattatttc ttatcttttg ttattttgct ggaggaaatc attaggtact 28021 tttttcagag tgtgaagatg taaaatattt cctgaatttg tgcacgattg gaagtcttca 28081 ttttgctcgc attgttggat aataattttg ctgcatgcag aatgagagtt ttaaaatccc 28141 ttttctttag ttttagtaga tatcctctgt tgcagatgag aagtcttttt cttatttctt 28201 tacaagtaaa tctgatgtct ctcttaaaaa gtttaggatt tttctttttt ttctagagtt 28261 cataaatttc acaaattgac aagaatatat taggtgtatt tttaagaatt attgctactc 28321 agttttaggt gggccttgtt tttttgtttg tttggttggt tggtttttgt tttgttttgg 28381 tttttttgag acaagatctc actctgtaac tcaggctgta gtgcagttgt gtgaccatgg 28441 ctcactgcag ccttgactgc ttgggctaaa gcaatcctcc tgcttcagcc tcccaagtag 28501 ctaggactac aggcatgagc caccatacca ggctactttt atttatttat ttactttttt 28561 ttggtagaga taagttctca gtgtgttgca catactgagt cttgaagtcc tgtgctcaag 28621 tgatcctccc accttggcct tccaaagtat cgagattata ggagtgagcc actgcaccca 28681 gcctaggtgg gcctttttga tctaaagacc aaagcttttt agaaaggtac attttctcta 28741 ttttttttct tttttctttc tctatgactt caaatttttc ttctcatatt ttctgcatgt 28801 cttaatattc tactctcttg aagattcctt ttactttttc ttcatattat gaatgtggtc 28861 tccagtatga ctattctgtc attctgagtg ttttggtctt aaaaactata tttttaattt 28921 ctaagaattt ccttgatgtc tctgttgtca taacaaactc acttgtatga tacaatattc 28981 acttaagctt ctaaggatat cactagtgca tcttttaaaa agacattttc ttttttcccc 29041 tgcattactt ttatttcctt cagaaaaaaa aaaattgatt ttgtttgggt tccatccttt 29101 tatgtttaca atttttctca aattgatctt ttattttttg atcataataa atatacatgg 29161 agtgttcagt taattaggat aaaaagctgg tgggaatagc atgactttat ggaatactga 29221 tttggtactt actgtgagta agtaggtggg gatctgccta tatgcaggct tcccttcagt 29281 atgcagagaa gtaagaaatc aaataaggaa gttggaatgc tctcatttgc taaataatga 29341 agacttcatt ctgaggatga aacacattca agtatttcct tactttgtga cactaccttt 29401 cttttgaata tttttgcata ttctctctgg cccaattgtt cttgatttgg gttctatact 29461 aaatcccctt ttcttttctt gccttctttt ttccaacctc tcctttggag atctcatcca 29521 ttcatgtgga tatacaccgg tgtggccatt ccaattgcta aaattttgga atgcttccat 29581 acttcttgga aagatccgtt ttataaggct cccgagatcc cccaacccct atcactactc 29641 cagctctctt aagccctccc ccaagagctc cctcccctaa attcctaatg gtccatcagc 29701 taaagtctca atgctggcac agcgggatac ttccagcatc ctgctttaag gtgaccagtt 29761 ctgattggtc agtacttatg actccaccct gaatcatgtt cccttacagt ggggatccat 29821 ggctatgcgt caatacccta gtcattccta gttgacttta cattcaattt cccaaaaggg 29881 aattcctcac ccctcaccta acagatgacc aagacatcaa gtcactgaga agataggaga 29941 tttttgcttt aagcaaaggt ctttacctaa gacattatct gtgcctcagc tttaccatag 30001 agatcttgtt cagggaacct atggaaggca tagataacac tttatttgac tgtcatagga 30061 atatcaagtg ctcagctaag tttttcccag caactgtatg acaatacaac tcacaattga 30121 ggaacctggc cagtactgta tttacatgta ggtatttaca gtttattaga aggagagttg 30181 tatgctatag atagcaggca aagtaataaa gttgttattt tcctatattt taaagccttt 30241 cttgtatttt tgctataaca cagggccgca ggaactctaa atgacagtga atgcttagat 30301 taaaaaccaa caggtctcac gcctgtaatc ccggcacttt gggaggccga ggcgggcaga 30361 acacgaggtc aggagatcaa gatcatcctg acaacagggt gaaaccccgt ctccactaaa 30421 aatacaaaaa aaaaaaaaaa aaaaaattag ccgggtgtgg tggtgggcgc ctgtagtccc 30481 agctactcgg gaagctgagg caggacaatg gcatgaaccc gggaggcgga acttgcagtg 30541 ggccgagatc gcgccactgc actccagcct gggcgacaga gcgagactcc gtctcaaaaa 30601 aaaaaaaaaa aaaaaacaaa aaaacaaaac ccaacaggtc atgaaggctt tgcaagtatc 30661 tcttaccacc aacaacacca aagcccccat tcctctccct cacattgaag tagaagaaaa 30721 caaagtccat atttcatgcg ttcctttgtc aaaataacaa attggttacg gcacatgtcc 30781 tgcaagaaat aaaatgtgtc cattgctcag tagtctctct tgcgaagtcc ccctctgtat 30841 ctgtaacgta aaattcctaa ggacataaat gtagttttaa ctattttacg aatagtacta 30901 aaataactgg catcctgaac ttatcaattc ttttgtatat tagatttaat aactttcttt 30961 gaaagtttca tatttgagaa taaaaattaa ctggcataaa ctatttcttc tgaaagatta 31021 aaagtgtttg aacagtaaat tacatgtttg agtcccccca aattgtatga cagaatttct 31081 tctgattgtt aatataataa tatctggttt actttctaga gaatgaatgt atttaattaa 31141 taatcataaa atttaatagt caaattaaga tggaagctaa agggaaaata ggtcataatt 31201 tctaactagg taagaatata gttatatcaa aattttcttt tcaaatgttt tatgtctatc 31261 agtatgaatt aaataatgtt gaattgctat ggtgacagtc tatgttaatc agcttttatt 31321 aactatcttt taaaatgaag aatgctatgg taacttcaca ctgttaatat ttttcataaa 31381 tttgtgtttt gctagtaaga ttctaataaa gcagagacaa ccaagtgttt ctaaactgat 31441 ttctgtttga gatctactga ggaaaactgt ctttgcattt ggtgaatttt gtaatgtaac 31501 atgcctcaaa tgattctcaa aacagatgtt tagaattaaa ttgaaagtta gaaactctag 31561 gtttaataaa gccatattgc cttatttatt ttgaattttc atttcttttt agaacctaaa 31621 ataactcgtc ctcccataaa tgtgaaaata atagagggat taaaagcagt cctaccatgt 31681 actacaatgg gtaatcccaa accatcagtg tcttggataa agggagacag ccctctcagg 31741 gtaagtggtt atgatgttaa aacacatata taaaatgtat tttaaaatat aacatttctt 31801 tacacactca gttacacact tacaaacttc tagtataaag tagtttccat gtacatttta 31861 accaaatgta aatatttctg tttgcatata tgcaaactgc atggcatttc atttgggtct 31921 ggctagggaa aaaagagatg ggaaccaata atgttaaaga tagaaaagga ggcaatgaaa 31981 aagcaaacct ggaatccttt gtatttgttg gctggctaaa tcatttattt ttttttaatg 32041 ttgaatctga gacttagggg atgaaaaaga aaaactaaaa cccaggcttt agaactgaca 32101 gtttctggaa ggagggaggg agacaaggtt cggaagaaaa gaaatgagat ctctggagag 32161 aagttaggcg aaaagactca agactcatac acaaatacct tggcaaatcc ctcctgagtc 32221 atgaagagta gtcacgcctg taattccagc acttcaggat gccaaggcct gaggtcagaa 32281 gttcaagacc agcctggcca acatggcgaa atcctgtctc tactaaaaat acaaaaatta 32341 gctgggtgtg gtggtgtgtg cctataatcc cagctactca ggaggctgag gcaggagaat 32401 aacttgaacc cgagaggcag aggttgcaag tgagccaaga tctcaccact gcactccagc 32461 ctgggcaaca gaatgagact ccatctcaaa aaaaaaaaaa gttattatcc atatgcttat 32521 tttgtactgc ctctgtatct tatccccaca tttattgata aattattatg aggcatcatt 32581 attgtctttc catctttata tcacctaaaa gattacagac tatgtttttc atttaacaat 32641 gcatagtata ttttaagagg aatacaaagg tgtcacttta tgtcaattaa ctgaactaag 32701 gtataaaatt gctcagcttt gctttattta aaataaaata aatattgcta atttttaatg 32761 attaattatc tggctttcct cttgttataa atcttggtgc atttcctaca atgacaaaca 32821 agggtggttg tacttatgtt actgaattta gggttcaaaa cagaaaagac agatgtaata 32881 tttaaactcc aaagagtaat tttaatatta tgtgtgaaat tttctagtat ttcaaaggac 32941 atgtactctt ctaaagatac catctagggt gcaaggtaaa cctgatagtt aaaagcaatg 33001 tgtttattta ttcatatttc aatagctttt ggggtactag tggtttttgg ttgcaaggat 33061 gaactgtata gtggccaagt ctgagatttt agcgtgccta ttacctgagt gctgtacatt 33121 atacccagta tatagttttg tatgtctcac caccccactc tgcaacattt cccccttcta 33181 aaagcaatgc ttttaatcag atttagctgt gactttgggg aagcaaaata agcccatata 33241 catatatata ttatacatat acatattata tatataatat atatatacac acactcatgg 33301 gatgaaagaa aataaaaata aactatacct cataggaccc tggtgaagat taatttaggt 33361 actcttgcac tatttcattt aatattgtat gttttacata ataagtggcc aataaaggtc 33421 aaagcgatat ctttgatgat gataatagtg atgacaataa gttgatgata tttggcaaat 33481 gtatccttga tagacccata aacatttttg aattcacgtc cctatctctg gcaggaaaat 33541 tcccgaattg cagttcttga atctgggagc ttgaggattc ataacgtaca aaaggaagat 33601 gcaggacagt atcgatgtgt ggcaaaaaac agcctcggga cagcatattc caaagtggtg 33661 aagctggaag ttgagggtaa ggagctgcat ttcttcccct gactgtgtga ccaggggcct 33721 cactgtctac tgtgaaggct gcacctgggc ttgggagaga agagatgtgg gcagcccact 33781 tccctcagtt gttccagata ttaggccata agttcaagcg tatgataaca gaaaaggaaa 33841 actgaaaaaa gaaagaaatt ttcactagta taaaaggtca tattccattg attactcaca 33901 atcactggta atttttacca aaacagacta aatttactgt aacagtaaaa taatagaaac 33961 ccattttaga atgccttcct ggtttggaca attcttccct catttaaaga cttgggcata 34021 ataattttaa tctttttaat catacagaac aactttaaaa agatgtgata aggaggaaaa 34081 agtagctatt ttcagatagt gttctatcac aaagcttgaa aaaaaaaaca ttaactcaaa 34141 tcgtaaagcc aaaaataatc ccagttctgt gagttatgtt atcaaaatcg tttttctttt 34201 ctttctgaaa atatttttta atcagctaat tcaataactt ggtgtgaaag gtcttcactg 34261 agaaatcaga atccaaatag gtctaggtgt tctatttgct tgttagtcgg gtccttcttg 34321 acctaaaatt gcaccacatt ttgcttaaaa agaactatca gcacacctct attaggcgaa 34381 taaactgagt acaaaccctt cctagctctt cctgttgtat gccagagaat taacattttt 34441 ggctcctagc tttctcacct gttaagtggg gtttgctcta tttaatgaag ttaggtgttg 34501 atagtgttta gcagagcatc tggtcctttg tgcaccctca ataaatgttg gctataagaa 34561 ttatcatcta tttttctgct tttctcttat ctgattgata agtgttagag tatcacatac 34621 tggcacaaat tacagttcaa tcaggaaaag acttgaagag ttctccatat tttactttga 34681 ttctgtccta ctttccttag gccaaaatct atctttttct gcatatttcc ttctcattca 34741 tatagttttc tattaactcc tttaagatta tttttatttc cttgatggac attcctgtca 34801 cagctttaat gatctcgttt cccacgtttg cctccaattg aggtaacatc tttattatgt 34861 cattgtacca attgctcata aaattttcat taattcctca tggaaaataa tgaggttggt 34921 gggaatagtg gctgtcagaa tataaaaata cattttcatc aagttgctgt aatttaatat 34981 cttctaaata atcagtgcta tttgaagctc cgtattcaac aaccagttga tatgatttat 35041 tcagtaaaaa ctaaataaac ctacaaaccc acccagacac acattcagac tcactgaata 35101 tctgtctgcc tagatccagt gttttcttgt tctgtctaag gaatgatgca gaattaatgc 35161 tatccatttg tataaaatat cacaaagagt ttttctcttt aagatattaa aaataagctt 35221 tctgtattat aatatttaat actgatcatt taggtcacta gcttcataga tattaaaaca 35281 acttgcttta cctttgacct agagaaaatt atcaccgaac tccattagtt ggagttatta 35341 tacagtttgg ttttgtgtta ccatttaatt ttgtatcatg cctgtcagta acattgaata 35401 ctgcctcttt tctcgtaacc tttaaatggt catgcttagt gctttaaaag ttaatatatg 35461 ctagagatag tattaaattt gctagaactg agagctcata atatcattta aagttattct 35521 aactgtaggt aagatgattt tcgcacacat ttagcacaca tgcctatttc taccctcatc 35581 ttagtcccta ttaaaatagc caaaatatgt gacatgctta gcacaattgc tggtacataa 35641 taagcattta ataaatggaa tctactatac ttattatgat taaaacataa aattgtaaca 35701 aatttgcttt ggctctggaa gctctgaaag gttgacttcc acttgaataa atagttgagg 35761 tattttcata agatataatg tagacgtgac ctatttagag gtaaggctaa ctcaacctac 35821 aactcagaac aagttttttt ttaaaaaaaa gcaactgaga aatgactgga aaaacctcaa 35881 aagtacatgc agatgcctgc tagtttggca atgatgagga ctgaagatga tgaggcaggg 35941 ccatcgtcag ttggggcaga cgagcatatg tatgtatcaa gtcgtaactc tgcaaattag 36001 ttatgcagtg actatatcga atcagaactc tatggtgcca tttgatgctg ggctacatgt 36061 aacacagatg ggcatacagg aaaagataga gttttgtcat tgatagcctc taataaagat 36121 aaacatgcca ggccatggat tgggtaccat gtgttaacta aatctttgtt gttacaactg 36181 tgaaagaaac accctaccac acagaagtaa agctcccttt ccagattgcc attctcagac 36241 tgctggacct ctgcaatgga aatgtaaagg tatcctatac tttggtcttg ccttaaaatg 36301 ttcaaacggt gacatacata attattgatg gaaccatcta actcaagcgt ggtgcagcat 36361 ggatgtcttt ctgaaaggat gtccaatggg aaggctaaca ttttaaaaag ttccattgag 36421 gctaaatgtt ttatgtggat tatcttgttt aattctcact aaaagtctgt aacaagggcc 36481 ctatattctg ccattttagg aaacagagga atagagagga tagctaactt acacaaggct 36541 gcacagatag ctgtgtctaa gaatttgagt caggctgaat actgtctgtt ctattaaaga 36601 atgagatagt cctgtgtgac attgtcaaga gaagtatcta gatgaaaatg aggggaaaac 36661 cagaattctg caaatgaagg agaggatggg agctgaaaaa aaatagacag gaggtattga 36721 caaatttttt gataaatttt tcagagaaaa gggaggagtc aaaaaaggaa gcagtagctg 36781 gagctatgtt tggtgtgtag atcacgttgc attgcaagat ttctcttcga aaaatattga 36841 aatgtaaaaa aatttaaatg ttaaaatatt aatgacactg agctcagaga gaagaaaaat 36901 ttgaacatac ataagagaac aaaatactca atgaaatgtg gtgctggata atgcacaagg 36961 gttgtatttg ggggccaagt agaatgataa actgtataca gagggtgacc acatgttctg 37021 gttttcccag gacagttctg gtttacacct gttgtcctgg aatcattatt aatagagtct 37081 ctcttttact ttcagaagta tccaagcttc cacgataaat tatatggtta ctctccttag 37141 acaggaagac agaatgtcct tgtaatagga agaaaagaga agagggaagt tttcagtata 37201 aatcagttca taagtatgat ggatggaatt tgagaaaatt ctgttcttat ggtctctatt 37261 tcctctagga aggagaaatt agggttatct tttgaaaaca cttttgttaa agggtcaggg 37321 aagggggtga ggatgaagtg agttctaaaa tagctgtgga atgggagaga tgactcacaa 37381 agtaaaccag gattgtaggg cagcattaaa gttttagtag agagcaggac cgtgaatatg 37441 gagtagcatc aatccacatg gttgcagggt ttttccctcc agtgttgctc tgctgtacag 37501 gtgtaagttc agaaaatagc agaaagctaa attcaaaggc aagacataaa tgttggagtt 37561 ttgtcaggaa ggaaaatagg gcaaaggatt tgagactatt gcaaaagaga gattgaagca 37621 tgaatcatgg aatctttagg taccaaatac acctataatt tctctttctt ttcttttctt 37681 tctttccgtc tttcttgttt gtttgttttg ttttgtgaca aagtctcact ctgttgctca 37741 ggctggagtg caatggcaca atcatagctt actatagcct caaactccta ggcttaagtg 37801 attctcccac ctcagcttct tgattagctg gggctacagg tgtgcactac tgtgctcagc 37861 tatttatttt atttatttta ttttattttt tttactttac tttattttat tttattttat 37921 tttattttat tttattttat tttattttat tttattttat tttattttat tttattttat 37981 tttattttat tttattttat tttattttat tttattttat tttattttat tttattttat 38041 tttattttat tttattttat tttattttat tttattttat tttattttat tttattttat 38101 tttattttat tttattttat tttattttat tttatttcat agagacaggg tcttgctatg 38161 ttgcccaggc tggtctcaaa ctcctcaagc aatcctccag ccttgacctc ccaaaatgtt 38221 gggattatag gcatgagcta ccatgcccag ccatacctat gatttaatat ccaaatatga 38281 aatatcctcg gatatgagcc taggattaaa cactatagct ccagcaatat aacagacaag 38341 ataatatgaa aatcttccaa ctagcccgga aatgctgggc tagttgtata actgataaga 38401 ataaaatata aatctctgga agctcaaaat ggacaggaac tgcaaaaacc ataagctcaa 38461 tgagctggtt tcttattgtt ctaaaggtaa tgggacaggt gctcatctcc ataacctagg 38521 agattggttt taagaccctt aaaggggcag gagacagggt cttggcccat gtgaaatgga 38581 ggttagcatt caaaaccttg tataaagctg agaaccacaa aagtagaaag atgggccaga 38641 aattccatct tcaggcacaa aaacacaaca caatggcttg tctgtcttta gtcgtgaggg 38701 agaaaaaacc aggtcatctt aggagtgaat attcaacact caggactata gcttccatag 38761 gcttgatatt gacttaatac catcagcaca gtctgggaat tctcagctgg aaaaatgaac 38821 atacaaactg gtttcaggct gggcacagtg gctcacccct gtaatcccag cacattggga 38881 ggctgatggc ttgagcactg gagaccaacc tgggcgacat ggcaaaactc catctctaca 38941 aaaaatataa aaattagcca ggtgtggtgg tacatgcctc tagtctcaac tatttgggag 39001 cctgaagtgg gaggatggct tgaacctggg aggtggaggc tgcagtaagc caagattgtg 39061 ccactgcact tcagcctggg caacagagtg agaccctgtc tcaaaataaa aaaataataa 39121 taaaaaacct acatacacat aaaacattgg ttccaggcca aaaaacccac acacacacaa 39181 aacattggtt ccaggccaaa aatttaacaa gaaaaaaaag ctaaaagaag aagcacttta 39241 cccaagttac ataggctttt catggatata cctacactga ggatgagttc acaatgcaaa 39301 attgtcacac ctacagaaaa caacctacct tgagtgagtg ttgtccaaca taatatacaa 39361 agaaaattca gttaaccaca taacatcata gaaattataa aataagtatg cttaaagtaa 39421 ttaaaaatgc aaaaggagga ataaggaaaa caaaaataca ttagggccag gcacagtgac 39481 tcacgcctgt aatcccagaa ctttgggagg ccaaggcagg cagattactt gaggtcagga 39541 gttcaagacc agcctggcca acattgtgaa accctgtctc tatacaaaaa ttagccgggc 39601 gtggtggtgc acgcctgtag ttccagctac tcagaaggct gagacaaaag gatctcttaa 39661 acccaggagg cagaggttgc agtgagccaa gattgcacca ctacactcca gcctgggcaa 39721 cagagtgaga ctttgtctaa aaaaaaaaat taaataaata aataaattag gaagacaggc 39781 ggttttgata aataattaaa cacaatttta acacataaaa atataattaa aattaaaatt 39841 caatggatga gtaatagtat attagagata aagagataat tcagccatta gaaatcagct 39901 cttcagaatt tagaattcag tgcagaaaga ttttgaaagc atagaaaaga tgaaattgaa 39961 tttaagaaat gataaaagat acattacaga aagagaaaat acagaaaata tgagaggcaa 40021 tactcaaaaa catgatgact aagaactttc cagcattgat gaaagactta aatcttcaag 40081 tacgtgaagc ataccaagtc ccaatcggta aaaatgaaga gcagagaaat aagcatttca 40141 cacccagtca aatcataagg aaacatcaaa gacaaagaga ttatcttaaa atattgaaga 40201 cagattattt ataagggaca acaattagga taacaataga gtgtggggaa actatcactt 40261 tcatctatcc ttacaatttg gtatagccgc atgaaggttt atgaaaaata aaaatcaaac 40321 tttaaaatgt atatagattt gtctcagcaa tttaacttct gacaatttat ctaaaagaat 40381 atttgcacaa gtgtatgttc aagattattt gttacaaagt tacttagtaa aaagttgtaa 40441 agaacttaaa tttgcttcaa taggacacca tctaaatatg tgatgtaatt ccatgcagcc 40501 attaaaaaga atgagatgga tttatataca ttaacttcta aaattatcta ccgtatatgt 40561 gacttgggtc tgctttccat ctctgagcct cagcttcctc ttctctaaaa tagagataaa 40621 agcagaacct acctcttagg atgcttgatt attagttatt atagacacat agtgtgtact 40681 atataattat ttgctgtttt attatttatt tcatgtattt aataagtact tgtatagtgc 40741 ttaccatgtg caaggtactg ttctaagtgc tttagaatat taattcatta tcaatataat 40801 atgttcataa gtgaaaaagt aagtaaagaa cagtatatct tattattata tattagagta 40861 catgtatatc gaactcttaa gtcatcatct ctgcatagag aattatatgg ggggtcccgg 40921 cacgatggct cacgcctata atcccagcac tttgggaggc cgaggtgggc gaatcacgag 40981 gttaggagtt tgagaccagc ctggccaaca tggtgaaacc ccatctctac taaaaataca 41041 aaaaattatc tgggcatggt ggcaggcacc tgaaattcta gctactcagg aggctgaggc 41101 aggaaaatca cttgaaccca ggaggcagag gttgcagtga gcagagattg tgccactgca 41161 ctccagccca ggcaacagtg caagattcca tctcaaaaaa aaaaaaaaga aagaaagaaa 41221 attatatggg gggtaacttc tattttatac tttatgtagg cctatacttt ttgcatcttt 41281 ataaagagaa ctttataatt aggaagaatt aatacatgta tttatgcttt ggaaaaaaaa 41341 cacttcttcc aaatattata ctatttttga taaagtaaca tgaatctttc tgttcattag 41401 tttgatattt ttgcagttct gttgctccat tgatctccaa gacaaactca gggatgggaa 41461 aagttttgtc aaaggtaatt gattcctatg ttgcttaggt tttcacaact cttggatatt 41521 ggctgaagaa ttttgaaggt ggaggttctg atgaacagga catagaacat gccatttctt 41581 tagggaagga atcaatccat aaagctgcta agcttgagac ctacaagagg aagctggcag 41641 agtcacctag atggaggaag tgaagggggt cagagaacag cagctgctgc tgaagtctcc 41701 actcatctga ctcttctttt ctatgtatag atggaaatct gaaatttatg attttatagt 41761 ctggaatagt ttgcaggatc cagcacaaaa gttttgttag ggttctgatt tctcagtgaa 41821 cattttccac actttgttgg gtgttactga cttacagcat aaagggaaaa gtaaaacaaa 41881 gggaagttcc tataggaaag ggaagcaccg ctaggtaaga actatttagg tatactgatt 41941 tgacattgac agggaagcct cagtcatctg ggaggcagaa gaaagttttc agtctcacaa 42001 ctgtggaggc tcttctggaa aggttaagcc ctgtctcagg cccccatgtg ccaaagggct 42061 ctaggagagg attcacggca ggatgtgacc agggaacatc ttattgtctg atgtcaccag 42121 agaaatctac atatcatatt tcatacattc taagatgctc attatttcat attttggcat 42181 atctgggtta catctcatca ttaatccctt acaatcacaa ttgaataaat tttagtttct 42241 ttgttgcaca ttttaatatc tctgaaattg agatttttct tacaggtgct aaaggcattc 42301 acacccagtt tgtggcttct gccctccagc taagatcgtt ccttagctgt ccccaaatat 42361 gagaatgaat atacaatgat aaaacaaaaa taaatcaacc atattggctc ataaagcttt 42421 ctttattttt aactagaaat tttccttctg cttgagatca tttcatttgt tcctcacaga 42481 aatgaaagca ttattttcag tgagatgatg ccacctagcc tttttccctc aaaacctttt 42541 atttgctgcc tattcatttt attaggttga aatagagact aagtggcttt tcagggccat 42601 atagaggaaa ttatctttta agagacaatt ttgtctgctt ctctaatcca cttcacattc 42661 tactttaggt atggtgtgta gccaaagagt gatctatgtt gtttttctta tatatctgaa 42721 accattttct cctgagtacc tctaaaggac aggaagacag atactcaggg gcagagggat 42781 atggcagtgg aacatgctga tttgaatggc agggctggaa ttttcagtga gggtttgcta 42841 tcatgattgc ttgggacaac ttttgaaatt ctgattttat ttccctgttt tgaccagtgg 42901 catatgcccc ctttaaaacg ctagaccaga gggccaacca tagtggctca cacctgtcat 42961 ctcggcactt tgggaggtcg aggcaggcgg atcacttgag gtcaggagtt agagaccagc 43021 ctgggcaaca tggtgaagcc acgtctctac taaaaataca aaaattagcc gggcatggtg 43081 gtgcacacct gtaatcccag ctactcagga ggctgaggca ggagaactgc ttgagcctgg 43141 gaggtggagg ttgcagtgag ctgagatgga gccactgaac tccagcctgg gcaacagatt 43201 gagaccctgt ctcaaaaaaa tagagagaga gagagagaaa caaataaaga gagagagaga 43261 gagagaatta actcctctga ccagtgcagg ggctcatgcc tgtaatccca atacattgga 43321 aggccaaggt aggtgaacct cttgaatcca ggagttcgag acaagcctgg gtgacatggc 43381 aaaaacctca tctctacact gaagtaaaat aaagtaaaat aaaaataaaa taccagacca 43441 tacaaatcaa atcttttaag gtgataacat aattactgtt ttttatagct ggggggtgtc 43501 tttgttataa gattttttaa acattgcaaa agactcattt aaaatttata aatatctaat 43561 tttctttttt cccctcacat tctctgcctt aactaagatt ttttaaaatg cacttattta 43621 tttgaggctg aatgtggctc ttactacatt ctgtgaatat cacattcaga tgaatactgc 43681 tttgtatata gaaactggct gaatgtagtg tacttgagac ccaaattaaa atagatggat 43741 gctggagtgt atcaagctct tgttaattgc attttctatt attatcttgt ttacccttga 43801 agctttaagc cattaaggaa aatattgggc agaagctgga atcaagagag ggctgtcagt 43861 cagcaattgc tggtgggaag aggtgtcttg gcaccaatac