Title:
N-SUBSTITUTED QUINOLINONE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/186023
Kind Code:
A1
Abstract:
The present invention belongs to the field of pharmaceutical chemistry. Specifically disclosed are a N-substituted quinolinone compound, a preparation method therefor and pharmaceutical use thereof. The compound of the present invention has a structure represented by formula (I), has excellent oil solubility, has a multi-target effect on the 5-HT 2A receptor, the dopamine D 2/3 receptor, the 5-HT 1A receptor and the 5-HT transporter, helps adjust the balance of intracerebral neurotransmitters, has relatively good efficacy on various diseases of the central nervous system, has few toxic and side effects, is very safe and tolerable, has good general druggability, and has good clinical application prospects.
Inventors:
WU CHUNHUI (CN)
HE YANG (CN)
LI JIAN (CN)
TIAN GUANGHUI (CN)
HE YANG (CN)
LI JIAN (CN)
TIAN GUANGHUI (CN)
Application Number:
PCT/CN2023/085136
Publication Date:
October 05, 2023
Filing Date:
March 30, 2023
Export Citation:
Assignee:
VIGONVITA LIFE SCIENCES CO LTD (CN)
International Classes:
C07D409/12; A61K31/496; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/24
Domestic Patent References:
| WO2011163594A2 | 2011-12-29 | |||
| WO2015131856A1 | 2015-09-11 |
Foreign References:
| CN1839134A | 2006-09-27 | |||
| JP2014162781A | 2014-09-08 | |||
| CN105985330A | 2016-10-05 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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