NANOCLUSTERS FUNCTIONALIZED WITH ADENOSINE TRIPHOSPHATE OR AN ANALOGUE AND THEIR USE

Title:

NANOCLUSTERS FUNCTIONALIZED WITH ADENOSINE TRIPHOSPHATE OR AN ANALOGUE AND THEIR USE

Document Type and Number:

WIPO Patent Application WO/2024/044636

Kind Code:

A3

Abstract:

Compositions, methods, and kits are provided for treating infections and cancer with metallic nanoclusters. In particular, metallic nanoclusters having a size of less than 10 nm that are conjugated to adenosine triphosphate (ATP) or an analogue thereof can be used to eradicate a cell in a growth arrest phase such as infectious bacterial or fungal cells. Such nanoclusters can also induce endoplasmic reticulum stress and inhibit growth of cancerous cells. Additionally, such metallic nanoclusters can be used to inhibit a purinergic P2X7 receptor and FtsH protease.

Inventors:

BEKALE LAURENT (US)
SANTA-MARIA PETER LUKE (US)

Application Number:

PCT/US2023/072735

Publication Date:

May 16, 2024

Filing Date:

August 23, 2023

Export Citation:

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Assignee:

UNIV LELAND STANFORD JUNIOR (US)

International Classes:

A61P35/00; A61K9/14; A61K31/7076; A61K47/69; A01N59/16

Attorney, Agent or Firm:

BUCHBINDER, Jenny L. (US)

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