aaaactgcaa ataagagcca 43921 gggagggtct agaagcagaa caaaaagaag agagtccttc tgggtacagg gttattgtag 43981 ggctccttca tgtttaaaca actccttatt tcctcagggc tttgaaaagc agcctcttgt 44041 caaaacgtgg agaggcattt tggggagtag caagggaagg caagtcatat ggagaattta 44101 agtggcttca gtgcatgagt ctccatcact tgtcaggaca cctgcgtgct gccagcccag 44161 tttctttgca atctgaaagg ctgcactatc tacccttaag gccaacaaat ctattcagaa 44221 actttttatc tgaagatatt tttgcagaca tatgaaatag gtaagacaag tagaattcca 44281 aaagatgaaa ataaataatt cctatctatc tatctatcta tctatctatc tatctatcta 44341 tctatctatc atgtcacaga agcagatgtc aatagacata actataaaag atcagcattg 44401 tcttcaaaat tttagacttc tggctgcctt ctttcctaga gatcaaattt acttgttgca 44461 tctacaaaag tggaagcaat catgtaatgt ttataccaca tttgatttgc tttttccttt 44521 gtttatgctg cagctcttaa tatcacaaat gccacagaga gaggtattta aaaccccacc 44581 gtgtgctgtg ctctcagtga ttgcagtttt aataaaattt gcagtggtcc tgttcccggc 44641 atcagtccta attgtttgat gccactaaca ggtttgattt gctgtcatga gtacattgtg 44701 catttgaaaa ccaaacaaag aaaaaaatca caaacctctg atatccctgg aggctatcat 44761 tgggaaaatt aaatctgcat gatttaatag gatgcatgtt ctaaaagagg agcttgaccc 44821 attgattttg actttagggg atattatggt atattatggt atggtttcat ctaaaaagtt 44881 ctataaggct ttcagagaag aatggtaaag tggtccttta gttgaacagt tgtcactgca 44941 tttctctaag aaaaagtcac ttgtataata atgatagcac tgaatagata atacataatg 45001 cttcaagtca acacatagtt aggccctctt aaagtgcagt gttaaagaaa atgtacttta 45061 aagtaattaa attgtttagt ataatgttga cattatatta tttgaaatga aaagttatcg 45121 tgacctgaaa tacatatact ctaattggag tgagttttta atatcagttt tcagatatta 45181 aaatgagatg cataagttca agcatacata cacagtaaag gaaaattgct ttctattcaa 45241 tgcattagtt catccaacaa agacacactg agcaatgttc caggtgcgac atgagacaga 45301 gaaggccatg cctccactgg gcttaatttc aaaatgtgac tattttgatt catgcaaaga 45361 tatcatggaa agctattaga attctatggc aagaaggagt tcaagtaatt ttatattcag 45421 ttattttctt cagatatcaa atacatgact ctgagactgt aattgttata tttatttccg 45481 tgaacaacaa actatacaag gcattatttt tggagaggac ttaatatagt ggttaataac 45541 atgggtggta ggatctcaag aaaactgcat gggctctaga gtctcaggta aacttcttga 45601 gtccaaatcc tggttctacc acctatcaca tgtgtaactt ccagtaggtt acttatctct 45661 ttgtgcttca gtttccctac ttgtaaaatt aggttaataa tactatctac ttcataaatt 45721 gaagaatgta gaagtagatg atatatttat agctcttaca agagtgactg acacagagta 45781 aacactcaaa tagaaattat caatgttagt tctagggcta atataacttc tgtgcaacag 45841 aagcagtgat ttacgcactt gtgcagacaa ttatagctcc cttttccatg tgtcatcttt 45901 atctctgagg tacaagcaat aaagtccaat ggcaaaaact aaatttttat ttttaatagt 45961 ttatttgtat taattttggt tctagcaaaa gaataataac caactttaaa tctgcaagga 46021 gaccccaaag tcatatagtt caattcctta gtttgtagat aaagaaattt gagactaggg 46081 gcagtggctc acgcctgtaa tcccagccct ttgggaggct gaggcaggag gattgcttga 46141 ggccaggagt tcgaggccag cctgggaaac atagtgagac ccccctctct aaaaaaagta 46201 tttatttaaa aatatttaaa aaaaataaat ttgagaccgg aaacatcttt tattttatag 46261 ataaagacac ttgagaccaa acaaattgtg actttgccca ggttggcaaa ggaacttgag 46321 tgtcttattc ctagtctagg acatgttcca ctacctattc cgattctttc ctctttttaa 46381 tatttatgtt gtgtagataa tactctgcag agttcacatg ctttagtatc agacagacct 46441 gggtgttaat cctgactgtg ctgcttacca gttatgtgag gtaggataat ttacttgacc 46501 tctgcaagtc tatttcctca tttgtgaaat ggggggtaat attatctaga acacagagtt 46561 cttaaaatgg actcagatag catattcaca gtgtctatgc agtagctctt tgataagtat 46621 ttgctgttgt tggtattgtt gtctgttgtt tacattgtta taaagctgga tgacatctat 46681 ccagagaata ccactagtca agcttcttga atttcataaa tagaatgtca acattaacaa 46741 ctgctcatct ggtctccaaa gaacataaat ctactttcaa tcagcaatgc tttgtacctg 46801 cattcttgtt acttgttaga gattataact ttggtgtggc ttcaccgtga caagtgataa 46861 agggaagctt atctaagaag ctgtgtaaag aggtgccttt aatggctaac aggagagagg 46921 ctatttggag tcaacctgtt aaaaaaaaaa atagtacaac aacataaaag tgaaggcggc 46981 cttcgtgtgt atcctgagct tatatcatat tttattcact atagaaatag atatttgcca 47041 aaaatcttgt tgaaaatact gatccattct agcactcact gctcccaagt aaatcccaag 47101 tgagaaatca ctttaaaaat ttagtgccat aaaaaatgat gagttcatgt cctttgtagg 47161 gacatagatg aagctggaaa ccatcattct cagcaaacta ttgcaaggac aaaaaaccaa 47221 acaccgcatg ttctcactca taggtgggaa ttgaacaatg agaacacttg gacacaggaa 47281 gggggacatc acacaccgga gcctgttgtg gggtcggggg agaggggagg gatagatagc 47341 attaggagat atacctaatg taaatgatga gttaatgggt gcagcacacc aacatggcac 47401 atgtatacat atgtaacaaa cctgcacgtt gtgcacaggt accctagaac ttaaagtata 47461 ataataataa aaaaaattta gtgcctggct gaagctctgt gaacaatggc tgcagaggag 47521 cttcctgcca gcctggggaa gccatagcct gcacatgatc tgtccctttt agtgaactaa 47581 ggttgacttg atggagccaa tgctggcaaa ggtctctgag gaaaactgac ctggatttat 47641 acaaggtcca gccttgcagg ttgtaaggga ggtcactttc atggcaggcc aagatccttg 47701 agatgttttg aaaatttgaa ggagaaagga attaggccaa aatgaataga tactgcagac 47761 gaaatcttat ggagaaattt ccttggactt acatccttag cctcagcaca gcaaattaat 47821 agaagcttgc agaagaccaa gctgagattt cttatagaga cctccagtgg aacaaactta 47881 aagaaggccc atatggttaa cgttcttgat gcccatatgg ttaacattgt tgatgcacct 47941 gtgtaaagaa ccaggctaaa tctaataagg ccatactcac tttgtcgtca agaatctttg 48001 agattctttt taatcaaaag tggggagact ataaggaaca atttgtgctt aaatggaaaa 48061 ttgtgtgttg tcattctaga gcacacctgt gttgtgtgat tccaattctg tgggagctgt 48121 tttaaagctt tataaattgt agataactgg cagcaatgct aaatcgttct cctccataga 48181 cttgcaaatg aattctgtcc agtggaaaag caaccaaaaa acccaatctg gctctgtttg 48241 cacagtcatt ttaatattcc tgatctataa atgggtctgt ccttgggatt ctcttttcac 48301 ctggttgcaa cacttcactg gtttccttgt gaatgagtta aataaaacct ttaactcatg 48361 tttattctga aaaaaaaaaa aaaaatcagt gcctgggttg gggagaaggg tctctgctga 48421 gaaactgaca ttttatccat tcctatagta agtactgtgt actttatttt cttttacttt 48481 attttttgct cggcctggca tgtatcttag aatccaattt gaagcttagt catagtatct 48541 gttacaccaa accatccaga ggttttctcc ctgatcctaa tatattgtta ttcatttaat 48601 ttatggccat atcaatatac cttccttaag atctctatgg aaagagaaag aaataactaa 48661 gttgacggat tcatggaact tctcctccaa gtggttctca aatgccagtg cacatcagaa 48721 gcatctggag atcttactaa atgacacagc ttcaggatgc attccccagt tattcatatt 48781 tgataggttt atgttagtgc tttttaacaa caccccaaag gatccttaat gcagtgaccc 48841 atgaaccaca ctttgaaaaa cactgacttc aggttttcta cttagaggga ctttattcca 48901 gatgaatcta aacaattcaa ggagaaagct tatctgcaaa tagtaagata tcaatgttag 48961 gatagcttca aattcatcca tttgtggaat gcctactatg ttctatgcaa tgaggtaatt 49021 cttaaggata cagacgaaag agagatgtgg ttcatttctt gaaaagtgtt caaattcagt 49081 gaggaagatg gatatgcaaa caagtaaaat gcaatatatt tacaatgata gaagtttgtg 49141 tagggttata tacacaggac agaggagata gggaaaggtc agggaaatct tcagagaggt 49201 gaaggccaac agggctttga ttgatgaaga gtgaggagct cttggtgagg atcatatcac 49261 attgagggag gaaaaagaaa atagaggaaa aaattcagat ttaccatgca agcacagcct 49321 gacactgact cataaccagg gagtaaaaga aggattagag agtttgggac agtatctatt 49381 agtggtgcta taaaaacaga ataaaccatg atttgactca caggctaaca tggagatcat 49441 cttcttggta tcttctcttg gacctttttt tctttttttt tttttttgag acagagtctc 49501 tctctgtcat tcaggctgaa gtgcagtggt gcaatctctg ctcactgcaa cctccgcctc 49561 ccaggttcaa gcgattctta tgcttcagcc tcctgagtag ctaggattac aggcatgtgc 49621 caccatgccc agctaattct tgtattttta gtggagatgg ggcttcacca tgttggccag 49681 tctgctctca agctcctggc ctcaagtgat ccacctgcct cagtcttcca aagtgctagg 49741 attacaggtg tgagccacca tgcctagccc tctcttagac ataattttaa acgggtagat 49801 acctaacatc ctgacaatgt gggaacctat ggtttggagg catatggcct tatctggcat 49861 ccagaattcc atctaaaagg ttacagaaat gttcccaacc caagccactt taggcaactg 49921 ggatactgtg gtatgattta agattaagtt tatggcttct atttattttt ccaactaaaa 49981 tttccggttg gctaaaacaa aaatcttatt cttaatagac ctcagctcgt ttaacgcatg 50041 tcagagtgca ggcatcttcc agagcttaga tcaaaaaagt tatttaaaag taaactaaga 50101 ttttgataaa cgtaccatgg ttatacagga tgctaacatt aggggaagtt gggtgaacag 50161 tacatggaaa ccttctatac tatctttgca actcttatgt aaatctaaaa ttatttcaaa 50221 ataaaaatgt tttaaaaagg taaactaaga aatacttctt tgtcctggta attaagcagt 50281 ttagcatctc ctcccatcaa aaacagaaaa tgaactttct ttaagaagaa aaaagtgaat 50341 caggaatgaa gtcacatatt ttattggctg atgattaaac ttctaatata ttttcagaac 50401 cagtttaaca aaagtgcggt tgctttatat acacctaaga ctgaaacaaa aacaagtaaa 50461 ctttgtgtag ctcttgtctg atttacatgg taaacatttc ttgctcgtac ccactattca 50521 ccatccatat ttacaagtga gaaaaacgtt accatctcaa aggccacaga aatgttccca 50581 acccaagcca tgggagggaa tcccacatca ttgaggcagg cagcccttat tttgtcctgg 50641 agaagagagt cactgtattt gaggatgatg tgtatgtttt ctaaaggagc ttgccttctg 50701 actccttcag agttggagcc acagtgggta aacctcttca ggcattgccc tgcttcaaag 50761 cagacagaaa cgtaaacagt ggcagtacac caggatcggg tttctttgct ttagctacca 50821 agagtcagga aagagaaacc aggtatttat ttaggtttgt cattattgct aggttttctt 50881 ttaatgataa gggtttgaga aaagaagtat ctgttcagaa acaaagtatc acagagcctc 50941 aataggatta ctttttcaac cacccagggc cacgtgtttt ttaagtcaaa tataaaaaca 51001 atttaaccca ttttgttctt tgtagtcctt gccttctaac aggcatctcc aactcagtta 51061 ttcttaaaat atgatgctag atgagacaaa tagtctattt aagagcagat tcaaataatc 51121 tgtatagatg agcatctatg ttttaataac agggtcgaaa gaatttctct ctctacagag 51181 tgatttctct gtctcaaata attcagttta tgaaaggagt taaggatatg ctttttaaca 51241 ccggaaaagg gtacttaaca tgatcaatat ctaggataca gccagctaaa gcagattgac 51301 gttacaaaat aaaataaagc cttctccctt tgaagtccgc taaaggaaca gctttcatga 51361 ctcagaaaga tatcctagag atcaaaaaag ctctggagaa agaaaaagaa ctagaagacc 51421 tggcttcaaa atttacctct agtacttccc agttatgagt tagctgctat attaattaat 51481 tgctttatat aaatcatgtc atttaatctt ctccacaatt ctatgagttg aaagttaata 51541 actacgtttt ctggataaaa aacctgaagt tcagagaagt tgaacagcaa ctcagaaaaa 51601 acagctagtg agagtgaagt gaggatccaa ttctaccacc tggattgctg ttagggtatt 51661 gtacatgagt gtaaggaaag tatcctacta ctaagatttt gacttcccaa cctctgagtt 51721 tgtcctttga aaaagccctg caatggtgtt cttatttacc aaatggtcag agattttctc 51781 aagatattga ctataaggaa aatgataaac aacttaatga aatggcacta tgaaaataaa 51841 ataatctagg aacaaatatt attttatttt catagtgcca tttcattaaa ttgcagcact 51901 attcacaata gcaaagactt ggaaccaacc taaaagccca tcaatgatag actggataaa 51961 gaaaatgtgg tacatatatg ccatggaata ctatgcagcc ataaaaagga aagagatcat 52021 gccctttgaa gggacataga tggagctgga agccattatc ctcagcaaac taacacagga 52081 acacaaaacc aaacaccaca tgttgtcact tataagtggg agctgaacga tgagaacaca 52141 tggacacatg gggggaacaa tacacactgg ggcctgttgg aggctgggag tgggaggaag 52201 gagagcttca ggaagagtag ctaacggatg ctaggcttat tacctaagtg atgggctgat 52261 ctgtgcagca aaccaccgtg gcacacgttt acctatgtaa caaacctgca catcctgcac 52321 ttgtacccct gaacttaaaa tagaagttgg gggaaaaaaa agaaaaaaga aaatattagc 52381 ttggtgcaaa agaaataatg gcaaaaactg caattacttt ttttgcacta acctaataaa 52441 gtgatcttca gaaaacagtc tactttttta aaaggcaaaa aacagagtgg tttatataat 52501 tggaataatt tttacatctc tttttgatac acacttctta ttttctaaaa ttttcacaaa 52561 tcatcttaaa cattaatgct gtcaccaaat aaattctcac aaagtaatag aaagctcagg 52621 aaattaatat ttgagaagta aatttagagg caaggataac ttaaactgag aagcatttat 52681 aattttccat tttgagaaat actctgtagc atttataaac attatatttt aattttctat 52741 ttcaataaat taatattgta ccagaatacc aaactgcatt tggaatcata ggcaactgtt 52801 atgtttgtcc tttcttgata tttgaaaaaa atgaccttcc ttttgaatgc tgccctcata 52861 atttaaaatt ggccttctcc ttcacagggg acattcacga taaactctca ataggcttta 52921 atttggagaa ttttagtttt gccttagcag cttttcttat atcttctctt aattctataa 52981 gtttaggctt tatatgtttt gaaattatat tgttaagtgc atacacatta attattgttg 53041 taattcctcc tctgcagatt gcatttttaa cctttggatg atgttcctct tcatcccttt 53101 tttataatac cttttagcat aattctgtat tgtttgatat taatatcatt accacatttt 53161 tcctttgttt tgtgttttcc tgtgctcttt gtttggtatt cttctatccc tttcttccaa 53221 cctccccaca atcttgtaag cagaatatag ataaatactt ttgtaattca atccaaaaga 53281 ctttattttt agtagataag tgtaggtctt tgtatttatt ctgaaaattt atttctatta 53341 ttctttagac gatttctatc atgtattatg ctgtttcttt tctctgcttc tttttttaat 53401 tccttttctg ttttctggta gatcattata tattttttta attctccact ttaacccaca 53461 ccacaaccac tttgctgatt ttgaaattgt ggatcacaat gttatatttc agtgattact 53521 tttacatttt aatatacata tatgatgcta taattctaac agtttaagat catgtaggat 53581 cttctccagt ctctttaact aaagcaagca tcttatcatt ctttaaaatc ttatctaaca 53641 gcaccttccc tcatcctctg tcactttcct tggcattatc caaaatttta tttatcttaa 53701 aacactgaat tattttatgg tccataaata gttctatcaa tatatgccac caattgctgt 53761 gttcatcatt caattttcat gtgccttttt tcttctgttt ccaatttctt atttctgaaa 53821 catattattc attagttcat tcaattagat ctgtgagcag atatctttgt ctttgtcttt 53881 gtatgtttga aaatgccact attttaccct gatcattcag gtgaacattg aaatctaagt 53941 tgacagatat tttccctcag tgttgtccta tgtcttctta catcaattga tgagaagtgt 54001 tctgtcattg taactataat tctttggtag gtaacagagt tcttctatct ggtcttttta 54061 cctttgatta ccagtacttt taccataatt tgtcatagaa tctgtattag ttatctgttt 54121 ctctgtaacg aattacacag aaactcaatg ttttaaaaca ataaacgatt atcacttcat 54181 agtttctata actcaggaag tacagagtga ctttcccagg ccaatgtatg gattatgttt 54241 gcagtaaaga tgttggccac ttctgcagtc atctgaaagc ttgaatgggc tgaaggatct 54301 aattcaaatg tggttgactc ataagttggt ataaattgat gctggccagt gcagagcctc 54361 cctttgtccc catgtgggtc tctcctcagg ctgcttgagt gtccccacac tatggtgcct 54421 tccttcccta agagtagatg atctaataga gaacaaggag gagttagtaa tgtttttcat 54481 ggtctagctt caaaagccac acacagtcac ttctgccaca tcctatttgt tagaagtgag 54541 tctaagtcca gcctacttcc aaggagagca gaggaactat actctacttt tccaagggag 54601 aatttgtgga caggttttaa aactacaata gtgtcaatgc aaaatgcacc agaaagtctc 54661 agtaacagaa tcacacaagc agaagaaaga acttcagagc ttgaagacaa ggcttgaact 54721 aaccaaatcc atcaaagaca aagaaaaaat aatttttaaa aatggacaaa gcctccaaga 54781 agtttaggac tatgttaaaa gtcaaaacct aagaatagtt ggaaggaaga agagaaagaa 54841 gataaatcta aaagtctgga aaacatattt gaggaaataa tcaaggaaaa cttccctggc 54901 ctcgctagag atctagacat ccgaatacaa gaagctcaaa gaacacctgg gaaattcatt 54961 gcaaaaaaat cattgcctag acacatagtt atcaggttat ctagaatcaa gacaaagaaa 55021 agaatcttga gagctgtgag gcaaaagcat caggcatctt ataaaggaaa atctatcaga 55081 gtaacagcag atttctcagc agaaacccta caagctagaa gaaattgggg tcctattttt 55141 agcctcctaa aacaaagcaa ttatcagcca agaattttgt atccagtaaa actaagcttc 55201 ataaatgaag gaaagataca gtctttccag acaaatgctg aattagccac cacaaagcca 55261 gcactacaat ctcaaatgaa ctctaaatct tgaaacagat tctggaaata caccaaaata 55321 gaacctcttt aaagtttaca tctcacagga cctatataac agtaacacaa tgaaaacaac 55381 aacaacaaca acaacaaggt attcaggcaa caaatagcac aatgaataga atagtacctc 55441 tcatctcaat actaacgtgg aatgtaaatg gcctaagtgc tccacttaaa agatacagaa 55501 tagcagaatg gataagaatt tcaccaacca agtttctact gtcttcaaga gactcaccta 55561 acacataagg actaacataa acttaaggta aaggggtaga aaaacatatt ccatacaaac 55621 agacaccaaa agcgagcagg agtcgctatt cttatatcag acaaaacaaa ctatagagca 55681 atagcagtta agaaagacaa agagggagat tatataatga taaaaacact agttcaacag 55741 gaaaatatca caatcctaaa tatatataca ccttaacact ggagctccca aatttataaa 55801 acaattatta ctagacctta aaaataagat agatggcaac acactaacag tgagggactt 55861 taatactaca ctgatagcac tagacagatc atcaggacag aaagtcaaca aataaacaat 55921 ggaattaaac tataccctac aacaaatgga cctaacagat atttacagaa cattctaccc 55981 aacaaatgca gaatatacat tgtaatcatc agcacatgga acattctcca agacagacca 56041 tatgataggc cacaaaacaa gtctcagtga atttgagaaa atagaaatta tatcaaatat 56101 tctctcacac cacagtgaaa taaaactgga aatcaactcc aaaaggaacc ctcaaaacca 56161 tgaaaataca tggaaattaa atgacctgct cctgaatgat tgttgggtca acaatgaagt 56221 caagatggaa atttaaaaat tatttggact gaacgataat agtaacaaat agtgagacaa 56281 cctatcaaaa cctctgggat acagcaaaaa cggtactaag aggaaaattc atagcattat 56341 ctgaaaaagc acatatagac aatccaaggc cacacctcca attctccatg caattggtga 56401 aacaagaaca atctaaacac aaatgcagaa gaagaaaaga aatataaaag atgagagcag 56461 aactaaatga aattgaaatg gaaaaaaata caaaagataa atgaaacaaa aagctggttc 56521 tttgaaaaga taaataaaat cgatagacca ttagctagat taaccaagaa aagaagacag 56581 aaaattcaaa taagctttat tagaaatgaa atggaaggta ttacaactga tatcacagaa 56641 atatgaaaca ttattcaagg ctaatatgaa cacctttatg gacataaact agaaaaccta 56701 gaggagatgg ataaactcct ggaagtatac aaccctccta gattaaacca ggaagatgta 56761 gaaactctga gcagaccaat aacaagcaga aagattgaaa tggtaatttt aaaattgcca 56821 agaaaaagca gtccaggacc agacagattc atagctgaat tgtatcagac attcaaagaa 56881 gaattggtac caatcctatt gacactattc cacaagatag acaaagaggg aatcctccct 56941 aaattattct atgaaggcag tatcacccta atactaaacc aggaaagagc ataaccaaaa 57001 aagaaaacta cagaccaata cacctgatga acacagatgc aaaaattctc aacaaagtac 57061 tagtgaactg aatccaacaa cataccaaaa atataatcta ccatgatcaa gtgggtttca 57121 taccagggat gcagggatgg tttaacatat gtaactcaat aaatgtgata caccacataa 57181 acagaatcaa aaacaaaaat cacgatcatc tcagtagaca cagaaaaagc atttgacaaa 57241 attaagcatc ccattatgat taaaaccctc agcaaaatca gcatagaaaa gacatacctt 57301 aaggtaataa aagccatcta tgacaaaccc acagccaacg ttatactgaa tggggaaaag 57361 ctgaaagtgt tacccctgag aactgaaaca agacaaggat gcccactttc accacttcta 57421 ttcaacatag tactggaagt cctagccaga gcaatcagac aagagaaaga aataaagggc 57481 atccaaatca gtaaagagga agtcagaatg tcactgtttg ctgatgatat aatcttatac 57541 ctagaaaacc ctaaagactc atccaaaaaa ctcttagaac tggtagatga attcagcaaa 57601 gtttcaggat acaaaattaa tgtacacaaa tcagtagttc tcctatacag caacagtgac 57661 caagctgaaa atcaaatcaa gaactcaact gcttttacaa tagctacaaa aataaaataa 57721 aatacttaag aatatatcta accaaggagg tgaaagacct ctacaaggaa aactacaaaa 57781 tactgctgaa agaaatcata gatggcacaa agaaatggaa acacatcccg tgctcataga 57841 taggtagaat caatattgtg aaaatgacca tactgcctaa agcaatctat aattcaatgc 57901 aattcccatg gaaataccac gattactctt tacagaacta gaaaaagcaa tcctaaaatt 57961 catatggaac ctaaaaagag cccacatggc caaagcaaga ctaagcaaaa agaacaaatc 58021 tggatgcatt accttaccca acttcaaacc atactacaac gccacagaca ccaaaacagc 58081 atggtactgg tataaaaatg ggcacagaga tcagtggaac tgaattgtga acccagaaat 58141 gaagccaaat acttacagtt aaccgatctt tgacaaagca aacaaaagta taaagtgggg 58201 aaaggacacc ctattcaata aatggtgctg ggataattgg caagccacat gtagaagaat 58261 gaaactggat cctcacctct caccttttac aaaaatcaac tcaagataga tcaaggactt 58321 aaattgaaga cctggaacca taaaaattct agaagataac atcagaaaaa ctcttctaga 58381 cattggctta ggcaaagact tcataaccaa gaactaaaag caaatgcaac aaaaacaaag 58441 aaaaatagat gggacttggc cgggtgcatt ggctcatgcc tgtaatccct gcactttggg 58501 aggccaaggc tggcagatca cttaaggtca ggagttgaag accagcctgg ccaatatggt 58561 gaaaccccat ctctactaaa aatacaaaaa ttagctgggt gtggtggtac gtgcctgtag 58621 tctcagctgc cctggaggct gaggcagagg aatcacttga aactgggagg tggaggttgc 58681 agtgatccta gatagtgcaa ctgcactcca gcctgggcaa cagagcgaga caccatcatg 58741 ggaagaaaaa aaaaaacatg ggacttaatt aaactaaaaa gcttctgtac agcaaaagaa 58801 ataatcagca gagttaacag acaaccccca gagtgggaga aaattttgca aataatggat 58861 ctgaccaagg agtaatattc agaatctaca aagaactgaa acagcaagaa aaaaaaaatc 58921 ccatcaaaaa gtgggctaag gacatgaaca gacaatctca aaagaagata tacaaatggc 58981 caacaagcat ggaaaaatgc tccacatcac taattatcag ggaaatgcaa atcaaaacca 59041 caacgtgata tcaccttact cctgcaagaa tggctataat aaaaaataat agatgttggc 59101 atgggatgtg gtgaaaaggg aacactttta tattgttgtt gggaacgtaa actagtacaa 59161 ccactatgga aaacagtgtg gtgattcttt aaagaactaa aagtagatct accatttgat 59221 ccagcaatcc cactactagg catgtaccca gaggaaaaga agtgattata caaaaaagat 59281 acctgcacat gcatgttcat agcagcacaa tttgcaattg caaaaatata gaaccagccc 59341 aaatgctcat caatcaacca gtggataaag aaaatgtgag acatataaat acacacacat 59401 acatacatat acacacacac catggaatac tactacatat acatacacac acacacacac 59461 acacacacac acatacatac catggaatac tacttatcca taaaaaggaa tgaaataatg 59521 gcattcacag caacctggtt ggaattggag atcattattc taagtgaagt aactcaggaa 59581 tggaaaacca aacattgtat gttttcatgc ataagtggga gctaagataa tgaggatgca 59641 aaggcataag aacgacacat tagactttgg ggactcaggg gaaaagagtg gaagggggat 59701 gagggataaa agactatata ttacgtacag tttaccctgc tcaggtgatg ggtgcaccaa 59761 aatctcagaa atgaaaaaat tttaaaaact acaacaatgt caaattgttt gtattaatcc 59821 tcctatgcaa