Title:
N-TERMINAL AND/OR C-TERMINAL CLEAVED SOLUBLE PH20 POLYPEPTIDE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/249408
Kind Code:
A1
Abstract:
The present invention relates to a recombinant PH20 polypeptide in which 1 to 7 amino acid residues have been deleted from the N-terminus of mature animal wild-type PH20, and a use thereof. The PH20 polypeptide, in which enzyme activity and productivity have been increased by deleting the N-terminus and/or C-terminus, provided by the present invention exhibits a higher expression level and greater enzyme activity than existing recombinant PH20 polypeptides, and thus can bring about a reduction in treatment costs resulting from reduced production costs when used industrially.
Inventors:
PARK SOON JAE (KR)
KIM KYUWAN (KR)
YUN SANG HOON (KR)
SONG HYUNG-NAM (KR)
KIM KYUWAN (KR)
YUN SANG HOON (KR)
SONG HYUNG-NAM (KR)
Application Number:
PCT/KR2023/008621
Publication Date:
December 28, 2023
Filing Date:
June 21, 2023
Export Citation:
Assignee:
ALTEOGEN INC (KR)
International Classes:
C12N9/26; C07K14/47
Foreign References:
| KR20220069045A | 2022-05-26 | |||
| US20150010529A1 | 2015-01-08 | |||
| US5721348A | 1998-02-24 | |||
| KR20170065032A | 2017-06-12 | |||
| KR20200130451A | 2020-11-18 |
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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