Title:
N-SUBSTITUTED PHENYLSULFONAMIDE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/262657
Kind Code:
A1
Abstract:
The present invention relates to an N-substituted phenylsulfonamide compound and a use thereof. Specifically, the present invention provides a compound represented by formula I, or an optical isomer thereof, or a racemate thereof, or a pharmaceutically acceptable salt thereof. The compound described in the present invention has an excellent inhibitory effect on transient receptor potential channel proteins, and has an excellent therapeutic effect on transient receptor potential channel protein-related diseases, such as inflammatory bowel disease, irritable bowel syndrome, pain, and inflammation.
Inventors:
WANG YOUXIN (CN)
ZHANG LINGLING (CN)
DING QIANG (CN)
ZHANG LINGLING (CN)
DING QIANG (CN)
Application Number:
PCT/CN2022/098183
Publication Date:
December 22, 2022
Filing Date:
June 10, 2022
Export Citation:
Assignee:
SHANGHAI LEADO PHARMATECH CO LTD (CN)
International Classes:
C07D307/52; A61K31/341; A61K31/381; A61K31/40; A61K31/402; A61K31/415; A61K31/4164; A61K31/4178; A61K31/4192; A61K31/426; A61K31/428; A61K31/443; A61P1/00; A61P1/04; A61P25/00; A61P29/00; C07D207/335; C07D231/12; C07D233/64; C07D249/06; C07D261/08; C07D277/28; C07D307/54; C07D307/79; C07D333/20; C07D333/34; C07D405/12; C07D409/12; C07D409/14; C07D417/12
Domestic Patent References:
| WO2020097408A1 | 2020-05-14 | |||
| WO2010126002A1 | 2010-11-04 | |||
| WO2008038955A1 | 2008-04-03 | |||
| WO2014163162A1 | 2014-10-09 | |||
| WO2010075353A1 | 2010-07-01 |
Foreign References:
| CN101511800A | 2009-08-19 | |||
| KR20150144121A | 2015-12-24 | |||
| US20210130380A1 | 2021-05-06 |
Other References:
WANG XIAOYU, ZHANG CHEN, LI JUE, JIANG CHONG, SU FU, ZHAN ZHEN, HAI LI, CHEN ZHONGHUA, WU YONG: "Ruthenium-catalyzed 1,2,3-triazole directed intermolecular C–H amidation of arenes with sulfonyl azides", RSC ADVANCES, vol. 6, no. 73, 15 July 2016 (2016-07-15), pages 68929 - 68933, XP093015511, DOI: 10.1039/C6RA14020C
SIVA SENTHIL KUMAR BOOMINATHAN; JEH‐JENG WANG: "A Palladium- and Copper-Catalyzed Synthesis of Dihydro[1,2-b]indenoindole-9-ol and Benzofuro[3,2-b]indolines: Metal-Controlled Intramolecular CC and CO Bond-Forming Reactions", CHEMISTRY - A EUROPEAN JOURNAL, vol. 21, no. 47, 7 October 2015 (2015-10-07), DE, pages 17044 - 17050, XP071878385, ISSN: 0947-6539, DOI: 10.1002/chem.201503210
GUILLAUME PONCET-MONTANGE; YANAI ZHAN; JENNIFER P BARDENHAGEN; ALESSIA PETROCCHI; ELISABETTA LEO; XI SHI; GILBERT R LEE; PAUL G LE: "Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2", BIOCHEMICAL JOURNAL, vol. 466, no. 2, 1 March 2015 (2015-03-01), GB , pages 337 - 346, XP055540874, ISSN: 0264-6021, DOI: 10.1042/BJ20140933
SIVA SENTHIL KUMAR BOOMINATHAN; JEH‐JENG WANG: "A Palladium- and Copper-Catalyzed Synthesis of Dihydro[1,2-b]indenoindole-9-ol and Benzofuro[3,2-b]indolines: Metal-Controlled Intramolecular CC and CO Bond-Forming Reactions", CHEMISTRY - A EUROPEAN JOURNAL, vol. 21, no. 47, 7 October 2015 (2015-10-07), DE, pages 17044 - 17050, XP071878385, ISSN: 0947-6539, DOI: 10.1002/chem.201503210
GUILLAUME PONCET-MONTANGE; YANAI ZHAN; JENNIFER P BARDENHAGEN; ALESSIA PETROCCHI; ELISABETTA LEO; XI SHI; GILBERT R LEE; PAUL G LE: "Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2", BIOCHEMICAL JOURNAL, vol. 466, no. 2, 1 March 2015 (2015-03-01), GB , pages 337 - 346, XP055540874, ISSN: 0264-6021, DOI: 10.1042/BJ20140933
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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