tcccagtgcc acttgaaagg cagtcttcaa gtacttctga aaaatactca 59881 tccccaaaac acaggcaaaa aattttgatt cagtaaccta aattgtgtgt ctggcattta 59941 attgtttgtt tgtttgcttg cttaaacttc ataagtgatt caatgaattt cgagttttaa 60001 aagccaccac tttaactgat ctggggtttc atgtattgct tcaagcctag aaaatctcca 60061 ccactatgtc ttcaaatata acctctctgc tcttccttct cttctctact gctcacactc 60121 ctgtaagcat atattagagc tctaaatctg ttcttcccat cttttagtta atctttcaca 60181 tttctgtcca tctttctctc tggcctcagg gctgtatgat ggcttaagtg ccatcttctg 60241 attcattaat tcttcacttg accttgtcca agcttgagtt tatcatatct tttgtgtctc 60301 tgcttgttat tatcaatttc tagcatttct actattatat gtatttcaat tttgcctgtt 60361 tgttttataa tttattttta tacatatact attatttaag gttcttaaac tccttttgaa 60421 cttctttgtt ttcttccaga gtaaattaat cccccagtta ctgaattcat taagttgaaa 60481 gtcaatttat tattgcttag caattgtttt cctaatgtgc tttgaaatta tgatttgcca 60541 ctgtaaatct tatcatcatc tctctgaaat gatttattcc ttttccagta attttggggg 60601 ttgccctcta cttccttcat tcatataaga tatttcaggg agcaatttta ggactctatt 60661 ctgtaatgtt ttgacattca atccagaccc agtcactaaa ccgtcaaaag cataacacat 60721 gttctgacta cgatactatg actgctttgg tttcaagcag cgagcctcca atcccccatc 60781 tcatatagta cacttctaga gaaatcaaac ttcaagcccc tttctctgtt tatagaattg 60841 gaactcagca gtgactactt atctgttgtg ttttgtctac tttcttatac actgagatat 60901 tcatcttgtt ttttaatatg gctttgtctt tttaggtagc aaaaaattat atcttcatta 60961 ttgctatgta cttatattct acctagatga ctgaattgta atatcataac accaacttga 61021 gtagtactct ttgtgctata attattatat atcatcatat aaattctatc cagctgaata 61081 tataaaaata aaaatttata ttattgtttg aaagaggtca aaagtattga tgtttaaaag 61141 tgatattttt atccatctag aaaacacaag agtatcaact ccaaagctac tttaactaat 61201 atgataatta atcctattta caaataaaat gcacttatgt acacatatat taacagtttt 61261 cctatatagc agaaataacg cattagaaat taattgaaat aatggcattc acagcaacct 61321 ggttggaatt ggagatcatt attctaagtg aagtaactca ggaatggaaa accaaacatt 61381 gtatgttttc atgcataagt gggagctaag ataatgagga tgcaaaggca taagaatgac 61441 acattagact ttggggactc aggggaaaag agtggaaggg ggatgaggga taaaagacta 61501 catattacgt acagtttcat tcttgttagg tggatagaag tgggaaaagg gtcttataga 61561 tagtaagtat aaagagattg gttttggttt gattttgatt tacagatatt ctctctcctt 61621 tacaacacag ttgatcaaaa tggattgcta ctatggtact gagtttctca taaataaaac 61681 ttttcaagaa aattatggat tactatttac cttggatgtt gaagtgaagt gaataaatta 61741 tatctcagat tagtccaata agagcagtca ttgattattc taaataccct attggacagt 61801 tccaacaaaa taggatgaaa atgccccact aatgcaactg gcaaataact tgtttaacaa 61861 taaatgtgtt cttctttcta caagagactg tgctggactt tagaggaaaa taaagcagca 61921 acaaaagtct gatactaatc ccagtttaat tctagcccta acctccctaa agaagattac 61981 aaatcaattt ggaagacaag aacaatgcat tacatataaa gcagttaaat aaaaatttag 62041 taattaaatg ggaataaaga ctatgaagca gaatatttta aaaatgataa gtggtaaaac 62101 aataagttca gaagtcaaga gtgatcctag taggctaggc gagcaggata tgtggaaaaa 62161 ctaggactac tgtttgagct cgaaatgacc aaaaaagtca tacagcgaat aactatacct 62221 gagcttaaat aggcctatag acttttcttg cataattttc tctaatttaa agtaacctca 62281 attgtgtgtg catgcatgta aatgtgtgta tgttaatgca taaacatata taaatttgta 62341 tctataaaga ggtataatat atttgcatta gaaagaaatt ttgatagtct ataactgaaa 62401 ctataatttc tggtagaact tctaagcttc ctcccaggaa aatgacaaat cttagacatt 62461 ctttcatgtc ttgagttcat ccactgttta cttacagtgg atgaaatagg tgtattcttt 62521 caaaattttg cactgcttcc aatcccaaat aaggcaaaat gaacaatagt agcaacaata 62581 acatcaaact gaaaaatttc aaaggaaaat taatattatc taaaattgag cctacgctca 62641 aagtagagtt caagtatagt cctgtataga tcatggagtg aaactgaaac gagactcaga 62701 attgacctgc agttgccctt gaaccctgac aaagaacact ctaagagaag aaaatgacaa 62761 gtgaatataa ttctcaaaat ttactaatgg aaaaagttta ctgatactct ttaactttag 62821 tggaataaag ttttggagat accacagttg cagaataaag acacttaata tccctataaa 62881 aacaccatgg ccatcccaac cactctaagt tacttggctg ataaaggaaa tagaaaaaga 62941 gagagaggga gagagttttt gttttgtttt gttttgtttg tttgtttttc caaacttaga 63001 aacaaacaca ttgttctggg gctctagaaa gatgtgtcca gcccgaaggc attcaaatgc 63061 aatttttcaa gtctaatctg gcccagtcat ggaccttctt tcatttctcc tgattgaggt 63121 atgtgataca gacagggaat ctgcagtttc ctaatgtcca gatgaccagt tttaaatatg 63181 aaagaaacta atatttatcc aatacctatg ctttaccagg aaccgttacg aatattgtaa 63241 aaaaaagatt tcttcatttg aaggtacatt tgacagacga cctctaaatc tccttttaac 63301 gataaatata ttcaattcag aagttttaaa tagtttttga acttgatgct tataaacaaa 63361 aaccaagaat gtaccactga gttgatggag gtagggaaag ttcagacagt agaatctaaa 63421 tgaggaatca caaattcact taaatgtaag gggattgggt gttaagtgta aatatgagac 63481 cttctcattg ggaagactca atgtctgaaa agggggttga atttctggct ctgcacctgc 63541 agcaaatctc caagacttag atcctttgtc cggaaaatgg gctaattttg gcggggagga 63601 agtgaagggt ttcactattt atttatgaca aatattcaac actcacaatt ctctccaatc 63661 agaagttctt tgagatgctg ttggtcttga ccagtcagag aatggagtca tctgactcac 63721 ccattctgag aatggtccta cagacactat aggttttaaa ttggccatta aacctgccta 63781 taaccttgtc aaccttggct aagttcatct ggatggatgc atggtccttg gcacccatga 63841 tgcggttgct ggcggaacat ttccactgca tgttcaggtc cacaaactca ggctggataa 63901 tatcaattat gttcaattac agagacatgg ggagagtcaa atgagatcga gtaaaaaatg 63961 tgcatgaaaa tatccacaat ctgtgaaaga ctatgcaagt gtattattgt cattgaatgt 64021 tgttagcaat agcatggcca ttttttactt acaaataaat attgcagttg acatattact 64081 aactctaaga aaggttcaaa tttacatgaa caaataaaac ttcaggaaag aaaactagag 64141 ttccacttgg ggactacgtc tgacatggtt atattaaaca ttttggaaca attaatttgg 64201 ttttgttgtc tctcttctag gatttttaaa catttataaa ttctcaattc tttctattca 64261 atctaaacat tttacaatat cctgtggacc ttacttcctt agtagattcc cagaaggtaa 64321 tgatttgctc ctttctgctc tccaagcagc ttctgtgttg gtgcagagtt gcagatctct 64381 gttggtggta ggttctattc tgcagaaacc ccctaatcct ctgtttacca caacatgagt 64441 ctattgccat agaaatgata gctgagatcc cagattgaac accactgact tcacagcagg 64501 gcctggtaag aggagactct aagctacaag gggggaacgc aatgtatgag aatagtaggc 64561 actctgtagc cttgaaagaa agggtaactg tcaacattag aataaaaatt catgaaagag 64621 ctacattgtt aggtatgctg tagtttattt tctgtataat actgcctggc taaaagtaat 64681 cattctgaaa tcttatgtca tttaacagtt tgctttcaaa aggtctgcag ttttccttga 64741 ttgcatttgt ttcttattga aataagaaac aagcagcttc taattaatct tgttgcacaa 64801 ctgatgtttc tgtggtcaaa gatttccctt ttcatgatgt gttgttttgt ttgcgtgttt 64861 attgtgtgtg tttgttttgt cttgttttta ttaacagaag aaagtgaacc cgaacaagat 64921 actaaaggta tttttttttc tttctgcatg gcttcttttt aattgtgtag ctcttttcaa 64981 ttgtttattt ttgttgacct tataaacagc tctaagtgcc atttttaaag aaataacaaa 65041 caatgtatgg ggaatattaa gtcacagcac ttaacggtgt tattagatag gcttctttat 65101 tatataatat gcttactgac catttgcatt tcttaagcaa gattgagtta aaagtaatgt 65161 ttaaatttgg tgtctctgga aatacaaaca aaatgaaatg aaataaatca gcatgagagt 65221 ataaatccca catagattgg aaaagaaaga taccctttga ctaaaagact tttggtgggg 65281 gttggggggc tttacagtct ttggataaat gttaggatgt caaggtgcca atttggtttt 65341 tattgtgatg atttcaacaa gatcaggagt attatgcaat tgctccaaat caataaaaat 65401 taagttattt taattgcaca gagacatatg tttgtagtgg aatatgttta gaggaaaata 65461 gctggaaatt aaatttgtat gggaaaaatt ctactttttc cccaacagtt ttctgtcaac 65521 agtttctgtt ttctgtaaaa aaaaaaaaaa aaaagaaaaa agaaaaaaaa aaaaggtacc 65581 ttgcattctg attaagcccc aaactttgtg ctcttctaac ctaaaatttg atatttgggg 65641 gatgaaattt gtgagttctc atgtaataga gttgactgta ggaattaatc tcaaactggt 65701 attatttaaa acagtacctc cttatcttag tatctcatat aaagtacaga taatgttttc 65761 ttatttttaa ataccaggtt gcttacaatt aaatacaggt aaaaaagcat tttacctggt 65821 cctatgtgaa ttttttttct taatttattc ctatcagtca ttgctggttt gaatcatgta 65881 acctaaaaac ccttttcaaa ggaagctaga aaataacaaa agaggaaggg aaaataaaat 65941 ccatgggagc tccttgtgtc ctttgaaata actgctcaga aatagaaatt gataagagac 66001 ttaagtattc ctctggcact gctcccttac caagaaaaga gaggtagttc atctccagcc 66061 aaaccactca tttatttcag gacttaacat ggatgccctg tcccttgggc tttttattac 66121 actccagtgc aatttcagag tgaattatgc ctttatcttt ttactatacc ttactcctta 66181 agatgacaat caataataaa actgattaca tatctgaaag tgctttgaaa taaggagaga 66241 gagagaatat aatgtgggta tgttataaaa gattttagaa ttgctggctt cttgagccca 66301 attttgaata taggattctc cacttgcagt tagcctgcaa gtctgctcaa gagacattaa 66361 agccccaaac tcatgaatag atcccatgag agaaaaccca gagttaaata tattaccttg 66421 gtctattttc catgttgcag atgcacttgc ttacccacag gaaaccaagt ggtttagggc 66481 tcacagtgaa ttggagaagg atggataaga ctatgtacag aaagaggggt ttgatgattt 66541 ttttgtttaa aaatccatat caaaacagtt ataaatgctt tccaacttac taagtaattt 66601 aatgttcctt ctattaagtg gtttaattgt ttatgtaaca aaaacacttt tatattcttt 66661 tatgcagata aaacacaaaa tagggatatt ctatgcccat tttatttaat aagaaacatg 66721 tcatataact ttttaaattg atgacctaga atgcattttc agattgtgac taccactgaa 66781 ataatgggat ttactgttga cttgtgtcca agtttgttat tgccggtgta ttattattca 66841 tggaggttaa tctggcattt atttttaatt gcaactgact ttattgttta caatgcttga 66901 aaaacatgtc aaaatttccc tcatcacctt tttacctttc atatttgaaa aatggtaaat 66961 ttgagtatta tgcaattgct cagatagagt tgggtaaaaa catatcagct ttattgctga 67021 taaggctgga atgaaaaata aagatttcta ttccatgtga ggattagact aacataactt 67081 atgtttcctc atcctcttcc tccccacccc actctttccc cttgactctt agttgtagga 67141 tgaagaagcc ctgacctggt aaacttactt acacacatca accctatatc cttcttagat 67201 gcaagagagc tgggagactg atagctcaga ataggattga gatacacata acatatccaa 67261 gtcccttccc ccaaccttac cagagaagtc atcatgttcg ttcatttatt tattcgttca 67321 ctcagcaaat attcattgag tgcctaccat atatatatac catgcagggt tctagaaata 67381 gagacagata tgtagataga tatatagatt gtatcagtca gctcatgtta aaaagcaaag 67441 caaaccttgc ccttgtgatg cttacattct agagaggaga gactgacaaa aaacaaacaa 67501 gcaaacaaat aaatcagtaa ttaccaaatg attcagatag tggtgatatg atacaatata 67561 aacaagggta aggggaatgg ggatgagaaa gtactatgat aaggaaacat ttgagtagaa 67621 acccagaaga catctgctat ctcctttgag aagggaggaa gactgggagg aagggtggaa 67681 actaactttc aatactgaaa aaagggggtt gagtttctat tttatcattt agagagcatg 67741 tgagagtgca ggagaaagca gcttcccttt aatccctggc cttattgtcc tcttaaccta 67801 atccactgca cttaatgaaa cccatggtca gccatagcct atctgccccc ttcagggaga 67861 agtttatcag cagtctcata ttcatgaagc tacctataat gtcagcagta ctcctgtacc 67921 tgcctgtgcc acactggagc ccccagaaag ttcccatgga gggcagagta ttacattagt 67981 taaattaatt ccaaagtcac gttgaattga ctctgtttta tttaccatac cacactatgc 68041 ttagttgtgt tgtgcaatgt ggataatcag aggtttcaca ataagcccaa atgatattcc 68101 aaatataata acagccaaaa gaaaaaaaac tgctataaat taggacaaaa taaaaccttt 68161 ccaagaagaa tttaaagtcc ccaaattaaa actcttggct tcataaatta aagcagcaaa 68221 acataatcga aattacatta ttctccaatt ttttattctg ctcatcttca gccagaaggc 68281 tttcattcaa aaggcgtttt tgattcaaaa agttcaaggg tatagtcaat gttactagaa 68341 cagttttcta gcacatgtga ggttgaaatg tgctagattt tccaaatctc tcaaagatcc 68401 tgcttgtttc agattctcgg gcagtgggat ccatagatgg tcatgcagta gtcccacact 68461 caaaaaattt aggaaacaca agcatagccc caacccctac aagagttatt ttagccagat 68521 gatgcacatg gactctaagt ctccattatt gtaaccagaa aacattagaa gagtacctgg 68581 acgcaccctc actacgatgc ctgtcagtgt tagttgtcaa gagtctgtaa cgtgtgaatt 68641 tagattaagt tgggagaata agaatccaag cagaggcaca cattgcattt gggtgatatg 68701 tctcttaagt ctcttttaat ctataatgga tcactctttc ttttttaccc cctaatgcta 68761 atgattttcc ctgttaaata tctgggtttg attgaattgc atctccatag tgttctttga 68821 aatgttcctc aaccctttaa tttttgtaga ttgttaattg gaccccagga cttacttaaa 68881 atcaggctca attttgcttc tgggggacag attcagcttc attttaaaca tttgatagca 68941 ttctttgtta ttttttaata atctcttttt gccttgaaga cagcaccttc cttgcatttc 69001 ttttctcctg gttttgggac ccacatttct atatctaaaa tatcaatatc aaaagatagg 69061 aagtcaaatt aatttaaatc tgcaaaaagc ccccaatagt caaacaaatc aaatgttcct 69121 taatctcttt aaattatgca atgcttttta agaggtactc aacaatgaga ccaactggaa 69181 acactactct ggacctgttc tatcattgtc ctgcgtatct ccttatgtag cacatgtggt 69241 ctcccatact ttagtttaga atccaatatt cacaaatttc aatttaacta gaattaagtt 69301 tcaaagcatt gtgctaattg gggcttcata ctctaatatt atattctgtg cttaagtcct 69361 agaaatcaaa aagtaggagc ataaaatata cttacagtat aataggccat ccaaaagatt 69421 ccgtaatagt ttaaacaaac actgaatttg aagtcagaag acttgagtcc aggtttctca 69481 ctcatcattc ttgttacctt gggaaaccaa cttacttaaa ttaacaaaga tttggttttc 69541 actgctataa gataagaaca ggaatctagc caatctctgg agtctcttcc aagtttaatg 69601 attctgtgaa tctaagtacc ctccaatttg taatgcattg tgagcctcaa tcccactgtt 69661 tagttaaagg taaaatttct tcctacatca aaataacctc ctcttactta atcagtgggg 69721 attcagggtc agaaaggaat agaaattact cattctgctg cctacacttt atctaaaata 69781 tccttttttt tttttgccca atatatcatc tgaaaagttt gacacaattt gtctgccctc 69841 ccactatgat acagttgagg gtgtaaagtg taattatttg attaattcaa taaaatacta 69901 tcctgtgctt gctctggtca ggaactctgc ctgaaacaat acagcagtca acgaaaggca 69961 aggcttttgg cttcaaacaa tctaatggga aaggggaata atagacaagt aaaaaataaa 70021 taaggtaatt tcagatagtt gtaaggtctg taaagacaat aatgtaggct gatgaaaagt 70081 gaatgggggg aggattacac ttgatgttgt gtgagtaaga aggacctttc tgagaaaatg 70141 tcacttaaac agagacttga atgattcaag gaacctacta cttgaggatc tgggggatga 70201 gtggtctagg cagaggaaga acaagggcaa gtttccatgt taagaacaag ctcagtgtgt 70261 ccttgagtgg tgagaaatat agggttataa cataaagggc ttggaggctc ggccatggca 70321 tgtggtatta tccttaaaac agagcaaaca ctgaagaact gcacacaggg gaacatggtc 70381 taatttgcat ttctaaaaga ccaccctagc ttgaccattt cctgcaggag cgtcactcac 70441 cacttctgtc ttcctaacag tttttgccag gatcctgcgg gctcctgaat cccacaatgt 70501 cacctttggc tcctttgtga ccctgcactg tacagcaaca ggcattcctg tccccaccat 70561 cacctggatt gaaaacggaa atgctgtgag tgtcatgtgt gtggggactt gtctggggaa 70621 gacccattgg tggtgaactt caggatagac catatagttg tagttaccca gatctctgtc 70681 attggtctca cctacaccac ttttcaaagc ctcccaatat ctttgtccta gaagccattg 70741 ccatagaaat caaactccaa gagtttgctt ccttccatgt atcatgagga atactagaaa 70801 accaatttct ttctttgtgc ctttgtgtaa atgggaagtg gtaataatat cttcccatat 70861 aagtaaaata attttcatta aactcatcac cgaaagatta gttccctgct agaggctact 70921 ttgatggaaa gtaatccgga gttagaatca gtgtcagttc agcattcttt tcttcatttt 70981 caatagtggt aataataact gatgtatatt aagtagttat tttcagccag gctctattcc 71041 aagcacttta cctacataca tttatttatt tatttattca ttctacaaat atgtattgag 71101 cttctgaaca tcaaacacta ttctaggccc tgtggataca ggagtaaaca aaacaggcaa 71161 agttctctgc cctcaaagag cttaccttct catggggaaa tacgggaaaa tatatgttgt 71221 atgtgtatgg tgtcaaatgc catgcagaaa aataaatcag gaaaaggaga cagaaagttc 71281 aaccttagga gaaatcagaa ctctcctaca ctgttcatgg gaatgggaat tactacagtc 71341 actatggaaa acagtatggc ggttactcaa aaagctaaaa atggaattgc catatgatcc 71401 accaatccac tactgggtat acagtcaaaa gaaagaaaat cagtatatct aagaggtatc 71461 tgcactccca tgtttattgc ggcactattc acaataacca agatatagaa tcaaactaag 71521 tatccatcaa tggatgaatg gatacagaaa atgtggtaca tatacacaat gaaagaaata 71581 ttactaatcc ataagaagaa taaaatcctg ttatttgcaa caacatggat ggaaccgcag 71641 gacattatgt taagtgaaat aaaccagaca cagcaagaaa agtatttcat gttctctttc 71701 ataactaaaa aaattgatct catggagata gagagtagaa tgatggatat cagaggctgg 71761 gaaaggtagt ggggaaggga ggataaagag gggttcgttc atgggtacat aagttagaag 71821 gaacaatatt gagtgcttag tagctttatt agtcagttct cgcatcgcga taaagaaata 71881 cctgagactg ggtaatttat aaagaaaaga ggtttaattg gctcatggtt ctgcaggcta 71941 ttcaggaagc ataatggctt ctgcttctgg ggaggcctcc agaaacttac aatcatggca 72001 gaaagcaaag tgggagcaag acatctcaca tggccagagc aggaaggaga ggaaaggtgc 72061 cacacacgtt taaacaacca gatctcacaa ttcactcact cactatcatg agaacagcac 72121 tgaggggatg gtgttaaccc attcatgaga cttctgtccc catgatccaa tcaccccacg 72181 ccaggcccaa ctccaacact gggaattaca attcgacttg agatttggtg gggacacaga 72241 tctaaaccat agcaatagca caacaggaca actatacata gttcacgata ttgaactaca 72301 tagcacaata caatatttaa gtatttcaaa atatcaagaa gagtggaatt ggaatgttcc 72361 tagcacaaaa aaatgacaaa ttacttaggt gatggatatc ccaattatcc taatttgatc 72421 attacacatt gtatgcttat atcaaaattt cacatgtacc ccataaatat gtacaactat 72481 tatatatcca taaaatttta aattaagaaa cattttaaac agaaagttag acctcaggag 72541 gaagattata tttttaaaag aatgatcagt gaaggctcat ttggacaaag acatttgaac 72601 aaagatctga aggagttgaa gggtgaagtt acatagataa ctgggggaac ataactagac 72661 aaagtctctg agataatggt atacatggca tgtcagaaaa acagcaagga gaccaatgtg 72721 gttagtgggg agtaagcaaa gggtcaagag atgagaggca ggcattgtgg atcctatagg 72781 ccgtgtggtc atttagacaa ctttgctttt atttgagtga gatgaggtgc cactgtaggt 72841 ctgtttctgt tgtctgtttt cccactgatt cttgttcatt ttgtgttgtt tccttgtgtg 72901 cctagctatc tttgattacc tgctgtgcat tgttttgtat aaaaatatca ggaactattt 72961 tgaggtctag atgaaggtat tttcctccaa agagaatttt gcttgtttct gccagggaca 73021 agaggttact gctaatcttg taccaccttc aactaagctc aaggtatgaa gctccttggg 73081 catcccagat aattataaca tgaccagtaa ttcattatgt ggactattta acttgtagtt 73141 cacactgata gctccctgat atctagttct tttatatctt aatttattat atctcttatt 73201 agactcttaa gggcatgaag ttttgattta tctcctgact ccctaaggcc atccaaagga 73261 aagttcaaat tttctgggtt tggaaaactc tctaagggta aataagattt tcttagtttg 73321 ttacatctgt taaaaatttt tttttcaaaa ttttaatttt ctcactgtgt agctttgtct 73381 gaataaccta acatcaacat ctgagacaga aacctaccat ggatttttat tgtcattata 73441 tagactttaa ccactttggt ttgcaccgag tctttagttt ctgatactct ttatgaggtt 73501 aagaaaatgt atttttattc ttaatttgat aattattttt aatataaata tattttaaaa 73561 tcaataaaac acttcatcat caattacatc ctctttttga tgtcattttt cactttaaat 73621 tgcaaagttt cccttatatt gaaccattct ttcatttctg aatacattgc ttttttgttt 73681 aattttttaa ttgtgttgtt tcaattttct gtatttcttt caggattatt tgcatctatt 73741 ttcaataaca gaaatggttt tgtcttttag taggctatca tgatcaggct ttgttaatat 73801 ttttccaatc ttatagaata gactgccaag tttacatagt ttcctttgat acagagcttg 73861 aggtgagaaa gttgagatgc aagtctttct tatactccaa gacattttcc tctactatac 73921 caataattac tgcttctctc ttctccacat cctttctatg tagactccat tgaaatgaat 73981 ttctttcaaa acttcaatct ttctcttctt tatgctctgc atatgtttgt ggaggaaata 74041 gggggcccta ttttatctgt caggttattc tcaagctcta gtgtccacca tgattgtcaa 74101 ctataggaac ccacaacaga aaatctcatt cgcaatctct atctcacagg tagatgcctc 74161 agcctggtgc catatgcata cattatagct cccagagttc ttcaattact ttgctgactt 74221 tcttaaagtt ggctcctgct tacagcccct gctatctgaa gtttgaaatt ttccatgact 74281 ttgtagggaa aatgtatcca ttctcctctc agtaaacctc ttcttttgtg ctaggtttca 74341 gctacttagt tgatgttaat ttttctatct atcaaatcac ctctttttat cttccagaat 74401 ttgctggaaa tatctgatcc tttgattata ataccatctt tctatatatt tacttttctt 74461 aattttgtat ttatctttta ggatttcagg tccataaaca agggttaaac atgtgagcta 74521 agattattat tactgtaact ctgatgttaa tgaacatgac ttgcatagag cactatctta 74581 ttattttctt tgtcatttaa aaatattcag cagagcaagt tcttttgcta ctatctaagc 74641 ctaccttaag caggctctgt gatttttctg gttactatta gatgatttga aatcattaac 74701 attatcccaa cttagtcatt taagtgtcta gtcctaagta ataaccaaag catccaatgg 74761 cattcacagt tcctcccttc tcagggatat ttcagcttaa ctttcatata agaaaaaatt 74821 gcagttggct tcttacctca tgctcactca ttcttccccc atttcctagc tgctctttat 74881 gaccccagaa ggggtgggtg ggaggtaggg aggagcaata actggtgcaa gagagctcta 74941 attcaactga tgcacttgta agttggcttt ataccttctg tgcctgccag atatttaaaa 75001 ctgactctta ccctcataga cctattcatg attcttcaga aatcagggaa cattaagatg 75061 ataccagtga tgcattttcc tcaggctatc catctttggc cacattagca agtccccaat 75121 ttgttagttg atggaaagtc tctttgtgtt ggggtctaat cagtccccca aaaagtcatc 75181 ttgggaggac tgaaaatgac tcccaatcag atcttctata aaaccttttt attgacaaac 75241 tctggaagcc cagaccattg gactctgtct tctttgttcc ttccattgga gctgccagac 75301 atcctttaga ttttacaggt gggaattaca tacttgtcta atgtgtctcc aaattgcaag 75361 tgtgttagag tccccaagat cacattcatg tctgatgatt catgagaagg actcacagat 75421 tttagataag ctgttatgat tatggcttat tgcaggaaaa ggatatagat taaaatcatc 75481 aaagaggcat cagttttcct cttctagtga agttgcatgg acagcacttc attctcccag 75541 caacaatgtg tgacagcatg catgaagtat tgtcaaccaa ggaggctcac cctaaccttg 75601 gtgtccagag tttttactgg agctcagtta catagatgtg gagtgctcac ataactagtc 75661 ttagctagtt tccagcccct ccaaaggtca aactaataca acgtggccta ggattccaag 75721 tattcactat cattcacatt attatcataa accatccagc