Title:
N-(3-PYRROLIDINYL)BENZAMIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1995/029891
Kind Code:
A1
Abstract:
An N-(3-pyrrolidinyl)benzamide derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof and a medicine containing the same, having a potent and selective antagonism against dopamine D3 and/or D4 receptors and useful as a psychotropic agent, schizophrenia remedy, and so forth. In said formula, R1 represents hydrogen, lower alkyl, aralkyl, or three- to eight-membered cycloalkyl or cycloalkyl-lower alkyl; R2 represents four- to sixteen-membered bi- or tricyclic bridged hydrocarbon group; R3 represents lower alkoxy, amino, or mono- or di(lower alkyl)amino; R4 represents hydrogen, halogen, optionally hydroxylated lower alkyl, lower alkoxy, cyano, nitro, amino, mono- or di(lower alkyl)amino, acyl or -S(O)m-R5; R5 represents lower alkyl, amino or mono- or di(lower alkyl)amino; m represents 0, 1 or 2; X represents a bond, -O-, -S(O)n-, -NH- or -CONH-; and n represents 0, 1 or 2; provided when R1 represents cycloalkyl, the case where X represents -CONH-, R3 represents lower alkoxy and R4 represents halogen is excepted.
Inventors:
OHMORI JUNYA (JP)
MAENO KYOICHI (JP)
HIDAKA KAZUYUKI (JP)
NAKATO KAZUHIRO (JP)
SAKAMOTO SHUICHI (JP)
TSUKAMOTO SHIN-ICHI (JP)
MAENO KYOICHI (JP)
HIDAKA KAZUYUKI (JP)
NAKATO KAZUHIRO (JP)
SAKAMOTO SHUICHI (JP)
TSUKAMOTO SHIN-ICHI (JP)
Application Number:
PCT/JP1995/000818
Publication Date:
November 09, 1995
Filing Date:
April 26, 1995
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
OHMORI JUNYA (JP)
MAENO KYOICHI (JP)
HIDAKA KAZUYUKI (JP)
NAKATO KAZUHIRO (JP)
SAKAMOTO SHUICHI (JP)
TSUKAMOTO SHIN ICHI (JP)
OHMORI JUNYA (JP)
MAENO KYOICHI (JP)
HIDAKA KAZUYUKI (JP)
NAKATO KAZUHIRO (JP)
SAKAMOTO SHUICHI (JP)
TSUKAMOTO SHIN ICHI (JP)
International Classes:
C07D207/14; (IPC1-7): C07D207/14; A61K31/40
Foreign References:
| JPS53139728A | 1978-12-06 | |||
| JPS5069066A | 1975-06-09 |
Other References:
J. MED, CHEM., 24(10), 1224-30 (1981).
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