Title:
N-HYDROXYCARBOXAMIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2003/070691
Kind Code:
A1
Abstract:
It is intended to provide a novel N-hydroxycarboxamide derivative which is excellent in physical properties such as stability and dissolution properties and a potent histone deacetylase (HDAC) inhibitory activity. It is found out that a novel N-hydroxycarboxamide derivative, which is obtained by using tranexamic acid as a lead compound, and its salt have a potent HDAC inhibitory activity. This N-hydroxycarboxamide derivative is useful in treating, relieving and preventing diseases concerning cell proliferation. In particular, it is expected that this derivative is highly efficacious as an anticancer agent or a carcinostatic agent. Moreover, it is expected that the above N-hydroxycarboxamide derivative is efficacious as an immunosuppressant or a gene therapy potentiator and usable in treating, relieving and preventing neurodegenerative diseases.
Inventors:
UESATO SHINICHI (JP)
NAGAOKA YASUO (JP)
YAMORI TAKAO (JP)
NAGAOKA YASUO (JP)
YAMORI TAKAO (JP)
Application Number:
PCT/JP2003/001681
Publication Date:
August 28, 2003
Filing Date:
February 18, 2003
Export Citation:
Assignee:
OSAKA IND PROMOTION ORG (JP)
UESATO SHINICHI (JP)
NAGAOKA YASUO (JP)
YAMORI TAKAO (JP)
UESATO SHINICHI (JP)
NAGAOKA YASUO (JP)
YAMORI TAKAO (JP)
International Classes:
A61K31/166; A61K31/17; A61K31/18; A61K31/404; A61K31/47; A61K48/00; A61P25/00; A61P25/14; A61P25/28; A61P35/00; A61P35/02; A61P37/06; A61P43/00; C07C259/08; C07C311/19; C07D209/42; C07D215/48; C07D215/54; (IPC1-7): C07C259/08; A61K31/166; A61K31/17; A61K31/18; A61K31/404; A61K31/47; A61K48/00; A61P25/00; A61P25/14; A61P25/28; A61P35/00; A61P35/02; A61P37/06; A61P43/00; C07C259/10; C07C275/26; C07C311/19; C07D209/42; C07D215/48; C07D215/54
Domestic Patent References:
| WO2001038322A1 | 2001-05-31 |
Other References:
LAVOIE R. ET AL.: "Design and synthesis of a novel class of histone deacetylase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 21, 2001, pages 2847 - 2850, XP002954135
JUNG M. ET AL.: "Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 22, 1999, pages 4669 - 4679, XP002144226
JUNG M. ET AL.: "Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 22, 1999, pages 4669 - 4679, XP002144226
Attorney, Agent or Firm:
IKEUCHI SATO & PARTNER PATENT ATTORNEYS (OAP TOWER 8-30, Tenmabashi 1-chome, Kita-k, Osaka-shi Osaka, JP)
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