attgcccaaa atctcagata 75781 tataaagata ttcttattac acaggatatt ccaaggggca gaggtcatct ctcaggagcc 75841 aaaggccaga cctttctttg gaatgtgtag ggtttgagca cctcgagccc attgagttag 75901 cccttcaact ttttactgca cagcagtaaa acacatttat aactctccgg gtggtcccat 75961 ggaggatact tttatccctt aaggagatgg gtgcatgtcc aacccagtcc tttgggtgga 76021 ttgagaatgg ctttcaatat ggctgaacaa cccaaacctt tataactcat ctaactggtg 76081 gctattttca gttttcattt cctccaggac aggctgtcca actttttggt atcttggctg 76141 tagtgaacat atattatcat attacaatat attaatggta ccatttggag atcaaagaag 76201 tgtcccaaat cgggacactt taatatccac atcatcccaa attgtgttta atgcaagcat 76261 cacaacaaga aaatggggga cttcttttta aggaaggcaa aaccttatgg tataattcaa 76321 atgatattaa gtataatttc tacccaatcc aaggcacatt ccttcatgga cttgaactat 76381 ttcatgtctt catgactttc tcttctccag gattacatta gtatttaggg ctgccataat 76441 agaataccac agatagggtg tcttaaaaaa cagaattttt tttcctacag ttctaaaagc 76501 tggaagtcca aggtcaaggt gctatcaggg ttggtttctg gtaaggcctc tcttcctggc 76561 ttgcagatgg cttcacatgg ttatctccct gtattctcac agggctttct ctccttgtgt 76621 gtgcacttct ggtgtctgtg cctacaatga tgagcgccaa aaatcccaga gtgttttttc 76681 ataacacagt tctcattcca aaatagtttt tattcctctc ttttatagac cattataagg 76741 tttcttcctc taaattaaat aacagtgact aaaactaagg caaatactct ggagcaaaat 76801 aaaaactaaa aaacagatag ccttaaagca ggaagttacc ctgtcactag ggcttggcat 76861 actgtaggct ttagaagcat ttcgcggcat gaaagaatgg taaccctgag gcatctccat 76921 gtaataagtt aatttgtata ctgcttttaa ataaagttaa acaacttaca gtttcagaaa 76981 gatagaaggg aagagcattc ggaagactgg gagtgaagtt tcccgggcct gaacccttat 77041 tcaaaggcgt ctcgacatgg ataacctcga gaacattatg ctaagtgaaa taagccagat 77101 acagaaaggc aaataccaaa tgatctcact tatatgtgga atctaagagt tgaactcata 77161 gaagcacaga atagaatagt ggctgtcagg gatgggagga tggggagatg atcatcaaag 77221 ggtacaaagt ttcagtcatg caagatgaat taagtactgt agatgtaatg tacaatatgg 77281 tgactacagc taacaacact gtattgcgca cttgaaattt gctaagaggg tagatcctaa 77341 gtgttctcaa aacacacaca caaaggtaac catgtgagat gatacttcac tagcttgatt 77401 gcagtaatca tttcataata tacatatata tctcaaaaca tcaccttgtt caccttaaat 77461 atatacaatt tctatttgtg agttatacca ccaataagct aaaaaaaatt aaaagtctaa 77521 atttttttaa aggagtttca aaaactaatg ctttgctcta tacttgtacc tggccccacc 77581 cttgtctctc taaagcaggg tgccctagga agactgattg gctgtagccc caaaaggtga 77641 gaactaggac ataagataag aaagggaaga agggaaaggg agagaaggaa gtggggaaca 77701 aagtgcgtca atgtgtgaaa ttttagttgg atgttgtaaa acaggaaaaa aaatgccaaa 77761 ttctatggct accccaataa caaagaatgt cttatggcaa tggcaccctc caagtcatat 77821 aattcattta ttattgtcac tttcactatt gttttcgctg aagtcttttt tctgttactt 77881 gaacaaaatc atttttttcg taatttgtta ataaaattgt ttcattttat ctgtctatcc 77941 tacatccctt caaatacagt acacaaacaa atgaacgtgc ttttccagct tgtaacttga 78001 ggcatggtag aatgagaatt agatggggag ttggaagact gaggttgtaa atgcccctct 78061 ttagttaatg tgattttggg gtccgtttac aactcagaca ctgattttct catatctatc 78121 tacactaaca cagacgtcag gtggctgtca aagatgatct ctaatggtat aattagagac 78181 atcagggcta atgttctcta attttgtcca gttatgataa agtaacttgg agtgcctgtt 78241 ctttacctct ctaagaacgt ttcaagtgtc atttaaaatt tgattcttat ttgtcaatgt 78301 gttttttggc tcctctgtgg aaactgttat agtcttaagc ctgtcaaggg agtataaaga 78361 catcctaaga aaatttggag actgggccgg gtgcggtgac tcactcctgt aatcccagca 78421 cttttggagg ccaaggtggg aggattatga ggtcaggatg gagaccatcc tggctaacac 78481 ggtgaaaacc tcgtatctac taaaaataca aaaaatttag tcaggcgtgg tggcacatgt 78541 ctgtagtccc agctacttgg gaggctgagg cagaagaatc acttgaatcc aggaggtgga 78601 ggttacagtg agccaagatt gcgccactgc actccagtct gggcaacaga gagaaactcc 78661 atctcaaaaa ataaacaaaa taaaattggg agactgacaa tataacttca ctaatttgtc 78721 tatgtaaaaa tagtaataaa gaaaatggaa aggtatatac tttttaaatt tctagtattt 78781 tcaaaagatt catatgaggt tataaatgga agataaatga ttattctctg tcgaagttta 78841 ggaataacaa gagtaggata gtttaagata gttgaggcct tattgagacc ccaacttatt 78901 cattcaacat gtgactcaca aaaagtgaaa ggcaaaatag atttatcacc tcagattcta 78961 aaacaggaat aaaacaaaca aagtgacttt catccaggaa gaaagcaaaa gtacatccgc 79021 agttcttacg gtcagagagt gtgtgctgct cttagagcca agtttagttc ttggtaattc 79081 tacccaagtc tgaaaggaaa tcaagatgac tgtccacatt gacgcaaatc acaggacatg 79141 gaggcaatgt caggcattta atgttgtaaa agttgcaaac cagaaatccc atggaggaga 79201 acacagagaa tcctatagtc ctgatatcat ttttggtgga atgaacaaag acgaacgcag 79261 agctgggaga tatttggcac agaatgaaac agagtttgaa ctgtggctct tcactcacta 79321 cgagttagta aactaatgcc atagcacgct gctcagtaca atgggtactc tgaaagaagt 79381 gagtgctccc tttctcccct gctgtgaacc tgccagtgaa ccaaaaccct taacagttag 79441 agccaaagag caggagaaag tccagcaacg tgtcccaaag tgattagaaa ctatcttgct 79501 ttcctcctat ggaaatacca agcatttttt gtggaaatct gaattcacag atgaagttca 79561 gagtgaatag taacattcct tttgttttac aatcttggaa atagtagttt ggcatggaaa 79621 gagcagagct tactttttaa aaagaaaatt atttgtattt ttataaccag atttatttat 79681 agttatacca gtaatatctc tgttattttg gcatgcaact aaaaaatata gaaaaatttc 79741 atgtccctct tgctttgtcc aataaatata atttctaaaa tattgtagaa gttgaataat 79801 tttaacttgt tagaagaatt ttataaaata aacagccaaa tcacctaggt tgaaggttgt 79861 cttttagaat tttcttaaag ggaggcatat ctatatttag acatattttt aagaggcagt 79921 agttttgctt taaaatatat gacctgtgaa gtccttttat cttactagct gtgtaaacca 79981 aaataattac atgtaacaag tcttatgtgg aataattcag cagccagttt gaaagaggct 80041 aattaatatt tgtggctaca ttaatcagaa aaactatgga aatgtctctt ggtttattat 80101 ccctttttct atgattcata aacagacatt attacaactg cataaacatg aaccctactg 80161 ggcaacatcc tttttttttt ttttattttt ttccccaaga tggagtcttg ctctgtcatg 80221 aggctggagt gcagtggcgc gatctcagct cactgcaacc tccacctcct gggttcaagc 80281 aatgctcctg cctcagcctc tggagtagct gggactacag gtgggtgcca tcaagcccag 80341 ctaacttttt gtattcttag tagagacagg gtttcaccat gtgagccagg atggtcttga 80401 tctcctaacc tcgtgatctg cctgccttgg tcttccaaag cgctgggatt acaggcatga 80461 gccactgcac ccggccctgg gccatattct aacagttcca caggatattt ccagccagct 80521 ggaactatct gcaagacagg gccattgagg ccagaatacc tttcagaggt cttccctagc 80581 taaggtcaaa tcataaaatt atcggattat ccatagctgg gggtggattc tctcaagacc 80641 gcattagtaa tgtattaatg atacattaag aagtactcca caggtctata actgctcaat 80701 caccttcaaa gagtttttac acacattatg tcaggcatga attattatgc ctatttaata 80761 gagcttccta tcctactgcc tctttttaga aaaaaaagtt ttattgtgat ctttattgta 80821 tacatttaag gtacaaaaca tgatgtttag ataaacatat acagtgaaat gattactata 80881 gtcaagcaaa ttaacaagtc catctcctca catagttaca gctaacttag aaagacagaa 80941 catcacaccc agagcaggga gctgtgtctc cagctccctc aggtccatat acctgagtga 81001 cttggagaaa atcatgcatt tcctgtaact accagacgta gtcacctcaa ttaagtaatc 81061 tgttttgctt aggcatacct tggtaaaagc tcacagtact aatctggacc cacccctttg 81121 atctttgaaa cctgaggtgc gaaaaaatat caaaatggag ggcagaggga tttgttttta 81181 ttttcagatc atcaaaaata ctaaactgtt gatcagaacc atccatgaag aaagaaaaac 81241 aaattcaaac tatgactaat ggggcctgct gtgcgtgagt cacaaactga atcaagcaag 81301 gcctctggaa gcagggggaa aagcattcag gagtcacttt gtactcaagc atgaacctcc 81361 taaagtgttg gtctctttgc tgaactattt caacacctgg atgaagtcca ggagaagaga 81421 cgtcaggcag tttaaaaatt gcttctcttt cctactaagg atgttttcag tgaccttgag 81481 gaggtgttta agaatgactt tcttaggtgt gaacatgaaa acagtgggac ttagggcaac 81541 atttggggag attccttgct tcaaagttgt ctctaaggca ttgcacattc ctacttcttg 81601 caggagggaa ctgtctttcc aaaggatttt gcaaactgtt ctgcttttgc ttatctaaac 81661 tggaaagaga tatataaaca aaatataaaa tacaaaataa cataaagtct gttgattgag 81721 catagaggct tggggtcttt agcttttttt cttattgttg ctttgtatta aaattcaagg 81781 gagtccaaat attttcagtc cccttgatct aactgggata ctcatacaat gagacattgc 81841 acttctgata aatatgataa tgatgagttt agtttgaatt cccaactgag tgcatgtctc 81901 ttaaaaacat ttttctcttc actttgtaaa tttcttatag agtctaggtt gctcatctgg 81961 ggaaaatgcc acaatacttg atctgacctg gaaagattcc cagtgaaggt aaattgatac 82021 tcacataagc cagtttttat cataagaatt gagactagta ctgaaggtaa agaataaaaa 82081 gctagttgga caaacgttca ctgcatgatt gctacacagt gcttggtgcc agggatagcc 82141 agccacctgg cagctaggaa gaaagctggc cttacctcag agctttcttc ttcctggcta 82201 gtcaaactgt gaaaatcctt tctcatgcaa cacaataaaa taattggctc caaaatgtct 82261 cattctcagc ctcattccct aatactggac acaggaatct ctttcagcca agcagccaag 82321 ctcaggccaa catgggacgt acctccactc ctttaagata aagtcaaagc ataacaccag 82381 ctgattcctt aactgtcatt tcactccagt ttccctcaat tggcatcatg tttccctgat 82441 ataagcagcg ttaattaaag attagttatt gaaaaggtgg tattgtgctc aagaaaacag 82501 tgaaaaaaga accaccattt aaaaaaaatg ccaccacctt aacaatgaca tttgtcagat 82561 atgtattttg ttcatggttg gttgatttgt taaggtagtt gttactcttg ttttctaatg 82621 actgctcatt tgttctctct tctaggacta gggaaggcac tgtaacataa tgattaaaag 82681 cataggcttt ggtgtcagac acgctaggat gcaaattcta actatgcaac cttgtaaaat 82741 gtgctgggca gctatctttc ctacagagtt ggagtaatgt tgactaatat atatgcattt 82801 gtataaatta agctgttaat tgtgtgtcaa tattgcattg atatcttggc tctttaagga 82861 catttgattt tctggtttaa gtagtacctc ctgcatgaac ttcctgacgt gttgaactat 82921 ttcaacacct ggatgaagtc caggagaaga gaggtcaggc agtttaaaaa ctgcttctgt 82981 ttcctactaa ggatgttttc ggtgaccttg aggtattatg tatgtattat gtatgtcatg 83041 cctcagagac agacttggct tcacaaccat ttttcctgac aaccatccac ctatctgaca 83101 tgcatttatg gggaactgaa caggagttat gaaaataagt ccttaagtct gcaacctctc 83161 atacttaact gtcatctgta ggacactgaa gacatatatc agaggatcca caccgtatat 83221 aattcatgcc ttgtattggt tatctatggt tgtatcacaa atcagcccaa agcttagtga 83281 cttaaaccaa taactattag tgctcacaag tctgtggttc aactgggtgg ttttgctgat 83341 ttggttttgc tgctgggcag gactgcctga tcttggctgg tcaagttcct gtgatcggca 83401 gattgaaaag gtggtagttg gttcagaata gccttatgcg taccttggat ggttgttgtt 83461 ggttcccacc tggggcagag gggataaacg ggccaggtgt gtttcatctt ctaccatgct 83521 ggctcttgct tgtttatagg cagtcccagg ttccataaac aagaaagcaa gccacaatgt 83581 gcaagaacgt tagtttctgc tcattcattc caaaacacat cacaaggcta atctagattc 83641 aaattatgga ggaaaatgct acttcttgag ggaagagcta caaagtcaca ttgcaagggc 83701 atggacacag ggagggaaaa tcttttggct atgtttgcag tgtaccacat gcacttgatt 83761 ataatcttaa tgcttttccc ttcaaatcta ctgacatagt atagtgggaa atccttgact 83821 gagttctttt attttccttt actctgtcag gtttcttctg ggtccattca agagagtgtg 83881 aaagaccgag tgattgactc aagactgcag ctgtttatca ccaagccagg actctacaca 83941 tgcatagcta ccaataagca tggggagaag ttcagtactg ccaaggctgc agccaccatc 84001 agcatagcag gtaggatgcc ccttcacatt tgcgttgttc caggagaggg gagagttgat 84061 actattctac aatatcgagc attggagaaa atctcccttt tcttttatct cttatttcag 84121 ttgcatttgg gctatttcct cccccatggg gatactccgg aggtgaccta gatatggatt 84181 ttggcagatt tgctgcctgg aaaactaaat cctcaatacc tacccaagtg gtaggtaaca 84241 gcttccagga actcacttct tccttccttc ttgtttttct tatctttttt ccttttctcc 84301 atttctcttt cctccctccc tccttccctc cctcgctccc ttttttcctt ccttctttcc 84361 ttccttccct tattccctcc ttcattcctc cctccttccc tccctccctc ttcccttccc 84421 tccctccctc ttttcctttt ctttaatttc ctttcctttt ccccactcct cgttctctct 84481 tttggttgat caaactttcc aagtctctca tggagaaagt tggcagacat tcaacatggt 84541 catgccaatt tctgcatggc tatttcttgc gggcattttt acctgtgagc atgatccctg 84601 tggtctttcc cttccctgct tcagcaagcc acagcaggtc ttacaggtgt tttcaagaaa 84661 aaggctgaca cacggatttc taggatgttt gtgttgagtt ctaaaggttt atttttaaaa 84721 tgtaaatgtc ccaaaggctt ctgagaacat ttatagaatt cctagagatg gaaataatcc 84781 ctgtatcagg aaatgccagg catattagat tcatagcgtg cctagggctc aagggtcagg 84841 agagaggtgc ttggcctgac atgtaaggca agcacggata gagcttgtgc ctagggccaa 84901 ctccccacag cctgctgttt cttattacag tgccacctct ttgatcttcc ctgatgggga 84961 actttccagt aatgtctgtg atttgtaata tgaggtgaat aaaaaccaca gataaatgat 85021 aaggagcact ggacaaggct ggccctctgg gactgcctat gaaggaaaag gaagacttca 85081 aaattaaggt tccctctcct ttctcccccc agtgatatct ctgcctacca tgtcttcaga 85141 caccatatca gttattctag catttccaca ggtgggaaat tatttctccc agaaaatgaa 85201 aagtcttcta aaagtaaatt caactcaatt taacaaataa taataatatc acataataag 85261 taatagtata atcatataat ataaatagta ataagaatta ctatttacat agcactttgc 85321 tgtttataaa gcacttttac atgcatttat caaatactct agatgacgcc cattgtgttg 85381 ggtagagtaa gagatgaaaa gttaatttaa aaatgggtcc tgccttccag ggactctgca 85441 tctagaagga agtcagtcag tcacgtatat tatggcactg gctgtattct attgcagaag 85501 catacacaaa atacaacagc agaacaagag aggcaggatg tcagggaatc cttggaaaag 85561 aggtatcatt ggagcagaag atgtggatat gagatgacta ggttgaagtc aaacctttca 85621 aacctgttca aaaaacagca aatcagtggt caaggctaga ccacgagaga gacagcaggg 85681 aggtggaaag tggaaacaaa agttgaaaca tgggctctag ccaggttatg aagagcctgc 85741 ataggtttag tatattattt cattgatgag aagtcattta atgatttaga agaaataagt 85801 gcaatagata tatcctctag caaattaaca gatgctgagg tgttaggagg ttgagaagtg 85861 cggcaagctg tcaggaggct cttccaggtg tctcaaaaag tcatgaaggt ctgaacagca 85921 gcagcagcat tggttcaaag ggaagaggag agatgcacag gacaaatcag gatagaaata 85981 aggtttgcaa atgcttgaaa atggcagtgg gctagaagga tgagttcaga tgtgtctgat 86041 tttgaaaggt gcccaggaca agcaataata tataaacaca aagcatatga acaggagaag 86101 gtccaggaga taatagaata ctcaaaaatg ttgatgcctt tgaattacct ggaattattc 86161 tggtctcact gtctttgtat tatttgacat ttgatcaaga cctactgtta aataaacata 86221 tatttataaa aatctatcaa tatatattta tataacatat atgtatgtat gtgtgtttat 86281 atacacacac atggagagag agagagaatc acatttaaat atgaatactc catccaagaa 86341 aataaactga tctactttaa tttaacctgc actttcactg gcagaagaaa aatactaatg 86401 ttactaatct taggagagtc tcatttcagg tcattattca gtcactcaaa gatacccgtg 86461 ccagagctct ttctcccttt tcttccttct ttctctttcc ctagatggca aaggagaaga 86521 ggatttgtat ttaggcagtg gtgtcttctg gacacccccc acaccactgc taacccccgg 86581 atctctagtg aagtctgcag ctgaacttgt gattttatct cttggcttgg ttagggccca 86641 ggggacctcc ctggctggct tagcctgttt gagacatctt ttggagcagc acagccctct 86701 gcatctcagc caaatccttc atcatgccat tgtctacact ctgctctgca acctcagaag 86761 ctaggtctcc ctgtctgtcc ctactgtggc cctgtggctg gcctgctgaa ttccaactca 86821 gctccttcag tactcctcac agggcctgaa gcaacttcta gatcactttc aaggcataca 86881 gaattcagga gagatttggg cttgctaact cagttctgct gtctgcccaa ccttgtcatg 86941 ctaccatttt cacattaatg ttgccatcca tgttggagta agggatccct gtggggtgtt 87001 ttacttatag catcctaaat aagaagttag aaaaactcca tctgcttttg gctttttcct 87061 taattgatca atacacctct attctaggat ttgcattcag aaaagggatc tataaaatct 87121 ataaaatatc caaattttta atctccctac cttcctcctt ttcacagcat atgaagctgg 87181 aagagcaggt ggtcaggaat ctcccccaac cttcagtgca gtaatcttta gagcctactc 87241 atcataagta caaaggtggt tgtgaaggca gtgctataac cactgagggg aacctaataa 87301 aatgggtata tctactccac acaagggaag attcatccca tggacacaat ctttaagatg 87361 ccgagaggac tacagggcat gattgccacc atactatatg cagcaacatc atgacttcat 87421 tcctgtccta gcccagatga gaacctgatc caactccata aacggaacac caacagggaa 87481 atctgtaacc ttaaaaaaac ggcatcttcc agtggtagaa agagcctaaa ggtctgagac 87541 aggcagtata ggaaggccat gtcctagggt gtagggagag gtcatcttag atatcagtgt 87601 tgagaaagac cagaatgagg atggggacaa tcagcaatgg ccacccagga aaaataacag 87661 tggaatttgc atgggggaag ggatggtggg agcaatgcaa agattggcat gtggcagcag 87721 agagcaactt gcaatctgct gcagcagcag aggtgagtgc ctatgaagag cagttatctc 87781 tgtaggaata atggttgtgt agactagaac cagctatgac ttttcatgag cttgacaatg 87841 gcagtgcgat ggaggtcagc tttagagtgg ggagaagttg gggaccctgg aagtgaggct 87901 tgaagccact ctggacaggg gtatgtttac agtagctacc caaggaactt gggtagaggt 87961 agagaaggca gcataaggag agggttaacc tataactggg acctgggact ttgctcttct 88021 gaaccacaaa ggcaacaatt aaatctgacc atatacagaa tcatagtgct gcacgatgtt 88081 cggagtcaag taaagaaatg agagttgtta ctcgaaaact gaaaaatgga aaagactaaa 88141 aaggtctaga gtggatatga taaatgagaa acatgcctat taattaaaaa attgctacac 88201 atctagtgtt attccctgga ataagaccct tttgtccaac ccctgatttg tttgtctggt 88261 tgattctcac tgattattag gggacttgac actcctcgac ttttcccaaa atttcccgag 88321 gcagacctaa taagggtgtg tcatgagtgt gattgaataa gacttctgaa ctcccatgag 88381 acaacttcca ttttctcttc ctctttgacc tgctcttgtg agttagacct gctagaagcc 88441 ccatgaaggt ccctctggaa tcactgagga aactacctcc caacactggg gtgctccgtg 88501 gactgatatt ttagggaaat gaggctactt cgatgaaaaa gggatccttg gagcctcttt 88561 cattcagggt catttgaaag aagcatggcc ttatgctccc cagatctccc agaactcaag 88621 tatggtatct gctttctcca tttctgcttt tggcccctct ctcggcatcc gatgaggctg 88681 gccagaagtc cagaacttca agtcagacat ggcgcctctt ttgccattct ggcaatgctt 88741 ccttaatgcc aaactctgct gtctcattta accatctcca tcctccccta tgtgactagt 88801 acccctagta gtcaacagcc ccctctgtca tgttcctcgt gtttcccttt gaaatttcta 88861 ctccatctgt ttatttgctc ttcccagcag gaaaactgga aatggaaaaa gctgatctta 88921 tgcttatgct taggattatg tctaatgata tttctagtgt ttgaaggaca acaaaaaata 88981 aagatcaggc ttcatttttc caaaaccctt ccatgtgtct gcccaaatcc ttatgcattg 89041 ttttagaaat gtgatatatt tctttctgac tcatttacat ttactgttag tcatcaaaag 89101 gagtcagaaa aacttttgga acctctccct atgaaccagg aagttgcatt tcccctccag 89161 tcacaacccc ataaagcctc aagttgcaaa gtaaacttgc caggatgctg ggcatttggc 89221 aagatgcttc tctttgtcat cagaaccctc agccctgtgg aagaaagcaa gacagcctat 89281 gataccaata gtgagcatag tcctaaaaca gccggagacc atgaaaatgg acacagggat 89341 tcagaagaga aaaatacagg ccgggtgtgg tgactcacac ctgtaacccc aacactttgg 89401 gagtccgagg tgggcagatc acctgaagtc aggagttcga gaccagcttg ggcaacatgg 89461 tgaaactcca tctctactaa aaaatacaaa aattagccag gtatggtgac gcatgcctgt 89521 aatcccagct acttgggagg ccgaggcatg agagtcactt gcacctggga gatggaggct 89581 gcaatgagct gaaattgcac cactgcacca cggcactcca gcctgagcaa tagagtgaga 89641 cttcatctca aaaaggaaaa aaaaaaaaaa gagagagaga gagagagaga aataaaatac 89701 atatttgtat ttcccattct caatggcacc aacaggtcct tcatcagaga gtgcagtcca 89761 tggttctatc catgtttatc cagtctcaga gtacagggac gagcctatgg tcacacaccc 89821 ctctaatgta agccgctccc cattctacca acaaccccca ctttctatat tgccccttct 89881 ttgaatcgac ctcagggtct aagccttttg gtcactaaat ttaaaagtca catgaataca 89941 agtagtatca aaactgagca ggagggaaaa atctgatgtg gtaatactgg agtctcccaa 90001 actccccaga tgaaccacat ggttttattt ttcttatttc aaaagaggtg atgtttcaca 90061 ctactacaga aaaaaaaaat ggaactttga acactatttc ataatcagta tagctgattg 90121 aatgtactga catgtttcat gctctttctc atgtctgata gccacactcc tgtttcctcc 90181 caatgttgga gataattctt gagacttggt aacagagcag tagcacgtaa tttgctttac 90241 cactcagtgc ttcaaccatc ataggtaaag agtgttctta tcaacaaaac agacaccatc 90301 cctggcattc catgctggct ttctctggtt ttaaattaat taaagtcatt ttgtttttgt 90361 tcttaataaa agggaaaagg ataaatgagt aacagccagt agccacatta aattgctacc 90421 agatgttctg cagttaggca taaaaggtaa gcatcctttt acaatcaggc agctttctta 90481 tattagaaca gttctgtttc agaagagagc caatgttttt gctgacttct agataatttt 90541 aaagatacta taatattggt ggatatttta agaattttta aatactacaa atattggtgg 90601 gatattttga gaatttttta aaattgaatt ctgagcttaa agcactttat agttgcaagg 90661 ttcttggacc ccttcctcat ctcctagcca tacaccccca caaaaataaa agaaaatgca 90721 agtggagaca tttcctatag aagctcatta tcccctccca ggtactatgg ctggattctc 90781 ttttgcattg gcttatctcc atgctccttc cacattacaa aatgagggct ctatcattta 90841 cataaccttg gcccccttgc ttttcaatag atcttcctgc tcagctgcta ttagaatctg 90901 cctttgtatt tccaaattat atgccatttt ctctggaaga attttccagt gttccactgt 90961 ctttcttccc actattgtat ttgtataatg gcagaactgc catgagattt gggggcatga 91021 aggcacttct ttcctgagtt cagcagtgac atagagttct cttcattctc tttcatagcc 91081 tttggtcatt ttaattaaga gactcttgca ggcctctagc ccggttcact aaaatttaaa 91141 ttctctctaa tttataattt gttgacatca ttggcatcac ctcttagatg atcaaaatga 91201 caatcctata acccagcctg cctatctcag taaaacagaa agaatctact agatgttttt 91261 cagaatgtaa atagatataa catttataat gattttccta ttgtccagca aattatctcg 91321 cagttggagt cctgcaaatg ttagagacat cttgatgttt ccttcatagt cactccagag 91381 tctgttagtt cttatgtata aagaaatttc acaaagaaat ccagcttttc tcactgctaa 91441 aaggatgtgg ccttctgtcc ctaagcaaag tgacccattt aggggaggga taaaatttta 91501 gagcttatta ttggctaaaa ccctactctg gatcaaaagt ttgtttttaa agtgcattgt 91561 agattgcaga acaactatga atcactcata aagagaggta acaaagacct gaggctatat 91621 gtgtaaccag tgtattgaac aatttaaacc tgacaggtac acagagaaaa tggtgttttc 91681 