Title:
MUTAGENIC STRAIN OF LACTOBACILLUS PLANTARUM, MUTAGENESIS METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/177456
Kind Code:
A1
Abstract:
Mutagenesis is carried out on hyaluronidase-producing Lactobacillus plantarum to obtain a high hyaluronidase-producing mutant strain of Lactobacillus plantarum CnT012-56, the accession number being: CGMCC NO.16836. Lactobacillus plantarum CnT012-56 is used for fermentation to produce hyaluronidase so that the enzyme activity of the resulting hyaluronidase after isolation and purification can reach 70,000 IU/ml and the molecular weight of the resulting hyaluronidase is 63 kDa.
Inventors:
HAN XIUYUN (CN)
Application Number:
PCT/CN2019/128321
Publication Date:
September 10, 2020
Filing Date:
December 25, 2019
Export Citation:
Assignee:
SHANDONG AWA BIOPHARM CO LTD (CN)
International Classes:
C12N1/20; C12N9/26; C12N13/00; C12P1/04; C12R1/25
Foreign References:
| CN107988115A | 2018-05-04 | |||
| CN102559559A | 2012-07-11 | |||
| CN103255076A | 2013-08-21 | |||
| CN102439144A | 2012-05-02 | |||
| JP5921151B2 | 2016-05-24 | |||
| CN105647827A | 2016-06-08 | |||
| CN109880758A | 2019-06-14 | |||
| CN110408607A | 2019-11-05 |
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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