Title:
N-substituted 2-cyanopyrrolidines
Document Type and Number:
WIPO Patent Application WO1998019998
Kind Code:
A3
Abstract:
N-(N'-substituted glycyl)-2-cyanopyrrolidines, e.g. the compounds of formula (I) wherein R has various significances, are novel. They inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.
Inventors:
VILLHAUER EDWIN BERNARD (US)
Application Number:
PCT/EP1997/006125
Publication Date:
July 16, 1998
Filing Date:
November 05, 1997
Export Citation:
Assignee:
NOVARTIS AG (CH)
VILLHAUER EDWIN BERNARD (US)
VILLHAUER EDWIN BERNARD (US)
International Classes:
A61K31/40; A61K31/401; A61K31/44; A61K31/4427; A61K31/4439; A61K31/454; A61K31/505; A61K31/506; A61P3/00; A61P3/10; A61P43/00; C07D207/16; C07D401/12; C07D403/12; (IPC1-7): C07D207/16; C07D401/12; C07D403/12; A61K31/40; A61K31/44; A61K31/505
Domestic Patent References:
| WO1990012005A1 | 1990-10-18 |
Foreign References:
| EP0172458A2 | 1986-02-26 | |||
| EP0115639A1 | 1984-08-15 | |||
| EP0132580A1 | 1985-02-13 |
Download PDF: