Title:
N-SUBSTITUTED ARYLAMINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/012397
Kind Code:
A1
Abstract:
The present invention relates to a compound having a structure represented by formula I, formula II, formula III, formula IV, formula V or formula VI, or a stereoisomer or pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound, and a use thereof.
Inventors:
LI QINGENG (CN)
CHEN JIE (CN)
LI CHANGWEN (CN)
WANG KAI (CN)
JIANG SHUAI (CN)
LIAO JIAN (CN)
TAN BO (CN)
SHEN YI (CN)
DONG XIAOHU (CN)
CHEN JIE (CN)
LI CHANGWEN (CN)
WANG KAI (CN)
JIANG SHUAI (CN)
LIAO JIAN (CN)
TAN BO (CN)
SHEN YI (CN)
DONG XIAOHU (CN)
Application Number:
PCT/CN2023/106526
Publication Date:
January 18, 2024
Filing Date:
July 10, 2023
Export Citation:
Assignee:
JIANGSU NHWALUOKANG PHARMACEUTICAL RES AND DEVELOPMENT CO LTD (CN)
International Classes:
A61K31/27; C07C271/64; A61P23/02
Foreign References:
| CN106928127A | 2017-07-07 | |||
| CN114075184A | 2022-02-22 | |||
| CN110156665A | 2019-08-23 |
Other References:
EKENSTAM BO, EGNÉR, BÖRJE; PETTERSSON, GÖSTA: "Local Anesthetics. I. N-Alkylpyrrolidine and N-alkylpiperidinecarboxylic Acid Amides", ACTA CHEMICA SCANDINAVICA, vol. 11, no. 7, 1 January 1957 (1957-01-01), pages 1183 - 1190, XP093128468
MCMASTER PAULL A., D, BYRNES EUGENE W, BLOCK ALAN J, TENTHOREY PAUL A, : "New Antiarrhythmic Agents. 5. a-Aminoaceto-2,6-xylidides with Functionalized Amide Alkyl Substituents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 24, no. 1, 1 December 1981 (1981-12-01), pages 53 - 58, XP093128476
AXEL TRAUTMANN; JOHANNA STOEVESANDT: "Differential diagnosis of late‐type reactions to injected local anaesthetics: Inflammation at the injection site is the only indicator of allergic hypersensitivity", CONTACT DERMATITIS: ENVIRONMENTAL AND OCCUPATIONAL DERMATITIS, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 80, no. 2, 11 October 2018 (2018-10-11), US , pages 118 - 124, XP071454294, ISSN: 0105-1873, DOI: 10.1111/cod.13130
KHAIRULLINA V. R., TARASOV G. P., GERCHIKOV A. YA., ZARUDII F. S.: "Modification of N 1-(2,6-dimethylphenyl)-N 2,N 2-diethylglycinamide and 4-amino-N[2-(diethylamino)ethyl]benzamide in order to increase their antiarrhythmic effect", PHARMACEUTICAL CHEMISTRY JOURNAL, SPRINGER NEW YORK LLC, US, vol. 45, no. 10, 1 January 2012 (2012-01-01), US , pages 597 - 604, XP093128481, ISSN: 0091-150X, DOI: 10.1007/s11094-012-0688-1
MCMASTER PAULL A., D, BYRNES EUGENE W, BLOCK ALAN J, TENTHOREY PAUL A, : "New Antiarrhythmic Agents. 5. a-Aminoaceto-2,6-xylidides with Functionalized Amide Alkyl Substituents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 24, no. 1, 1 December 1981 (1981-12-01), pages 53 - 58, XP093128476
AXEL TRAUTMANN; JOHANNA STOEVESANDT: "Differential diagnosis of late‐type reactions to injected local anaesthetics: Inflammation at the injection site is the only indicator of allergic hypersensitivity", CONTACT DERMATITIS: ENVIRONMENTAL AND OCCUPATIONAL DERMATITIS, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 80, no. 2, 11 October 2018 (2018-10-11), US , pages 118 - 124, XP071454294, ISSN: 0105-1873, DOI: 10.1111/cod.13130
KHAIRULLINA V. R., TARASOV G. P., GERCHIKOV A. YA., ZARUDII F. S.: "Modification of N 1-(2,6-dimethylphenyl)-N 2,N 2-diethylglycinamide and 4-amino-N[2-(diethylamino)ethyl]benzamide in order to increase their antiarrhythmic effect", PHARMACEUTICAL CHEMISTRY JOURNAL, SPRINGER NEW YORK LLC, US, vol. 45, no. 10, 1 January 2012 (2012-01-01), US , pages 597 - 604, XP093128481, ISSN: 0091-150X, DOI: 10.1007/s11094-012-0688-1
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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