Title:
NERVE CELL STIMULATOR COMPRISING IgG AND/OR Fc FRAGMENT OF IgG
Document Type and Number:
WIPO Patent Application WO/2010/058517
Kind Code:
A1
Abstract:
Disclosed are a pharmaceutical or food composition for improving a memory/learning ability by a convenient and safe means and a method for improving a memory/learning ability. Specifically disclosed is a nerve cell stimulator comprising an effective amount of an IgG and/or a Fc fragment of an IgG. The IgG is preferably derived from a whey protein. A pharmaceutical or food composition containing the nerve cell stimulator can improve a memory/learning ability, and is expected to exhibit a wide varieties of effects including the treatment or prevention of aging-related diseases such as ischemic reperfusion injury of the liver, the formation of stress-induced gastric mucosal lesions, cardiovascular disorders, diabetes, apoptosis-related diseases and Alzheimer's disease, the improvement or prevention of aging of skin, and/or hair growth.
Inventors:
YOKOYAMA MINEHIKO (JP)
ASAMI YUKIO (JP)
UCHIDA MASAYUKI (JP)
KINO KOHSUKE (JP)
ASAMI YUKIO (JP)
UCHIDA MASAYUKI (JP)
KINO KOHSUKE (JP)
Application Number:
PCT/JP2009/005291
Publication Date:
May 27, 2010
Filing Date:
October 09, 2009
Export Citation:
Assignee:
MEIJI DAIRIES CORP (JP)
YOKOYAMA MINEHIKO (JP)
ASAMI YUKIO (JP)
UCHIDA MASAYUKI (JP)
KINO KOHSUKE (JP)
YOKOYAMA MINEHIKO (JP)
ASAMI YUKIO (JP)
UCHIDA MASAYUKI (JP)
KINO KOHSUKE (JP)
International Classes:
A61K39/395; A23L1/305; A61K8/64; A61P1/04; A61P1/16; A61P3/10; A61P9/00; A61P17/00; A61P25/02; A61P25/28; A61Q7/00
Domestic Patent References:
| WO2009035055A1 | 2009-03-19 | |||
| WO1998022138A1 | 1998-05-28 |
Foreign References:
| JP2008179572A | 2008-08-07 | |||
| JPH03128329A | 1991-05-31 | |||
| JPH06189787A | 1994-07-12 |
Other References:
RAMSEY, M.M. ET AL.: "Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus", J NEUROPHYSIOL, vol. 94, no. 1, 2005, pages 247 - 254
SVENSSON, J. ET AL.: "Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice", J ENDOCRINOL, vol. 189, no. 3, 2006, pages 617 - 627
YUTAKA MASUDA ET AL.: "ddY Mouse ni Okeru Gakushu Shogai Model to IgG", EXP ANIM, vol. 42, no. 3, 1993, pages 421 - 425
HARADA, N. ET AL.: "BOVINE COLOSTRUM IMPROVES COGNITIVE FUNCTION IN MICE BY INCREASING THE PRODUCTION OF INSULIN-LIKE GROWTH FACTOR-1 IN THE HIPPOCAMPUS", THE 50TH ANNUAL MEETING OF THE EUROPEAN SOCIETY FOR PEDIATRIC RESEARCH (DENSHI-BAN SHOROKUSHU) REF, NO. A-142-0000-00452, 10 August 2009 (2009-08-10)
SVENSSON, J. ET AL.: "Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice", J ENDOCRINOL, vol. 189, no. 3, 2006, pages 617 - 627
YUTAKA MASUDA ET AL.: "ddY Mouse ni Okeru Gakushu Shogai Model to IgG", EXP ANIM, vol. 42, no. 3, 1993, pages 421 - 425
HARADA, N. ET AL.: "BOVINE COLOSTRUM IMPROVES COGNITIVE FUNCTION IN MICE BY INCREASING THE PRODUCTION OF INSULIN-LIKE GROWTH FACTOR-1 IN THE HIPPOCAMPUS", THE 50TH ANNUAL MEETING OF THE EUROPEAN SOCIETY FOR PEDIATRIC RESEARCH (DENSHI-BAN SHOROKUSHU) REF, NO. A-142-0000-00452, 10 August 2009 (2009-08-10)
Attorney, Agent or Firm:
KUZUWA, Kiyoshi (JP)
Seiji Kuzuwa (JP)
Seiji Kuzuwa (JP)
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