Title:
NANOEMULSION COMPRISING IMIDAZOQUINOLINE-BASED MATERIAL AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/147710
Kind Code:
A1
Abstract:
The present invention relates to a nanoemulsion comprising an oil layer comprising imidazoquinoline-based tol-like receptor 7 or 8 agonist and an oil, and a use thereof as an adjuvant and vaccine. According to the present invention, it is possible to provide a vaccine adjuvant in the form of a nanoemulsion that can dissolve an insoluble imidazoquinoline-based material in oil using a dispersion medium material and disperse the oil solution easily and reproducibly in a water-soluble manner.
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Inventors:
LIM YONG TAIK (KR)
KIM SUN-YOUNG (KR)
KIM SUN-YOUNG (KR)
Application Number:
PCT/KR2018/001891
Publication Date:
August 16, 2018
Filing Date:
February 13, 2018
Export Citation:
Assignee:
DANDI BIOSCIENCE INC (KR)
International Classes:
A61K9/107; A61K31/4745; A61K39/00; A61K39/39; A61K47/14; A61K47/44
Foreign References:
| KR20110009157A | 2011-01-27 |
Other References:
HEO, MIN BEOM ET AL.: "Programmed Nanoparticles for Combined Immunomodulation, Antigen Presentation and Tracking of imminunotherapeutic Cells", BIOMATERIALS, vol. 35, 2014, pages 590 - 600, XP028762522
BACHELDER, ERIC M. ET AL.: "In Vitro Analysis of Acetalated Dextran Microparticles as a Potent Delivery Platform for Vaccine Adjuvants", MOLECULAR PHARMACEUTICS, vol. 7, no. 3, 2010, pages 826 - 835, XP055537339
CHEN, QIAN ET AL.: "Photothermal Therapy with Immune-adjuvant Nanoparticles Together with Checkpoint Blockade For Effective Cancer Immunotherapy", NATURE COMMUNICATIONS, vol. 7, 21 October 2016 (2016-10-21), pages 1 - 13, XP055537345
LIN, WENJING ET AL.: "Co-delivery of Imiquimod and Plasmid DNA via an Amphiphilic pH-responsive Star Polymer that Forms Unimolecular Micelles in Water", POLYMERS, vol. 8, 2016, pages 1 - 1 7, XP055537349
BACHELDER, ERIC M. ET AL.: "In Vitro Analysis of Acetalated Dextran Microparticles as a Potent Delivery Platform for Vaccine Adjuvants", MOLECULAR PHARMACEUTICS, vol. 7, no. 3, 2010, pages 826 - 835, XP055537339
CHEN, QIAN ET AL.: "Photothermal Therapy with Immune-adjuvant Nanoparticles Together with Checkpoint Blockade For Effective Cancer Immunotherapy", NATURE COMMUNICATIONS, vol. 7, 21 October 2016 (2016-10-21), pages 1 - 13, XP055537345
LIN, WENJING ET AL.: "Co-delivery of Imiquimod and Plasmid DNA via an Amphiphilic pH-responsive Star Polymer that Forms Unimolecular Micelles in Water", POLYMERS, vol. 8, 2016, pages 1 - 1 7, XP055537349
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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