Title:
N4-ISOBUTYRYLOXYCYTIDINE ANALOG SYNTHESIS AND COMPOSITION FOR TREATING VIRAL INFECTION COMPRISING ANTI-VIRAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/167382
Kind Code:
A1
Abstract:
The present invention relates to N
4-isobutyryloxycytidine analog synthesis and to the anti-viral use thereof against dengue virus, influenza virus, and SARS-CoV-2 virus.
Inventors:
CHO JONG HYUN (KR)
AN YEON JIN (KR)
CHOI SEMYEONG (KR)
CHOI EUN RANG (KR)
NAM YE EUN (KR)
SEO EUN WOO (KR)
AN YEON JIN (KR)
CHOI SEMYEONG (KR)
CHOI EUN RANG (KR)
NAM YE EUN (KR)
SEO EUN WOO (KR)
Application Number:
PCT/KR2022/013638
Publication Date:
September 07, 2023
Filing Date:
September 13, 2022
Export Citation:
Assignee:
UNIV DONG A RES FOUND FOR IND ACAD COOP (KR)
International Classes:
C07H19/067; A61K31/7068; A61P31/14; A61P31/16
Foreign References:
KR20170123308A | 2017-11-07 | |||
CN111548384A | 2020-08-18 |
Other References:
PAYMODE DINESH J., VASUDEVAN N., AHMAD SAEED, KADAM APPASAHEB L., CARDOSO FLAVIO S.P., BURNS JUSTINA M., COOK DANIEL W., STRINGHAM: "Toward a Practical, Two-Step Process for Molnupiravir: Direct Hydroxamination of Cytidine Followed by Selective Esterification", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 25, no. 8, 20 August 2021 (2021-08-20), US , pages 1822 - 1830, XP093038654, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.1c00033
IVANOV MAKSIM A., ANTONOVA ELENA V., MAKSIMOV ALEKSEY V., PIGUSOVA LYUDMILA K., BELANOV EVGENII F., ALEKSANDROVA LYUDMILA A.: "New N4-Hydroxycytidine Derivatives: Synthesis and Antiviral Activity", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 71, no. 7, 1 January 2006 (2006-01-01), pages 1099 - 1106, XP093066626, ISSN: 0010-0765, DOI: 10.1135/cccc20061099
YEON JIN AN: "MEDI.P-554 Synthesis and evaluation of β-D-N4-hydroxycytidine (NHC) prodrugs against SARS-Cov-2 in vitro", 128TH GENERAL MEETING OF THE KOREAN CHEMICAL SOCIETY; 13-15 OCTOBER 2021, KOREAN CHEMICAL SOCIETY, KOREA, 1 January 2021 (2021-01-01) - 15 October 2021 (2021-10-15), Korea, XP009551559
AN, Y. K. et al. Modification and evaluation of β-D-N4-hydroxycytidine (NHC) prodrugs against SARS-Cov-2. 2021, 제24회 한국유기합성학회 학술대회 및 정기 총회 (2021 the 24th Korean Society of Organic Synthesis Conference and Annual Meeting.)
IVANOV MAKSIM A., ANTONOVA ELENA V., MAKSIMOV ALEKSEY V., PIGUSOVA LYUDMILA K., BELANOV EVGENII F., ALEKSANDROVA LYUDMILA A.: "New N4-Hydroxycytidine Derivatives: Synthesis and Antiviral Activity", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 71, no. 7, 1 January 2006 (2006-01-01), pages 1099 - 1106, XP093066626, ISSN: 0010-0765, DOI: 10.1135/cccc20061099
YEON JIN AN: "MEDI.P-554 Synthesis and evaluation of β-D-N4-hydroxycytidine (NHC) prodrugs against SARS-Cov-2 in vitro", 128TH GENERAL MEETING OF THE KOREAN CHEMICAL SOCIETY; 13-15 OCTOBER 2021, KOREAN CHEMICAL SOCIETY, KOREA, 1 January 2021 (2021-01-01) - 15 October 2021 (2021-10-15), Korea, XP009551559
AN, Y. K. et al. Modification and evaluation of β-D-N4-hydroxycytidine (NHC) prodrugs against SARS-Cov-2. 2021, 제24회 한국유기합성학회 학술대회 및 정기 총회 (2021 the 24th Korean Society of Organic Synthesis Conference and Annual Meeting.)
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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