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Title:
NANO-SILVER/DOUBLE-MODIFIED CHITOSAN ANTIBACTERIAL HYDROGEL DRESSING INDICATING WOUND INFECTION CONDITION BY MEANS OF COLOR-CHANGING EFFECT AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/087864
Kind Code:
A1
Abstract:
A nano-silver/double-modified chitosan antibacterial hydrogel dressing indicating a wound infection condition by means of a color-changing effect and a preparation method therefor. The preparation method for the hydrogel dressing comprises: firstly, carrying out quaternization water-soluble modification by using chitosan with a high molecular weight, and further carrying out catecholation water-soluble modification to prepare double-water-soluble modified chitosan; then reducing silver nitrate by using the double-water-soluble modified chitosan to prepare a nano-silver/double-water-soluble modified chitosan solution; and finally, sequentially adding the double-water-soluble modified chitosan, the nano-silver/double-water-soluble modified chitosan, curcumin, a zwitter-ion, acrylamide, a cross-linking agent and an initiator to deionized water, mixing and stirring same until uniform, followed by centrifugal defoaming and pouring, and reacting same by means of a one-pot in-situ free radical polymerization method to prepare a nano-silver/double-modified chitosan antibacterial color-changing hydrogel dressing. The nano-silver/double-modified chitosan antibacterial color-changing hydrogel dressing shows a huge application potential in the fields of intelligent indication-type wound repair hydrogel dressings, etc.

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Inventors:
JIN XIAOQIANG (CN)
YE ZHAOMING (CN)
BAO XIAOJIONG (CN)
TENG WANGSIYUAN (CN)
Application Number:
PCT/CN2022/117686
Publication Date:
May 25, 2023
Filing Date:
September 08, 2022
Export Citation:
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Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61L26/00; C08B37/08
Domestic Patent References:
WO2012143788A12012-10-26
Foreign References:
CN113975458A2022-01-28
CN109260509A2019-01-25
CN109663146A2019-04-23
CN105478792A2016-04-13
CN112007209A2020-12-01
CN106729940A2017-05-31
CN102552964A2012-07-11
CN108524999A2018-09-14
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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