NOVEL Sin3 MODULATOR AND MEDICAL APPLICATION THEREOF

WIPO Patent Application WO/2019/044844

A1

The present invention provides a drug for the prevention and/or treatment of mental illness, the drug including as an active ingredient a Sin3 modulator, in particular the following compound or a pharmacologically acceptable salt thereof. This drug for the prevention and/or treatment of mental illness is especially useful in mental illnesses such as ASD, depression, and epilepsy.

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HASHIMOTO HITOSHI (JP)
AGO YUKIO (JP)
KAWASE HARUKI (JP)
KOUJI HIROYUKI (JP)
MISHINA TADASHI (JP)
KASAI MASAJI (JP)
YOSHIMORI ATSUSHI (JP)
NISHIMURA YOSHIFUMI (JP)
KURITA JUNICHI (JP)
HIRAO YUKA (JP)

PCT/JP2018/031791

March 07, 2019

August 28, 2018

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PRISM BIOLAB CO LTD (JP)

A61K45/00; A61K31/5395; A61P25/00; A61P25/08; A61P25/24; A61P43/00; C07D498/04

WO2011099502A1

2011-08-18

JP2012505153A

2012-03-01

CONFORTI, P. ET AL.: "Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models", JOURNAL OF NEUROCHEMISTRY, vol. 127, 2013, pages 22 - 35, XP055581841, ISSN: 1471-4159
UEDA, H. ET AL.: "A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 27, September 2017 (2017-09-01), pages 4705 - 4709, XP085203715, ISSN: 0960-894X, DOI: doi:10.1016/j.bmcl.2017.09.006

TAKASHIMA, Hajime et al. (JP)

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