tccaaccaat ggggactgag gaattatgcc ttttagaatc tccttgccct tctcaagagc 91741 aaacccttta caaactttca ggcagattcc ataatttcca ggtaatgttt agagattaaa 91801 aacccagcct gatctagttt aaaactctcc tcttacataa tttaaacctc atctgcttca 91861 ctctctccac tgccagccaa tcttccattc aggaacatgg agagtagaca aaatgggtct 91921 gctactatta tacacccttc ccttcttccc tttcctcctg ttcctcttca tctctggcat 91981 atttaaggag aagaggattt acaaggaagg cggcaaatgt gttttcctaa atggaatatg 92041 ttttagttct ttctctgtta attgttattg cttctctgac taataataat aatgttaaca 92101 attgcaaggt acattctcag tgcccagtgc catatatata tacatatata tatatatata 92161 cacatatata tatacatata tatatataca tatatatata tatatatgaa tttatttaac 92221 acccacaact caatgaaatg gatactttta ttatccccat ttcacagatg agcaaactaa 92281 tgctcagaaa ggtgcccagt ctgacacagc tagtaaatgg cagaaccggt attgaaaccc 92341 agcaggtgca gcatccaggc ttttaatgcc ttgatgggtt attaatgtct ctctattgca 92401 ggtggtacct gaatactgac tgtctcctag gacatttggg ttctttggag ggtccttcgg 92461 aagactgtgt attgcacagt gccctgatgt gggagattct ttactggttc aacctctcat 92521 aatccccagt ccttgatctc aatccctatt gaggtaacct gcaattgctt atgactgggg 92581 ttctttgtct ggtgtccagt cttcttggta acttagctac cttcatagca tccactgaac 92641 acacaggaat gtcccatgtc cctaccatcc caatggtggg gagttctatt cctggaccct 92701 ctcactctgc cctcagattg ttgcaattct ttttagacag taatattatt aaaaaaaaaa 92761 aaagacaaaa caaatgcttt ccttgtctct gagtcctagt ctcttaattc ttaggcagtt 92821 gaaaaatgac tccatgagat gtgttgttac catttacatt gtatcattca agaatgagaa 92881 gatctaggga aataattcat cccctttctc cttatatttg ctgagatgcc cttcatcttt 92941 acttgaaggc tgagaaccaa agctatttgt ctggttatag ggcctacaaa ttgcaacaaa 93001 ggttggggtg attgtgcctt ttagtaaatt ccaaggaaaa atgtcaagtt gtatgtgtgt 93061 gtgtgtctgt gtatgtttac atatttccta cgtgtgtgtg tctgtgtgtg tgtgtttaca 93121 tgtttcctat aatcatttgt cttgcttttt gagggcattc caactactgg tggaaaaaat 93181 aaataaatac aagggggtcc atgctgtgag tagttgaaat gaaaatactg gtgttttgat 93241 gggattaatt cagtacattt ataatagact aattcaccca aaatcaactt ctaaaaccag 93301 tttgccttaa ctcacttaac tcaatttcag ttagcctgat gactattgca tctaatgttg 93361 aaaattcaga attaaaaatg aaatattggc tggatacagt ggctcatgcc tgtatcccag 93421 cactttggga ggctgaggcg ggtggataat ttgaggttgg gagttcgaga ctagcctggc 93481 caacatggtg ataccccatc tctactaaaa atacaaaaat tagccaggca gggcagcagg 93541 tgcctgtagt cccagctact caggaggctg aagcaggata atcgcttgaa cctgggaggc 93601 aaaggttaca gtgagccaag attgtgccac tgagctccag cctgggcaac agagtgagac 93661 tctgtcttga aaaaaaaaaa aaagaaaaag aaagaaagaa acatttacca aataatatgg 93721 ctgagtattt atgactaatt tttgtattgc taatacttta tcacatatag ggaatcatga 93781 gattgttaca tattgttgtg actgtctttt tctgttccag tcattttgaa cacttgcatt 93841 attctttagc caatttgtca aaaaaaaaaa gtctttttct ttacaatttt gaatttctgc 93901 taaaaatatt tagtggaatg aaatttattc cattaaaaaa acgaaccttt tgattattat 93961 tgtctccttg ctactttcct ttattataag agtctatgaa ctctacatgt atgtgtatat 94021 atatacatat gtatgcatta accaaattag catactctca gagctcattt ctgtttagtg 94081 aggtattcgt attttaaaag aataaagaaa aatgggtccc tcttttgatc accattccat 94141 gttatttatc aagagatgta attgataaag gttttatttt gttttgtttt gagacagagt 94201 ctctctctct tcctcccaag ttggaatgca gtggtgtgtg atctcggctc attgcagcct 94261 ctgcctgagc tcaagagatc ctcctgccac agccttccaa atagctggga ctacaggtgt 94321 gtgccataac gcccagctaa tttttgtatt ttttgtaaag aaggagtttc accatgttgc 94381 tcagactggt cttgaattcc tgggctcaaa tgatcctcct gcctgggtct cccaaagtgc 94441 tggaattaca ggcatgagcc accatgcctg gccctaattg ataaagtttt aaaatgcaaa 94501 atgtgcatca tttccaaatg aatttatagt gagaatcata acattttgaa aaacagtttt 94561 caaaatgcca ctggagtgtt aacaaattaa taccatctgt gatgactttt ccattctgcc 94621 aaaacctgat aaagctctgc tgaagtaaag aaattggttt cacagagcca gcacactgaa 94681 tgggcaaaag ctggaagtat tccccttgaa aaccagaata agacaaggat gcccactctc 94741 accactccta ttcaacatag tactagaagc cctggccata gcaatcagat aagggaaaga 94801 agtaaaaggc atccaaatag gaagagggga actcaaagta tccctgtttg cagataacat 94861 gattctatat ctagaaaacc ccatagtctc tgcccaaaag ctccttgagc tgttaagcaa 94921 catcagcaaa gtttcagggt acaaaattaa tgtacaaaag tcagtaaatt cctatatacc 94981 aacaatcacc aagccaaatc agaaacacaa tcccattcac gattgccaca aaagaataaa 95041 taccgaggaa tacagctaac caggaaggtg aaagatctct gcaataagaa ttacaaaaca 95101 ctgctcaatg tgcttaaagc aatttataga ttcaatgcta ctgctatcaa acaaccaacg 95161 acattcttca cagaactaga aacaaaacta ttctaaaatt catatagaat caaaaaaggg 95221 cccaaacagc caaggcaacc ctaaacaaaa agaacaaagc tggaggaatc atgctatctt 95281 acttcaaact atactacagg actgcagtaa ccaaaacagc atggtactgg tacaaaaaca 95341 gacatataga ccactggaag agaatagaga gctcagaaat aaaaccacac acttacaacc 95401 atctagtctt aggcaaagct ggcaaaaaca ggcaatgggg aaagaatccc tatttaataa 95461 atggtgctgt gatagcaggc tagccatatg taaaagattg aagctggatc ccttccttac 95521 accatataca aaaatcaact caagatggat tatagaccta ataaaaccta aaacagtaaa 95581 cctgaaagat aacttaggaa atacattttg gccataggaa ctggcaaaaa tttcatgatg 95641 aaaatgccaa aagcacttgc agccaaagca aatctgacaa atggaactta attaaactta 95701 agagcttcta catagcaaaa gaaactatca acagagtaaa caggcaactt acagagtgga 95761 gaaaatattt acaaaccata catctgacaa aggtctaata tttcagaatc tacagggaaa 95821 ttatacatac aaggaaaaaa acaaacaacc tcatttaaaa gtgagcaaag gacataaaca 95881 gacacttttg aaaagaagac atacatgcag ccaacaagca tatgaaaaaa tgctcaatat 95941 cactaatcat tagagaaatg caaatcaaaa ccacaatgag ataccatgtc actccagtta 96001 gagtggctat tattaaaaag tcaaaacata acagatgctg tctgagacca gcctggacaa 96061 catggcaaaa cctcgtctct actagaaatc caaaagttag ccaggtgtgg tggcacatgc 96121 ctgtaatccc agctgcttgg gaggctgagg caggaaaata acttgaaccc aggaggcaga 96181 ggctgcagtg agccaagatc acaccactgc actccctcct gggccacaca gtgagactcc 96241 acctcaaaag aaataaaaaa ttaaaaaata acagacactg gcgaggttgc tgagaaaagg 96301 gaactcttat acactgctgc tggtggtgta aattagttca accactgtgg aaagcagtgt 96361 ggtaagtcct aagataacaa aaacagaact accattcgac ccagcaattc cgctactgag 96421 tatatattca aaggaatata aatcagtcta ccataaagac acatgcatgc aaatgttcgt 96481 tgcagcacta ttcataatag ccaagatgtg gaatcaacct aaatgcctat caatgacaga 96541 ttggacaaag gaaatgtggc acatatacac catggaatac tacgtggtca taaaaaataa 96601 taagatcatg tcctttgcag gaacatgtat ggaactggag gccactatcc ttagcaaact 96661 aatgcaggaa caggaaacta aatactgcat gttcccactt ataagtggga gctaaataat 96721 gagaacacat ggacagaaag aggggaacaa cagacactgg gatctacctg agggtagagg 96781 gttggagaaa ggagaggatt aggaaaaaaa aaaatagaac aactttcggg cactatggtt 96841 agtacgcggg tgatgaaata atctatacac caaactcgca agtcacaagt ttacctacac 96901 aacaaacctg aattatgtac ccccgaacct aaaatcaaag ttaaaatatt cttcaggatc 96961 actgaataaa aagctcataa agattcaaaa aagtcataca ctcaaagtta taaaaacctt 97021 ctagttacca accctcacca atctcaaaga gaatgattag aaatacaagc tcattgtatt 97081 ttaagaagat tgacctctca gagaaattca tgttacagcc cttaaaaatc ccccccaaaa 97141 taacacccaa atggatctaa aaccttcaaa acggagttag acctcaacat taggagaaat 97201 tttaatatgg caaattggtt ttagacaaag catatgtttt actgtttatt ttcgtaatga 97261 gggttgagag gacaggacga agtaaccata aagcacttgg taaagagtgt gaagttttta 97321 atttacaaga aagaaaatgg aataattcag aaatgctggt tatatcacac ccttgccggg 97381 attctcatgc cttggcagag tctgagttgg ggctgtttgt cctgggaatc acataccacc 97441 agaggagagg cgtattctcc tcagagccct gagtttttac atccgtgagc atgggcagct 97501 acataatttg cagggctagg tgttccaaaa acggtaagga tttcaaggta gggagagcag 97561 aacattaaat taagcccgag gcccttctga gtgcagatgc catgcagcta cccagggcac 97621 acagccttga ggcagccagg tctatgagaa caaccattgc ctactttctc ttctaccctc 97681 tctcctctgc atgttctttt cttttctcct tctccttctt ttttcttttt ttccaagtct 97741 gctttatgca tcttctctgt taacctccac atcttgcttt tttttttttt tttttttttt 97801 tttgagacgg agtctcgctg tcgcccaggc tggagtgcac tggcgcgatc ttggttcact 97861 gcaggctccg ccccccgggg gttcacgcca ttctcctgcc tcagcctccc acgtagcggg 97921 attacaggcg cccgccacct cgcccggcta attttttgta tttttagtag agatggggtt 97981 tcaccgtgtt agccaggatg gtctcgatct cctgacctca tgatccgccc acctcggcct 98041 tccaaagtgc tgggattaca ggcgtgagcc accgcgcccg gcccacatct tgatttctta 98101 atgtaaagtc cctgggtagc taatggaggg aaattctgag cttagatatt gccttggtgg 98161 atgttaccca tgattgactc agtttgaaaa gaacctgctt cctaaagata ctcaatattt 98221 tcttcatttc ctccgaatct gcccattaat gcagcatctg gcctcctagc agaagcggag 98281 aacttttcag aaacttagag atcagtagta tcaaaacaat ctcagccaaa gcataagatg 98341 aaaatgtact aacgttcttt cttttctcct ttaatttgac ttcctgtggg aacttccttt 98401 cctgttaata gaatggaggt aagaaactgt tattgtaaca attgtttcca atgttttgtt 98461 ttgtagggat ttcgtttgtt tgtttttgtc tgtgagaggg tcttgtgttg cccaggctgg 98521 agtgcggtgg agtatgtttt gtttttgtta tttgacatgc catttattga gtgtttacta 98581 tttgctgagc actgtaacat tttagaaact ttctaatttc taatcctttt agtaagtatg 98641 atgaagtgaa agacaggtaa cctctactga atacttacta tggatcgggc actgtgctga 98701 gcttcacatg cattatttaa atctatcttc aagacatccc catggaatgg gtattattgt 98761 tatctctatt ttgcagaaaa aaaaaataaa aaaacctaag aaagtttctt tgaactggag 98821 agttcaagtg gcttacacag ccagtaaatg ataaagttag aaatggaacc cagaactgcc 98881 aaactccccc ttatagctct aacctatata taagaaggta tcccttgcaa tataaccttt 98941 tgcaacttac agtgttttat ttgcagtact tttaaaactg accttcataa aactctatgg 99001 agtgtaatta attttaagac agcattctta gcacatagcc tacgtttaaa aacaggcagc 99061 aggatacaaa attttggtta gatagcaaaa ataagttcaa gagatttaga gtacaataca 99121 gtgactatca ttaataacaa tgtattgtat tcttgacaac cactgagaat agattttaag 99181 tgttctcatc atcagaaaat ggtaagtatg tgaggtaatg catttgttaa ttagctcaat 99241 ttagtcatcc cacaatgcgt acatgtttta aaacatcatg tggtacacaa taaaaaaaac 99301 agtttttttt aactaaaaac accttttaaa gttttactgt taaaaaggtc ttaagaaata 99361 ccatttggat gtatatattg ctctgaaaag cagtgaaaat catgatacac attatatgaa 99421 aaattaaact agttttaagt atataggata gtgatttgtc ataattgact gcattccagt 99481 ttgttaatgt ggtatcaaaa attctcagtt caaaaaaaag aaaaaattct gagtccattt 99541 tttaatctaa atattgcttt aataattttt attaacaatt ttggagctac tgccttagca 99601 gagtaaagtt tatctaaact aaaattaata aaagtgccat ttaataaccc tccttctgaa 99661 aaaaacaggc agcaggccaa atttgtcctg tgggttgtac ttgctgaccc ctgccttgga 99721 gaataaatta tatacaaaga cactagacgc gaaagaatag aaacagttcc cgtttgcttt 99781 gaaggttgga agtagcacag aatctgtcat tacctttgtt gggaatgttc aaggagagat 99841 aaggcagttg ctaaaaaagg gaagatttgt ctgaagcaga ggagaggtac agctgtcaag 99901 tgtgcctgtg cagggaggga gggaagtaag gtgtggagtt tccactagag tcttggggtt 99961 gtcataacac aaacatgcca tggctggtca tctggaatgc ccttgggaca aaatattatg 100021 tgttcaaagg gagtagacat ctccctcaga gaaacttgaa gataacattt taaaatgttc 100081 tattgaatgt gattcatgcg tttcaaagta gagagaaata ggagtaagag gtgcagtgag 100141 aattctttac ctactccctt tgaccacata gggttgtctg ttataaaaga agttgaaaag 100201 gagatccgag atcaaatatc cattattgcc tctacaagaa agggaacttt tctgaaagag 100261 aagtcaactg agtttatatt gtaaggaggc aagagaggga ctgtttccat gtgcaatatt 100321 aactagcatt attagaagct agtctggctg atgattccga aataaccagc attctgtgaa 100381 tggatccctg tgacctctgt cccacggttc taatgagcaa caggaccagc tgcttctagt 100441 gttgccccat cagcagtacc acgaactgca ggcagagaaa cacaacttta gctggacatg 100501 gaggggtctt gtcacttaca aaagacaaca gaagacacca atggaaatta tttgcattta 100561 tctcattccc cagttcttgc tgtgagctcc ttttaaaaat gtttgaagtg atagatttag 100621 gggtttgagg gacaaaatgt tccagttggc ctctgtgtct tgcatctaga atttgatcac 100681 tgtgtaaaat tgaaggctta tatttctgca caagaggaga ggaaaaggaa gtggttgaaa 100741 cactgaaact ataggtagtt gatagataaa caaattcaga tatatataaa tttagataga 100801 tagatagata gattagatag atagatagat agatagatag atagataggt aggtagatca 100861 tcggtcttgt gtgtgcctta ccttttagag ctaatccaag cactgatata ataccaaagc 100921 caagtcctta attattccag gaacatcata gaaatgaaat gtagaaaact aataataatc 100981 atatactttg tatgtgtatg ttttttccca gcacataaag ggtttgtata agctagtggt 101041 catcaagctg ttaggaagaa aaagcaaaat taaaactaag atcttctcat ttctattcaa 101101 aacctattgt ctttttttct ttttcatttt tattttgcat tatatactta atgctgtaaa 101161 actaatgagg attcaatact agcagaaatt cagacagagg ggttcattat tagttgattg 101221 ttagtaatcc ttatctctga agttattttc attaattttt cttttgtgta ctttttctta 101281 gtttccagtt ttttaaaaaa gtgtgttttg atgtataatt aaaggaaaca tcatgaaatg 101341 tctattattt ttaaaaatac tcatggaaaa tgagtaacag catcattgaa tagttaacac 101401 atgacagcaa aacctgaatg aataattctc agctcggaga cactgagaaa tatttaattt 101461 ttacatggtg gagttttttc tgttaagcgt aaagagtcac acatgctctt attcatcccc 101521 ctttatgccg agatattacg tcaacatgtg agaccatttc gtaaaccagt ttgagatatt 101581 tctggttact ccttattata tagtttctta aagcacagtg tagaagctgg ttagggatta 101641 attcctttcc ttcccatcct aacagtcatg gctgacacct atataacaat gacaggttaa 101701 caagagaaga gcataacaaa tatgtttgat cacagtttta cataacatgg gacccttcag 101761 aataaagacc ccagatacag ggaaagcaat cctttttttc tgagacagag tctcgctctg 101821 tcacccaggc cggagtgcag aggtgcaatc tcagctcact gcaacctctg ccccccagat 101881 tcaagtgatt ctcctgcctc agcccctcga gtagctggga ttacagatgt ccgccaccac 101941 gcccggctaa tttttatgtt tttagtagag actgggtttc tcgatgtcgg ccaggctggt 102001 ctcaaactcc tgacctcagg tgatccaccc atctcggcct cccaaagtgc tgggattaca 102061 ggtgtgagcc accacactca gccaaagcaa tccattttta tgcttaggtt caatgaagta 102121 tgaacagctg tgtagaaata tgattagaca caaagggtat gatctaatgc taacaggctg 102181 agtggggaaa ctagcccatc ctgcttgttc agatttttct cagcccctct gtgcagcact 102241 cactcctccc aggcaagagg taggatccct ctggaatgag ggtctgaatt tctttatggc 102301 caggtgttac acagaaaagc tgggggtggg tagagtaaat gtttaggttt tatggctggc 102361 cttgaggaaa aggcgttctg gtgtctgatc tgacttggag aagagggatt ctagtgtcta 102421 aggtttgcct gagggaagaa agagaggaga gacaggaggg cagaaggtct gtttctgagg 102481 ctgcttctta ggccttcacc ttggggtgtc gtttactgag cctcaacaac agcatccttg 102541 tttctgtcta attttctctg ggggttttct cacctttacc ttgagaaagt ttttgtggag 102601 ttttgtgctt tcttattcaa ggccttcatt ttaaatattc ccaacaaaca aagggataca 102661 gtaaaactca tgttggctaa ttagaaaaag gccagtatga attaaaggaa gactctatat 102721 tacaaaatat tgttttaaag tatagctgtg tttcttggaa gttcatcatt ttacctgaat 102781 gtattatatc tcattccaat gaatttgctt taaagacctg ccagtggtgg tttgtaatta 102841 tagtattaat tttttaaatt caattggggt cacgtaacaa ttttaaaatt tgacacaaat 102901 tctaatttgt ttaattttct tactttaaat tctttatata aagacaatga aaaactaaat 102961 tcgatagttg tacaaatcta aatgagaata taacttaaga gttttcttaa gtcattacta 103021 acactatgga agatctgata gaacacataa gaatatactg agaccatcac agtgcctaca 103081 cataataagt attcaatata tgtttgtcag gtgagaatat gagttgttat aattcccagc 103141 attatattaa gggaacaagt agatgtgtga agagagtacc aatagcattt tccattctcc 103201 caattgtctt cagttattat agcagataag tttttaatcc tatgtttgtg ctagcactag 103261 catttacagg tttctccctg atatatggcc cattaacaca caataatccg agttcagagt 103321 aattacttac atcattcaac agaatagatc actgaggcac tgggtgacca gttgactttc 103381 catgtgatga gacatgatga gaaaacagca aagctgaagg tgctacttgg ctcctctgga 103441 agccatattt ctgctttctc ctccctacat cactttcttt ttctttaatg gaattctagg 103501 aagatgtgtg agtgggagaa tctgagtgtg gaaggtgttg caaagatgta tatgttgtca 103561 aaaattaagg taaactatca taacacataa ataaactatg ttcctaaagc tgcaaacttt 103621 ttaggtgaga gcaattattc ttatgctcaa ttatttgtta accatcatga tgaaatgtct 103681 tccagatgca tctttgctta tatcagctta ttaactaaga gtagtcagat tctatttata 103741 atgtaaaata ttaaaaatac ccaaatctat tcagtccttc atagttccca aagctttcca 103801 catctatcgt cacatttggc cttctcaata gccctgtgga gtagctagag atgatataat 103861 tgcagctgga aatgaagaca atattcaaat ggagcgtgtc aaccaattta ctagtacaat 103921 tttctcctat ttctgagaca cagatgtgaa aaccaaaaaa aaaaagaaaa gcagaatgaa 103981 tgccaagaaa tagcatgtga ttagaaatgt tgttcatttc ttctttcagt aaaccacaga 104041 aagataacaa aggctactgc gcccagtaca gaggggaggt gtgtaatgca gtcctggcaa 104101 aagatgctct tgtttttctc aacacctcct atgcggaccc tgaggaggcc caagagctac 104161 tggtccacac ggcctggaat gaactgaaag tagtgagccc agtctgccgg ccagctgctg 104221 aggctttgtt gtgtaaccac atcttccagg agtgcagtcc tggagtagtg cctactccta 104281 ttcccatttg caggtaaaat ctcaaaaata agtcaaagga aaaattccat ttttctatct 104341 gcacaacaga aggagttttt gaaaaatgtt gtaatatgca acagtaaaag gaaaagctgg 104401 ttttcatcca aaataggagg ttaatgcctg ggtgcagtgg ctcatgcctg taatcccagc 104461 acttcgggag gccgaagtgg gtggatcact tgaggtcagg agtttaacac cagcctgtcc 104521 aacatggtga aaccccgtct ctactaaaca tacaaaaatt agccaggtgt ggtggtgcac 104581 ttgtaatccc agctactcgg gaggctgagg caggagaatc acttgaactg gggaggcaga 104641 ggttgcagtg agccgagatt gcaccactgc actccagcct gagtgttgag actctgtctc 104701 aaacaaacaa acaaatagga ggtaattaat cagacaatat ttctaccata taaatcacta 104761 aagataacct aaaatacaag tacttagaac ctctagaaaa tatcataaat ggtgtaatat 104821 tccattactc ttgttattgt tcacattatt atcatatcca taaatatccc agatttctat 104881 cagatgaaag gagaaatctt aaacatggac ctcattagta agccaagata gagaaaataa 104941 aaactgtaca ttatttgtca ataaatgaga tcatgccaag catctctgaa tgttatttta 105001 aagtacattc catccaaaat tctaagttct gatgctgttg cctcatttgg gtggttatag 105061 gaaggaatta gattataaat agatattttg ttaaactccc atacttttta aatattgaaa 105121 ttgataaatt tatgttcaat agaattatct tcatctttaa ttacttctta tgtagaaaaa 105181 aaagaatcta gtttttgagc taaatagaac aaagttcaaa tactgttagt tctgctttct 105241 cgatgtgtgt ggtcttggct aaacttcagt ttcctcatct gcacggtaga attgagagga 105301 ttaaaggaaa aatcacactc atggaatatg tcagaaacta gatagacatt gttattccta 105361 aattttctgt tgaggaaacc ccatgacaac aaccaacaca gcacatttcc acttctattt 105421 tgataaaacc agaaactatt taaatattgc aataatttga ggacactctc tatttagcat 105481 tcaataacaa cagtatggtc attaaattag agttttgtat tcctcaattt actgcaaagt 105541 ttgagggttt ggagacacta taagagtaat ataatttgtt tattcatcta agaagattgt 105601 attgtgatca ggcatgttat ctaaaaatct ctagggactt cagcattgac agaataagaa 105661 ggggaaagag aaggagagaa aaagtaaaat tactgcaaaa aaaaatggga agagtgggtg 105721 aggggcagta aaatttgttt taatagaact taagaaatac tgatgctatt tcaactgtcc 105781 ttgcagttat ttgaaaaaat agtgtctctg ttaattatca cttctttagt ttagatttct 105841 ctttcttggg cttctttata ggattctcca aaattgttta tttgacgtac tgctcaacag 105901 tgaaaatcct tttgctagaa agtagcacgt gtataataaa cagaatgtaa ccagcaaaat 105961 aaagtgacag tagattctat cagcttttcc tttagtacta ctaacataat ttgtggtggc 106021 cacgggatag ttatcatact tacacagtga cactcaggca aatcagctca acaccatgga 106081 tagatgcttg agagaaataa taattagatt agaaaaattc tctgtgtgtg tgacagccat 106141 tgtggttttc tgattacaaa acccacaaga ctccattgta taaaaaaaga acacagtact 106201 ttcattgcta aaacccagaa agttggtcac tactgaggtg tgtgtttact tatatttact 106261 tatatctata tttctgtact ctgaattcta tttcatggat ggtttctcta tttttgcatt 106321 agagactttg ggtttaatta ctgtctttat aattaatttc aatttgtgct acgaatttcg 106381 caggttttca tcttttaaaa aattattgtt tactcattat ataattattt ttattacatg 106441 ttgacattgg caaaatgttt ctaaatttca tatttaaaaa taattatata agttatataa 106501 tacaattata tattaactta acaataatta tcaataataa ttaataatta ttatattaat 106561 aataaataat acttaatatg atataactaa ttataagcta tataattata tattatagta 106621 tataacttat ataattgata taatttacaa ttatatatta attatataac atataattaa 106681 tatataatta taattatagt ttataataat ataattatat attatatagc tcactatata 106741 attattttta aatataaaat ttagaaacat tttgccaatg tccacatgta aataccattt 106801 agaatttgat cagaatgatg ctaagtttat acaattaact tagggcacag agctatattt 106861 acattactga gtattctcat ttaggagtat ggtatgccat tctttttatg tagatcttgt 106921 attatgcctg ctagtaaaat ttgatgattt ctttcttact tttttttaat taaatttatg 106981 actaggtgtg ttttatagtc attgctgttg ttgcaagagt attaattata atatagttat 107041 tacaggaggc tagaatgtcc ataaaacata gagatgcaat taattccctt gttccttatt 107101 ttaataaaac tgccattaat ttctttagaa tttgtacatt ttagagttga actatgtaat 107161 tttttggatc atattaatca gatttctaaa aatgtattct tttttttgag gtagttagtt 107221 gatagaagta taatttatat acaagaaact gtgccccttt taaccatata gttcagagtt 107281 tgacaaacgt atacaacaat gtaaccacta ccccaatcaa gacatagaat gttttcacca 107341 cccataaatt tctcttatgc tcatttcctt cttttttttt tttttttttt tttgtccctg 107401 ggttcaagca attctcctgt ctcagcctcc caagtagctg ggactacagg cacctgtcac 107461 caggtatttt tgtattttta gtagagatgg ggtttcacct tgttggtcag