Title:
N-AND O-SUBSTITUTED 4-[2-(DIPHENYLMETHOXY)-ETHYL]-1-[(PHENYL)METHYL]PIPERIDINE ANALOGS AND METHODS OF TREATING CNS DISORDERS THEREWITH
Document Type and Number:
WIPO Patent Application WO2001098266
Kind Code:
A3
Abstract:
N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl]piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred compounds exhibit highly differential behavior as between the DAT and SERT and between the DAT and the norepinephrine transporter (NET). The compounds have utility in treating CNS disorders, including but not limited to cocaine addiction, depression, and Parkinson's disease.
Inventors:
DUTTA ALOKE K (US)
Application Number:
PCT/US2001/040964
Publication Date:
April 04, 2002
Filing Date:
June 14, 2001
Export Citation:
Assignee:
UNIV WAYNE STATE (US)
DUTTA ALOKE K (US)
DUTTA ALOKE K (US)
International Classes:
A61P25/16; A61P25/30; C07D211/22; C07D211/26; C07D211/40; C07D211/56; (IPC1-7): A61K31/445; A61K31/4468; A61K31/4545; C07D211/08; C07D211/40; C07D211/56; C07D405/06; C07D405/12; C07D409/06; C07D409/12
Domestic Patent References:
| WO1999025686A1 | 1999-05-27 |
Foreign References:
| US5344835A | 1994-09-06 | |||
| US5232929A | 1993-08-03 | |||
| US5300499A | 1994-04-05 |
Other References:
DATABASE CAPLUS [online] (COLUMBUS, OHIO, USA); DUTTA ET AL.: "Structural activity relationship studies of novel piperidine analogs", XP002906928, accession no. STN Database accession no. 1996:32788
DATABASE CAPLUS [online] (COLUMBUS, OHIO, USA); DUTTA ET AL.: "Potent and selective ligands for dopamine transporter", XP002906927, accession no. STN Database accession no. 1998:85298
DATABASE CAPLUS [online] (COLUMBUS, OHIO, USA); DUTTA ET AL.: "Tolerance in the replacement of the benzhydrylic on atom", XP002906925, accession no. STN Database accession no. 1998:505470
DATABASE CAPLUS [online] (COLUMBUS, OHIO, USA); HOEPPING ET AL.: "Synthesis and biological evaluation of two novel DAT binding technetium complexes", XP002905361, accession no. STN Database accession no. 132:119356
DATABASE CAPLUS [online] (COLUMBUS, OHIO, USA); DRESEL ET AL.: "In vivo imaging of serotonin transporters", XP002906926, accession no. STN Database accession no. 1999:196775
DATABASE CAPLUS [online] (COLUMBUS, OHIO, USA); DUTTA ET AL.: "Potent and selective ligands for dopamine transporter", XP002906927, accession no. STN Database accession no. 1998:85298
DATABASE CAPLUS [online] (COLUMBUS, OHIO, USA); DUTTA ET AL.: "Tolerance in the replacement of the benzhydrylic on atom", XP002906925, accession no. STN Database accession no. 1998:505470
DATABASE CAPLUS [online] (COLUMBUS, OHIO, USA); HOEPPING ET AL.: "Synthesis and biological evaluation of two novel DAT binding technetium complexes", XP002905361, accession no. STN Database accession no. 132:119356
DATABASE CAPLUS [online] (COLUMBUS, OHIO, USA); DRESEL ET AL.: "In vivo imaging of serotonin transporters", XP002906926, accession no. STN Database accession no. 1999:196775
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