Title:
NANO MICROSPHERE FOR IMPROVING ORAL BIOAVAILABILITY OF CHITOSAN OLIGOSACCHARIDE, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/184828
Kind Code:
A1
Abstract:
Provided are a chitosan oligosaccharide nano microsphere and a preparation method therefor. The method comprises: preparing a sodium alginate aqueous solution, a chitosan oligosaccharide aqueous solution and a calcium chloride aqueous solution as aqueous phases, adding the sodium alginate aqueous solution into an oil phase, after high-pressure homogenization, adding the chitosan oligosaccharide aqueous solution, after high-pressure homogenization again, adding the calcium chloride aqueous solution, stirring and curing, and then freeze-drying to obtain the nano microsphere. The particle size of the prepared nano microsphere is about 800 nm, the drug loading rate is 15.63%, and the entrapment efficiency is 30.05%. Compared with the chitosan oligosaccharide which is not microspherized, the bioavailability is improved.
Inventors:
SHI JINSONG (CN)
LIU PENG (CN)
LI HENG (CN)
GONG JINSONG (CN)
JIANG MIN (CN)
XU ZHENGHONG (CN)
ZHANG CHAO (CN)
DING ZHENZHONG (CN)
XU JUNSHAN (CN)
GAO XIAOYAN (CN)
LIU PENG (CN)
LI HENG (CN)
GONG JINSONG (CN)
JIANG MIN (CN)
XU ZHENGHONG (CN)
ZHANG CHAO (CN)
DING ZHENZHONG (CN)
XU JUNSHAN (CN)
GAO XIAOYAN (CN)
Application Number:
PCT/CN2022/113196
Publication Date:
October 05, 2023
Filing Date:
August 18, 2022
Export Citation:
Assignee:
YANGZHOU RIXING BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K31/7016; A61K9/52; A61K31/702; A61K31/722; A61K47/36; A61P1/00; A61P3/06; A61P3/10; A61P35/00; A61P37/04; A61P39/06
Domestic Patent References:
| WO2017107628A1 | 2017-06-29 |
Foreign References:
| CN112755239A | 2021-05-07 | |||
| CN106334191A | 2017-01-18 | |||
| CN105694120A | 2016-06-22 | |||
| CN102516405A | 2012-06-27 | |||
| CN103520139A | 2014-01-22 |
Other References:
YI-YONG LANG, LI ZHENG,ZHANG XIAO-LI,WANG QIANG: "Preparation of Chitosan-alginate Microsphere Carriers ", JIEFANGJUN YAOXUE XUEBAO - PHARMACEUTICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY, ZHONGGUO RENMIN JIEFANGJUN, ZONGHOUQINBU, WEISHENGBU, YAOPIN YIQI JIANYANSUO, CN, vol. 28, no. 5, 20 October 2012 (2012-10-20), CN , pages 432 - 435, XP093095246, ISSN: 1008-9926, DOI: 10.3969/j.issn.1008-9926.2012.05.17
FENGHONG LI, XIANG LIYING, XUAN TIANYI, CHEN XU, ZHANG MENG: "Preparation of sodium alginate/chitosan nanosphere in reverse emulsion", NEW CHEMICAL MATERIALS, vol. 44, no. 12, 15 December 2016 (2016-12-15), pages 106 - 108, XP093095248
FENGHONG LI, XIANG LIYING, XUAN TIANYI, CHEN XU, ZHANG MENG: "Preparation of sodium alginate/chitosan nanosphere in reverse emulsion", NEW CHEMICAL MATERIALS, vol. 44, no. 12, 15 December 2016 (2016-12-15), pages 106 - 108, XP093095248
Attorney, Agent or Firm:
BEIJING ZHUANYING PATENT AGENCY CO., LTD. (CN)
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