Title:
MYELIN SHEATH REPAIR AGENT
Document Type and Number:
WIPO Patent Application WO/2022/138936
Kind Code:
A1
Abstract:
The present invention provides an agent for the treatment or prevention of central demyelinating diseases that contains an APJ receptor agonist.
Inventors:
IKEDA RIEKO (JP)
Application Number:
PCT/JP2021/048303
Publication Date:
June 30, 2022
Filing Date:
December 24, 2021
Export Citation:
Assignee:
NAT CENTER NEUROLOGY & PSYCHIATRY (JP)
International Classes:
A61K45/00; A61K38/16; A61P9/10; A61P21/00; A61P25/00; G01N33/68
Domestic Patent References:
| WO2006019193A1 | 2006-02-23 |
Foreign References:
| JP2014534255A | 2014-12-18 | |||
| CN112546198A | 2021-03-26 |
Other References:
HAJIMASHHADI ZAHRA; ABOUTALEB NAHID; NASIRINEZHAD FARINAZ: "Chronic administration of [Pyr1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats", NEUROPEPTIDES, vol. 61, 2 September 2016 (2016-09-02), GB , pages 15 - 22, XP029896517, ISSN: 0143-4179, DOI: 10.1016/j.npep.2016.08.010
RAHUL RAI, ASISH K. GHOSH, MESUT EREN, ALEXANDER R. MACKIE, DANIEL C. LEVINE, SO-YOUN KIM, JONATHAN CEDERNAES, VERONICA RAMIREZ, D: "Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan", CELL REPORTS, vol. 21, no. 6, 1 November 2017 (2017-11-01), US , pages 1471 - 1480, XP055759096, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.10.057
VAFAEI-NEZHAD SAEED, NIKNAZAR SOMAYEH, NOROUZIAN MOHSEN, ABDOLLAHIFAR MOHAMMAD-AMIN, ALIAGHAEI ABBAS, ABBASZADEH HOJJAT ALLAH: "Therapeutics effects of [Pyr1] apelin-13 on rat contusion model of spinal cord injury: An experimental study", JOURNAL OF CHEMICAL NEUROANATOMY, vol. 113, 1 April 2021 (2021-04-01), GB , pages 1 - 11, XP055946613, ISSN: 0891-0618, DOI: 10.1016/j.jchemneu.2021.101924
MURAMATSU, RIEKO: "Elucidation of the molecular mechanism that controls the development of myelin sheath", 2019 RESEARCH RESULTS REPORT, 1 January 2019 (2019-01-01), Japan, pages 64 - 65, XP009538293
LUO HUAIQING, HAN LI, XU JIN: "Apelin/APJ system: A novel promising target for neurodegenerative diseases", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 235, no. 2, 1 February 2020 (2020-02-01), US , pages 638 - 657, XP055946622, ISSN: 0021-9541, DOI: 10.1002/jcp.29001
RAHUL RAI, ASISH K. GHOSH, MESUT EREN, ALEXANDER R. MACKIE, DANIEL C. LEVINE, SO-YOUN KIM, JONATHAN CEDERNAES, VERONICA RAMIREZ, D: "Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan", CELL REPORTS, vol. 21, no. 6, 1 November 2017 (2017-11-01), US , pages 1471 - 1480, XP055759096, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.10.057
VAFAEI-NEZHAD SAEED, NIKNAZAR SOMAYEH, NOROUZIAN MOHSEN, ABDOLLAHIFAR MOHAMMAD-AMIN, ALIAGHAEI ABBAS, ABBASZADEH HOJJAT ALLAH: "Therapeutics effects of [Pyr1] apelin-13 on rat contusion model of spinal cord injury: An experimental study", JOURNAL OF CHEMICAL NEUROANATOMY, vol. 113, 1 April 2021 (2021-04-01), GB , pages 1 - 11, XP055946613, ISSN: 0891-0618, DOI: 10.1016/j.jchemneu.2021.101924
MURAMATSU, RIEKO: "Elucidation of the molecular mechanism that controls the development of myelin sheath", 2019 RESEARCH RESULTS REPORT, 1 January 2019 (2019-01-01), Japan, pages 64 - 65, XP009538293
LUO HUAIQING, HAN LI, XU JIN: "Apelin/APJ system: A novel promising target for neurodegenerative diseases", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 235, no. 2, 1 February 2020 (2020-02-01), US , pages 638 - 657, XP055946622, ISSN: 0021-9541, DOI: 10.1002/jcp.29001
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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