Title:
NOVEL PROCESS FOR PRODUCING DIBENZO[b,f]THIEPINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/003827
Kind Code:
A1
Abstract:
A process for producing diaryl sulfide derivatives useful as intermediates for medicinal compounds and a process for producing dibenzo[b,f]thiepine derivatives by using the intermediates. A halogen-substituted phenyl derivative represented by general formula (1) (wherein X is halogeno and R¿1? to R¿5? each is hydrogen, lower alkyl, lower cycloalkyl, aryl, halogeno, lower alkoxy, amino, lower N-acylamino, nitro, lower alkylthio, or carboxy) is reacted in the presence of a metal catalyst with a disulfide derivative represented by general formula (2) (wherein R¿6? to R¿10? have the same meaning as R¿1? to R¿5?) to give a diaryl sulfide derivative represented by general formula (3) or a salt thereof. The diaryl sulfide derivative or its salt gives benzo[b,f]thiepine derivatives as medicinal compounds by known techniques.
Inventors:
OHTSUKA NAOMI (JP)
JINNO SHUJI (JP)
OKITA TAKAAKI (JP)
JINNO SHUJI (JP)
OKITA TAKAAKI (JP)
Application Number:
PCT/JP1998/003129
Publication Date:
January 28, 1999
Filing Date:
July 13, 1998
Export Citation:
Assignee:
NIPPON SUISAN KAISHA LTD (JP)
OHTSUKA NAOMI (JP)
JINNO SHUJI (JP)
OKITA TAKAAKI (JP)
OHTSUKA NAOMI (JP)
JINNO SHUJI (JP)
OKITA TAKAAKI (JP)
International Classes:
C07C319/14; C07D337/14; C07C323/62; (IPC1-7): C07C319/14; B01J23/72; B01J27/122; B01J31/24; C07C321/30; C07C323/09; C07D337/14
Domestic Patent References:
| WO1997025985A1 | 1997-07-24 |
Foreign References:
| JPS617249A | 1986-01-13 | |||
| JPH0899953A | 1996-04-16 | |||
| JPH02262554A | 1990-10-25 | |||
| JPH07224028A | 1995-08-22 |
Attorney, Agent or Firm:
Sudou, Asako (Kajino-cho 5-chome Koganei-shi Tokyo, JP)
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