gctggtctcg 107521 aactcctgac ctcaggtgat tcacctgcct cggtctccca aagtgctgag attacaggcg 107581 tgagccaccg cgcccagccc tcttatgctc atttctaatc aacttcccat tatctctaaa 107641 ggcatcgtcg ttctgatttc tctgacaact agttttgctt gttcctgaat ctcatactca 107701 tgaaattgta taatatatac tgctttgtgt ctgacttctt ttgttcaaca tgtttttgat 107761 attcatccac attgctacat gtaacagtgg tttgttcctt ttcattgcag cttttatttg 107821 tgtggttgag atggaaatag ttatgtgaag aagtaggtag ggtcaagctc cccttcatgc 107881 tgcctaagaa ttataaagca attaatttga acaactgcag tatcaaaagg aaagttagta 107941 tagaaatgtt aggccactca agatgacaga ctcatcagcc acaacaaaaa agtcagatac 108001 cagctttaga cacaaaggat caaccaaata atttattcct gcaatttgta gtttattcca 108061 attttgtttg gtattatacc tcctaattat tgagaggaat caagtctcat caatcataaa 108121 tcattaatcc ttgccaacaa atgtgtatta ttttccattt tgttaacgag ttgttactac 108181 tatataataa agccatttca ttttattata tttatataca acaaccgctt tacagtattc 108241 tattagattt ttgattgata gtctatggtt cctctgatgg aaaaatatgg tctataaatt 108301 attatatata gtttatatat aatataaaac tataaatctt aattagattc tactctttct 108361 taattgaaat ttcagaaatt tttactagaa ttaaaattaa attttatctt catgtgctag 108421 cacaaaatac atttattaac tttccagcat ttatgtccca gatcagttta catgcctgag 108481 ccacagatgt tctttctaat cttgaaaata attcaccttt ttgaaagaaa aaaatccctt 108541 tcattgaaat gttaaattta ttagaaaatc atagttattt cctaaatcta tgtcattcac 108601 agtatacatt taaatttttt ttctaattcc cattgttatt taaataagta gttttattgg 108661 gaaaatgtta ttttttaaaa tcctcatcat caaatatttt gttcccattg aagtaagaaa 108721 atataatcta aaaattttta cattttaata ttttatagag gttttttctc tgatatataa 108781 taataaaaat tggcatttat aaagacttag tctcttccat taacatacaa aattcatata 108841 tttatgttca atcctttctg ctcttaaatg agtattagct atttggtcca atagtttaat 108901 agtgatgcgt caaaattttc acaattgtgt ttccaagaat gttttcttgc aattctgact 108961 cctgcttttt gcaccaagaa atattaaact aaaattgaat ttactgctga taactggtaa 109021 gtttgatctt catttttttg ttatatcttt tgaaaaagtc tctaccttta ttcatcaaac 109081 tagttcagaa gttgtcaacc attttatatt ctacttctac ttgcttgtga tatttttaaa 109141 agcgtgctat cactcatggt tttctaatta ttaggttggt acaaaagtaa ttgtgttttt 109201 tttccattaa aagtaatggc aagaaccgca attacttttg ccccaaccta acataagcag 109261 tcattcaatg atgtgtgcct cttttcatga acgacatgga attttattgt ctaacaaata 109321 tttattgatc tccttctggg ctccaagtac tacactgagc atttgggata tattaatgaa 109381 cataataaac aacttatata taactttaga aggtgttaaa tgtcatggaa aaagaaaaaa 109441 ggaatgcttt aaggaagacc agaaataaca aacggagagg agaaagttgt aactttaaaa 109501 ataaggtgtt cagggtagac ttaattaagt tagcataatt gtactgaatc ttccacactt 109561 gttctttgaa actttacctg aaattatcaa ccgtatttgt attgttcaat tatattttat 109621 ttgcatatgc tcaatttttg gaacattatt cttagctttt acatttgatt tcataatcat 109681 gtataagtag atacttggag gagcttatac tatgttactt atcattgata ctcattgtca 109741 ttcatttcaa ataaaatatt tctttttctt aaattcctaa tttaaattca cttcttgttc 109801 attcatctca tctttactca tctctcattc agctggagta ggtgtttttc acatgtaaaa 109861 aaaaattctg tcattgtaca tatgtgtttt tgactgggta tttaagtctg tgttaacaca 109921 agtgttagct tttgcgttag ttctcctcac ttgtgttact tatcctcaaa actgtggact 109981 ctgaccaatt attttctggc catgttgtaa taaagaggaa gaagaaagca atcctgactt 110041 ttgttccttt gtaaggaaca ttttcctctc tccagattgt agaaagatta tttctttaat 110101 tgttgagatt caaaatattt gtaaaattca tttggggata gatttattct cattgttttc 110161 tttcatgtaa tataaataat ataaaaataa tgggtaatat gccctaaaca ttgtgccctt 110221 ttcatcttaa aaatgttttc ttataccaca tctttgatta ttttctattt tttatgtgct 110281 ctggttctct tgctaagaaa cactattatt tgattttgaa cttcttactt gctccacctt 110341 atcagttatt tcacacatta ttttcatctg tttagccctt cttgcattca gttaggtcct 110401 ttctttctgc attcaattga atatttaatt caaatttgtt tatttcttgc agtgccattt 110461 gttttctatt ttcaatgaag attgttaagt gttggtttta ttttttgtgg tttctatttt 110521 ctgtagttac ttccatgttc aaattatcct actttttagt ctatagttca tcttgatttg 110581 ttttttcttg tgaaaaactc tgctatagag ggcatgcttt agtgcatggc aatgaaaaca 110641 aagcaaacca aaagccattc attaatgtgt tcttctgttt agaataaaaa aatttcccag 110701 gtatttgctt cttctgccta atgtggagta tggagttgtt ttcatatgtc ccatattgat 110761 ttacacttta actatgctgt ctgcgtgcaa aaaaatgtgc ttatacaacc caggggtgga 110821 accaagctaa gcaactctcc tcaggtcctt tacctgctca gaagtcttga aagccccatt 110881 atactccctt ctcccttacg cacaccaaga attataaatc ccattgtttt cttcatataa 110941 gaatatattt gcatctcatc acattcatat gcacagcctt ttattctatg catactcaat 111001 tagcacatat tggcaagtta ggaaagtagg agtgtgggaa taagtatgaa aaaagacacc 111061 attgtggcat atatatacac acacacacac acacacacac actcttacaa tttcctcctc 111121 tctgaatcct tcagatactg aataaaggac atctgctatt attatgttta atttatttaa 111181 ttatctttaa tttcctctta ttattaaccc caaatacctt aatttgaaat taaccaggtt 111241 tttcctatgc agtttgtcct attttctatc aggcttaaac aaatactaat ctgcaaaatt 111301 ccaagtagtc caattagtgt ttcttcagcc ccttcactca taatacaaca tgtagatgaa 111361 cataacagct tcatattcaa acagataata ctttggcttt ctcagatgga agcacgcaga 111421 gcaatgggac aggattccgt gcctcaaagt aagggctgag taaggaccca gatgccctcc 111481 tataagctgc cagggaggtg gtggtgttct gtttcagagg acaaagcaca cagaggccca 111541 gactgtgttc ctcgagccct acccattagc cccaagatca tagaaaaatc ttccaagctg 111601 gaaactggtt gacaatgatc ctgactttca gtaggtgtgt tttttaaact ctgtatacct 111661 ttttcctcta cctgtgttgt tatttgaata tgaagttggg agaagacata tcagagattc 111721 ccaatctaat acgttttaaa tttgacgttt ttttccctta gactagcatt aattgtgttt 111781 cacaacaaaa cgagatagca tttcatctca cgggacagta cactagattt catgaggtct 111841 catattattt acagtaaaaa gtttctttca taaacgcgct tttttcaaga acaatttacc 111901 atgatgatgt cttgaaaaca cagaatttag gctctgccac aaatttgctt taacatgtaa 111961 tgattcatca agttttgttc tccatatact attttagaga gtactgcttg gcagtaaagg 112021 agctcttctg cgcaaaagaa tggctggtaa tggaagagaa gacccacaga ggactctaca 112081 gatccgagat gcatttgctg tccgtgccag aatgcagcaa gcttcccagc atgcattggg 112141 accccacggc ctgtgccaga ctgccacatc taggtaacac agagttctcc caagactttg 112201 gaggttaaga gaaatttact attttgaaga aactaaggtg tgaacttaaa gcttctaata 112261 tttctaggca tttctaattt tttttttttg agttctgcct tccttagata cctactagcg 112321 gaatcctaat gctatcctaa ttgtacagat tagcgtaaag atttatttca tttgctctaa 112381 aataaatgaa acagcacttt taattactgc ttgacatttt agattctttc atagggaatc 112441 ttatgagagc ttgtaacatt ttctggagtg tgtagaaaaa tggctaagaa acatcttata 112501 ttttgtcagc agagtggaat aaaggaataa agtccttttt cttagccaag aaagcatgct 112561 aaaataagac acatgtttga aaatgctgat ctcacaaaac aaaattgaat tgcttcatgt 112621 tgctttaatg aactttgttt gtaaggaact atgttgttat ccctaacagc tggtttaatt 112681 tcaaagaccc aattctttca cattcgaatg caaagaatgt tttccagttg tatattaaaa 112741 agctgagaga gaacttgcat ttcttagcac tcactctctc acagaatatg tgagatatct 112801 ggatgctcac ttaaaacaaa tttttatcct ttccccttca gattataaca aagaaaacct 112861 aaaaagtaag taattgtgtt tgtgcccttg aaaccttatg tgtatgtaat tggattcatg 112921 catgtgtgtt tacacttata tttcctgatg cccagaacag aatgtacagc cgctctcaaa 112981 gtcttctcac catactcatc cagggtataa catgagggaa aatcatggaa ggtctcagtt 113041 tataactttt aattagaccg tagagagtac catatttagt gagtcataca aatgctatct 113101 cccacctcaa ggtttttagt ctgttttatt tcttatatgg ctataagtaa gccaaattta 113161 aaatgtcacc ttttgatttt atattcttga ttcagtataa tctaattatg tatagatgaa 113221 acccaacatt tatttcttca ttgagccaat tcatgatctt catttgtgac aatagatccc 113281 tcttttggaa gttaggtatt tttttaagac agctgatttc cagtataaag tttataggat 113341 caaatcaaat ggctttaaaa aggtcatcac aaaaatctct gggaaagaat tcaagaaggt 113401 tgcttgaaaa gggatgtcgt acaaaataac ttgtatcaga tagtgcttta acctgtcaga 113461 atgcagaaat cctcaggatg aaattagaaa agcttttcat gtcaactaac ttcctctggt 113521 ctcagcgttc taaggcttaa atcacactta cttcctgtaa tacatattcc agccctaatc 113581 tcctctgcat ttgactaggt gccaggactt gattttacca gcttgcttaa aggaccaaca 113641 cttaaaagta ttaaaagcaa gaatgctact ggtcctagtt gaattactca gaggtattaa 113701 acaagaagag ttatggaaac cttaaaaatc tattattctg gtagcctgtc aaattgttat 113761 tcccaaatcg aaggaataaa aaaaaatttc aattctttgt tatatgagca gccaaagttt 113821 actttgattg gactttgaat tgattactgt gctctttgtt atccatcgat tgctcactca 113881 tccattcaaa cattcattga gggtttgctg tgtggaagga ccagaccatt catcttaaat 113941 tagacaggaa caatacacaa aaaagcatcc acatttctgc ctttcacact aattataaag 114001 gaattttgag cagcacaaac tagctacaat aataaatttt ctagtcttta aaaaacagct 114061 ttatgaaatc ttcgatacat gtaagaaaat gagctcctaa tgtcatgaac taaccattta 114121 aactgaaagt agggcaggga atatctgaaa gtatgctcct tgagttaagg caattattat 114181 taaaagagtt ggctttagca ggtcaatagt ggagcaaaga aaacatcctt attaggcagt 114241 gtcccatatt ttataggggt gtgtaaagac cttaagtatt ttccaaagag tgtcttgatt 114301 tctgagtaaa ctctaaagaa tatcaccagc tcatttggag gggtcacaaa agagctgtta 114361 atcatttgtt tatctttgca ttattttctt cttccttgag catagggact agaatttcag 114421 tagtttttct tttttataat ttctttggct gaagtgaaac atctttttga gcaggcaatg 114481 cctttgtgct atttacatta tttgtaagca aggattacac tattcctctc ttccgtgaga 114541 cttcacatac tttattacag aaacactcag cagtgaatct gtcttctatt tcagagcttc 114601 tgtggagaaa aggttaattt gtcttaatca ttgaaataat tacttttctc ttgaattctc 114661 tttttccttc catctttgct ctttctatac atatacatgg agaataaagg acccaatgaa 114721 tgtacccaaa tccaaactga ctagtgtgat acatacatta tctctcttaa tactcccaat 114781 agttctacaa aattaagtac tatgaacgtc ctccatttta cttacaaccc aacatgagaa 114841 agagagatta agcaatgtgt ccaattttac ccatctagta aggtgataag ccagaatttg 114901 aactgaaatc tatctgattc tggctctgtc ttcagagcca gaatgttata cctgatgcat 114961 ttctgttatt actaatgttt cttaaaaaat tccaagacct catgtgtaat aaagcttaac 115021 tgattgttta actgattcat tcttgaataa attccactac cttttcacat ttgttataat 115081 tgattattct taagaagctc taattgataa aaattttatt gttcacaatt ttaaatcacc 115141 caggccactt gatgatttga ctttttgtta acatttaaat gaatacatgc tttgtgtccc 115201 agaccatttt tccataatga tcagctacta ttttgcccac gaatgaaatc atgaagcgtc 115261 agtgtctctg tgtgtgtgtg tgtgtgtgtg tgtctgtgta aaactcatga attatttcat 115321 aatttgaaat gtggtttggg taatttttgt ggtaatatta aagttacaag ttcttagaaa 115381 attggagttt aaagtaactt taacagttat ttaatctaaa gtctcccaca atgaaagaat 115441 cttttctaga gcatctctga cagaaacatt ccattttccc tcctgaattt atttctcaat 115501 tcctttgtag aatacattaa ttatttcaac aatttagcta tgtagaacta aattctggtt 115561 ctctagaact gtcaacaact gatcttcact ctatttcttt gatttattta taatctgtat 115621 gatagtcctt aaaatatttg gagacaggca ctcaatctct ctgtagtctt ctcttcttca 115681 cattaaatat ctccaatttt taactttttc ttttgcaact gacttccaaa atcctcacct 115741 ccatgtttac tttttactgg ctgccacaag cttgagaata tccagaactg aacacaaagc 115801 acagaacatg atctgatcag aattgcaatg caaccatatt ttctgtgata aggccttgtt 115861 cttttatgag tatagattaa actcatgcta gctgtctaat aatttcatga cattaatagc 115921 ccttctatac acatatgggt ttactgattt ccttgatttt ctaataaatt ttctactaga 115981 ccaatccaat tcataattat ttttattaca ttcttctagc atttataata atttgtactt 116041 tacatgttta gttactatgt tctatgaggc atagtgatcc aagacacttt tctttttata 116101 tgaagctctt taccaatgta aaatgtcact cttgtcttgt tttagtgctt ttagctttaa 116161 atttctagta ttaataatgg taattttttc cttgtattta tgttaaccta gcacctcttt 116221 gttcctcttt tatttttctt ttcttataaa caacatatac ctgggtttac tccaatcaga 116281 tagccatttt ctattaatag gaggatttag cctgttcata ttttatatca caactgatat 116341 actctatttt atccctacta tcttaactgt atattttcta ttcgctttac gtttttgctt 116401 cttctttttc tttttcttta cttgttactg gttatgtttt ctccactgct aagtgaaagt 116461 cagacaccaa ttctttctac acatcgcagt gctctattta ttcttcattt ctgcccaccc 116521 catgggactt tcagaatctc caggagatcc tcagactgct tggatcttct tccttacctc 116581 ccctggtact cttaggtttc tctttgcaga gtgattctca atattgagtc ttacctagcg 116641 aattagccaa gactccaccc atcacagccc cttcacatgt atcctgaagt tattttctga 116701 ttcaattgtt attaagagtc tcctcatgta tttccttaga agggaaagtg tcttgggaga 116761 cagaatccct gaagccttgt gtgttatcaa attgttttct tttatttggg tagttgaaaa 116821 gtgtattaac tgggtatgga actcctgagt gacatttctt tgggtggttt atagatgtga 116881 tttcactctt ttctagcttc tagtgttgga agcaggtagt ctggtgtgaa tttatttttt 116941 tcctgtaagt aatttattct ttctatctag gcagaaactt tttgattttt ccctttatcc 117001 gtgatatctg tatgataaaa attgtttaat catgtgctat tgaacatctc tttccaactc 117061 catgataggg cttcatgttg ggagcttgag ataagctatg atgggaatct ttatcccatt 117121 gaaatcagga tggtagacag acctttctaa tgcaaaaagt tgatcatgct attccacctc 117181 gtaaaacact cctataagac cctccatttg ctgcagggca tagtccaaat tacttaaatt 117241 ggtatacaag gacttttatc actaaacctg atatctgcag ctttacctat agatactccc 117301 caactccaac aatgaaactt ctaggtgcac ttttagaaag gcatcacatc tgcttagttc 117361 agatcttggt atatgctatt acttctttat agaatactat ctctctaccc tgactccatt 117421 ctactctctt aattccccca tcccacacac acgtttgtgt gtgttttttt gttttgtttt 117481 gttttgtttt gttttgtttt gtttgagacg gagtctcact ctgtcgccca ggctggagtg 117541 cagtggcaca atcttggttc actgcaagct ccgcctcccg ggttcacgcc atcctcttgc 117601 ctcagcctcc cgagtagctg ggactacagg cgcccaccac catgcccagc taattttttg 117661 tatttttagt agagatgggg attcaccgtg ttagccagga tggtctcgat ctcctgacct 117721 cgtgattcac ccgccttagc ctcccaaagt gctgggatta caggcgtgag ctactgctcc 117781 cagcccacac cttttcctta gtctgttcag gttgctataa caaaatgcca cagactgggt 117841 ggcttataca cagaaattta tttctcacag ttctggagtc caagaagtcc aagatcaagg 117901 tgccagcaga tttggtatct ggtgaggacc cattcctcat agacatagct gtcttctccc 117961 tgtgtcctca catggcagaa cgggcgaggg agctttcttg gacctctttt ataagggcat 118021 taattccatt tatcaggact ctacccttat tcatttcaac acatgaatgt gggggaaaga 118081 cacaaagact cagatcatca taaccttcaa ctggttactg gctactcacc atttatgttt 118141 aacttacagt tactcactct agaaaacctt ctcagtatgt ctaaacctga gttagtgcca 118201 gccctgaacg agactcacaa gcatcgtgtt cttactactc ctataatgct tcttatattt 118261 tgttttattt ctccatttat tcacttgtgt ctcatgacaa gcaaagactt ctcatgttca 118321 ccacagtgtt ctggatacct aacagtcact attgatttag tgaatgcatt tacatatgga 118381 tgaatgagtg tataaactcc cgtagtgttc agaggaaaag aatcaagaca gaaaattggt 118441 gagagaaaag ataaaaagga aaaagaatga cgattcaaag tgatccttta gacccaaaga 118501 gatcattgat gtagttcaag ggaagatcag atcaaatcag aagcagtcat caaggaataa 118561 caaaacaaaa ctatcttgaa ggaaagaaac atttaaatcc ataaagcaaa attattgttc 118621 caactatgtc atttcttgca ttttaaaaaa actcactaaa tcatcataga tttttctttt 118681 aacatgacag taaattctac tttctgattc tttttagaaa aactaacctt atatttacca 118741 gtgaaattac actaccaact ttactaatta cattatattc cctcacatgt tatatatggt 118801 gtgagatgct ctgtaaactc caaatacaaa aatagttatt tctccctatc ttttaataat 118861 tgttccaact ttattattag cagaaagcaa agctcgtcaa tttaagccac cccctaccac 118921 caccacccac ccatcttaga tcgagaaaac ttgggatgac tcagtccaaa gagaatcaga 118981 ctagctttca agtcagtcag agaggaacct ggtcagtctg ttgagtccac cactcctgtg 119041 gtgccggatg aggcatgctg tcactgatct tgcgcagatg ttttattgct gtgctgatgt 119101 tcttccagtt ccaggtgcct gcctgagtca cagtggtgac caggcctggc atccgcaggc 119161 ttcagaatca cttgcttagc cattggtact cagggcataa tcactgggtc cacttcatgt 119221 atgactaaga agtcatacat gagcgtctct tgtagcctcc aattttgcaa gtgccctatt 119281 tcaaatgctt taggcatcta ctgccataaa ggttttattt tgactttgta atatgttata 119341 ttaatatgtc cccttctatt aaatcattat tctctgacta tgatgtagtc agttgctaat 119401 atttcgttta ggatcttcta aacttaggtt gtataatcta tgtatgctct tttcttctgt 119461 gctaacattg ccaggttgtg atattggtat tataataatt tctaaaataa tttgaaagaa 119521 ttttctctta ctggaacata ttataaatat ggaaatttta tctctttcaa gactaaaaga 119581 atgtctttta taatgtgatg acttaaaaat ctagtttcct gcctatggta atatttatat 119641 tttctaatgc ttcaaatttg gggattaata tgttcctatc attttcctta aggtgtgaaa 119701 tataataatt acacattatt ttaattaact ttgaatctgt tataactttt ttatcatttc 119761 taattttctg tttgtacctt ttctctttaa ttaaaattcc attgattaga ctactatatg 119821 aatatttata aaaccaacta ttgatctttt aattctatca tttgtgttac gtgtattcta 119881 acttattaac ttctgcttgt gtatggctgt tactttatta cctattatct tttgttttct 119941 gtagttattg tttcttaccc aaagtcttgg gttaaatgtt cagttcattt actttcattc 120001 ttttttatct agtggaagga gataacacta tgactttatc tttgagcaca actttggcta 120061 aataaaatac acactattaa gaggcttgtg tctaatctat aactatagtt actctctagt 120121 ttttgatcaa aaagtcattg atttttttct ttttaaaaat gtcccattgg attttattta 120181 atctattatt aattgcactt tggccattaa gtagatatgc ataatttctg cctttaaaat 120241 ttattgagat taatccacaa atatttgaaa ggaaggttta ttctctattt ttgggtacaa 120301 aggtcattct tagctattaa aacattgttg ctgattattt taaaatactc tgtatccctg 120361 tttttgtctt tactcaatct gttaagagga tttaaatgtg attaataagg ttcttttaat 120421 acatatacaa tggactttgt actctacaaa tagtggtatg agtatggcat cttttggttt 120481 ccaacagtaa tgctgatttt actttataca tatcacatcg gccttttaaa ttgaagtttg 120541 acaggagttc agtttttaga tgaattaact tctcatttgt ctcctaatat tttcattttt 120601 catcttcttt catgattttt cttctgtttg taaactgaca gtaaatgtat ataaaagctc 120661 agctctagac aatcctgatg tcaagtgtaa ttatgtgaaa atattttatt tgataatttc 120721 catgatttat gtcaggtcat agataatatg attcagtata aatggcacca gcccaagatc 120781 tacatttatc tcagaaaaaa aaaacctatt tcctctctct gagtctcatc tttaaaattc 120841 tattattcta taagctggat ttacttacaa ctagacctta ctgaacttta taaatatata 120901 accagggaga acctgataca taaatatatt attatcatga aatttatttt actgattgct 120961 taaatacaaa aaattgcttc ttaaaggttt gagaatgaat gaaataatta ttctttactt 121021 acagcattcc caccaatgac gtcctcaaag ccaagtgtgg acattccaaa tctgccttcc 121081 tcctcctctt cttccttctc tgtctcacct acatactcca tgactgtaat aatctccatc 121141 atgtccagct ttgcaatatt tgtgcttctt accataacta ctctctattg ctgccgaaga 121201 agaaaacaat ggaaaaataa gaaaaggtga gattctagtt tcagctaacc atgtgtagta 121261 atattttaaa gccttgtgtt ttatggagtt ggtatgacgt gaggaatata tatgacactg 121321 caactctcta aatatatccg tagccctgct ttaaaattaa gcacccccat catgatcttt 121381 acaaatgtca atgacttttt ggcatgggat caaatcaaat gccctagggt tactgtttca 121441 caaaaggtaa aatctaaaca ataatttgga ggaaaatggc tattcctgct ccttgtcttc 121501 tcctcaggcc tgttgccatt gctggcttgg agagctaaac atttctgaga aaatgtgcct 121561 tttgactcta gaccaaacaa aatattttat tgctctcaaa acgaaggatc tttggctgcc 121621 ttagtataac ttgttttcat tactcttaaa tgccatattt cttagaatct aagtctaagt 121681 acaaagatct aacctgcttc tgagctcatt cctgatcttg cctgtcttgc ctgcagagaa 121741 tcagcagcag taaccctcac cacactgcct tctgagctct tactagatag acttcatccc 121801 aaccccatgt accagaggat gccgctcctt ctgaacccca aattgctcag cctggagtat 121861 ccaaggaata acattgaata tgtgagagac atcggagagg gagcgtttgg aagggtgttt 121921 caagcaaggt aaagttacct atggaaaaaa aaactccatt gaaatatgtt atgtctgaaa 121981 agctaccaaa ctattagctt ggtatatata taatattagc tttatatata tatacacaca 122041 catatatata tatatatcaa gctaatgata tagtacatat atatgtacac tgtgtgtgta 122101 tatatatata cacacacaca tatacatata tacacacagt gtaatataca gtattatata 122161 gtattaatac aatattatat atgtattata tggtaataat atactatata aaatagtttt 122221 tatcaagtta gttaattctg gccaggtgcg gtggctcgtg cctgtaatcc cagcactttg 122281 ggaggctgag gcgggaggat caccttagtc aggaattcaa gaccagcctg gccaacatgg 122341 cgaaaccccg tctctactaa aaatacaaaa ttgagccagg catggtggtg cacaactgta 122401 gtcctagcta ctcgggagtc tgaggcagaa gaattgcttg aagccggaag acagaggttg 122461 cagtgagcca agatcgcgcc actgcactcc agcctgggtg acagagcaag actctgtctc 122521 aaaaaaaaaa aaaaaaagaa aagaaaaact agttaattct ttacatcatt aaccttattt 122581 gtattgcata atacacttca aatcttaatt tcccctcttt gctggaaaac agtagcctat 122641 atggagataa tatattttac tgcacttaaa ataggtaatt tattggagat gtaaatgtgt 122701 cttcacttct acgattttta aattataaga aattagtaat atagttcaat aatatttcct 122761 tttcaggaaa gaatttacca tatattttta atcataattt cttacattgt tttaaataac 122821 tccttacatt ataatataat gtatagatat taagtagatg ttcatgaaat gacaaacaga 122881 aaaggaataa aaaggcaaaa atttataaaa aatgagctca agaaaggagt atgtattagg 122941 gccaatatta gcctatgtat cacctttgtg cgaattggaa taaaataccc tttctgctgc 123001 atggatatgg ctccacagac acacagctga gccagagaat atgaatttgg ttttaatctc 123061 caactggcac ttcggcctgg tgctcttggg caagacacaa cttaatctcc acccatggtg 123121 gccctggcgt agaggttaca tgaatagtga aaatctcaca caaacatgtc ttggaaacca 123181 aaatttgcaa ggcaccactt taggctcaat ggagggtaca