Title:
N-TERMINAL MULTIFUNCTIONAL CONJUGATION OF PROTEINS AND PEPTIDES FOR BIOSENSING
Document Type and Number:
WIPO Patent Application WO/2024/054632
Kind Code:
A3
Abstract:
In various embodiments alpha helical peptide-based bridges for molecular biosensing "on-chip" are disclosed. The Peptide-based bridges serve as common bridges for great diversity of biosensing applications and targets including nucleic acids, proteins, antigens, antibodies, small molecules. The primary sensor element is preferably a "molecular wire" such as an alpha-helical peptide integrated into a current monitoring circuit. The engineered peptide may contain a central conjugation site for attachment of various probe molecules including nucleic acids, proteins, antigens, antibodies. The probe-containing bridge empowers the sensor to detect interactions with specific target molecules.
Inventors:
RIZO JOSE (US)
SINHA PREM KUMAR (US)
BYRNE-BAILEY KATHRYNE (US)
SIGALA CRUZ LAMBERTO (US)
FULLER CARL (US)
MERRIMAN BARRY (US)
SINHA PREM KUMAR (US)
BYRNE-BAILEY KATHRYNE (US)
SIGALA CRUZ LAMBERTO (US)
FULLER CARL (US)
MERRIMAN BARRY (US)
Application Number:
PCT/US2023/032293
Publication Date:
April 11, 2024
Filing Date:
September 08, 2023
Export Citation:
Assignee:
ROSWELL ME INC (US)
International Classes:
G01N27/327; C07K19/00; C12Q1/68; C12Q1/6869; G01N27/26
Attorney, Agent or Firm:
SALEHI, Dianoosh (US)
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