Title:
NANOCARRIER HAVING MICELLAR STRUCTURE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/242147
Kind Code:
A1
Abstract:
The present invention relates to a nanocarrier having a micellar structure, and a use thereof, and more specifically, to: a nanosome having a monolayer structure for delivering macromolecules; a drug carrier thereof; a contrast agent thereof; and a use thereof as a composition for treatment. The nanosome, according to the present invention, has excellent cell permeability and blood-brain barrier permeability, and exhibits an excellent intracellular material delivery effect. Further, the size of the nanosome may be easily adjusted by adjusting the length of an alkyl chain of fatty acid, and an optimal condition for improving material delivery efficiency may be configured by adjusting the molarity between the fatty acid and a lipopeptide constituting the nanosome, or the molarity between the lipopeptide and an encapsulated material. Thus, the nanosome, according to the present invention, may be usefully employed in basic research and clinical fields as a drug delivery system which enables conventional limitations to be overcome.
Inventors:
KIM YONG HO (KR)
SUH MINAH (KR)
KANG EUN SUNG (KR)
NAM JI YOUNG (KR)
LEE BOK SOO (KR)
BAE DO HYUN (KR)
KIM HAN JOO (KR)
LEE JAE CHEOL (KR)
LEE EUNA (KR)
THACH TRUNG THANH (KR)
SUH MINAH (KR)
KANG EUN SUNG (KR)
NAM JI YOUNG (KR)
LEE BOK SOO (KR)
BAE DO HYUN (KR)
KIM HAN JOO (KR)
LEE JAE CHEOL (KR)
LEE EUNA (KR)
THACH TRUNG THANH (KR)
Application Number:
PCT/KR2020/006713
Publication Date:
December 03, 2020
Filing Date:
May 22, 2020
Export Citation:
Assignee:
IMNEWRUN BIOSCIENCES INC (KR)
International Classes:
A61K9/107; A61K47/12; A61K47/42; A61K49/00; A61K51/12
Foreign References:
| US20050032722A1 | 2005-02-10 | |||
| KR20140046994A | 2014-04-21 |
Other References:
LEHTO, T.: "Saturated fatty acid analogues of cell -penetrating peptide PepFectl4: role of fatty acid modification in complexation and delivery of splice-correcting oligonucleotides", BIOCONJUGATE CHEMISTRY, vol. 28, 2017, pages 782 - 792, XP055764380
MOUT, R. ET AL.: "Direct cytosolic delivery of CRISPR/Cas9-ribonucleoprotein for efficient gene editing", ACS NANO, November 2017 (2017-11-01), pages 24 52 - 2458, XP055675446
TESAURO, D: "Peptide-based drug-delivery systems in biotechnological applications: recent advances and perspectives", MOLECULES, vol. 24, no. 351, 19 January 2019 (2019-01-19), pages 1 - 27, XP055764384
THACH, T. T.: "Lipopeptide-Based Nanosome-Mediated Delivery of Hyperaccurate CRISPR/Cas9 Ribonucleoprotein for Gene Editing", SMALL, vol. 15, November 2019 (2019-11-01), XP055764388
MOUT, R. ET AL.: "Direct cytosolic delivery of CRISPR/Cas9-ribonucleoprotein for efficient gene editing", ACS NANO, November 2017 (2017-11-01), pages 24 52 - 2458, XP055675446
TESAURO, D: "Peptide-based drug-delivery systems in biotechnological applications: recent advances and perspectives", MOLECULES, vol. 24, no. 351, 19 January 2019 (2019-01-19), pages 1 - 27, XP055764384
THACH, T. T.: "Lipopeptide-Based Nanosome-Mediated Delivery of Hyperaccurate CRISPR/Cas9 Ribonucleoprotein for Gene Editing", SMALL, vol. 15, November 2019 (2019-11-01), XP055764388
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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