aagatgagta agccatagtt 123241 cctacgtcat ggaatttaga ttctggacaa agattaaaag gttaggatgt ggctgggcgc 123301 gatggctcac acctgtaatc cccgcagttt gggaggccga ggtggtcata tcacgaggtc 123361 aggagattga gaccatcctg gctaacacag tgaaaccctg tctctactaa aaatacaaaa 123421 aattagccag gtgtggtggc gggtgcctgt agacccagct actcaggagg ctgaggcagg 123481 agaatggtgt gaacccagta tgtggagctt gcagtgagcc tagatcatgc cactgcactc 123541 cagcctggat gacagagtga gactctgtct caaaaaaaaa aaaaaaaaaa aaggttagga 123601 tggcaatgat aatcctattg ggggtgtata cttcagaatt cctataattt gtaaataatg 123661 catctttcaa acttcattgt ttgaaattgt tgaaaataac accagtgatt tttattagtt 123721 gacatcaagg agttttaagt atgttgtctt tctttgattc tgtggctctg ggaaaggctg 123781 cgtgagactt aaccagcctt ttacacaggg gaggtgggag gatatgtata aatgtgggta 123841 ggtataaaga tatgatgtcc atgatctttg gtttcttttt caataaatgt atctctcagg 123901 gcaccaggct tacttcccta tgaacctttc actatggtgg cagtaaagat gctcaaagaa 123961 gaagcctcgg cagatatgca agcggacttt cagagggagg cagccctcat ggcagaattt 124021 gacaacccta acattgtgaa gctattaggt atgaaaatac aagtgaggat atgtatttca 124081 tcagaaaaca gaggctttcc aagtttttct ccccttgttc gtgctttttc cttttctcct 124141 tgatcagtga gacgtttcag ttccttttca aatttagctt cttcaccttg gtctatccca 124201 accctatagg acattcatgg cttaatggat tatccctctt taaattcatc acttcaattt 124261 gtctctgtct ttgctgcctc ctatttataa aaatgtttaa aatgtcccca ttgtaaaaaa 124321 ttaatactgc ttctccatca caaaatttat caatattgaa aagtctatat attttactta 124381 ttttgtttct cctctttctt ccctaactag aatgtcatga gcagcgattt gtatcttttc 124441 tgttcattgt tgagttccag tttattccca gattcataaa ttcaacacaa attttacaaa 124501 tatttagttt gtattaatta cacagcaatt aataaaactt ttcaaaaatc tgtgctctcg 124561 gctgggagca gtggctcatg cctataatct cagcacttta ggaggccgag gcaggcagat 124621 cacttgaggt caggagtttg acaccagcct ggcgaacaag gtgaaatccc atctctacta 124681 aaaatagaaa aattagctgg gtgtggtggt gtgggcctgt aatcctagct actcgggagg 124741 ctgaggcatg agaatcgctt acaccggggg ggcagaggtt gcagtaagcc aagattgcac 124801 cactgcacca cagcctgggt gacagagtga gattccatct ttaaaaaagg aagaaaaaaa 124861 aaatctgtgc tctcatagag catacattca ctctatatga ggagacagat aataaaaaaa 124921 aaacaaaaat atgggatgct ggatattaag ttctacagac tttttaaagt gttaaagcag 124981 agaagttgga atgtgagcta caaagtttga agacttcagt gaaaatatta catttatata 125041 aagacctggc agaggcaagg gaataacagt gtggatatct tgggaaagaa cattccaaaa 125101 agaatgagaa gcatttgcaa aggtactgtg gcaagagcag atgtggcatg cttgaggaat 125161 agcaaggaga tgaatgtggc tggagcagag tgaaagatgg ggagagttat caaagatgag 125221 atcagagagg taatggggga ggtaggcagg tcctgtcagg ccttattaaa aacattggct 125281 tttaatctaa gttgggaaac aaatggagag tttcagccaa gacatgacat gacacaactc 125341 acattttttc agatcttctc tggctgcttt cttgagcatt gcatgaaggg aagcaatgaa 125401 atcaggaaga cagtaaacag gtattgcaat gatgcagcaa gagaagatga tggcatgggc 125461 caggtggtgg tagtgaagat cgtgagaagt gattctcttc catgtgtaat gtgaaagtag 125521 agccaaataa tttgctgaca gaccaaatat gagatgtgca aaaaagggaa aagtcaaaga 125581 tagtatcgaa gtatttggct gtgcagatga gtgaatggag gtgccattgg ctgagttgag 125641 gaatactcag aaggaacagg ttcctttagt ggagagagtg ggaattcatt taaagatgtg 125701 gtttttgtcc aggcactgtg gctcacgcct gtaatttcaa cactttgtga ggccgaggcg 125761 agcagatcac ctgaggtcag gaattcgaga ctagcctggc caacatggtg aaaccccatc 125821 tctactaaaa atacaaaaat tagccgggtg tggtggcaca cgcttgtaat cccagctgct 125881 tgagaggctg aagcaggaga attgcttgaa cctgggaggc ggaggttgca gtgagccgag 125941 attgtgccat tgcactccag cctgtgtgac agagtgagac tccatctggg aaaaaaaaaa 126001 gacgtgtttt ttggcgatgc ttattcaaca tccacatgat ccacatgaag ttaaggatgc 126061 atgtggatat ggaggcctag agttctggta aggatgatct ggttagacat gaatccaagg 126121 ctattgcagt acacagagta tttaaagcca tgaggttgag taagacacct aagtatggag 126181 aaagcaagcc agaacagaga agaggtccaa ggaccaaggc ctggagcatt ccagtattta 126241 gtgtgagaaa gaggagatga acaagaaaaa caaactaaaa acgagcaacc aatgaaatag 126301 aagtaaatca agagagtgtg gtgtcctgga tgtcaaatga agtattttaa ataggtgaaa 126361 gtgagcatgt catatgcatt aagtcaagtg agaggaggac tataaagtga ccttgaattt 126421 gtaaacatgg atgttcactg gtaaccccga gaagagaggt ttcttaggaa tgttgggggc 126481 agaggaaatg taagtgagct caaaagaaga ggaagagaaa atctggagaa aaagtataaa 126541 caacttgttt tgccataaag gtgaaccaag gaacatggat agagctgaag ggggcagaaa 126601 gaagcatgct tcctttcatg tggaagtaat agcacatttg taaattaatg agaatgatcc 126661 cgtaaagaga aaaattgatg acagggttgg caaatagtgg aagtaacatc tttgaacagt 126721 gagagggaat ggaatcttgg cactgttgga tggattggcc tttgtaaaga gaatgctcag 126781 atcaaccata gtaataagag agaattggct ggagattgta gccagtctct tctgattgat 126841 ttagttttct ctgtgaggta ggaatcaaga tctcatctga gggtgaggaa tgggagaaga 126901 gttgaagatt tgaggaaaga gaagaaataa attgtcatct aagaaaatcc atttttacat 126961 aaaatataaa atggactaga gaaacataat atgattggca agaacattaa aagcttactt 127021 gaaattagag attacacatt taacatgaga ctggtcagca tggttgtgta tttatccaaa 127081 tgctgccagc tgggcataga ctcgttaaga ggagttaaat tttaccagaa ttagcatttt 127141 gccacacaag taagttgaag tcaaattgag gcaaataaga gaggtgtatg caaaggagtg 127201 attattatga ttgatcaagg aacttaagct gtttaaggaa ggaagacaaa acgtgaagaa 127261 agtagggatc attaaaaggg ggtaggatca atagattaaa agtttcaggg ggaggagcca 127321 agatggccga ataggaacag ctccggtcta cagctcccag cgtgagcgac gcagaagacg 127381 ggtgatttct gcatttccat ctgaggtacc gggttcatct cactagggag tgccagacag 127441 tgggcgcagg ccagtgtgtg tgcgcaccgt gcgcgagccg aagcagggcg aggcattgcc 127501 tcacctggga agcgcaaggg gtcagggagt tccctttctg agtcaaagaa aggggtgacg 127561 gacgcacctg gaaaatcggg tcactcccac ccgaatattg cgcttttcag accggcttaa 127621 gaaacggcgc accacgagac tatatcccac acctggctcg gagggtccta cgcccacgga 127681 atctcgctga ttgctagcac agcagtctga gaccaaactg caaggcggca acggggctgg 127741 gggaggggcg cccgccattg cccaggcttg cttaggtaaa caaagcagcc aggaagctcg 127801 aactgggtgg agcccaccac agctcaagga ggcctgcctg cctctgtagg ctccacctct 127861 gggggcaggg cacagacaaa caaaaagaca gcagtaacct ctgcagactt aagtgtccct 127921 gtctgacagc tttgaagaga gcagtggttc tcccagcacg cagctggaga tctgagaacg 127981 ggcagactgc ctcctcaagt gggtccctga cccctgaccc ccgagcagcc taactgggag 128041 gcacccccca gcaggggcac actgacacct cacacagcag ggtattccaa cagacctgca 128101 gctgagggtc ctgtctgtta gaaggaaaac taacaaccag aaaggacatc tacaccgaaa 128161 acccatctgt acatcaccat catcaaagac caaaagtaga taaaaccaca aagatgggga 128221 aaaaacagaa cagaaaaact ggaaactcta aaacgcagag cgcctctcct cctccaaagg 128281 aacgcagttc ctcaccagca acagaacaaa gctggatgga gaatgatttt gacgagctga 128341 gagaagaagg cttcagacga tcaaattact ctgagctacg ggaggacatt caaaccaaag 128401 gcaaagaagt tgaaaacttt gaaaaaaatt tagaagaatg tataactaga ataaccaata 128461 cagagaagtg cttaaaggag ctgatggagc tgaaaaccaa ggctcgagaa ctacgtgaag 128521 aatgcagaag cctcaggagc cgatgcgatc aactggaaga aagggtatca gcaatggaag 128581 atgaaatgaa tgaaatgaag cgagaaggga agtttagaga aaaaagaata aaaagaaatg 128641 agcaaagcct ccaagaaata tgggactatg tgaaaagacc aaatctacgt ctgattggtg 128701 tacctgaaag tgatgtggag aatggaacca agttggaaaa cactctgcag gatattatcc 128761 aggagaactt ccccaatcta gcaaggcagg ccaacgttca gattcaggaa atacagagaa 128821 tgccacaaag atactcctcg agaagagcaa ctccaagaca cataattgtc agattcacca 128881 aagttgaaat gaaggaaaaa atgttaaggg cagccagaga gaaaggtcgg gttaccctca 128941 aaggaaagcc catcagacta acagcggatc tctcggcaga aaccctacaa gccagaagag 129001 agtgggggcc aatattcaac attcttaaag aaaagaattt tcaacccaga atttcatatc 129061 cagccaaact aagcttcata agtgaaggag aaataaaata ctttatagac aagcaaatgc 129121 tgagagattt tgtcaccacc aggcctgccc taaaagagct cctgaaggaa gcactaaaca 129181 tggaaaggaa caaccggtac cagccgctgc aaaatcatgc caaaatgtaa agaccatcga 129241 gactaggaag aaactgcatc aactaatgag caaaatcacc agctaacatc ataatgacag 129301 gatcaaattc acacataaca atattaactt taaatataaa tggactaaat tctgcaatta 129361 aaagacacag actggcaagt tggataaaga gtcaagaccc atcagtgtgc tgtattcagg 129421 aaacccatct catgtgcaga gacacacata ggctcaaaat aaaaggatgg aggaagatct 129481 accaagccaa tggaaaacaa aaaaaggcag gggttgcaat cctagtctct gataaaacag 129541 actttaaacc aacaaagatc aaaagagaca aagaaggcca ttacataatg gtaaagggat 129601 caattcaaca agaggagcta actatcctaa atatttatgc acccaataca ggagcaccca 129661 gattcataaa gcaagtcctg agtgacctac aaagagactt agactcccac acattaataa 129721 tgggagactt taacacccca ctgtcaacat tagacagatc aacaagacag aaagtcaaca 129781 aggataccca ggaattgaac tcagctctgc accaagcaga cctaatagac atctacagaa 129841 ctctccaccc caaatcaaca gaatatacat ttttttcagc accacaccac acctattcca 129901 aaattgacca catagttgga agtaaagctc tcctcagcaa atgtaaaaga acagaaatta 129961 taacaaacta tctctcagac cacagtgcaa tcaaactaga actcaggatt aagaatctca 130021 ctcaaagcca ctcaactaca tggaaactga acaacctgct cctgaatgac tactgggtat 130081 agaacgaaat gaaggcagaa ataaagatgt tctttgaaac caacgagaac aaagacacca 130141 cataccagaa tctctgggac gcattcaaag cagtgtgtag agggaaattt atagcactaa 130201 atgcctacaa gagaaagcag gaaagatcca aaattgacac cctaacatca caattaaaag 130261 aactagaaaa gcaagagcaa acacattcaa aagctagcag aaggcaagaa ataactaaaa 130321 tcagagcaga actgaaggaa atagagacac aaaaaaccct tcaaaaaatc aatgaatcca 130381 ggagctggtt ttttgaaagg atcaacaaaa ttgatagacc gctagcaaga ctaataaaga 130441 aaaaaagaga gaagaatcaa atagacacaa taaaaaatga taaaggggat atcaccaccg 130501 atcccacaga aatacaaact accatcagag aatactacaa acacctctac gcaaataaac 130561 tagaaaatct agaagaaatg gatacattcc tcgacacata cactctccca agactaaacc 130621 aggaagaagt tgaatctctg aatagaccaa taacaggctc tgaaattgtg gcaataatca 130681 atagtttacc aaccaaaaag agtccaggac cagatggatt cacagctgaa ttctaccaga 130741 ggtacaagga ggaactggta ccattccttc tgaaactatt ccaatcaata gaaaaagagg 130801 gaatcctccc taactcattt tatgaggcca gcatcattct gataccaaag ccgggcagag 130861 acacaaccaa aaaagagaat tttagaccaa tatccttgat gaacattgat gcaaaaatcc 130921 tcaataaaat actggcaaac cgaatccagc agcacatcaa aaagcttatc caccatgatc 130981 aagtgggctt catccctggg atgcaaggct ggttcaatat acgcaaatca ataaatgtaa 131041 tccagcatat aaacagagcc aaagacaaaa accacatgat tatctcaata gatgcagaaa 131101 aagcctttga caaaattcaa caacccttca tgctaaaaac tctcaataaa ttaggtattg 131161 atgggacgta tttcaaaata ataagagcta tctatgacaa acccacagcc aatatcatac 131221 tgaatgggca aaaactggaa gcattccctt tgaaaattgg cacaagacag ggatgccctc 131281 tctcaccgct cctattcaac atagtgttgg aagttctggc cagggcaatc aggcaggaga 131341 aggaaataaa gggtattcaa ttaggaaaag aggaagtcaa attgtccctg tttgcagacg 131401 acatgattgt ttatctagaa aaccccatcg tctcagccca aaatctcctt aagctgataa 131461 gcaacttcag caaagtctca ggatacaaaa tcaatgtaca aaaatcacaa gcattcttat 131521 acaccaacaa cagacaaaca gagagccaaa tcatgagtga acttccattc acaattgctt 131581 caaagagaat aaaataccta ggaatccaac ttacaaggga tgtgaaggac ctcttcaagg 131641 agaactacaa accactgctc aaggaaataa aagaggacac aaacaaatgg aagaacattc 131701 catgctcatg ggtaggaaga atcaatatcg tgaaaatggc catactgccc aaggtaattt 131761 acagattcaa tgccatcccc atcaagctac caatgacttt cttcacagaa ttggaaaaaa 131821 ctactttaaa gttcatatgg aaccaaaaaa gagcccgcat cgccaagtca atcctaagcc 131881 aaaagaacaa agctggaggc atcacactac ctgacttcaa actatactac aaggctacag 131941 taaccaaaac agcatggtac tggtaccaaa acagagatat agatcaatgg aagagaacag 132001 agccctcaga aataatgccg catatctaca actatctgat ctttgacaaa cctgagaaaa 132061 acaagcaatg gggaaaggat tccctattta ataaatggtg ctgggaaaac tggctagcca 132121 tatgtagaaa gctgaaactg gatcccttcc ttacacctta tacaaaaatc aattcaagat 132181 ggattaaaga tttaaacgtt agacctaaaa ccataaaaac cctagaagaa aacctaggca 132241 ttaccattca ggacataggc gtgggcaagg acttcatgtc caaaacacca aaagcaatgg 132301 caacaaaagc caaaattgac aaatgggatc taattaaact caagagcttc tgcacagcaa 132361 aagaaactac catcagagtg aacaggcaac ctacaaaatg ggagaaaatt ttcgcaacct 132421 actcatctga caaagggcta atatccagaa tctacaatga actcaaacaa atttacaaga 132481 aaaaaacaaa caaccccatc aaaaagtggg cgaaggacat gaacagacac ttctcaaaag 132541 aagacattta tgcagccaaa aaacacatga agaaatgctc atcatcactg gccatcagag 132601 aaatgcaaat caaaaccact atgagatatc atctcacacc agttagaatg gcaatcatta 132661 aaaagtcagg aaacaacagg tgctggagag gatgcggaga aataggaaca cttttacact 132721 gttggtggga ctgtaaacta gttcaaccat tgtggaagtc agtgtggcga ttcctcaggg 132781 atctagaact agaaatacca tttgacccag ccatcccatt actgggtata tacccaaagg 132841 actataaatc atgctgctat aaagacacat gcacacgtat gtttattgcg gcactattca 132901 caatagcaaa gacttggaac caacccaaat gtccaacaat gatagactgg attaagaaaa 132961 tgtggcacat atacaccatg gaatactatg cagccataaa aaatgatgag ttcatgtcct 133021 ttgtagggac atggatgaaa ttggaaacca tcattctcag taaactatcg caagaacaaa 133081 aaaccaaaca ccgcatattc tcactcatag gtgggaattg aacaatgaga tcacatggac 133141 acaggaaggg gaatatcaca ctctggggac tgtggtgggg tcaggggagg ggggagggat 133201 agcattggga gatataccta atgctagatg acacgttagt gggtgcagcg caccagcatg 133261 gcacatgtat acatatgtaa ctaacctgca caatgtgcac atgtacccta aaacttagag 133321 tataacaaaa aaataaaaaa ataaaaaata aaaaataaat gcatgaatac ccaaaaaaaa 133381 aaaaaaaaaa aaaaaaaaga aggcatttca gcatgcaaac aagtaatact tttaggaatt 133441 acactgactt cattgtaatg cataggaaaa ataaataatt cacaaataaa aaacaaacaa 133501 acaaaaaaaa agtttcagtg gggtcaaagg atttttagag ttagggcagt cgaggcagtg 133561 aactagggtg aaaaagggag gaagtgatga acaacaggta gagtaactga aaatgagatt 133621 atgggaggta tacaaatgta tggaatgaca aagtcagggg tatgacaatg tgagtgatta 133681 gctgaagttg ggcagaggtc taaggaaagg aagtaaagta atttagtggt caggatattg 133741 gaaggaatct agataaatat taaaagcaag aatttctata gtagtatctc gaatagtttc 133801 tggcacattg taggcactct ataaatattt gttcaataaa tgaataaacg atattaagta 133861 cataacaatt catcttgaaa acacttcttc catttcctca actcctaaac attcatttat 133921 tcattcttca tcacacaaaa atctgaatct ggcttctgcc ccctaccctc cttatttact 133981 ttctcaaata gtatacattt agtcattaaa caaacataca tacatgcata ttttcaagat 134041 tatcaagcaa ttcctgtttc aacttttctt aaaatgttga ctctgtattc gtatacagtt 134101 tataacatcc tgaattcctg aaattgattc aaacagaaac tatgtacagt tttccaattt 134161 aaccacagta gcatgcttat acatcactac ttggagtttt ctctcatttt tattgtccaa 134221 caagaactga aacttatgtt gccgtttgtt aaatgctata tctaaattcc atttggatat 134281 ccaatgaaca caggttctat tttttatcaa gtatacataa gcagtaatca ttcatgcaag 134341 tgattccact actctcatag tttcttgtaa gttaatccca gtgaaataag atgacaatag 134401 tggaagaaag gggaattggg aaaatccata aaattcactt ctatcaataa aagaaatcta 134461 ctttgtttta tatatttgat acatcagcca cttattgaac atgttcgtat cttaaaaatt 134521 gtttcccttt tattgaaatc ctagtggata atggttttgt agtcataaat tgggaaaaat 134581 ggtataacta aagaaatatg cagaatttta gaatgggagt aggcattgaa tattatagac 134641 tcttacggaa tattctggca gtggagcaaa cagtagaaca atcaggtgag attattcatt 134701 gaagatgtca tgctaaagtt taaagacatg gcttgggcta ggcatgaggt tttcttatgc 134761 ccatccatct atgcatccat ccttaaatct atccatgcat ccacctatgc attaattcat 134821 ccatccaccc atcaacatat attgaaaacc catagtgagc catgtgtagt attagacctg 134881 aggttacaag gatgaataaa atacagtctt cctctcaata attattatat tttgaagtcc 134941 cacctaagag ttgggttgga gtaattacaa tatagaaaac attttgaggt cttaaataaa 135001 tgtatataca tatataattg taaattatat ctatacacat gtatatataa ttgttcataa 135061 taatcacaaa gtagaaatct tttgtatagt attttcttta tcagagtgga aaatttcatt 135121 aaatcaattt agttcaaaac tttatttctc agagaaatat tttgtcattt ttttccagta 135181 taagaaatta tttttaaatc aactcaacca gcataacaat ggtaaagcca gttgatgaga 135241 taggtaagtc cctgttaact aaagattatc caaaaaggat cccacagaag aaacttctaa 135301 gtattatcca gttggtattt ctttattttt tccctttagt ttacagaaat gtgctaattg 135361 aggtccttgg aattaaaaat taatgccaaa ataaataagc caagatagca gtattcctca 135421 tttctcctct ttttcaaaca gatactttta acttttgcct gaaaaaaccc aatagatcta 135481 ataatctatt tttaagatga tgtgaaatta tgcccatctt atctaatatt ccaagttctc 135541 cagtttccct ctcaaatata tcaagacttt aagatttgaa aatgatcttc tggctttaaa 135601 tctaagactt tatttatatt aacttttttg gtagcatgaa cattgtaaaa cctaaatttc 135661 aaaatgtttt actgcagcaa cttaaatact tcatctaaga cacttgaatt gtatttgtta 135721 ttgtttccaa acttgataca tctttcttat taacatcctt catagaagta aacagaaaca 135781 gacagcaatt acattacata ctcagagcaa gcatccattc ataaattaac tcaccaaaca 135841 ttatgaggca tctgctctgc cagacacgtg gtaggtgtgg ggaattttta aagaagaata 135901 aggttcaatc tctcctttca aagtgctaaa acgttgggga gaaacctcaa atagtcaaat 135961 gattataaaa taggatggta ggttctctgt gaaaggatga cagtaggaaa atctaacagt 136021 tactggaagg atcaggagct gaggcaccct agggagagtg ataaactgaa tcttaaaggc 136081 aaagaggaga tgtttaggca gagaaatagg gtcagggttc aaccatggtg ttgtcaacaa 136141 aaaaccaggg cctccagatt tcagagagaa gagccactcc agagaactga tacaccatgt 136201 acttatatgc accatgaact tgatgcacca tgtacgatgt acttatgaca agtgcccagg 136261 acaacagcgc tctgctggaa gtcctcaaaa actttagcca agggacagaa accccactac 136321 ccagagtgca tttcctagct gagactcctt ttgtgttgtg attaaaagga tacaaatatt 136381 aaaaaacaaa catacgacaa caacaacaaa aaacagggct tcatatgttc tgacatggtc 136441 gtttgctttt ggagtgctct ttccattgtt tcattgtaga aactgagact aacagggatg 136501 gtcttttggt tccaggagtg tgtgctgtcg ggaagccaat gtgcctgctc tttgaataca 136561 tggcctatgg tgacctcaat gagttcctcc gcagcatgtc ccctcacacc gtgtgcagcc 136621 tcagtcacag tgacttgtct atgagggctc aggtctccag ccctgggccc ccacccctct 136681 cctgtgctga gcagctttgc attgccaggc aggtggcagc tggcatggct tacctctcag 136741 aacgtaagtt tgttcaccga gatttagcca ccaggaactg cctggtgggc gagaacatgg 136801 tggtgaaaat tgccgacttt ggcctctcca ggaacatcta ctcagcagac tactacaaag 136861 ctaatgaaaa cgacgctatc cctatccgtt ggatgccacc agagtccatt ttttataacc 136921 gctacactac agagtctgat gtgtgggcct atggcgtggt cctctgggag atcttctcct 136981 atggcctgca gccctactat gggatggccc atgaggaggt catttactac gtgcgagatg 137041 gcaacatcct ctcctgccct gagaactgcc ccgtggagct gtacaatctc atgcgtctat 137101 gttggagcaa gctgcctgca gacagaccca gtttcaccag tattcaccga attctggaac 137161 gcatgtgtga gagggcagag ggaactgtga gtgtctaagg ttgaagacgt tcaaataaaa 137221 tgctgcagtt tcctctcaga ctctgtgagc caggggaatc ctacaccaga ggcccaacaa 137281 gacccacata ggaaagagta agagtaaaca tgagtagtgt gttgtttgct tcccagggag 137341 agcaaagaca gtgcaaaacc catgtggtag acggacccat tgaaagccag tgattggaaa 137401 cacaggctag gaaatgtgtc agataatgga gacaactatt cttcttcatg aaggtttgta 137461 atacacactg cacagggaag aatgtcatcc tgttcagttt ccaaagtagc tggtcacaga 137521 gtaaagctct gctgtattaa attttaatat gaaatgggat tcagagcttc attttttaat 137581 tgagttaatt cctgtccatt gtgaaagtag cttaatcgtc atgtaagaca cttaggtgaa 137641 gtacagaaaa ctaaaaagaa ggaaaagcca ctcattctgt ctccccccaa agacgagtct 137701 tagtgtttta ttaaatcttt cttgcattta atgcataatt ttatatttgt ttgtattctg 137761 cagagttgtg gttacatttt attgatagag ggtttctaag gaatgaaaca gcaaatcagc 137821 aagcctgtaa ctctgagttc ccttttctgt cctgtgcccc tccttttttc ctttctgtgc 137881 atttgtcatg aattaagtct gcttatttta ttcctccagt tttcttgaaa caagtttttg 137941 tatcttactg atttaccttt tcctttaaaa attgtattgg tatcttttcc attgctttaa 138001 tctttatttc ttcttctttc caggacttct gtcctttttt agttattaag ctattttttt 138061 cttttatttc attcatgtaa taaacactct ggcagaaata ataacatttt aaataccatt 138121 gtagattgat atgtatatgc cttttgcaaa gtattactat ttttcctgca tttgcctttg 138181 aagccacaca tttcaacatt ctcacctatt aatattatta ctagagtcta tttaaatctc 138241 ttaaaccata atttataata tgagatttca caagatacac ttgtggctct gagttatttc 138301 aaaactgata tttctgtgca ttctgacatt ttattccttt tagaaacaaa ttcagttggc 138361 tgtagaatta atatcgttct gcttaacaac tttgtgcatg acatattaac tgattttgtt 138421 gtatttcatg atttaaaaaa aaaagcagca gctctggaac tcagattcct gggggttcag 138481 attttttctc agtggatcct cacacaatac atctttatct aagtccatac atgatctgag 138541 tttatttctg atatagcagg aacccaaatt ctcctgaaaa cgaacaggga agagaaaata 138601 acagtctact ctataccagc ttatcttaat tcagactaat tggtagttag ggcattggag 138661 gaatggtgtg aattcttgaa agtagatttt cgctgtctgc tggaaaactc tgcctgaaat 138721 ccccaaatct gcctcatgta acagcttgac atctttggtg ggaaacctgc catttcttat 138781 tcatagtgtc tccaggcaac caagacaaaa atgtagaaat tttcctagac tttgccctct 138841 ctttcatcat cagttttcta ttagttttac ttcctaaaat cctcctgctg acatcctctt 138901 cccttcaacc caagagccaa