Title:
N-AROMATIC AMIDES COMPOUND AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/063407
Kind Code:
A1
Abstract:
The present invention relates to general formulas (I) and (II) an N-aromatic amide compound and a preparation method therefor, a pharmaceutical composition and a pharmaceutical preparation containing the general formulas (I) and (II), and applications of the general formulas (I) and (II) in preparation of a drug for treating an androgen-related disease. The definitions of R1, R2, R3, R4, R5, R6, W1, W2, W3, W4, and W5 in the general formulas are the same as those in the specification. The compound can be used alone or as a composition for treating various androgen-related diseases such as prostate cancer, prostatic hyperplasia, breast cancer, bladder cancer, and ovarian cancer, and further for the treatment of acne, hirsutism, alopecia, and other diseases.
Inventors:
YANG GUOHONG (CN)
YU LIJUN (CN)
HE JUNZE (CN)
DUAN MEIJUAN (CN)
YU LIJUN (CN)
HE JUNZE (CN)
DUAN MEIJUAN (CN)
Application Number:
PCT/CN2019/106287
Publication Date:
April 02, 2020
Filing Date:
September 17, 2019
Export Citation:
Assignee:
SHENZHEN EDK PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C07D209/08; A61K31/404; A61K31/415; A61P5/28; C07D231/16
Domestic Patent References:
| WO2007038444A2 | 2007-04-05 |
Foreign References:
| CN104245675A | 2014-12-24 |
Other References:
ISHIDA, SYO ET AL.: "Copper-Catalyzed Amination of Congested and Functionalized a-Bromocarboxamides with either Amines or Ammonia at Room Temperature", ANGEWANDTE CHEMIE, vol. 56, no. 38, 15 August 2017 (2017-08-15), pages 11610 - 11614, XP055699618, ISSN: 1433-7851, DOI: 10.1002/anie.201706293
DATABASE Registry CAS; 24 May 2011 (2011-05-24), retrieved from STN Database accession no. RN1299363-11-3
DATABASE Registry CAS; 1 May 2011 (2011-05-01), retrieved from STN Database accession no. RN1288359-74-9
DATABASE Registry CAS; 28 April 2011 (2011-04-28), retrieved from STN Database accession no. RN1287181-00-3
DATABASE Registry CAS; 8 August 2012 (2012-08-08), retrieved from STN Database accession no. RN1387940-35-3
FERRONI, CLAUDIA ET AL.: "1, 4-Substituted Triazoles as Nonsteroidal Anti-An- drogens for Prostate", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 7, 8 March 2017 (2017-03-08), pages 3082 - 3093, XP055406231, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00105
ENDOCRINOLOGY, vol. 91, 1972, pages 427 - 437
BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 7, 1979, pages 565 - 569
JOURNAL OF STEROID BIOCHEMISTRY, vol. 6, 1975, pages 815 - 819
THE JOURNAL OF ENDOCRINOLOGY, vol. 113, 1987, pages R7 - R9
UROLOGIC CLINICS OF NORTH AMERICA, vol. 18, 1991, pages 99 - 110
ARCHIVES OF PHARMACAL RESEARCH, vol. 38, no. 11, 2015, pages 2076 - 82
PURE APPL. CHEM., vol. 63, no. 3, 1991, pages 419 - 422
CHEMICAL REVIEWS, vol. 95, no. 7, 1979, pages 2457 - 2483
JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 576, 1999, pages 147 - 168
See also references of EP 3858811A4
DATABASE Registry CAS; 24 May 2011 (2011-05-24), retrieved from STN Database accession no. RN1299363-11-3
DATABASE Registry CAS; 1 May 2011 (2011-05-01), retrieved from STN Database accession no. RN1288359-74-9
DATABASE Registry CAS; 28 April 2011 (2011-04-28), retrieved from STN Database accession no. RN1287181-00-3
DATABASE Registry CAS; 8 August 2012 (2012-08-08), retrieved from STN Database accession no. RN1387940-35-3
FERRONI, CLAUDIA ET AL.: "1, 4-Substituted Triazoles as Nonsteroidal Anti-An- drogens for Prostate", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 7, 8 March 2017 (2017-03-08), pages 3082 - 3093, XP055406231, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00105
ENDOCRINOLOGY, vol. 91, 1972, pages 427 - 437
BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 7, 1979, pages 565 - 569
JOURNAL OF STEROID BIOCHEMISTRY, vol. 6, 1975, pages 815 - 819
THE JOURNAL OF ENDOCRINOLOGY, vol. 113, 1987, pages R7 - R9
UROLOGIC CLINICS OF NORTH AMERICA, vol. 18, 1991, pages 99 - 110
ARCHIVES OF PHARMACAL RESEARCH, vol. 38, no. 11, 2015, pages 2076 - 82
PURE APPL. CHEM., vol. 63, no. 3, 1991, pages 419 - 422
CHEMICAL REVIEWS, vol. 95, no. 7, 1979, pages 2457 - 2483
JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 576, 1999, pages 147 - 168
See also references of EP 3858811A4
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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