Title:
NANOASSEMBLIES BASED ON CURCUMIN OR CURCUMIN DERIVATIVES, AND METHOD FOR PRODUCING SAID NANOASSEMBLIES
Document Type and Number:
WIPO Patent Application WO/2023/223244
Kind Code:
A1
Abstract:
The present invention relates to a nanoassembly formed by the self-assembly of a compound selected from compounds of formula (Ia): [Chem. 6], R representing an alkyl group; and compounds of formula (Ib): [Chem. 7], the compound of formula (Ib) being associated with at least one superparamagnetic nanoparticle.
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Inventors:
LARTIGUE LÉNAÏC (FR)
COUPEAU MARINA (FR)
DESSAL CAROLINE (FR)
CHAUVET MAËLA (FR)
COUPEAU MARINA (FR)
DESSAL CAROLINE (FR)
CHAUVET MAËLA (FR)
Application Number:
PCT/IB2023/055093
Publication Date:
November 23, 2023
Filing Date:
May 17, 2023
Export Citation:
Assignee:
UNIV NANTES (FR)
CENTRE NAT RECH SCIENT (FR)
CENTRE NAT RECH SCIENT (FR)
International Classes:
A61K31/12; A61K9/00; A61K9/51; A61K31/166; A61K33/26; A61K41/00; A61K47/30; A61K47/69; A61K49/08; A61K49/10; A61K49/18; A61P29/00; A61P35/00
Other References:
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MANCARELLA SERENA ET AL: "Polymer-Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells : Polymer-Coated Magnetic Nanoparticles for Curcumin...", MACROMOLECULAR BIOSCIENCE, vol. 15, no. 10, 17 June 2015 (2015-06-17), DE, pages 1365 - 1374, XP093018396, ISSN: 1616-5187, DOI: 10.1002/mabi.201500142
XU QIU ET AL: "Synthesis and Identification of New 4-Arylidene Curcumin Analogues as Potential Anticancer Agents Targeting Nuclear Factor-κB Signaling Pathway", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 23, 9 December 2010 (2010-12-09), pages 8260 - 8273, XP055152779, ISSN: 0022-2623, DOI: 10.1021/jm1004545
HOSHYAR, N.GRAY, S.HAN, H.BAO, G: "The Effect of Nanoparticle Size on in Vivo Pharmacokinetics and Cellular Interaction", NANOMED, vol. 11, no. 6, 2016, pages 673 - 692
ZHANG, S.LI, J.LYKOTRAFITIS, G.BAO, G.SURESH, S: "Size-Dependent Endocytosis of Nanoparticles", ADV. MATER., vol. 21, no. 4, 2009, pages 419 - 424
LU, F.WU, S.-H.HUNG, Y.MOU, C.-Y: "Size Effect on Cell Uptake in Well-Suspended, Uniform Mesoporous Silica Nanoparticles", SMALL, vol. 5, no. 12, 2009, pages 1408 - 1413
XU, W.ZHOU, M.GUO, Z.LIN, S.LI, M.KANG, Q.XU, Y.ZHANG, X.XIE, J.: "Impact of Macroporous Silica Nanoparticles at Sub-50nm on Bio-Behaviors and Biosafety in Drug-Resistant Cancer Models", COLLOIDS SURF. B BIOINTERFACES, vol. 206, 2021, pages 111912
JIANG, W.KIM, B. Y. S.RUTKA, J. T.CHAN, W. C. W: "Nanoparticle-Mediated Cellular Response Is Size-Dependent", NAT. NANOTECHNOL., vol. 3, no. 3, 2008, pages 145 - 150, XP037569886, DOI: 10.1038/nnano.2008.30
TPNNESEN, H. H.KARLSEN, J: "Studies on Curcumin and Curcuminoids", Z. FÜR LEBENSM.-UNTERS. FORSCH., vol. 180, no. 2, 1985, pages 132 - 134
KURIEN, B. T.SINGH, A.MATSUMOTO, H.SCOFIELD, R. H.: "Improving the Solubility and Pharmacological Efficacy of Curcumin by Heat Treatment", ASSAY DRUG DEV. TECHNOL., vol. 5, no. 4, 2007, pages 567 - 576, XP055427736, DOI: 10.1089/adt.2007.064
J.V. JOKERSTT. LOBOVKINAR.N. ZARES. GAMBHIR: "Nanoparticle PE-Gylation for imaging and therapy", NANOMEDICINE (LOND), vol. 6, no. 4, 2011, pages 715 - 28
MANCARELLA SERENA ET AL: "Polymer-Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells : Polymer-Coated Magnetic Nanoparticles for Curcumin...", MACROMOLECULAR BIOSCIENCE, vol. 15, no. 10, 17 June 2015 (2015-06-17), DE, pages 1365 - 1374, XP093018396, ISSN: 1616-5187, DOI: 10.1002/mabi.201500142
XU QIU ET AL: "Synthesis and Identification of New 4-Arylidene Curcumin Analogues as Potential Anticancer Agents Targeting Nuclear Factor-κB Signaling Pathway", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 23, 9 December 2010 (2010-12-09), pages 8260 - 8273, XP055152779, ISSN: 0022-2623, DOI: 10.1021/jm1004545
HOSHYAR, N.GRAY, S.HAN, H.BAO, G: "The Effect of Nanoparticle Size on in Vivo Pharmacokinetics and Cellular Interaction", NANOMED, vol. 11, no. 6, 2016, pages 673 - 692
ZHANG, S.LI, J.LYKOTRAFITIS, G.BAO, G.SURESH, S: "Size-Dependent Endocytosis of Nanoparticles", ADV. MATER., vol. 21, no. 4, 2009, pages 419 - 424
LU, F.WU, S.-H.HUNG, Y.MOU, C.-Y: "Size Effect on Cell Uptake in Well-Suspended, Uniform Mesoporous Silica Nanoparticles", SMALL, vol. 5, no. 12, 2009, pages 1408 - 1413
XU, W.ZHOU, M.GUO, Z.LIN, S.LI, M.KANG, Q.XU, Y.ZHANG, X.XIE, J.: "Impact of Macroporous Silica Nanoparticles at Sub-50nm on Bio-Behaviors and Biosafety in Drug-Resistant Cancer Models", COLLOIDS SURF. B BIOINTERFACES, vol. 206, 2021, pages 111912
JIANG, W.KIM, B. Y. S.RUTKA, J. T.CHAN, W. C. W: "Nanoparticle-Mediated Cellular Response Is Size-Dependent", NAT. NANOTECHNOL., vol. 3, no. 3, 2008, pages 145 - 150, XP037569886, DOI: 10.1038/nnano.2008.30
TPNNESEN, H. H.KARLSEN, J: "Studies on Curcumin and Curcuminoids", Z. FÜR LEBENSM.-UNTERS. FORSCH., vol. 180, no. 2, 1985, pages 132 - 134
KURIEN, B. T.SINGH, A.MATSUMOTO, H.SCOFIELD, R. H.: "Improving the Solubility and Pharmacological Efficacy of Curcumin by Heat Treatment", ASSAY DRUG DEV. TECHNOL., vol. 5, no. 4, 2007, pages 567 - 576, XP055427736, DOI: 10.1089/adt.2007.064
J.V. JOKERSTT. LOBOVKINAR.N. ZARES. GAMBHIR: "Nanoparticle PE-Gylation for imaging and therapy", NANOMEDICINE (LOND), vol. 6, no. 4, 2011, pages 715 - 28
Attorney, Agent or Firm:
CABINET CHAILLOT (FR)
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