N-HETEROCYCLIC FIVE-MEMBERED RING-CONTAINING CAPSID PROTEIN ASSEMBLY INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF - CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD

Title:

N-HETEROCYCLIC FIVE-MEMBERED RING-CONTAINING CAPSID PROTEIN ASSEMBLY INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2020/151252

Kind Code:

A1

Abstract:

Provided is a compound of formula I or II, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and the medical uses thereof in treating diseases benefiting from the capsid protein assembly inhibitor, particularly diseases caused by hepatitis B virus infection.

Inventors:

ZHANG YINSHENG (CN)
AO WANGWEI (CN)
LI YUAN (CN)
WANG HUI (CN)
SHEN HANGZHOU (CN)
NI JIE (CN)
ZHANG HUAN (CN)
WU JIE (CN)
ZHANG LI (CN)
CAO KAI (CN)
LU PENG (CN)
LIU XUSHI (CN)
WANG JIE (CN)
ZHAO TIANXIAO (CN)
GE XINGFENG (CN)
LU DANDAN (CN)
CHEN SHUO (CN)
MA XUEQIN (CN)
SHI WEI (CN)
WANG XIAOJIN (CN)
XU HONGJIANG (CN)

Application Number:

PCT/CN2019/108483

Publication Date:

July 30, 2020

Filing Date:

September 27, 2019

Export Citation:

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Assignee:

CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)

International Classes:

C07D207/34; A61K31/40; A61P31/20

Domestic Patent References:

WO2019185016A1	2019-10-03
WO2017156255A1	2017-09-14
WO2018039531A1	2018-03-01
WO2018050110A1	2018-03-22
WO2019165374A1	2019-08-29
WO2014184350A1	2014-11-20
WO2015011281A1	2015-01-29
WO2017156255A1	2017-09-14

Foreign References:

CN105431413A	2016-03-23
CN105658624A	2016-06-08

Other References:

MAYUR BRAHMANIA ET AL., NEW THERAPEUTIC AGENTS FOR CHRONIC HEPATITIS B
"Greene's Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC.
See also references of EP 3915972A4