NOVEL DIBENZ[b,e]OXEPIN DERIVATIVES

WIPO Patent Application WO/1990/003373

A1

The invention provides dibenz[b,e]oxepin derivatives represented by general formula (I), wherein R1 and R2 each represent a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, one of R3 and R4 is a group represented by general formula (II), [wherein R5 represents a hydrogen atom or a lower alkyl group, A represents a hydroxy group, -O(CH2)m-R6 (wherein m represents an integer of 1 to 6 and R6 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a 5- or 6-membered cyclic amino group or a lower alkoxycarbonyl group), a 5- or 6-membered cyclic amino group, a di(lower alkyl)-amino group or -NH(CH2)n-R7 (wherein n represents an integer of 0 to 3, and R7 represents a hydrogen atom, a hydroxy group, a phenyl group, a thiazole group or a 5- or 6-membered cyclic amino group)] and the other represents a lower alkoxy group.

SAITA MASARU (JP)
INOUE HISATAKA (JP)
HACHIYA TERUMI (JP)
NAKASHIMA MIKIO (JP)
YAHIRO SHIGENORI (JP)
TANIGUCHI YASUAKI (JP)
DEGUCHI YOSHIKI (JP)
HAMANAKA SHOJI (JP)
TSUJI MASAYOSHI (JP)
NODA KANJI (JP)

PCT/JP1989/000932

April 05, 1990

September 12, 1989

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HISAMITSU PHARMACEUTICAL CO (JP)

C07D313/12; C07D417/12; (IPC1-7): C07D313/12; A61K31/335; A61K31/425; C07D417/12

JPS5035179A	1975-04-03
JPS5058084A	1975-05-20
JPS5532708B2	1980-08-26
JPS5821679A	1983-02-08

JOURNAL OF MEDICINAL CHEM., vol. 19, no. 7, 1976, pages 941 - 946
ARCH. INT. PHARMACODYN., vol. 227, 1977, pages 142 - 154
See also references of EP 0436025A4

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