tgactcaacc tctaccgttg cccaccctgt ctattagctg 138961 gccttcctct catttcagac ctgaacagat tctgtaggat acaacgacag taaggcggtc 139021 cttagtcaca gttctggttc ataaatagcg aggtcagcat ttaggactga gacctaaaga 139081 agtgcttcag ataaaaatca tgagtctaag tccaaaattg atactgtaat ccaaatgact 139141 gaataaagaa taaagttgca gcgtgtgtct aaagcagaaa gtcaagatgc caacaaagca 139201 gaaaagttgg agagggccac cagcaagtct agaacttgag catagatatc catggcttat 139261 tttagatggt tcatgtatgc tctgcaaaat tcaaagacag cttcgggctt tctccgctga 139321 taaagttttg ttgtaaaaga cagacataga agtcaggctg acagaaaata gagtaacagt 139381 aatcataaaa attataatat cagctagcat ttattgaaat cttaccatgt gtattctgag 139441 gcctttaaat atatgaactt aaacctcaca acatccctgt aatgttggta ctatcattat 139501 atacatttta gttttgcttt gttttgtttt gtttttgaga cggagtctcg ctctgtcgcc 139561 caggctggag tgcagtggca cgatcttggc tcactgcaag ctcagcctcc aacagtcaca 139621 gagagattgt gcaactggcc cgagtgcaca cagcaacaga gcctactttt tgaccaaaag 139681 aggccgaatt ctcaaccact atactgtaga gcctctgtac atgatagaag caataactga 139741 acctcagtaa ctctgtggaa gtgatttgta atttgcatgt cgtttcaagc acactctata 139801 tctatatttt attctattaa cttcctaagt ctttttaatg aatagcaaaa aaagtatatt 139861 tcagcattat caatttaagt taatcataac atctaatagg tgacatgttt attttttcat 139921 gagttctaat tacattttca agttaagatc actgacttat tccctaagtg ctcgatctaa 139981 tgttctgaat cacaggagta tagatgcatt attcaccaat attgtttact tttttaaata 140041 agattttttt tcatggtaga atcatcatat acattcaaaa aggtagacaa aagagagaca 140101 ctcacagtgt cactgttacc aagtgccagg acagatatca gtaaggcacc agcagtcatt 140161 tttagtgatc aaataccaaa catggtaaga taccagagta tttttcacat gacacccaaa 140221 aacatattct ctgctatcgt ggtagagcag aaaaagaaca ctttcttttc attttacagt 140281 atattacgaa cctgttccac gtcattaaat attcttctaa aaacccaatt ttggaataat 140341 attctatttt attcatatac tgtaatttag ctaatcaatc ttgtattttt gaacatttag 140401 gttttttcca atttttatca ttataaaaaa tgctgtaatt aacatcctta tttgttcatg 140461 tccacatttc tttttatgaa aattcagaga aaggaaatgt ctggaccaaa tggcatgtac 140521 aatattaaca cttctgttat gtggtttcat attctgcaga aatattactg ccacttctac 140581 attgtacaag agatctcata gccctaaaca tttgctttca tagataattt tctgtttttt 140641 agaaatcttt tgtctctttg gttatagaaa aagagaacct ctttttaatt ttatttttta 140701 aattactagt caggttgaat gtttcttgtt cctaggtcat taacagtttt tattttggca 140761 attgtctaca gcccattttt ctgctgtgtt cattttctaa tcgaattatg ggatttatct 140821 tgtaaaaagc ctattaagcc tttttcatac tttacacaag agatcacatc tacttacttt 140881 accttaaaat aacatttact tattttctta taaaagtaat atattatgtt tgaaaagaaa 140941 aataatatgc aataatatac aataatatgt ataatcataa tagacaataa taaaaatgaa 141001 aaaacaccaa ccagaggtaa ttaacattaa catcataata ttcttccagg ctttttcaga 141061 tagacaggta ggtaagtagg ttggtaggta aatagataga tagatgatac atagagagag 141121 atagatagat aatttaaaca aaaataagat catactgcta cattacttca agccttgctt 141181 ttatcactta atatatctta aacatcttct acatgaacaa gtattcatgt gcaacattaa 141241 ttttgatggt tgaatagtat tatacagatt tatcgtaatt gacataacta ttctactgtt 141301 agacatttgg tttatttcta tttttccatt ataaaatgta atgtttggat catcctgttg 141361 ctaaattttg taagcattta tcttaagtga tttctttagc tataactcct agaagtgaaa 141421 tttctagatt aaaggataaa tgcactttta atacttttta aatatattaa aaaattacct 141481 tcctgaatta ttttattaac atgtacctct cctagtcaga taagacagcc catttatttc 141541 agtctcacca atactgagta tagcatttta atcattgcca atataatagc taatagctta 141601 aagttatttc atagcttata tttacacttc tttaaatact aataaaattg aacattgttt 141661 aatgttttga ggatacttga ttggtgattt gcctcctact attatttttc tactgggtat 141721 atctttttct tgttgctttg taagagcact ttatatatta aggagttaaa ttttgtgata 141781 tatgtttcaa ctacttttat catgttaaaa atatagactt ctatttgtct tttattgtag 141841 gttttatcaa tcagaaaaga atgttgactt ttccgtccat tcagatgatt gtggcttttt 141901 tccctaatgg atttgttaat atgttcaatt gtatgaattt atttcctaat gtagcgatat 141961 ccttgtcttc taggaataaa ctttttgggc gaatcatatc aatcttctac ttaactacca 142021 aattaattta catatatttg catcaatatt aagttcataa aattaaaagt ttatcatttt 142081 catctctgtt agagttttgt attggcatta gcatttgtat tagcattgta ttaggaaaaa 142141 ctcaggagtt tttctctata atcttggtta gtttattttt aaataattgt tatttatgaa 142201 agtaatacat aaaaatgttg tttaaaaaaa ctcacaagag ggtaaaaatt aaaaaaataa 142261 taaaagttcc cttcttcctt ttcatctcta gtcccagcct aagtgctaac cacttcaccc 142321 atttatagtg ttagttcttc tggtgattac cagtgcaatt ctaacaaata ggtttgcatt 142381 tctctttctg aattgatcaa ttttttaaaa atatgcagca ctctgactca aactcccttt 142441 ctttttcctg agatatgtta acttctaatg ttatattgtt tatcacaact ttcacaaata 142501 tttctaaata aaggttacct actgattctg gattgtgcta cataaaatta gagcttccaa 142561 atttccctcc atcacttctc cctgctctct actctcacaa tcagtcaact atacacctat 142621 ttctacgctg tcaactatat gttcatttct atgaatctgt aatatttgca ttttgttctg 142681 gaacaaatta agatttaggt gctttgacta gattgattct aaacatcaaa aaacaaaaat 142741 aaaatatctg caattatgtg atcatgtatt tatgcattgc caaataatgg tattccatta 142801 ttttaatttg ataagataaa tttaatatac attaattctt atttcctcta ttttatggaa 142861 gaaatatttt taaaaatcac aaaactttta cattcgcttc tcttcctgat atttattttt 142921 cctttttctt ctgcctctct tctttcgtgc ccttttttcc gaaaattatt ttgatgattt 142981 tttttattca ccatacataa ttacaaatga agagttgctc tggttcgtat tggtagtaga 143041 agtggggtcc ctttgctgtt ttgttggtat attcacccag tgtgacctct tttccgtggg 143101 atggctacct ctgggctctg attatgtggc tcatagggaa gtataggcag cctgagtcag 143161 aatccccaca gttccaaagt gatggaagac tgtactctga gatacaatat tttgacgtat 143221 ttcactccca gggagagcta cttgctattc tttcactgct tccattaccc aaaagagtat 143281 gatattctcc ccattttctg tattgcctca cacctaggac ccttcaaacc cacaccaacg 143341 acctctcagg caaattgatc tattcagata gcagtttaca gggatagaca tgaggcctct 143401 tggcccacct gctctataca caatcttcta gtcgaccatc ctgattgaca acccacagcc 143461 cacccctgtc tctgtatttg ctgactcaga gcatggagac tttatacatg tgaaatcaca 143521 tctcccctcc cctcacgctt ggcttgtgtg tattgcaaaa gctgcaattt agtttttcct 143581 gtgccttgtc ttacccatgg ataagaacac taagatactt tccgcttttt gaatatttgt 143641 caaagtgatg gcacttggat tggtttcagc atgtacatag attgattctt attcatatac 143701 atttactgtc atattgggga aatcttgagg ggaaaagaaa agcctcttac taccatgttc 143761 atcaagagtc ctctctggaa tagttgaaat agtttaggag ttatcggttc actccttcgt 143821 cttgtttgcc tccagatttc ttttttcctt cttttcctgt ttcttaatgt tggaacagcc 143881 cacacctcaa tccttggatg acatctccct tttatctgta ttcatcccta gtgatctctt 143941 ctggttgcaa ggctataaat gccatctgta tgctgagatt tttttatttt tagttcaaac 144001 ctctctcccc aactttacac tcacatttct aactgtgtgt tatagatgat agctttagat 144061 tctcctcctc aggactaggc tttctgcttg atctaggagc aaagctgaaa actgctatgg 144121 agcttggtgt tgccttgata ccgaggagga gtctcagagc ctctccagtg caaatacaca 144181 cttgcagtgt cctagtgctg ctgacttacg tactcattct aaagagggta gattgtatcc 144241 attttaatag ctctcaatac ccttgcccat tcccattaca gctggcagaa attccccagc 144301 tgcaaatggg ttgcatttat ctgttaccca ttcctgattt gcagcacgat tgactgtttc 144361 cttttctgcg tggtctatgt gtcactccat gagaatctgg gagaggagaa ctcgatatgg 144421 tgctcattcc atcattttaa ccatagtgtt ctttattgtg aagaggtatc ccggttagag 144481 tggagtcaaa gctttatagc aagtgtattt caggtaacta ttcttttact tgtttcagat 144541 ctatttcagt agcacagcca ccaagataga acacttataa gcccttattt tggtatagat 144601 caccagagaa accactcacc actcgcactt ggccttcagt actgagtcat tacatattgg 144661 aaggtcagaa actacatcaa caggaaagac ccataggtgt gggggtctga tatatttgcc 144721 agtacatttc ttatcattac aaacaaagat ttatgtgtgt ctagatgt hu6-75; SEQ ID NO: 78 G*C*T *A*G*G *G*T*G *G*T*C *T*T*T *T*A*G *A*A*A *T*G*C *A *represents a phosphorothioate linkage, and each sugar of the oligonucleotides is a 2’-MOE modified sugar. hu6-69; SEQ ID NO: 79 G*G*T *C*A*A *G*C*T *A*G*G *G*T*G *G*T*C *T*T*T *T*A*G *A hu6-58; SEQ ID NO: 80 C*T*G *C*A*G *G*A*A *A*T*G *G*T*C *A*A*G *C*T*A *G*G*G *T hu6-39; SEQ ID NO: 81 G*A*A *G*T*G *G*T*G *A*G*T *G*A*C *G*C*T *C*C*T *G*C*A *G hu6-27; SEQ ID NO: 82 G*T*T *A*G*G *A*A*G *A*C*A *G*A*A *G*T*G *G*T*G *A*G*T *G hu6-12; SEQ ID NO: 83 A*T*C *C*T*G *G*C*A *A*A*A *A*C*T *G*T*T *A*G*G *A*A*G *A hu610; SEQ ID NO: 84 G*T*G *G*G*A *T*T*C *A*G*G *A*G*C *C*C*G *C*A*G *G*A*T *C hu619; SEQ ID NO: 85 G*G*T *G*A*C *A*T*T *G*T*G *G*G*A *T*T*C *A*G*G *A*G*C *C hu628; SEQ ID NO: 86 G*G*A *G*C*C *A*A*A *G*G*T *G*A*C *A*T*T *G*T*G *G*G*A *T hu637; SEQ ID NO: 87 G*G*T *C*A*C *A*A*A *G*G*A *G*C*C *A*A*A *G*G*T *G*A*C *A hu646; SEQ ID NO: 88 A*C*A *G*T*G *C*A*G *G*G*T *C*A*C *A*A*A *G*G*A *G*C*C *A hu656; SEQ ID NO: 89 C*T*G *T*T*G *C*T*G *T*A*C *A*G*T *G*C*A *G*G*G *T*C*A *C hu669; SEQ ID NO: 90 G*G*G *A*C*A *G*G*A *A*T*G *C*C*T *G*T*T *G*C*T *G*T*A *C hu681; SEQ ID NO: 91 C*A*G *G*T*G *A*T*G *G*T*G *G*G*G *A*C*A *G*G*A *A*T*G *C hu693; SEQ ID NO: 92 C*C*G *T*T*T *T*C*A *A*T*C *C*A*G *G*T*G *A*T*G *G*T*G *G hu6110; SEQ ID NO: 93 T*G*A *C*A*C *T*C*A *C*A*G *C*A*T *T*T*C *C*G*T *T*T*T *C hu6125; SEQ ID NO: 94 A*A*G *T*C*C *C*C*A *C*A*C *A*C*A *T*G*A *C*A*C *T*C*A *C hu6139; SEQ ID NO: 95 G*G*T *C*T*T *C*C*C *C*A*G *A*C*A *A*G*T *C*C*C *C*A*C *A hu7-75; SEQ ID NO: 96 A*C*T *A*T*G *T*C*A *G*T*A *G*A*T *T*T*G *A*A*G *G*G*A *A hu7-66; SEQ ID NO: 97 T*C*C *C*A*C *T*A*T *A*C*T *A*T*G *T*C*A *G*T*A *G*A*T *T hu7-53; SEQ ID NO: 98 T*C*A *G*T*C *A*A*G *G*A*T *T*T*C *C*C*A *C*T*A *T*A*C *T hu7-45; SEQ ID NO: 99 A*A*A *A*G*A *A*C*T *C*A*G *T*C*A *A*G*G *A*T*T *T*C*C *C hu7-33; SEQ ID NO: 100 G*T*A *A*A*G *G*A*A *A*A*T *A*A*A *A*G*A *A*C*T *C*A*G *T hu7-22; SEQ ID NO: 101 A*A*C *C*T*G *A*C*A *G*A*G *T*A*A *A*G*G *A*A*A *A*T*A *A hu7-10; SEQ ID NO: 102 G*G*A *C*C*C *A*G*A *A*G*A *A*A*C *C*T*G *A*C*A *G*A*G *T hu73; SEQ ID NO: 103 C*A*C *T*C*T *C*T*T *G*A*A *T*G*G *A*C*C *C*A*G *A*A*G *A hu717; SEQ ID NO: 104 C*A*C *T*C*G *G*T*C *T*T*T *C*A*C *A*C*T *C*T*C *T*T*G *A hu730; SEQ ID NO: 105 G*T*C *T*T*G *A*G*T *C*A*A *T*C*A *C*T*C *G*G*T *C*T*T *T hu744; SEQ ID NO: 106 G*A*T *A*A*A *C*A*G *C*T*G *C*A*G *T*C*T *T*G*A *G*T*C *A hu758; SEQ ID NO: 107 A*G*T *C*C*T *G*G*C *T*T*G *G*T*G *A*T*A *A*A*C *A*G*C *T hu766; SEQ ID NO: 108 A*T*G *T*G*T *A*G*A *G*T*C *C*T*G *G*C*T *T*G*G *T*G*A *T hu776; SEQ ID NO: 109 G*T*A *G*C*T *A*T*G *C*A*T *G*T*G *T*A*G *A*G*T *C*C*T *G hu785; SEQ ID NO: 110 T*G*C *T*T*A *T*T*G *G*T*A *G*C*T *A*T*G *C*A*T *G*T*G *T hu796; SEQ ID NO: 111 A*C*T *T*C*T *C*C*C *C*A*T *G*C*T *T*A*T *T*G*G *T*A*G *C hu7111; SEQ ID NO: 112 C*C*T *T*G*G *C*A*G *T*A*C *T*G*A *A*C*T *T*C*T *C*C*C *C hu7136; SEQ ID NO: 113 C*C*T *G*C*T *A*T*G *C*T*G *A*T*G *G*T*G *G*C*T *G*C*A *G hu7146; SEQ ID NO: 114 G*G*G *C*A*T *C*C*T *A*C*C *T*G*C *T*A*T *G*C*T *G*A*T *G hu7158; SEQ ID NO: 115 G*C*A *A*A*T *G*T*G *A*A*G *G*G*G *C*A*T *C*C*T *A*C*C *T MuSK HUMAN_Ig3_Domain (SEQ ID NO: 116) ARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQ LFITKPGLYTCIATN KHGEKFSTAKAAATIS MuSK MOUSE Ig3 Domain (SEQ ID NO: 117) ARILRAPESHNVTFGSFVTLRCTAIGIPVPTISWIENGNAVSSGSIQESVKDRVIDSRLQ LFITKPGLYTCIATN KHGEKFSTAKAAATVS MuSK 34 (spanning the exon/exon junction 3-4) Forward CCTGCAAGTGAAGATGAAACCTAAA (SEQ ID NO: 118) MuSK 34 (spanning the exon/exon junction 3-4) Reverse ATGAATCCTCAAGCTCCCAGA(SEQ ID NO: 119) MuSK 67 (spanning the exon/exon junction 6-7) Forward GGCTCCTGAATCCCACAATG (SEQ ID NO: 120) MuSK 67 (spanning the exon/exon junction 6-7) Reverse GAATGGACCCAGAAGAAACAGCA(SEQ ID NO: 121) GAPDH (HKG) Forward CCTCAACGACCACTTTGTCA(SEQ ID NO: 122) GAPDH (HKG) Reverse TTACTCCTTGGAGGCCATGT(SEQ ID NO: 123) YWHAZ (HKG) Forward CGAAGCTGAAGCAGGAGAAG(SEQ ID NO: 124) YWHAZ (HKG) Reverse TTTGTGGGACAGCATGGATG(SEQ ID NO: 125) Region 1 – MuSK Exon 7 ACTCTGTCAGGTTTCTTCTGGGTCCATTCAAGAGAGTGTGAAAGACCGAGTGATTGACTC AA GAC (SEQ ID NO: 126) Oligonucleotide Bld51 (SEQ ID NO: 127) TTGAATGGACCCAGAAGAAA Oligonucleotide Bld52 (SEQ ID NO: 128) CTTGAATGGACCCAGAAGAA Oligonucleotide Bld53 (SEQ ID NO: 129) TCTTGAATGGACCCAGAAGA Oligonucleotide Bld54 (SEQ ID NO: 130) CTCTTGAATGGACCCAGAAG Oligonucleotide Bld55 (SEQ ID NO: 131) TCTCTTGAATGGACCCAGAA Oligonucleotide Bld56 (SEQ ID NO: 132) CTCTCTTGAATGGACCCAGA Oligonucleotide Bld57 (SEQ ID NO: 133) ACTCTCTTGAATGGACCCAG Oligonucleotide Bld58 (SEQ ID NO: 134) CACTCTCTTGAATGGACCCA Oligonucleotide Bld59 (SEQ ID NO: 135) ACACTCTCTTGAATGGACCC Oligonucleotide Bld60 (SEQ ID NO: 136) CACACTCTCTTGAATGGACC Oligonucleotide Bld61 (SEQ ID NO: 137) TCACACTCTCTTGAATGGAC Oligonucleotide Bld62 (SEQ ID NO: 138) TTCACACTCTCTTGAATGGA Oligonucleotide Bld63 (SEQ ID NO: 139) TTTCACACTCTCTTGAATGG Oligonucleotide Bld64 (SEQ ID NO: 140) CTTTCACACTCTCTTGAATG Oligonucleotide Bld65 (SEQ ID NO: 141) TCTTTCACACTCTCTTGAAT Oligonucleotide Bld66 (SEQ ID NO: 142) GTCTTTCACACTCTCTTGAA Bld51; SEQ ID NO: 143 T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A Bld52; SEQ ID NO: 144 C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A Bld53; SEQ ID NO: 145 T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A Bld54; SEQ ID NO: 146 C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G Bld55; SEQ ID NO: 147 T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A Bld56; SEQ ID NO: 148 C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A Bld57; SEQ ID NO: 149 A*C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G Bld58; SEQ ID NO: 150 C*A*C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A Bld59; SEQ ID NO: 151 A*C*A*C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C Bld60; SEQ ID NO: 152 C*A*C*A*C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C Bld61; SEQ ID NO: 153 T*C*A*C*A*C*T*C*T*C*T*T*G*A*A*T*G*G*A*C Bld62; SEQ ID NO: 154 T*T*C*A*C*A*C*T*C*T*C*T*T*G*A*A*T*G*G*A Bld63; SEQ ID NO: 155 T*T*T*C*A*C*A*C*T*C*T*C*T*T*G*A*A*T*G*G Bld64; SEQ ID NO: 156 C*T*T*T*C*A*C*A*C*T*C*T*C*T*T*G*A*A*T*G Bld65; SEQ ID NO: 157 T*C*T*T*T*C*A*C*A*C*T*C*T*C*T*T*G*A*A*T Bld66; SEQ ID NO: 158 G*T*C*T*T*T*C*A*C*A*C*T*C*T*C*T*T*G*A*A Oligonucleotide Bld25-1 (SEQ ID NO: 159) CCAGAAGAAACCTGACAGAGTAAAG Oligonucleotide Bld25-2 (SEQ ID NO: 160) ACCCAGAAGAAACCTGACAGAGTAA Oligonucleotide Bld25-3 (SEQ ID NO: 161) ATGGACCCAGAAGAAACCTGACAGA Oligonucleotide Bld25-4 (SEQ ID NO: 162) GAATGGACCCAGAAGAAACCTGACA Oligonucleotide Bld25-5 (SEQ ID NO: 163) CTTGAATGGACCCAGAAGAAACCTG Oligonucleotide Bld26-1 (SEQ ID NO: 164) CTCTTGAATGGACCCAGAAGAAACC Oligonucleotide Bld26-2 (SEQ ID NO: 165) CTCTCTTGAATGGACCCAGAAGAAA Oligonucleotide Bld26-3 (SEQ ID NO: 166) CACACTCTCTTGAATGGACCCAGAA Oligonucleotide Bld26-4 (SEQ ID NO: 167) TTCACACTCTCTTGAATGGACCCAG Bld25-1; SEQ ID NO: 168 C*C*A*G*A*A*G*A*A*A*C*C*T*G*A*C*A*G*A*G*T*A*A*A*G* Bld25-2; SEQ ID NO: 169 A*C*C*C*A*G*A*A*G*A*A*A*C*C*T*G*A*C*A*G*A*G*T*A*A* Bld25-3; SEQ ID NO: 170 A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A*C*C*T*G*A*C*A*G*A* Bld25-4; SEQ ID NO: 171 G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A*C*C*T*G*A*C*A* Bld25-5; SEQ ID NO: 172 C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A*C*C*T*G* Bld26-1; SEQ ID NO: 173 C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A*C*C* Bld26-2; SEQ ID NO: 174 C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A* Bld26-3; SEQ ID NO: 175 C*A*C*A*C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A* Bld26-4; SEQ ID NO: 176 T*T*C*A*C*A*C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G* Oligonucleotide Bld25-A (SEQ ID NO: 177) ACCCAGAAGAAACCTGACAGAGT Oligonucleotide Bld25-B (SEQ ID NO: 178) CCAGAAGAAACCTGACAGAGT Oligonucleotide Bld25-C (SEQ ID NO: 179) GGACCCAGAAGAAACCTGACAGA Oligonucleotide Bld25-D (SEQ ID NO: 180) ACCCAGAAGAAACCTGACAGA Oligonucleotide Bld25-E (SEQ ID NO: 181) GGACCCAGAAGAAACCTGACA Oligonucleotide Bld25-5-A (SEQ ID NO: 182) GAATGGACCCAGAAGAAACCTGA Oligonucleotide Bld25-5-B (SEQ ID NO: 183) ATGGACCCAGAAGAAACCTGA Oligonucleotide Bld25-5-C (SEQ ID NO: 184) TTGAATGGACCCAGAAGAAACCT Oligonucleotide Bld25-5-D (SEQ ID NO: 185) GAATGGACCCAGAAGAAACCT Oligonucleotide Bld25-5-E (SEQ ID NO: 186) TTGAATGGACCCAGAAGAAAC Oligonucleotide Bld26-2-A (SEQ ID NO: 187) CTCTTGAATGGACCCAGAAGAAA Oligonucleotide Bld26-2-B (SEQ ID NO: 188) CTTGAATGGACCCAGAAGAAA Oligonucleotide Bld26-2-C (SEQ ID NO: 189) CTCTCTTGAATGGACCCAGAAGA Oligonucleotide Bld26-2-D (SEQ ID NO: 190) CTCTCTTGAATGGACCCAGAA Oligonucleotide Bld26-B (SEQ ID NO: 191) CTCTTGAATGGACCCAGAAGA Oligonucleotide Bld26-C (SEQ ID NO: 192) CACTCTCTTGAATGGACCCAGAA Oligonucleotide Bld26-D (SEQ ID NO: 193) CACTCTCTTGAATGGACCCAG Bld25-A; SEQ ID NO: 194 A*C*C*C*A*G*A*A*G*A*A*A*C*C*T*G*A*C*A*G*A*G*T Bld25-B; SEQ ID NO: 195 C*C*A*G*A*A*G*A*A*A*C*C*T*G*A*C*A*G*A*G*T Bld25-C; SEQ ID NO: 196 G*G*A*C*C*C*A*G*A*A*G*A*A*A*C*C*T*G*A*C*A*G*A Bld25-D; SEQ ID NO: 197 A*C*C*C*A*G*A*A*G*A*A*A*C*C*T*G*A*C*A*G*A Bld25-E; SEQ ID NO: 198 G*G*A*C*C*C*A*G*A*A*G*A*A*A*C*C*T*G*A*C*A Bld25-5-A; SEQ ID NO: 199 G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A*C*C*T*G*A Bld25-5-B; SEQ ID NO: 200 A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A*C*C*T*G*A Bld25-5-C; SEQ ID NO: 201 T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A*C*C*T Bld25-5-D; SEQ ID NO: 202 G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A*C*C*T Bld25-5-E; SEQ ID NO: 203 T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A*C Bld26-2-A; SEQ ID NO: 204 C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A Bld26-2-B; SEQ ID NO: 205 C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A*A*A Bld26-2-C; SEQ ID NO: 206 C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A Bld26-2-D; SEQ ID NO: 207 C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A Bld26-B; SEQ ID NO: 208 C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A*G*A Bld26-C; SEQ ID NO: 209 C*A*C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G*A*A Bld26-D; SEQ ID NO: 210 C*A*C*T*C*T*C*T*T*G*A*A*T*G*G*A*C*C*C*A*G Region 2 – MuSK Exon 7 GGGGAGAAGTTCAGTACTGCCAAGGCTGCAGCCACCATCAGCATAGCAGGTAGGATGCCC CT TCACATTTG (SEQ ID NO: 211) SEQ ID NO: 212 TTTCTTCTGGGTCCATTCAA SEQ ID NO: 213 TTCTTCTGGGTCCATTCAAG SEQ ID NO: 214 TCTTCTGGGTCCATTCAAGA SEQ ID NO: 215 CTTCTGGGTCCATTCAAGAG SEQ ID NO: 216 TTCTGGGTCCATTCAAGAGA SEQ ID NO: 217 TCTGGGTCCATTCAAGAGAG SEQ ID NO: 218 CTGGGTCCATTCAAGAGAGT SEQ ID NO: 219 TGGGTCCATTCAAGAGAGTG SEQ ID NO: 220 GGGTCCATTCAAGAGAGTGT SEQ ID NO: 221 GGTCCATTCAAGAGAGTGTG SEQ ID NO: 222 GTCCATTCAAGAGAGTGTGA SEQ ID NO: 223 TCCATTCAAGAGAGTGTGAA SEQ ID NO: 224 CCATTCAAGAGAGTGTGAAA SEQ ID NO: 225 CATTCAAGAGAGTGTGAAAG SEQ ID NO: 226 ATTCAAGAGAGTGTGAAAGA SEQ ID NO: 227 TTCAAGAGAGTGTGAAAGAC SEQ ID NO: 228 CTTTACTCTGTCAGGTTTCTTCTGG SEQ ID NO: 229 TTACTCTGTCAGGTTTCTTCTGGGT SEQ ID NO: 230 TCTGTCAGGTTTCTTCTGGGTCCAT SEQ ID NO: 231 TGTCAGGTTTCTTCTGGGTCCATTC SEQ ID NO: 232 CAGGTTTCTTCTGGGTCCATTCAAG SEQ ID NO: 233 GGTTTCTTCTGGGTCCATTCAAGAG SEQ ID NO: 234 TTTCTTCTGGGTCCATTCAAGAGAG SEQ ID NO: 235 TTCTGGGTCCATTCAAGAGAGTGTG SEQ ID NO: 236 CTGGGTCCATTCAAGAGAGTGTGAA SEQ ID NO: 237 ACTCTGTCAGGTTTCTTCTGGGT SEQ ID NO: 238 ACTCTGTCAGGTTTCTTCTGG SEQ ID NO: 239 TCTGTCAGGTTTCTTCTGGGTCC SEQ ID NO: 240 TCTGTCAGGTTTCTTCTGGGT SEQ ID NO: 241 TGTCAGGTTTCTTCTGGGTCC SEQ ID NO: 242 TCAGGTTTCTTCTGGGTCCATTC SEQ ID NO: 243 TCAGGTTTCTTCTGGGTCCAT SEQ ID NO: 244 AGGTTTCTTCTGGGTCCATTCAA SEQ ID NO: 245 AGGTTTCTTCTGGGTCCATTC SEQ ID NO: 246 GTTTCTTCTGGGTCCATTCAA SEQ ID NO: 247 TTTCTTCTGGGTCCATTCAAGAG SEQ ID NO: 248 TTTCTTCTGGGTCCATTCAAG SEQ ID NO: 249 TCTTCTGGGTCCATTCAAGAGAG SEQ ID NO: 250 TTCTGGGTCCATTCAAGAGAG SEQ ID NO: 251 TCTTCTGGGTCCATTCAAGAG SEQ ID NO: 252 TTCTGGGTCCATTCAAGAGAGTG SEQ ID NO: 253 CTGGGTCCATTCAAGAGAGTG

EQUIVALENTS [0531] Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. The scope of the present invention is not intended to be limited to the above Description, but rather is as set forth in the following claims: