Title:
N-HYDROXYFORMAMIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2004/024677
Kind Code:
A1
Abstract:
An N-hydroxyformamidine derivative represented by the formula (I) wherein R1 represents hydrogen, C1-4 alkyl, C1-4 alkoxy, or halogeno; A represents C1-10 alkylene or a group represented by the formula (II) (wherein m, n, and p each is an integer of 0 to 4); and R represents N,N-di(C1-6 alkyl)amino, dioxanyl, dioxanyl substituted by C1-4 alkyl, C1-4 alkoxy substituted by C1-4 alkoxy, or a group represented by the formula (III) (wherein s and t each is an integer of 1 to 4; B represents methylene, oxygen, sulfur, nitrogen, nitrogen substituted by C1-4 alkyl, nitrogen substituted by phenyl, or nitrogen substituted by benzyl; R2 represents hydrogen or C1-4 alkyl; and r is an integer of 0 to 2); or a pharmaceutically acceptable salt of the derivative. Also provided is a medicine having an inhibitory activity against an enzyme producing 20-HETE, which relates to microvascular constrictive or dilative activity, cell proliferative activity, etc. in major organs such as the kidneys and cerebral blood vessels.
Inventors:
SATO MASAKAZU (JP)
KAKINUMA HIROYUKI (JP)
AMADA HIDEAKI (JP)
KAKINUMA HIROYUKI (JP)
AMADA HIDEAKI (JP)
Application Number:
PCT/JP2003/011603
Publication Date:
March 25, 2004
Filing Date:
September 11, 2003
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
SATO MASAKAZU (JP)
KAKINUMA HIROYUKI (JP)
AMADA HIDEAKI (JP)
SATO MASAKAZU (JP)
KAKINUMA HIROYUKI (JP)
AMADA HIDEAKI (JP)
International Classes:
A61P9/00; A61P13/12; A61P43/00; C07C251/34; C07C259/14; C07D295/135; C07D319/06; (IPC1-7): C07C259/14; C07D295/12; C07D319/06; A61K31/155; A61K31/357; A61K31/40; A61P9/00; A61P13/12; A61P43/00
Foreign References:
| EP1226819A1 | 2002-07-31 |
Attorney, Agent or Firm:
Kitagawa, Tomizo (LTD. Intellectual Property Division 24-1,
Takata 3-chom, Toshima-ku Tokyo, JP)
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