Title:
N-BENZYL-2-BROMO-3-METHOXYPROPIONAMIDE AND METHOD FOR PRODUCING INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/159028
Kind Code:
A1
Abstract:
The present invention provides an industrially excellent production method by which N-benzyl-2-bromo-3-methoxypropionamide can be safely produced in high yield at lower cost. The production method of the present application comprises, in the following order, an amidation step in which diacrylic anhydride is reacted with benzylamine in a solvent to obtain N-benzylacrylamide, a bromination step in which the N-benzylacrylamide is reacted with bromine in a solvent to obtain N-benzyl-2,3-dibromopropionamide, and a methoxylation step in which the N-benzyl-2,3-dibromopropionamide is reacted with methanol in the presence of a base to obtain N-benzyl-2-bromo-3-methoxypropionamide.
Inventors:
NAGAHAMA MASAKI (JP)
SAITO KENTA (JP)
SAITO KENTA (JP)
Application Number:
PCT/JP2017/041899
Publication Date:
September 07, 2018
Filing Date:
November 21, 2017
Export Citation:
Assignee:
API CORP (JP)
International Classes:
C07C231/12; C07C51/56; C07C57/04; C07C231/02; C07C233/05; C07C233/09; C07C235/06
Domestic Patent References:
| WO2014133135A1 | 2014-09-04 | |||
| WO2012069855A1 | 2012-05-31 | |||
| WO2010052011A1 | 2010-05-14 | |||
| WO2012069855A1 | 2012-05-31 |
Foreign References:
| JP2012512217A | 2012-05-31 | |||
| JP2015502375A | 2015-01-22 | |||
| JP2002363129A | 2002-12-18 | |||
| CN102070747A | 2011-05-25 |
Other References:
BRADLEY J. SPARKS ET AL.: "Mussel-Inspired Thiol–Ene Polymer Networks: Influencing Network Properties and Adhesion with Catechol Functionality", CHEMISTRY OF MATERIALS, vol. 24, no. 18, 2012, pages 3633 - 3642, XP055540770
CHOY YS ET AL.: "Mussel-inspired dopamine- and plant-based cardanol-containing polymer coatings for multifunctional filtration membranes.", ACS APPLIED MATERIALS & INTERFACES, vol. 6, no. 23, 2014, pages 21297 - 21307, XP055542066
CHOY YS ET AL.: "Mussel-inspired dopamine- and plant-based cardanol-containing polymer coatings for multifunctional filtration membranes.", ACS APPLIED MATERIALS & INTERFACES, vol. 6, no. 23, 2014, pages 21297 - 21307, XP055542066
Attorney, Agent or Firm:
SANADA, Tamotsu (JP)
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