Title:
NANO MATERIAL FOR OSTEOCLAST ACIDIC CLOSED REGION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/203434
Kind Code:
A1
Abstract:
Disclosed are a nano material for an osteoclast acidic closed region and a preparation method therefor. The nano material for an osteoclast acidic closed region comprises a nano material, bone-targeting molecules and a compound which causes an osteoclast acidic closed region to undergo a chemical reaction. After the nano material is subjected to bone targeting molecular modification, a compound which causes an osteoclast acidic region to undergo a chemical reaction is entrapped; and osteoclasts are inhibited by means of accurate mature osteoclast targeting and a biological cascade reaction regulated by a physiological chemical reaction. A new way of thinking and a new tool are provided for the pharmaceutical treatment of abnormal osteoclast activation.
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Inventors:
LIN XIAN FENG (CN)
GU CHEN HUI (CN)
WANG QING QING (CN)
FAN SHUN WU (CN)
GU CHEN HUI (CN)
WANG QING QING (CN)
FAN SHUN WU (CN)
Application Number:
PCT/CN2020/084300
Publication Date:
October 14, 2021
Filing Date:
April 10, 2020
Export Citation:
Assignee:
SIR RUN RUN SHAW HOSPITAL ZHEJIANG UNIV SCHOOL OF MEDICINE (CN)
International Classes:
A61K47/69; A61K33/00; A61K47/54; A61P19/10
Foreign References:
| CN111481678A | 2020-08-04 | |||
| CN109125292A | 2019-01-04 | |||
| CN109517163A | 2019-03-26 | |||
| CN101541347A | 2009-09-23 |
Other References:
XIE YONGHUI; LIU CHENCHEN; HUANG HONGWEI; HUANG JIAN; DENG AIPING; ZOU PING; TAN XUEYING: "Bone-targeted delivery of simvastatin-loaded PEG-PLGA micelles conjugated with tetracycline for osteoporosis treatment", DRUG DELIVERY AND TRANSLATIONAL RESEARCH, SPRINGER, GERMANY, vol. 8, no. 5, 19 July 2018 (2018-07-19), Germany , pages 1090 - 1102, XP036578466, ISSN: 2190-393X, DOI: 10.1007/s13346-018-0561-1
KATO KOHTARO, MATSUSHITA MISAO: "Proton concentrations can be a major contributor to the modification of osteoclast and osteoblast differentiation, working independently of extracellular bicarbonate ions", JOURNAL OF BONE AND MINERAL METABOLISM, SPRINGER, TOKYO, JP, vol. 32, no. 1, 1 January 2014 (2014-01-01), JP , pages 17 - 28, XP055856780, ISSN: 0914-8779, DOI: 10.1007/s00774-013-0462-9
KATO KOHTARO, MATSUSHITA MISAO: "Proton concentrations can be a major contributor to the modification of osteoclast and osteoblast differentiation, working independently of extracellular bicarbonate ions", JOURNAL OF BONE AND MINERAL METABOLISM, SPRINGER, TOKYO, JP, vol. 32, no. 1, 1 January 2014 (2014-01-01), JP , pages 17 - 28, XP055856780, ISSN: 0914-8779, DOI: 10.1007/s00774-013-0462-9
Attorney, Agent or Firm:
HANGZHOU JUNDU PATENT FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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