Title:
NANOCOMPOSITE FOR NUCLEIC ACID DRUG DELIVERY USING HIGHLY DISPERSIBLE CELLULOSE NANOCRYSTAL
Document Type and Number:
WIPO Patent Application WO/2022/005178
Kind Code:
A1
Abstract:
The present invention relates to the preparation of cationic cellulose nanocrystals (CNCs) with improved dispersibility and a method for delivering nucleic acid drugs using same.
Inventors:
ROH YOUNG HOON (KR)
LEE YOON SUK (KR)
KIM YOUNG MIN (KR)
LEE YOON SUK (KR)
KIM YOUNG MIN (KR)
Application Number:
PCT/KR2021/008210
Publication Date:
January 06, 2022
Filing Date:
June 29, 2021
Export Citation:
Assignee:
UIF UNIV INDUSTRY FOUNDATION YONSEI UNIV (KR)
International Classes:
A61K48/00; A61K9/51; A61K31/713; A61K47/38; A61K47/69; A61P35/00
Foreign References:
| US20170037155A1 | 2017-02-09 |
Other References:
KIM YOUNG MIN, LEE YOON SUK, KIM TAEHYUNG, YANG KYUNGJIK, NAM KEONWOOK, CHOE DEOKYEONG, ROH YOUNG HOON: "Cationic cellulose nanocrystals complexed with polymeric siRNA for efficient anticancer drug delivery", CARBOHYDRATE POLYMERS, APPLIED SCIENCE PUBLISHERS , LTD BARKING, GB, vol. 247, 1 November 2020 (2020-11-01), GB , pages 116684 - 11, XP055887972, ISSN: 0144-8617, DOI: 10.1016/j.carbpol.2020.116684
"Master Thesis", 1 August 2019, GRADUATE SCHOOL, YONSEI UNIVERSITY DEPARTMENT OF BIOTECHNOLOGY, article LEE YUNSEOK: "Cellulose nanocrystals complexed with polymeric nucleic acid for siRNA delivery", pages: 1 - 81, XP055887992
LI NA, ZHANG HAN, XIAO YI, HUANG YUSHU, XU MENGDA, YOU DONGLEI, LU WEI, YU JIAHUI: "Fabrication of Cellulose-Nanocrystal-Based Folate Targeted Nanomedicine via Layer-by-Layer Assembly with Lysosomal pH-Controlled Drug Release into the Nucleus", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 20, no. 2, 11 February 2019 (2019-02-11), US , pages 937 - 948, XP055887994, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01556
LEE SEUNG-HWAN, HYUN-JI KIM; JIN-CHUL KIM: "Nanocellulose Applications for Drug Delivery : A Review", JOURNAL OF FOREST AND ENVIRONMENTAL SCIENCE, vol. 35, no. 3, 30 September 2019 (2019-09-30), pages 141 - 149, XP055888000, ISSN: 2288-9744, DOI: 10.7747/JFES.2019.35.3.141
"Master Thesis", 1 August 2019, GRADUATE SCHOOL, YONSEI UNIVERSITY DEPARTMENT OF BIOTECHNOLOGY, article LEE YUNSEOK: "Cellulose nanocrystals complexed with polymeric nucleic acid for siRNA delivery", pages: 1 - 81, XP055887992
LI NA, ZHANG HAN, XIAO YI, HUANG YUSHU, XU MENGDA, YOU DONGLEI, LU WEI, YU JIAHUI: "Fabrication of Cellulose-Nanocrystal-Based Folate Targeted Nanomedicine via Layer-by-Layer Assembly with Lysosomal pH-Controlled Drug Release into the Nucleus", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 20, no. 2, 11 February 2019 (2019-02-11), US , pages 937 - 948, XP055887994, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01556
LEE SEUNG-HWAN, HYUN-JI KIM; JIN-CHUL KIM: "Nanocellulose Applications for Drug Delivery : A Review", JOURNAL OF FOREST AND ENVIRONMENTAL SCIENCE, vol. 35, no. 3, 30 September 2019 (2019-09-30), pages 141 - 149, XP055888000, ISSN: 2288-9744, DOI: 10.7747/JFES.2019.35.3.141
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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