Title:
N1-BENZO[1,3]DIOXOL-5-YLMETHYL-N2-SUBSTITUTED BIGUANIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2010/044581
Kind Code:
A2
Abstract:
The present invention relates to an N1-benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative expressed in chemical formula 1, to a pharmaceutically acceptable salt thereof, to a preparation method thereof, and to a pharmaceutical composition containing the same as an active ingredient. The N1-benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative of the present invention shows superior hypoglycemic action and superior hypolipidemic action even at a lower dosage as compared with conventional drugs, and thus can be used for the prevention and treatment of metabolic syndrome disorders such as diabetes, non-insulin-dependent diabetes, obesity, arteriosclerosis, and the like, or cancer involving P53 gene deficiency.
Inventors:
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
CHEON HYAE GYEONG (KR)
KIM KWANG ROK (KR)
RHEE SANG DAL (KR)
JUNG WON HOON (KR)
LEE JONG CHEOL (KR)
JUN SUNG SOO (KR)
CHEON HYAE GYEONG (KR)
KIM KWANG ROK (KR)
RHEE SANG DAL (KR)
JUNG WON HOON (KR)
LEE JONG CHEOL (KR)
Application Number:
PCT/KR2009/005855
Publication Date:
April 22, 2010
Filing Date:
October 13, 2009
Export Citation:
Assignee:
HANALL PHARMACEUTICAL CO LTD (KR)
KOREA RES INST CHEM TECH (KR)
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
CHEON HYAE GYEONG (KR)
KIM KWANG ROK (KR)
RHEE SANG DAL (KR)
JUNG WON HOON (KR)
LEE JONG CHEOL (KR)
KOREA RES INST CHEM TECH (KR)
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
CHEON HYAE GYEONG (KR)
KIM KWANG ROK (KR)
RHEE SANG DAL (KR)
JUNG WON HOON (KR)
LEE JONG CHEOL (KR)
International Classes:
C07D317/48
Foreign References:
| US3531499A | 1970-09-29 | |||
| US5376686A | 1994-12-27 | |||
| US20040116428A1 | 2004-06-17 |
Attorney, Agent or Firm:
JANG, Seongku et al. (Trust Tower #275-7,Yangjae-dong, Seocho-ku, Seoul 137-130, KR)
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