Title:
MUTATED CLASS II MAJOR HISTOCOMPATIBILITY PROTEINS
Document Type and Number:
WIPO Patent Application WO2002046400
Kind Code:
A3
Abstract:
Provided are methods for directed mutagenesis and selection of MHC Class II proteins and single chain proteins with improved conformational stability and/or binding affinity for at least one cognate ligand. THe improved proteins are useful for identificaiton of T cells that are specific for the MHC Class II proteins and for treatment of disorders inlcuding autoimmune diseases, with the disorder determining the choice of the particular improved protein, peptide-protein complex or other ligand protein complex.
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Inventors:
KRANZ DAVID M
STARWALT SCOTT
BLUESTONE JEFFREY A
STARWALT SCOTT
BLUESTONE JEFFREY A
Application Number:
PCT/US2001/047830
Publication Date:
January 23, 2003
Filing Date:
December 10, 2001
Export Citation:
Assignee:
UNIV ILLINOIS (US)
International Classes:
C07K14/705; C07K14/74; C12N15/10; C40B40/02; (IPC1-7): C12N15/10; C07K14/74; C12N15/62; C12N15/81
Domestic Patent References:
| WO1999036569A1 | 1999-07-22 | |||
| WO1999021572A1 | 1999-05-06 | |||
| WO1999058693A1 | 1999-11-18 | |||
| WO2001048145A2 | 2001-07-05 | |||
| WO2002046399A2 | 2002-06-13 |
Other References:
CHO B K ET AL: "A yeast surface display system for the discovery of ligands that trigger cell activation", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 220, no. 1-2, 1 November 1998 (1998-11-01), pages 179 - 188, XP004144115, ISSN: 0022-1759
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